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Protein

Cleavage stimulation factor subunit 1

Gene

Cstf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 1
Alternative name(s):
CF-1 50 kDa subunit
Cleavage stimulation factor 50 kDa subunit
Short name:
CSTF 50 kDa subunit
Short name:
CstF-50
Gene namesi
Name:Cstf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914587 Cstf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509451 – 431Cleavage stimulation factor subunit 1Add BLAST431

Proteomic databases

EPDiQ99LC2
MaxQBiQ99LC2
PaxDbiQ99LC2
PeptideAtlasiQ99LC2
PRIDEiQ99LC2

PTM databases

iPTMnetiQ99LC2
PhosphoSitePlusiQ99LC2

Expressioni

Gene expression databases

BgeeiENSMUSG00000027498
ExpressionAtlasiQ99LC2 baseline and differential
GenevisibleiQ99LC2 MM

Interactioni

Subunit structurei

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi2121171 interactor.
IntActiQ99LC2 1 interactor.
MINTiQ99LC2
STRINGi10090.ENSMUSP00000112076

Structurei

3D structure databases

ProteinModelPortaliQ99LC2
SMRiQ99LC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati106 – 145WD 1Add BLAST40
Repeati171 – 210WD 2Add BLAST40
Repeati215 – 254WD 3Add BLAST40
Repeati260 – 301WD 4Add BLAST42
Repeati303 – 343WD 5Add BLAST41
Repeati395 – 431WD 6Add BLAST37

Domaini

The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3 (By similarity).By similarity
N-terminus mediates homodimerization.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0640 Eukaryota
ENOG410XPWJ LUCA
GeneTreeiENSGT00910000144253
HOGENOMiHOG000234077
HOVERGENiHBG051144
InParanoidiQ99LC2
KOiK14406
OMAiITHSPNA
OrthoDBiEOG091G07AW
PhylomeDBiQ99LC2
TreeFamiTF314234

Family and domain databases

Gene3Di1.20.960.501 hit
2.130.10.102 hits
InterProiView protein in InterPro
IPR032028 CSTF1_dimer
IPR038184 CSTF1_dimer_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF16699 CSTF1_dimer, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q99LC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL
60 70 80 90 100
LHLIKLGMEN DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE
110 120 130 140 150
TCYVTSHKGP CRVATYSRDG QLIATGSADA SIKILDTERM LAKSAMPIEV
160 170 180 190 200
MMNETAQQNM ENHPVIRTLY DHVDEVTCLA FHPTEQILAS GSRDYTLKLF
210 220 230 240 250
DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT LRLYDINTFQ
260 270 280 290 300
CFVSCNPQDQ HTDAICSVNY NPSANMYVTG SKDGCIKLWD GVSNRCITTF
310 320 330 340 350
EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS
360 370 380 390 400
GRQVHRTQAV FNHTEDYILL PDERTISLCC WDSRTAERRN LLSLGHNNIV
410 420 430
RCIVHSPTNP GFMTCSDDFR ARFWYRRSTT D
Length:431
Mass (Da):48,382
Last modified:June 1, 2001 - v1
Checksum:i8BD7BEFE422824D2
GO

Sequence cautioni

The sequence BAB27929 differs from that shown. Reason: Frameshift at position 314.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011943 mRNA Translation: BAB27929.1 Frameshift.
AK050686 mRNA Translation: BAC34379.1
AK078667 mRNA Translation: BAC37353.1
AK145001 mRNA Translation: BAE26180.1
BC003440 mRNA Translation: AAH03440.1
CCDSiCCDS17130.1
RefSeqiNP_077161.1, NM_024199.2
XP_006500135.2, XM_006500072.3
UniGeneiMm.26944

Genome annotation databases

EnsembliENSMUST00000116375; ENSMUSP00000112076; ENSMUSG00000027498
GeneIDi67337
KEGGimmu:67337
UCSCiuc008ocp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCSTF1_MOUSE
AccessioniPrimary (citable) accession number: Q99LC2
Secondary accession number(s): Q3UMB8, Q8BJW1, Q9CSU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome