ID   ABCF2_MOUSE             Reviewed;         628 AA.
AC   Q99LE6; Q3UA24; Q8C1S5; Q9JL48;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=ATP-binding cassette sub-family F member 2;
GN   Name=Abcf2 {ECO:0000312|MGI:MGI:1351657};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Brain, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2] {ECO:0000312|EMBL:AAH03300.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N {ECO:0000312|EMBL:AAH03300.1};
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH03300.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAF31422.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 376-628.
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAF31422.1};
RX   PubMed=10708515; DOI=10.1006/geno.1999.6102;
RA   Schriml L.M., Dean M.;
RT   "Identification of 18 mouse ABC genes and characterization of the ABC
RT   superfamily in Mus musculus.";
RL   Genomics 64:24-31(2000).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
RC   Pancreas, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC       EF3 subfamily. {ECO:0000305}.
CC   -!- CAUTION: Lacks transmembrane domains and is probably not involved in
CC       transport. {ECO:0000305}.
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DR   EMBL; AK003005; BAC25016.1; -; mRNA.
DR   EMBL; AK087990; BAC40079.1; -; mRNA.
DR   EMBL; AK147937; BAE28242.1; -; mRNA.
DR   EMBL; AK151545; BAE30491.1; -; mRNA.
DR   EMBL; BC003300; AAH03300.1; -; mRNA.
DR   EMBL; AF213382; AAF31422.1; -; mRNA.
DR   CCDS; CCDS19125.1; -.
DR   RefSeq; NP_001177372.1; NM_001190443.1.
DR   RefSeq; NP_038881.1; NM_013853.2.
DR   RefSeq; XP_006535789.1; XM_006535726.3.
DR   RefSeq; XP_006535790.1; XM_006535727.3.
DR   AlphaFoldDB; Q99LE6; -.
DR   SMR; Q99LE6; -.
DR   BioGRID; 205214; 22.
DR   IntAct; Q99LE6; 2.
DR   STRING; 10090.ENSMUSP00000030795; -.
DR   iPTMnet; Q99LE6; -.
DR   PhosphoSitePlus; Q99LE6; -.
DR   EPD; Q99LE6; -.
DR   MaxQB; Q99LE6; -.
DR   PaxDb; 10090-ENSMUSP00000030795; -.
DR   PeptideAtlas; Q99LE6; -.
DR   ProteomicsDB; 285957; -.
DR   Pumba; Q99LE6; -.
DR   DNASU; 27407; -.
DR   Ensembl; ENSMUST00000030795.10; ENSMUSP00000030795.9; ENSMUSG00000028953.11.
DR   GeneID; 27407; -.
DR   KEGG; mmu:27407; -.
DR   UCSC; uc008wsb.2; mouse.
DR   AGR; MGI:1351657; -.
DR   CTD; 10061; -.
DR   MGI; MGI:1351657; Abcf2.
DR   VEuPathDB; HostDB:ENSMUSG00000028953; -.
DR   eggNOG; KOG0927; Eukaryota.
DR   GeneTree; ENSGT00630000089910; -.
DR   HOGENOM; CLU_000604_36_6_1; -.
DR   InParanoid; Q99LE6; -.
DR   OMA; QYEGTML; -.
DR   OrthoDB; 25181at2759; -.
DR   PhylomeDB; Q99LE6; -.
DR   TreeFam; TF105208; -.
DR   BioGRID-ORCS; 27407; 5 hits in 78 CRISPR screens.
DR   ChiTaRS; Abcf2; mouse.
DR   PRO; PR:Q99LE6; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q99LE6; Protein.
DR   Bgee; ENSMUSG00000028953; Expressed in hindlimb stylopod muscle and 253 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03221; ABCF_EF-3; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR032781; ABC_tran_Xtn.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19211:SF15; ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2; 1.
DR   PANTHER; PTHR19211; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF12848; ABC_tran_Xtn; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR   Genevisible; Q99LE6; MM.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..628
FT                   /note="ATP-binding cassette sub-family F member 2"
FT                   /id="PRO_0000093324"
FT   DOMAIN          91..330
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          401..618
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         123..130
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         435..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   MOD_RES         223
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT   MOD_RES         309
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT   MOD_RES         517
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT   CONFLICT        537
FT                   /note="W -> R (in Ref. 3; AAF31422)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        579
FT                   /note="R -> I (in Ref. 3; AAF31422)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   628 AA;  71782 MW;  66E0C76F29A82BD8 CRC64;
     MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR ETTGDGEVDL
     LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF HGQELLSDTK LELNSGRRYG
     LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY HLTREMPPSE KTPLQCVMEV DTERAMLERE
     AERLAHEDAE CEKLMELYER LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM
     RVALARALFI RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI
     IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF GHGSAKLARQ
     AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV IMVQNVSFKY TKDGPCIYNN
     LEFGIDLDTR VALVGPNGAG KSTLLKLLTG ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL
     DLSPLEYMMK CYPEIKEKEE MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP
     HMLFLDEPTN HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP
     GDILAYKEHL KSKLVDEEPQ LTKRTHNV
//