Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisome assembly factor 2

Gene

Pex6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 478ATPSequence analysis8
Nucleotide bindingi745 – 752ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly factor 2
Short name:
PAF-2
Alternative name(s):
Peroxin-6
Peroxisomal biogenesis factor 6
Peroxisomal-type ATPase 1
Gene namesi
Name:Pex6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385054 Pex6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846081 – 981Peroxisome assembly factor 2Add BLAST981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ99LC9
MaxQBiQ99LC9
PaxDbiQ99LC9
PeptideAtlasiQ99LC9
PRIDEiQ99LC9

PTM databases

iPTMnetiQ99LC9
PhosphoSitePlusiQ99LC9

Expressioni

Tissue specificityi

In the teeth, expressed in ameloblasts and odontoblasts (PubMed:26593283). Expressed in the retina, at higher levels in the ganglion cell layer and photoreceptor layer at the joint between the outer and inner segments (PubMed:26593283, PubMed:27302843).2 Publications

Gene expression databases

BgeeiENSMUSG00000002763
CleanExiMM_PEX6
GenevisibleiQ99LC9 MM

Interactioni

Subunit structurei

Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interacts with ZFAND6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230326, 6 interactors
IntActiQ99LC9, 1 interactor
MINTiQ99LC9
STRINGi10090.ENSMUSP00000002840

Structurei

3D structure databases

ProteinModelPortaliQ99LC9
SMRiQ99LC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0736 Eukaryota
ENOG410XNT9 LUCA
GeneTreeiENSGT00550000074953
HOGENOMiHOG000241031
HOVERGENiHBG002311
InParanoidiQ99LC9
KOiK13339
OMAiPSVSWHD
OrthoDBiEOG091G048C
PhylomeDBiQ99LC9
TreeFamiTF106428

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q99LC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVLRVLD PFPTETPPLA VLLPPGGPWP ATGLGLVLAL RPASESPAKP
60 70 80 90 100
ALLVAAVEGS GAQGEQRGPG PPPLLVSRAL LRVLALGPGA RVRARLVRRP
110 120 130 140 150
PALGWALLAT APGPGLGPRV GPLLVRRGET LPVPGSRVLE TRPALQGLLG
160 170 180 190 200
PGTRLAVTEL RGRAKLGQES RDHSHPPPPP VVSSFAASHS VRRLRGVLGG
210 220 230 240 250
TGDALGVSRS CLRSLGLFQG EWVWVAQVAE LPNSSQPRLA QVQVLEPRWE
260 270 280 290 300
LSERLGPNSG QQPGEPLADG LVFLPATLAF NLGCDPLEVG ELRIQRYLEG
310 320 330 340 350
SIAPENKGSC SPLPGPPFAR ELHIEILSSP HYSANGNYDH VLYRHFQTPR
360 370 380 390 400
VVQEGDVLCV STAGQVEILE GSLERLPRWR EMFFKVKKTV GEAPEGPASA
410 420 430 440 450
FLADTTHTSL YLAGTALSHV PSLPSGRSPP WDSLSPPGLE ALVNELCAIL
460 470 480 490 500
KPHLQPGGTL LTGTSCVLLQ GPPGSGKTTA VTAACSRLGL HLLKVPCSSL
510 520 530 540 550
CADSSRAVET KLQATFSRAR RCRPAVLLLT AVDLLGRDRD GLGEDARVAA
560 570 580 590 600
TLRHLLLDED ALSRCPPLMV VATTSRVQDL PTDVQTAFPH ELEVPVLSEA
610 620 630 640 650
QRLSILQALT AHLPLGQEVN LPQLARRCAG FVVGDLYALL THTCRAACTR
660 670 680 690 700
IRASGSAGGL SEEDEGDLCV AGFPLLAEDF GQALDQLQTA HSQAVGAPRI
710 720 730 740 750
PSVSWHDVGG LQDVKKEILE TIQLPLEHPE LLSLGLRRSG LLLHGPPGTG
760 770 780 790 800
KTLLAKAVAT ECSLTFLSVK GPELINMYVG QSEENVREVF ARARAAAPCI
810 820 830 840 850
IFFDELDSLA PSRGRSGDSG GVMDRVVSQL LAELDGLHST QDVFVIGATN
860 870 880 890 900
RPDLLDPALL RPGRFDKLVF VGASEDRASQ LRVLSAITRK FKLEASVSLA
910 920 930 940 950
NVLDCCPPQL TGADLYSLCS DAMMTALKRR VRDLEEGLEL RSSALLLTME
960 970 980
DLLQAAARLQ PSVSEQELLR YKRIQRKFAA C
Length:981
Mass (Da):104,549
Last modified:June 1, 2001 - v1
Checksum:i955DBBFB130117CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti520R → H in AAL06143 (Ref. 2) Curated1
Sequence conflicti895A → P in AAL06143 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003424 mRNA Translation: AAH03424.1
AY054409 Genomic DNA Translation: AAL06143.1
CCDSiCCDS28837.1
RefSeqiNP_663463.1, NM_145488.1
UniGeneiMm.299399

Genome annotation databases

EnsembliENSMUST00000002840; ENSMUSP00000002840; ENSMUSG00000002763
GeneIDi224824
KEGGimmu:224824
UCSCiuc008cud.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX6_MOUSE
AccessioniPrimary (citable) accession number: Q99LC9
Secondary accession number(s): Q6YNQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health