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Q99LD9

- EI2BB_MOUSE

UniProt

Q99LD9 - EI2BB_MOUSE

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Protein
Translation initiation factor eIF-2B subunit beta
Gene
Eif2b2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. guanyl-nucleotide exchange factor activity Source: RefGenome
  4. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to stimulus Source: UniProtKB
  2. central nervous system development Source: UniProtKB
  3. myelination Source: UniProtKB
  4. oligodendrocyte development Source: UniProtKB
  5. ovarian follicle development Source: UniProtKB
  6. regulation of GTPase activity Source: GOC
  7. regulation of translational initiation Source: RefGenome
  8. translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit beta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit beta
Gene namesi
Name:Eif2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2145118. Eif2b2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. eukaryotic translation initiation factor 2B complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Translation initiation factor eIF-2B subunit beta
PRO_0000156062Add
BLAST

Proteomic databases

MaxQBiQ99LD9.
PaxDbiQ99LD9.
PRIDEiQ99LD9.

PTM databases

PhosphoSiteiQ99LD9.

Expressioni

Gene expression databases

ArrayExpressiQ99LD9.
BgeeiQ99LD9.
GenevestigatoriQ99LD9.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon By similarity.

Protein-protein interaction databases

IntActiQ99LD9. 1 interaction.
MINTiMINT-4094186.

Structurei

3D structure databases

ProteinModelPortaliQ99LD9.
SMRiQ99LD9. Positions 73-344.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1184.
GeneTreeiENSGT00550000074908.
HOGENOMiHOG000208487.
HOVERGENiHBG051458.
InParanoidiQ99LD9.
KOiK03754.
OMAiRIITDHR.
OrthoDBiEOG7N0C4T.
PhylomeDBiQ99LD9.
TreeFamiTF101506.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LD9-1 [UniParc]FASTAAdd to Basket

« Hide

MPGAAAKGSE LSERIEGFVE TLKRGGGQRS SEDMARETLG LLRRLITDHH    50
WNNAGDLMDL IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS 100
DESDQQESLH KLLTSGGLSE DFSFHFAPLK ANIIEAINEL LVELEGTMEN 150
IAAQALEHIH SNEVIMTIGY SRTVEAFLKE AARKRKFHVI VAECAPFCQG 200
HEMAVNLSKE GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGSLRAVAG 250
THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG 300
DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYIYRLM SELYHPDDHV 350
L 351
Length:351
Mass (Da):38,898
Last modified:June 1, 2001 - v1
Checksum:i56FF1B8A96845853
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049731 mRNA. Translation: BAC33897.1.
BC003326 mRNA. Translation: AAH03326.1.
CCDSiCCDS26053.1.
RefSeqiNP_663420.1. NM_145445.3.
UniGeneiMm.29041.

Genome annotation databases

EnsembliENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788.
GeneIDi217715.
KEGGimmu:217715.
UCSCiuc007ogr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049731 mRNA. Translation: BAC33897.1 .
BC003326 mRNA. Translation: AAH03326.1 .
CCDSi CCDS26053.1.
RefSeqi NP_663420.1. NM_145445.3.
UniGenei Mm.29041.

3D structure databases

ProteinModelPortali Q99LD9.
SMRi Q99LD9. Positions 73-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99LD9. 1 interaction.
MINTi MINT-4094186.

PTM databases

PhosphoSitei Q99LD9.

Proteomic databases

MaxQBi Q99LD9.
PaxDbi Q99LD9.
PRIDEi Q99LD9.

Protocols and materials databases

DNASUi 217715.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004910 ; ENSMUSP00000004910 ; ENSMUSG00000004788 .
GeneIDi 217715.
KEGGi mmu:217715.
UCSCi uc007ogr.1. mouse.

Organism-specific databases

CTDi 8892.
MGIi MGI:2145118. Eif2b2.

Phylogenomic databases

eggNOGi COG1184.
GeneTreei ENSGT00550000074908.
HOGENOMi HOG000208487.
HOVERGENi HBG051458.
InParanoidi Q99LD9.
KOi K03754.
OMAi RIITDHR.
OrthoDBi EOG7N0C4T.
PhylomeDBi Q99LD9.
TreeFami TF101506.

Miscellaneous databases

ChiTaRSi EIF2B2. mouse.
NextBioi 375988.
PROi Q99LD9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99LD9.
Bgeei Q99LD9.
Genevestigatori Q99LD9.

Family and domain databases

InterProi IPR000649. IF-2B-related.
[Graphical view ]
Pfami PF01008. IF-2B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiEI2BB_MOUSE
AccessioniPrimary (citable) accession number: Q99LD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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