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Protein

Probable G-protein coupled receptor 146

Gene

Gpr146

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 146
Gene namesi
Name:Gpr146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933113. Gpr146.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 6421CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 10116ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14523CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini167 – 18822ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 23223CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini254 – 27724ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini299 – 33335CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Probable G-protein coupled receptor 146PRO_0000069623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99LE2.
PRIDEiQ99LE2.

PTM databases

PhosphoSiteiQ99LE2.

Expressioni

Gene expression databases

BgeeiQ99LE2.
CleanExiMM_GPR146.
ExpressionAtlasiQ99LE2. baseline and differential.
GenevisibleiQ99LE2. MM.

Structurei

3D structure databases

ProteinModelPortaliQ99LE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi285 – 2884Poly-Ser

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ99LE2.
KOiK08431.
OMAiTMPDVYF.
TreeFamiTF333506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSCGPLNST AWAEEPLCRN LRLGLWVLSL LYLGAGVPVS LGYNALLVLA
60 70 80 90 100
NLASKNTMTM PDVYFVNMAV AGLVLTALAP AYLLGPAHSR WALWSLSSEA
110 120 130 140 150
HVTLLILFNV ASLVTMYSTA LLSLDYYIER ALPRTYMASV YNTRHVCGFV
160 170 180 190 200
WGGAVLTSFS SLLFYICSHV SSRIAECARM QNTEAADAIL VLIGYVVPGL
210 220 230 240 250
AVLYALALIS RIGKEDTPLD QDTSRLDPSV HRLLVATVCT QFGLWTPYYL
260 270 280 290 300
SLGHTVLTSR GRTVEGHYLG ILQVAKDLAK FLAFSSSSVT PLLYRYINKA
310 320 330
FPGKLRRLMK KMHCGRRHCS PDPSGIQQVM AQA
Length:333
Mass (Da):36,572
Last modified:July 27, 2011 - v2
Checksum:iC51690838AB42988
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921L → V in BAC40804 (PubMed:16141072).Curated
Sequence conflicti192 – 1921L → V in BAE32614 (PubMed:16141072).Curated
Sequence conflicti192 – 1921L → V in AAH03323 (PubMed:15489334).Curated
Sequence conflicti283 – 2831A → P in BAC39803 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046512 mRNA. Translation: BAC32762.1.
AK087100 mRNA. Translation: BAC39803.1.
AK089232 mRNA. Translation: BAC40804.1.
AK154478 mRNA. Translation: BAE32614.1.
AK137454 mRNA. Translation: BAE23357.1.
AK154708 mRNA. Translation: BAE32777.1.
AK155876 mRNA. Translation: BAE33478.1.
CH466529 Genomic DNA. Translation: EDL19154.1.
BC003323 mRNA. Translation: AAH03323.1.
CCDSiCCDS19809.1.
RefSeqiNP_001033792.1. NM_001038703.2.
NP_084534.2. NM_030258.4.
XP_006504837.1. XM_006504774.1.
UniGeneiMm.270003.

Genome annotation databases

EnsembliENSMUST00000051293; ENSMUSP00000049707; ENSMUSG00000044197.
ENSMUST00000100514; ENSMUSP00000098083; ENSMUSG00000044197.
GeneIDi80290.
KEGGimmu:80290.
UCSCiuc009agm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046512 mRNA. Translation: BAC32762.1.
AK087100 mRNA. Translation: BAC39803.1.
AK089232 mRNA. Translation: BAC40804.1.
AK154478 mRNA. Translation: BAE32614.1.
AK137454 mRNA. Translation: BAE23357.1.
AK154708 mRNA. Translation: BAE32777.1.
AK155876 mRNA. Translation: BAE33478.1.
CH466529 Genomic DNA. Translation: EDL19154.1.
BC003323 mRNA. Translation: AAH03323.1.
CCDSiCCDS19809.1.
RefSeqiNP_001033792.1. NM_001038703.2.
NP_084534.2. NM_030258.4.
XP_006504837.1. XM_006504774.1.
UniGeneiMm.270003.

3D structure databases

ProteinModelPortaliQ99LE2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ99LE2.

Proteomic databases

PaxDbiQ99LE2.
PRIDEiQ99LE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051293; ENSMUSP00000049707; ENSMUSG00000044197.
ENSMUST00000100514; ENSMUSP00000098083; ENSMUSG00000044197.
GeneIDi80290.
KEGGimmu:80290.
UCSCiuc009agm.2. mouse.

Organism-specific databases

CTDi115330.
MGIiMGI:1933113. Gpr146.

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ99LE2.
KOiK08431.
OMAiTMPDVYF.
TreeFamiTF333506.

Miscellaneous databases

NextBioi349997.
PROiQ99LE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99LE2.
CleanExiMM_GPR146.
ExpressionAtlasiQ99LE2. baseline and differential.
GenevisibleiQ99LE2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone, Corpora quadrigemina and Lung.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGP146_MOUSE
AccessioniPrimary (citable) accession number: Q99LE2
Secondary accession number(s): Q3U3K8
, Q3U421, Q8BHR6, Q8BHU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.