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Protein

Probable G-protein coupled receptor 146

Gene

Gpr146

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 146
Gene namesi
Name:Gpr146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933113. Gpr146.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 64CytoplasmicSequence analysisAdd BLAST21
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 101ExtracellularSequence analysisAdd BLAST16
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 145CytoplasmicSequence analysisAdd BLAST23
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 188ExtracellularSequence analysisAdd BLAST22
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 232CytoplasmicSequence analysisAdd BLAST23
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 277ExtracellularSequence analysisAdd BLAST24
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 333CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696231 – 333Probable G-protein coupled receptor 146Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ99LE2.
PRIDEiQ99LE2.

PTM databases

PhosphoSitePlusiQ99LE2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044197.
CleanExiMM_GPR146.
ExpressionAtlasiQ99LE2. baseline and differential.
GenevisibleiQ99LE2. MM.

Structurei

3D structure databases

ProteinModelPortaliQ99LE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 288Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ99LE2.
KOiK08431.
OMAiTMPDVYF.
OrthoDBiEOG091G0HRG.
TreeFamiTF333506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSCGPLNST AWAEEPLCRN LRLGLWVLSL LYLGAGVPVS LGYNALLVLA
60 70 80 90 100
NLASKNTMTM PDVYFVNMAV AGLVLTALAP AYLLGPAHSR WALWSLSSEA
110 120 130 140 150
HVTLLILFNV ASLVTMYSTA LLSLDYYIER ALPRTYMASV YNTRHVCGFV
160 170 180 190 200
WGGAVLTSFS SLLFYICSHV SSRIAECARM QNTEAADAIL VLIGYVVPGL
210 220 230 240 250
AVLYALALIS RIGKEDTPLD QDTSRLDPSV HRLLVATVCT QFGLWTPYYL
260 270 280 290 300
SLGHTVLTSR GRTVEGHYLG ILQVAKDLAK FLAFSSSSVT PLLYRYINKA
310 320 330
FPGKLRRLMK KMHCGRRHCS PDPSGIQQVM AQA
Length:333
Mass (Da):36,572
Last modified:July 27, 2011 - v2
Checksum:iC51690838AB42988
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192L → V in BAC40804 (PubMed:16141072).Curated1
Sequence conflicti192L → V in BAE32614 (PubMed:16141072).Curated1
Sequence conflicti192L → V in AAH03323 (PubMed:15489334).Curated1
Sequence conflicti283A → P in BAC39803 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046512 mRNA. Translation: BAC32762.1.
AK087100 mRNA. Translation: BAC39803.1.
AK089232 mRNA. Translation: BAC40804.1.
AK154478 mRNA. Translation: BAE32614.1.
AK137454 mRNA. Translation: BAE23357.1.
AK154708 mRNA. Translation: BAE32777.1.
AK155876 mRNA. Translation: BAE33478.1.
CH466529 Genomic DNA. Translation: EDL19154.1.
BC003323 mRNA. Translation: AAH03323.1.
CCDSiCCDS19809.1.
RefSeqiNP_001033792.1. NM_001038703.2.
NP_084534.2. NM_030258.4.
XP_006504837.1. XM_006504774.2.
UniGeneiMm.270003.

Genome annotation databases

EnsembliENSMUST00000051293; ENSMUSP00000049707; ENSMUSG00000044197.
ENSMUST00000100514; ENSMUSP00000098083; ENSMUSG00000044197.
GeneIDi80290.
KEGGimmu:80290.
UCSCiuc009agm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046512 mRNA. Translation: BAC32762.1.
AK087100 mRNA. Translation: BAC39803.1.
AK089232 mRNA. Translation: BAC40804.1.
AK154478 mRNA. Translation: BAE32614.1.
AK137454 mRNA. Translation: BAE23357.1.
AK154708 mRNA. Translation: BAE32777.1.
AK155876 mRNA. Translation: BAE33478.1.
CH466529 Genomic DNA. Translation: EDL19154.1.
BC003323 mRNA. Translation: AAH03323.1.
CCDSiCCDS19809.1.
RefSeqiNP_001033792.1. NM_001038703.2.
NP_084534.2. NM_030258.4.
XP_006504837.1. XM_006504774.2.
UniGeneiMm.270003.

3D structure databases

ProteinModelPortaliQ99LE2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ99LE2.

Proteomic databases

PaxDbiQ99LE2.
PRIDEiQ99LE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051293; ENSMUSP00000049707; ENSMUSG00000044197.
ENSMUST00000100514; ENSMUSP00000098083; ENSMUSG00000044197.
GeneIDi80290.
KEGGimmu:80290.
UCSCiuc009agm.2. mouse.

Organism-specific databases

CTDi115330.
MGIiMGI:1933113. Gpr146.

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ99LE2.
KOiK08431.
OMAiTMPDVYF.
OrthoDBiEOG091G0HRG.
TreeFamiTF333506.

Miscellaneous databases

PROiQ99LE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044197.
CleanExiMM_GPR146.
ExpressionAtlasiQ99LE2. baseline and differential.
GenevisibleiQ99LE2. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP146_MOUSE
AccessioniPrimary (citable) accession number: Q99LE2
Secondary accession number(s): Q3U3K8
, Q3U421, Q8BHR6, Q8BHU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.