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Q99LE6

- ABCF2_MOUSE

UniProt

Q99LE6 - ABCF2_MOUSE

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Protein

ATP-binding cassette sub-family F member 2

Gene

Abcf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi123 – 1308ATP 1PROSITE-ProRule annotation
Nucleotide bindingi435 – 4428ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 2
Gene namesi
Name:Abcf2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1351657. Abcf2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628ATP-binding cassette sub-family F member 2PRO_0000093324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99LE6.
PaxDbiQ99LE6.
PRIDEiQ99LE6.

PTM databases

PhosphoSiteiQ99LE6.

Miscellaneous databases

PMAP-CutDBQ99LE6.

Expressioni

Gene expression databases

BgeeiQ99LE6.
GenevestigatoriQ99LE6.

Interactioni

Protein-protein interaction databases

BioGridi205214. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99LE6.
SMRiQ99LE6. Positions 103-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 330240ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 618218ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0488.
GeneTreeiENSGT00630000089910.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ99LE6.
KOiK06185.
OMAiTVTKWKG.
OrthoDBiEOG7RJPQW.
PhylomeDBiQ99LE6.
TreeFamiTF105208.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR
60 70 80 90 100
ETTGDGEVDL LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF
110 120 130 140 150
HGQELLSDTK LELNSGRRYG LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY
160 170 180 190 200
HLTREMPPSE KTPLQCVMEV DTERAMLERE AERLAHEDAE CEKLMELYER
210 220 230 240 250
LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM RVALARALFI
260 270 280 290 300
RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI
310 320 330 340 350
IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF
360 370 380 390 400
GHGSAKLARQ AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV
410 420 430 440 450
IMVQNVSFKY TKDGPCIYNN LEFGIDLDTR VALVGPNGAG KSTLLKLLTG
460 470 480 490 500
ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL DLSPLEYMMK CYPEIKEKEE
510 520 530 540 550
MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP HMLFLDEPTN
560 570 580 590 600
HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP
610 620
GDILAYKEHL KSKLVDEEPQ LTKRTHNV
Length:628
Mass (Da):71,782
Last modified:June 1, 2001 - v1
Checksum:i66E0C76F29A82BD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371W → R in AAF31422. (PubMed:10708515)Curated
Sequence conflicti579 – 5791R → I in AAF31422. (PubMed:10708515)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003005 mRNA. Translation: BAC25016.1.
AK087990 mRNA. Translation: BAC40079.1.
AK147937 mRNA. Translation: BAE28242.1.
AK151545 mRNA. Translation: BAE30491.1.
BC003300 mRNA. Translation: AAH03300.1.
AF213382 mRNA. Translation: AAF31422.1.
CCDSiCCDS19125.1.
RefSeqiNP_001177372.1. NM_001190443.1.
NP_038881.1. NM_013853.2.
XP_006535789.1. XM_006535726.1.
XP_006535790.1. XM_006535727.1.
UniGeneiMm.21629.

Genome annotation databases

EnsembliENSMUST00000030795; ENSMUSP00000030795; ENSMUSG00000028953.
GeneIDi27407.
KEGGimmu:27407.
UCSCiuc008wsb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003005 mRNA. Translation: BAC25016.1 .
AK087990 mRNA. Translation: BAC40079.1 .
AK147937 mRNA. Translation: BAE28242.1 .
AK151545 mRNA. Translation: BAE30491.1 .
BC003300 mRNA. Translation: AAH03300.1 .
AF213382 mRNA. Translation: AAF31422.1 .
CCDSi CCDS19125.1.
RefSeqi NP_001177372.1. NM_001190443.1.
NP_038881.1. NM_013853.2.
XP_006535789.1. XM_006535726.1.
XP_006535790.1. XM_006535727.1.
UniGenei Mm.21629.

3D structure databases

ProteinModelPortali Q99LE6.
SMRi Q99LE6. Positions 103-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205214. 8 interactions.

PTM databases

PhosphoSitei Q99LE6.

Proteomic databases

MaxQBi Q99LE6.
PaxDbi Q99LE6.
PRIDEi Q99LE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030795 ; ENSMUSP00000030795 ; ENSMUSG00000028953 .
GeneIDi 27407.
KEGGi mmu:27407.
UCSCi uc008wsb.2. mouse.

Organism-specific databases

CTDi 10061.
MGIi MGI:1351657. Abcf2.

Phylogenomic databases

eggNOGi COG0488.
GeneTreei ENSGT00630000089910.
HOGENOMi HOG000271637.
HOVERGENi HBG050440.
InParanoidi Q99LE6.
KOi K06185.
OMAi TVTKWKG.
OrthoDBi EOG7RJPQW.
PhylomeDBi Q99LE6.
TreeFami TF105208.

Miscellaneous databases

NextBioi 305418.
PMAP-CutDB Q99LE6.
PROi Q99LE6.
SOURCEi Search...

Gene expression databases

Bgeei Q99LE6.
Genevestigatori Q99LE6.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Brain and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary glandImported.
  3. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 376-628.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiABCF2_MOUSE
AccessioniPrimary (citable) accession number: Q99LE6
Secondary accession number(s): Q3UA24, Q8C1S5, Q9JL48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3