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Q99LE6

- ABCF2_MOUSE

UniProt

Q99LE6 - ABCF2_MOUSE

Protein

ATP-binding cassette sub-family F member 2

Gene

Abcf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi123 – 1308ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi435 – 4428ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family F member 2
    Gene namesi
    Name:Abcf2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1351657. Abcf2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628ATP-binding cassette sub-family F member 2PRO_0000093324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei309 – 3091N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ99LE6.
    PaxDbiQ99LE6.
    PRIDEiQ99LE6.

    PTM databases

    PhosphoSiteiQ99LE6.

    Miscellaneous databases

    PMAP-CutDBQ99LE6.

    Expressioni

    Gene expression databases

    BgeeiQ99LE6.
    GenevestigatoriQ99LE6.

    Interactioni

    Protein-protein interaction databases

    BioGridi205214. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99LE6.
    SMRiQ99LE6. Positions 103-614.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 330240ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 618218ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0488.
    GeneTreeiENSGT00630000089910.
    HOGENOMiHOG000271637.
    HOVERGENiHBG050440.
    InParanoidiQ99LE6.
    KOiK06185.
    OMAiTVTKWKG.
    OrthoDBiEOG7RJPQW.
    PhylomeDBiQ99LE6.
    TreeFamiTF105208.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99LE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR    50
    ETTGDGEVDL LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF 100
    HGQELLSDTK LELNSGRRYG LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY 150
    HLTREMPPSE KTPLQCVMEV DTERAMLERE AERLAHEDAE CEKLMELYER 200
    LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM RVALARALFI 250
    RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI 300
    IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF 350
    GHGSAKLARQ AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV 400
    IMVQNVSFKY TKDGPCIYNN LEFGIDLDTR VALVGPNGAG KSTLLKLLTG 450
    ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL DLSPLEYMMK CYPEIKEKEE 500
    MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP HMLFLDEPTN 550
    HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP 600
    GDILAYKEHL KSKLVDEEPQ LTKRTHNV 628
    Length:628
    Mass (Da):71,782
    Last modified:June 1, 2001 - v1
    Checksum:i66E0C76F29A82BD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti537 – 5371W → R in AAF31422. (PubMed:10708515)Curated
    Sequence conflicti579 – 5791R → I in AAF31422. (PubMed:10708515)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003005 mRNA. Translation: BAC25016.1.
    AK087990 mRNA. Translation: BAC40079.1.
    AK147937 mRNA. Translation: BAE28242.1.
    AK151545 mRNA. Translation: BAE30491.1.
    BC003300 mRNA. Translation: AAH03300.1.
    AF213382 mRNA. Translation: AAF31422.1.
    CCDSiCCDS19125.1.
    RefSeqiNP_001177372.1. NM_001190443.1.
    NP_038881.1. NM_013853.2.
    XP_006535789.1. XM_006535726.1.
    XP_006535790.1. XM_006535727.1.
    UniGeneiMm.21629.

    Genome annotation databases

    EnsembliENSMUST00000030795; ENSMUSP00000030795; ENSMUSG00000028953.
    GeneIDi27407.
    KEGGimmu:27407.
    UCSCiuc008wsb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003005 mRNA. Translation: BAC25016.1 .
    AK087990 mRNA. Translation: BAC40079.1 .
    AK147937 mRNA. Translation: BAE28242.1 .
    AK151545 mRNA. Translation: BAE30491.1 .
    BC003300 mRNA. Translation: AAH03300.1 .
    AF213382 mRNA. Translation: AAF31422.1 .
    CCDSi CCDS19125.1.
    RefSeqi NP_001177372.1. NM_001190443.1.
    NP_038881.1. NM_013853.2.
    XP_006535789.1. XM_006535726.1.
    XP_006535790.1. XM_006535727.1.
    UniGenei Mm.21629.

    3D structure databases

    ProteinModelPortali Q99LE6.
    SMRi Q99LE6. Positions 103-614.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205214. 8 interactions.

    PTM databases

    PhosphoSitei Q99LE6.

    Proteomic databases

    MaxQBi Q99LE6.
    PaxDbi Q99LE6.
    PRIDEi Q99LE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030795 ; ENSMUSP00000030795 ; ENSMUSG00000028953 .
    GeneIDi 27407.
    KEGGi mmu:27407.
    UCSCi uc008wsb.2. mouse.

    Organism-specific databases

    CTDi 10061.
    MGIi MGI:1351657. Abcf2.

    Phylogenomic databases

    eggNOGi COG0488.
    GeneTreei ENSGT00630000089910.
    HOGENOMi HOG000271637.
    HOVERGENi HBG050440.
    InParanoidi Q99LE6.
    KOi K06185.
    OMAi TVTKWKG.
    OrthoDBi EOG7RJPQW.
    PhylomeDBi Q99LE6.
    TreeFami TF105208.

    Miscellaneous databases

    NextBioi 305418.
    PMAP-CutDB Q99LE6.
    PROi Q99LE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99LE6.
    Genevestigatori Q99LE6.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Brain and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary glandImported.
    3. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
      Schriml L.M., Dean M.
      Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 376-628.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiABCF2_MOUSE
    AccessioniPrimary (citable) accession number: Q99LE6
    Secondary accession number(s): Q3UA24, Q8C1S5, Q9JL48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks transmembrane domains and is probably not involved in transport.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3