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Protein

Peroxisome assembly factor 2

Gene

Pex6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 478ATPSequence analysis8
Nucleotide bindingi745 – 752ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly factor 2
Short name:
PAF-2
Alternative name(s):
Peroxin-6
Peroxisomal biogenesis factor 6
Peroxisomal-type ATPase 1
Gene namesi
Name:Pex6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385054. Pex6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846081 – 981Peroxisome assembly factor 2Add BLAST981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ99LC9.
MaxQBiQ99LC9.
PaxDbiQ99LC9.
PeptideAtlasiQ99LC9.
PRIDEiQ99LC9.

PTM databases

iPTMnetiQ99LC9.
PhosphoSitePlusiQ99LC9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002763.
CleanExiMM_PEX6.
GenevisibleiQ99LC9. MM.

Interactioni

Subunit structurei

Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interacts with ZFAND6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230326. 5 interactors.
IntActiQ99LC9. 1 interactor.
MINTiMINT-4107252.
STRINGi10090.ENSMUSP00000002840.

Structurei

3D structure databases

ProteinModelPortaliQ99LC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0736. Eukaryota.
ENOG410XNT9. LUCA.
GeneTreeiENSGT00550000074953.
HOGENOMiHOG000241031.
HOVERGENiHBG002311.
InParanoidiQ99LC9.
KOiK13339.
OMAiPSVSWHD.
OrthoDBiEOG091G048C.
PhylomeDBiQ99LC9.
TreeFamiTF106428.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVLRVLD PFPTETPPLA VLLPPGGPWP ATGLGLVLAL RPASESPAKP
60 70 80 90 100
ALLVAAVEGS GAQGEQRGPG PPPLLVSRAL LRVLALGPGA RVRARLVRRP
110 120 130 140 150
PALGWALLAT APGPGLGPRV GPLLVRRGET LPVPGSRVLE TRPALQGLLG
160 170 180 190 200
PGTRLAVTEL RGRAKLGQES RDHSHPPPPP VVSSFAASHS VRRLRGVLGG
210 220 230 240 250
TGDALGVSRS CLRSLGLFQG EWVWVAQVAE LPNSSQPRLA QVQVLEPRWE
260 270 280 290 300
LSERLGPNSG QQPGEPLADG LVFLPATLAF NLGCDPLEVG ELRIQRYLEG
310 320 330 340 350
SIAPENKGSC SPLPGPPFAR ELHIEILSSP HYSANGNYDH VLYRHFQTPR
360 370 380 390 400
VVQEGDVLCV STAGQVEILE GSLERLPRWR EMFFKVKKTV GEAPEGPASA
410 420 430 440 450
FLADTTHTSL YLAGTALSHV PSLPSGRSPP WDSLSPPGLE ALVNELCAIL
460 470 480 490 500
KPHLQPGGTL LTGTSCVLLQ GPPGSGKTTA VTAACSRLGL HLLKVPCSSL
510 520 530 540 550
CADSSRAVET KLQATFSRAR RCRPAVLLLT AVDLLGRDRD GLGEDARVAA
560 570 580 590 600
TLRHLLLDED ALSRCPPLMV VATTSRVQDL PTDVQTAFPH ELEVPVLSEA
610 620 630 640 650
QRLSILQALT AHLPLGQEVN LPQLARRCAG FVVGDLYALL THTCRAACTR
660 670 680 690 700
IRASGSAGGL SEEDEGDLCV AGFPLLAEDF GQALDQLQTA HSQAVGAPRI
710 720 730 740 750
PSVSWHDVGG LQDVKKEILE TIQLPLEHPE LLSLGLRRSG LLLHGPPGTG
760 770 780 790 800
KTLLAKAVAT ECSLTFLSVK GPELINMYVG QSEENVREVF ARARAAAPCI
810 820 830 840 850
IFFDELDSLA PSRGRSGDSG GVMDRVVSQL LAELDGLHST QDVFVIGATN
860 870 880 890 900
RPDLLDPALL RPGRFDKLVF VGASEDRASQ LRVLSAITRK FKLEASVSLA
910 920 930 940 950
NVLDCCPPQL TGADLYSLCS DAMMTALKRR VRDLEEGLEL RSSALLLTME
960 970 980
DLLQAAARLQ PSVSEQELLR YKRIQRKFAA C
Length:981
Mass (Da):104,549
Last modified:June 1, 2001 - v1
Checksum:i955DBBFB130117CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti520R → H in AAL06143 (Ref. 2) Curated1
Sequence conflicti895A → P in AAL06143 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003424 mRNA. Translation: AAH03424.1.
AY054409 Genomic DNA. Translation: AAL06143.1.
CCDSiCCDS28837.1.
RefSeqiNP_663463.1. NM_145488.1.
UniGeneiMm.299399.

Genome annotation databases

EnsembliENSMUST00000002840; ENSMUSP00000002840; ENSMUSG00000002763.
GeneIDi224824.
KEGGimmu:224824.
UCSCiuc008cud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003424 mRNA. Translation: AAH03424.1.
AY054409 Genomic DNA. Translation: AAL06143.1.
CCDSiCCDS28837.1.
RefSeqiNP_663463.1. NM_145488.1.
UniGeneiMm.299399.

3D structure databases

ProteinModelPortaliQ99LC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230326. 5 interactors.
IntActiQ99LC9. 1 interactor.
MINTiMINT-4107252.
STRINGi10090.ENSMUSP00000002840.

PTM databases

iPTMnetiQ99LC9.
PhosphoSitePlusiQ99LC9.

Proteomic databases

EPDiQ99LC9.
MaxQBiQ99LC9.
PaxDbiQ99LC9.
PeptideAtlasiQ99LC9.
PRIDEiQ99LC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002840; ENSMUSP00000002840; ENSMUSG00000002763.
GeneIDi224824.
KEGGimmu:224824.
UCSCiuc008cud.1. mouse.

Organism-specific databases

CTDi5190.
MGIiMGI:2385054. Pex6.

Phylogenomic databases

eggNOGiKOG0736. Eukaryota.
ENOG410XNT9. LUCA.
GeneTreeiENSGT00550000074953.
HOGENOMiHOG000241031.
HOVERGENiHBG002311.
InParanoidiQ99LC9.
KOiK13339.
OMAiPSVSWHD.
OrthoDBiEOG091G048C.
PhylomeDBiQ99LC9.
TreeFamiTF106428.

Miscellaneous databases

PROiQ99LC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002763.
CleanExiMM_PEX6.
GenevisibleiQ99LC9. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX6_MOUSE
AccessioniPrimary (citable) accession number: Q99LC9
Secondary accession number(s): Q6YNQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.