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Protein

Transportin-2

Gene

Tnpo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of muscle cell differentiation Source: MGI
  • NLS-bearing protein import into nucleus Source: GO_Central
  • protein import into nucleus Source: MGI
  • protein import into nucleus, docking Source: GO_Central
  • protein import into nucleus, translocation Source: GO_Central
  • ribosomal protein import into nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:Tnpo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2384849. Tnpo2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207681 – 887Transportin-2Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LG2.
MaxQBiQ99LG2.
PaxDbiQ99LG2.
PeptideAtlasiQ99LG2.
PRIDEiQ99LG2.

PTM databases

iPTMnetiQ99LG2.
PhosphoSitePlusiQ99LG2.
SwissPalmiQ99LG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031691.
CleanExiMM_TNPO2.
ExpressionAtlasiQ99LG2. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-4084672.
STRINGi10090.ENSMUSP00000091051.

Structurei

3D structure databases

ProteinModelPortaliQ99LG2.
SMRiQ99LG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 36HEAT 1By similarityAdd BLAST28
Domaini31 – 99Importin N-terminalAdd BLAST69
Repeati41 – 79HEAT 2By similarityAdd BLAST39
Repeati88 – 121HEAT 3By similarityAdd BLAST34
Repeati127 – 164HEAT 4By similarityAdd BLAST38
Repeati171 – 201HEAT 5By similarityAdd BLAST31
Repeati214 – 241HEAT 6By similarityAdd BLAST28
Repeati253 – 280HEAT 7By similarityAdd BLAST28
Repeati296 – 386HEAT 8By similarityAdd BLAST91
Repeati394 – 422HEAT 9By similarityAdd BLAST29
Repeati434 – 461HEAT 10By similarityAdd BLAST28
Repeati475 – 508HEAT 11By similarityAdd BLAST34
Repeati516 – 549HEAT 12By similarityAdd BLAST34
Repeati557 – 595HEAT 13By similarityAdd BLAST39
Repeati603 – 654HEAT 14By similarityAdd BLAST52
Repeati665 – 696HEAT 15By similarityAdd BLAST32
Repeati704 – 737HEAT 16By similarityAdd BLAST34
Repeati745 – 780HEAT 17By similarityAdd BLAST36
Repeati788 – 821HEAT 18By similarityAdd BLAST34
Repeati830 – 861HEAT 19By similarityAdd BLAST32
Repeati864 – 884HEAT 20By similarityAdd BLAST21

Sequence similaritiesi

Contains 20 HEAT repeats.By similarity
Contains 1 importin N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOVERGENiHBG058963.
InParanoidiQ99LG2.
KOiK18727.
PhylomeDBiQ99LG2.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99LG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLTHEAE
360 370 380 390 400
RPDSSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTAI TIGRLGYVCP QEVAPMLQQF IRPWCTSLRN
810 820 830 840 850
IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV SPKDDLRDMF
860 870 880
YKILHGFKDQ VGEENWQQFS EQFPPLLKER LAAFYGV
Length:887
Mass (Da):100,456
Last modified:June 1, 2001 - v1
Checksum:i0A633DCE4DAC4E93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361D → G in BAC26611 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA. Translation: AAH03275.1.
AK029774 mRNA. Translation: BAC26611.1.
RefSeqiNP_001116315.1. NM_001122843.1.
NP_663365.3. NM_145390.4.
XP_011246644.1. XM_011248342.2.
XP_011246647.1. XM_011248345.2.
XP_017168136.1. XM_017312647.1.
XP_017168137.1. XM_017312648.1.
UniGeneiMm.220357.

Genome annotation databases

EnsembliENSMUST00000211601; ENSMUSP00000147583; ENSMUSG00000031691.
GeneIDi212999.
KEGGimmu:212999.
UCSCiuc009mpa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003275 mRNA. Translation: AAH03275.1.
AK029774 mRNA. Translation: BAC26611.1.
RefSeqiNP_001116315.1. NM_001122843.1.
NP_663365.3. NM_145390.4.
XP_011246644.1. XM_011248342.2.
XP_011246647.1. XM_011248345.2.
XP_017168136.1. XM_017312647.1.
XP_017168137.1. XM_017312648.1.
UniGeneiMm.220357.

3D structure databases

ProteinModelPortaliQ99LG2.
SMRiQ99LG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4084672.
STRINGi10090.ENSMUSP00000091051.

PTM databases

iPTMnetiQ99LG2.
PhosphoSitePlusiQ99LG2.
SwissPalmiQ99LG2.

Proteomic databases

EPDiQ99LG2.
MaxQBiQ99LG2.
PaxDbiQ99LG2.
PeptideAtlasiQ99LG2.
PRIDEiQ99LG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000211601; ENSMUSP00000147583; ENSMUSG00000031691.
GeneIDi212999.
KEGGimmu:212999.
UCSCiuc009mpa.2. mouse.

Organism-specific databases

CTDi30000.
MGIiMGI:2384849. Tnpo2.

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOVERGENiHBG058963.
InParanoidiQ99LG2.
KOiK18727.
PhylomeDBiQ99LG2.

Miscellaneous databases

PROiQ99LG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031691.
CleanExiMM_TNPO2.
ExpressionAtlasiQ99LG2. baseline and differential.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTNPO2_MOUSE
AccessioniPrimary (citable) accession number: Q99LG2
Secondary accession number(s): Q8C0U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.