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Protein

Transportin-2

Gene

Tnpo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Biological processi

  • negative regulation of muscle cell differentiation Source: MGI
  • protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:Tnpo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384849. Tnpo2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Transportin-2PRO_0000120768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei852 – 8521N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LG2.
MaxQBiQ99LG2.
PaxDbiQ99LG2.
PRIDEiQ99LG2.

PTM databases

iPTMnetiQ99LG2.
PhosphoSiteiQ99LG2.
SwissPalmiQ99LG2.

Expressioni

Gene expression databases

BgeeiQ99LG2.
CleanExiMM_TNPO2.

Interactioni

Protein-protein interaction databases

MINTiMINT-4084672.
STRINGi10090.ENSMUSP00000091051.

Structurei

3D structure databases

ProteinModelPortaliQ99LG2.
SMRiQ99LG2. Positions 2-886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 3628HEAT 1By similarityAdd
BLAST
Domaini31 – 9969Importin N-terminalAdd
BLAST
Repeati41 – 7939HEAT 2By similarityAdd
BLAST
Repeati88 – 12134HEAT 3By similarityAdd
BLAST
Repeati127 – 16438HEAT 4By similarityAdd
BLAST
Repeati171 – 20131HEAT 5By similarityAdd
BLAST
Repeati214 – 24128HEAT 6By similarityAdd
BLAST
Repeati253 – 28028HEAT 7By similarityAdd
BLAST
Repeati296 – 38691HEAT 8By similarityAdd
BLAST
Repeati394 – 42229HEAT 9By similarityAdd
BLAST
Repeati434 – 46128HEAT 10By similarityAdd
BLAST
Repeati475 – 50834HEAT 11By similarityAdd
BLAST
Repeati516 – 54934HEAT 12By similarityAdd
BLAST
Repeati557 – 59539HEAT 13By similarityAdd
BLAST
Repeati603 – 65452HEAT 14By similarityAdd
BLAST
Repeati665 – 69632HEAT 15By similarityAdd
BLAST
Repeati704 – 73734HEAT 16By similarityAdd
BLAST
Repeati745 – 78036HEAT 17By similarityAdd
BLAST
Repeati788 – 82134HEAT 18By similarityAdd
BLAST
Repeati830 – 86132HEAT 19By similarityAdd
BLAST
Repeati864 – 88421HEAT 20By similarityAdd
BLAST

Sequence similaritiesi

Contains 20 HEAT repeats.By similarity
Contains 1 importin N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
HOVERGENiHBG058963.
InParanoidiQ99LG2.
KOiK18727.
PhylomeDBiQ99LG2.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99LG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLTHEAE
360 370 380 390 400
RPDSSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTAI TIGRLGYVCP QEVAPMLQQF IRPWCTSLRN
810 820 830 840 850
IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV SPKDDLRDMF
860 870 880
YKILHGFKDQ VGEENWQQFS EQFPPLLKER LAAFYGV
Length:887
Mass (Da):100,456
Last modified:June 1, 2001 - v1
Checksum:i0A633DCE4DAC4E93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611D → G in BAC26611 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA. Translation: AAH03275.1.
AK029774 mRNA. Translation: BAC26611.1.
RefSeqiNP_001116315.1. NM_001122843.1.
NP_663365.3. NM_145390.4.
XP_011246644.1. XM_011248342.1.
XP_011246647.1. XM_011248345.1.
UniGeneiMm.220357.

Genome annotation databases

GeneIDi212999.
KEGGimmu:212999.
UCSCiuc009mpa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA. Translation: AAH03275.1.
AK029774 mRNA. Translation: BAC26611.1.
RefSeqiNP_001116315.1. NM_001122843.1.
NP_663365.3. NM_145390.4.
XP_011246644.1. XM_011248342.1.
XP_011246647.1. XM_011248345.1.
UniGeneiMm.220357.

3D structure databases

ProteinModelPortaliQ99LG2.
SMRiQ99LG2. Positions 2-886.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4084672.
STRINGi10090.ENSMUSP00000091051.

PTM databases

iPTMnetiQ99LG2.
PhosphoSiteiQ99LG2.
SwissPalmiQ99LG2.

Proteomic databases

EPDiQ99LG2.
MaxQBiQ99LG2.
PaxDbiQ99LG2.
PRIDEiQ99LG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi212999.
KEGGimmu:212999.
UCSCiuc009mpa.2. mouse.

Organism-specific databases

CTDi30000.
MGIiMGI:2384849. Tnpo2.

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
HOVERGENiHBG058963.
InParanoidiQ99LG2.
KOiK18727.
PhylomeDBiQ99LG2.

Miscellaneous databases

NextBioi373798.
PROiQ99LG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LG2.
CleanExiMM_TNPO2.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-887.
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTNPO2_MOUSE
AccessioniPrimary (citable) accession number: Q99LG2
Secondary accession number(s): Q8C0U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.