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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

Eif2b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:Eif2b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2384802. Eif2b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560561 – 305Translation initiation factor eIF-2B subunit alphaAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99LC8.
MaxQBiQ99LC8.
PaxDbiQ99LC8.
PRIDEiQ99LC8.

PTM databases

iPTMnetiQ99LC8.
PhosphoSitePlusiQ99LC8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029388.
ExpressionAtlasiQ99LC8. baseline and differential.
GenevisibleiQ99LC8. MM.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

BioGridi229070. 2 interactors.
IntActiQ99LC8. 1 interactor.
STRINGi10090.ENSMUSP00000031334.

Structurei

3D structure databases

ProteinModelPortaliQ99LC8.
SMRiQ99LC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1466. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074853.
HOGENOMiHOG000175731.
HOVERGENiHBG051457.
InParanoidiQ99LC8.
KOiK03239.
OMAiVRFRVIY.
OrthoDBiEOG091G0CQR.
PhylomeDBiQ99LC8.
TreeFamiTF101505.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99LC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGELIEYF KSQMKGDPKM ASAVAAIQTL LEFLKRDKGE TLQGLRANLT
60 70 80 90 100
YAIKTLCGVD SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF
110 120 130 140 150
LRRISLSRNK IANLCHTFIK DGARILTHAY SRVVLRVLEE AVAAKKRFSV
160 170 180 190 200
YITESQPDLS GKKMAKALSH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV
210 220 230 240 250
VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQEDVPDKF
260 270 280 290 300
KYKADTLKSV QTGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL

IKLYL
Length:305
Mass (Da):33,816
Last modified:June 1, 2001 - v1
Checksum:i9D9ED81F0D9B8411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003426 mRNA. Translation: AAH03426.1.
CCDSiCCDS39282.1.
RefSeqiNP_663346.1. NM_145371.4.
UniGeneiMm.28839.

Genome annotation databases

EnsembliENSMUST00000031334; ENSMUSP00000031334; ENSMUSG00000029388.
GeneIDi209354.
KEGGimmu:209354.
UCSCiuc008zqd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003426 mRNA. Translation: AAH03426.1.
CCDSiCCDS39282.1.
RefSeqiNP_663346.1. NM_145371.4.
UniGeneiMm.28839.

3D structure databases

ProteinModelPortaliQ99LC8.
SMRiQ99LC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229070. 2 interactors.
IntActiQ99LC8. 1 interactor.
STRINGi10090.ENSMUSP00000031334.

PTM databases

iPTMnetiQ99LC8.
PhosphoSitePlusiQ99LC8.

Proteomic databases

EPDiQ99LC8.
MaxQBiQ99LC8.
PaxDbiQ99LC8.
PRIDEiQ99LC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031334; ENSMUSP00000031334; ENSMUSG00000029388.
GeneIDi209354.
KEGGimmu:209354.
UCSCiuc008zqd.1. mouse.

Organism-specific databases

CTDi1967.
MGIiMGI:2384802. Eif2b1.

Phylogenomic databases

eggNOGiKOG1466. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074853.
HOGENOMiHOG000175731.
HOVERGENiHBG051457.
InParanoidiQ99LC8.
KOiK03239.
OMAiVRFRVIY.
OrthoDBiEOG091G0CQR.
PhylomeDBiQ99LC8.
TreeFamiTF101505.

Enzyme and pathway databases

ReactomeiR-MMU-72731. Recycling of eIF2:GDP.

Miscellaneous databases

ChiTaRSiEif2b1. mouse.
PROiQ99LC8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029388.
ExpressionAtlasiQ99LC8. baseline and differential.
GenevisibleiQ99LC8. MM.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BA_MOUSE
AccessioniPrimary (citable) accession number: Q99LC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.