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Q99LE6

- ABCF2_MOUSE

UniProt

Q99LE6 - ABCF2_MOUSE

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Protein
ATP-binding cassette sub-family F member 2
Gene
Abcf2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi123 – 1308ATP 1 By similarity
Nucleotide bindingi435 – 4428ATP 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 2
Gene namesi
Name:Abcf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1351657. Abcf2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628ATP-binding cassette sub-family F member 2
PRO_0000093324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99LE6.
PaxDbiQ99LE6.
PRIDEiQ99LE6.

PTM databases

PhosphoSiteiQ99LE6.

Miscellaneous databases

PMAP-CutDBQ99LE6.

Expressioni

Gene expression databases

BgeeiQ99LE6.
GenevestigatoriQ99LE6.

Interactioni

Protein-protein interaction databases

BioGridi205214. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ99LE6.
SMRiQ99LE6. Positions 103-614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 330240ABC transporter 1
Add
BLAST
Domaini401 – 618218ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0488.
GeneTreeiENSGT00630000089910.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ99LE6.
KOiK06185.
OMAiTVTKWKG.
OrthoDBiEOG7RJPQW.
PhylomeDBiQ99LE6.
TreeFamiTF105208.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LE6-1 [UniParc]FASTAAdd to Basket

« Hide

MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR    50
ETTGDGEVDL LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF 100
HGQELLSDTK LELNSGRRYG LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY 150
HLTREMPPSE KTPLQCVMEV DTERAMLERE AERLAHEDAE CEKLMELYER 200
LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM RVALARALFI 250
RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI 300
IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF 350
GHGSAKLARQ AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV 400
IMVQNVSFKY TKDGPCIYNN LEFGIDLDTR VALVGPNGAG KSTLLKLLTG 450
ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL DLSPLEYMMK CYPEIKEKEE 500
MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP HMLFLDEPTN 550
HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP 600
GDILAYKEHL KSKLVDEEPQ LTKRTHNV 628
Length:628
Mass (Da):71,782
Last modified:June 1, 2001 - v1
Checksum:i66E0C76F29A82BD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371W → R in AAF31422. 1 Publication
Sequence conflicti579 – 5791R → I in AAF31422. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003005 mRNA. Translation: BAC25016.1.
AK087990 mRNA. Translation: BAC40079.1.
AK147937 mRNA. Translation: BAE28242.1.
AK151545 mRNA. Translation: BAE30491.1.
BC003300 mRNA. Translation: AAH03300.1.
AF213382 mRNA. Translation: AAF31422.1.
CCDSiCCDS19125.1.
RefSeqiNP_001177372.1. NM_001190443.1.
NP_038881.1. NM_013853.2.
XP_006535789.1. XM_006535726.1.
XP_006535790.1. XM_006535727.1.
UniGeneiMm.21629.

Genome annotation databases

EnsembliENSMUST00000030795; ENSMUSP00000030795; ENSMUSG00000028953.
GeneIDi27407.
KEGGimmu:27407.
UCSCiuc008wsb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003005 mRNA. Translation: BAC25016.1 .
AK087990 mRNA. Translation: BAC40079.1 .
AK147937 mRNA. Translation: BAE28242.1 .
AK151545 mRNA. Translation: BAE30491.1 .
BC003300 mRNA. Translation: AAH03300.1 .
AF213382 mRNA. Translation: AAF31422.1 .
CCDSi CCDS19125.1.
RefSeqi NP_001177372.1. NM_001190443.1.
NP_038881.1. NM_013853.2.
XP_006535789.1. XM_006535726.1.
XP_006535790.1. XM_006535727.1.
UniGenei Mm.21629.

3D structure databases

ProteinModelPortali Q99LE6.
SMRi Q99LE6. Positions 103-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205214. 8 interactions.

PTM databases

PhosphoSitei Q99LE6.

Proteomic databases

MaxQBi Q99LE6.
PaxDbi Q99LE6.
PRIDEi Q99LE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030795 ; ENSMUSP00000030795 ; ENSMUSG00000028953 .
GeneIDi 27407.
KEGGi mmu:27407.
UCSCi uc008wsb.2. mouse.

Organism-specific databases

CTDi 10061.
MGIi MGI:1351657. Abcf2.

Phylogenomic databases

eggNOGi COG0488.
GeneTreei ENSGT00630000089910.
HOGENOMi HOG000271637.
HOVERGENi HBG050440.
InParanoidi Q99LE6.
KOi K06185.
OMAi TVTKWKG.
OrthoDBi EOG7RJPQW.
PhylomeDBi Q99LE6.
TreeFami TF105208.

Miscellaneous databases

NextBioi 305418.
PMAP-CutDB Q99LE6.
PROi Q99LE6.
SOURCEi Search...

Gene expression databases

Bgeei Q99LE6.
Genevestigatori Q99LE6.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Brain and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 376-628.
    Strain: C57BL/6J.

Entry informationi

Entry nameiABCF2_MOUSE
AccessioniPrimary (citable) accession number: Q99LE6
Secondary accession number(s): Q3UA24, Q8C1S5, Q9JL48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi