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Q99LD9

- EI2BB_MOUSE

UniProt

Q99LD9 - EI2BB_MOUSE

Protein

Translation initiation factor eIF-2B subunit beta

Gene

Eif2b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB
    3. guanyl-nucleotide exchange factor activity Source: RefGenome
    4. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to stimulus Source: UniProtKB
    2. central nervous system development Source: UniProtKB
    3. myelination Source: UniProtKB
    4. oligodendrocyte development Source: UniProtKB
    5. ovarian follicle development Source: UniProtKB
    6. positive regulation of GTPase activity Source: GOC
    7. regulation of translational initiation Source: RefGenome
    8. translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor eIF-2B subunit beta
    Alternative name(s):
    eIF-2B GDP-GTP exchange factor subunit beta
    Gene namesi
    Name:Eif2b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2145118. Eif2b2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. eukaryotic translation initiation factor 2B complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Translation initiation factor eIF-2B subunit betaPRO_0000156062Add
    BLAST

    Proteomic databases

    MaxQBiQ99LD9.
    PaxDbiQ99LD9.
    PRIDEiQ99LD9.

    PTM databases

    PhosphoSiteiQ99LD9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99LD9.
    BgeeiQ99LD9.
    GenevestigatoriQ99LD9.

    Interactioni

    Subunit structurei

    Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

    Protein-protein interaction databases

    IntActiQ99LD9. 1 interaction.
    MINTiMINT-4094186.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99LD9.
    SMRiQ99LD9. Positions 73-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1184.
    GeneTreeiENSGT00550000074908.
    HOGENOMiHOG000208487.
    HOVERGENiHBG051458.
    InParanoidiQ99LD9.
    KOiK03754.
    OMAiRIITDHR.
    OrthoDBiEOG7N0C4T.
    PhylomeDBiQ99LD9.
    TreeFamiTF101506.

    Family and domain databases

    InterProiIPR000649. IF-2B-related.
    [Graphical view]
    PfamiPF01008. IF-2B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99LD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGAAAKGSE LSERIEGFVE TLKRGGGQRS SEDMARETLG LLRRLITDHH    50
    WNNAGDLMDL IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS 100
    DESDQQESLH KLLTSGGLSE DFSFHFAPLK ANIIEAINEL LVELEGTMEN 150
    IAAQALEHIH SNEVIMTIGY SRTVEAFLKE AARKRKFHVI VAECAPFCQG 200
    HEMAVNLSKE GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGSLRAVAG 250
    THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG 300
    DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYIYRLM SELYHPDDHV 350
    L 351
    Length:351
    Mass (Da):38,898
    Last modified:June 1, 2001 - v1
    Checksum:i56FF1B8A96845853
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049731 mRNA. Translation: BAC33897.1.
    BC003326 mRNA. Translation: AAH03326.1.
    CCDSiCCDS26053.1.
    RefSeqiNP_663420.1. NM_145445.3.
    UniGeneiMm.29041.

    Genome annotation databases

    EnsembliENSMUST00000004910; ENSMUSP00000004910; ENSMUSG00000004788.
    GeneIDi217715.
    KEGGimmu:217715.
    UCSCiuc007ogr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049731 mRNA. Translation: BAC33897.1 .
    BC003326 mRNA. Translation: AAH03326.1 .
    CCDSi CCDS26053.1.
    RefSeqi NP_663420.1. NM_145445.3.
    UniGenei Mm.29041.

    3D structure databases

    ProteinModelPortali Q99LD9.
    SMRi Q99LD9. Positions 73-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99LD9. 1 interaction.
    MINTi MINT-4094186.

    PTM databases

    PhosphoSitei Q99LD9.

    Proteomic databases

    MaxQBi Q99LD9.
    PaxDbi Q99LD9.
    PRIDEi Q99LD9.

    Protocols and materials databases

    DNASUi 217715.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004910 ; ENSMUSP00000004910 ; ENSMUSG00000004788 .
    GeneIDi 217715.
    KEGGi mmu:217715.
    UCSCi uc007ogr.1. mouse.

    Organism-specific databases

    CTDi 8892.
    MGIi MGI:2145118. Eif2b2.

    Phylogenomic databases

    eggNOGi COG1184.
    GeneTreei ENSGT00550000074908.
    HOGENOMi HOG000208487.
    HOVERGENi HBG051458.
    InParanoidi Q99LD9.
    KOi K03754.
    OMAi RIITDHR.
    OrthoDBi EOG7N0C4T.
    PhylomeDBi Q99LD9.
    TreeFami TF101506.

    Miscellaneous databases

    ChiTaRSi EIF2B2. mouse.
    NextBioi 375988.
    PROi Q99LD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99LD9.
    Bgeei Q99LD9.
    Genevestigatori Q99LD9.

    Family and domain databases

    InterProi IPR000649. IF-2B-related.
    [Graphical view ]
    Pfami PF01008. IF-2B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiEI2BB_MOUSE
    AccessioniPrimary (citable) accession number: Q99LD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3