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Protein

Dehydrogenase/reductase SDR family member 4

Gene

Dhrs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateBy similarity1
Active sitei183Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 61NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859 RA biosynthesis pathway
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NDRD
Short name:
mouNRDR
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
Gene namesi
Name:Dhrs4
Synonyms:D14Ucla2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:90169 Dhrs4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546481 – 279Dehydrogenase/reductase SDR family member 4Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93N6-acetyllysine; alternateCombined sources1
Modified residuei93N6-succinyllysine; alternateCombined sources1
Modified residuei106N6-acetyllysineCombined sources1
Modified residuei217N6-acetyllysine; alternateCombined sources1
Modified residuei217N6-succinyllysine; alternateCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei228N6-succinyllysineCombined sources1
Modified residuei235N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99LB2
MaxQBiQ99LB2
PaxDbiQ99LB2
PRIDEiQ99LB2

PTM databases

iPTMnetiQ99LB2
PhosphoSitePlusiQ99LB2
SwissPalmiQ99LB2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022210
CleanExiMM_DHRS4
ExpressionAtlasiQ99LB2 baseline and differential
GenevisibleiQ99LB2 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205827, 1 interactor
IntActiQ99LB2, 5 interactors
MINTiQ99LB2
STRINGi10090.ENSMUSP00000022821

Structurei

3D structure databases

ProteinModelPortaliQ99LB2
SMRiQ99LB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 279Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000144022
HOVERGENiHBG105779
InParanoidiQ99LB2
KOiK11147
OMAiFELLGAY
OrthoDBiEOG091G0G3R
TreeFamiTF315405

Family and domain databases

InterProiView protein in InterPro
IPR029511 DHRS4-like
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PANTHERiPTHR43943:SF8 PTHR43943:SF8, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q99LB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKAGRLLGG WTQAWMSVRM ASSGLTRRNP LSNKVALVTA STDGIGFAIA
60 70 80 90 100
RRLAEDGAHV VVSSRKQQNV DRAVATLQGE GLSVTGIVCH VGKAEDREKL
110 120 130 140 150
ITTALKRHQG IDILVSNAAV NPFFGNLMDV TEEVWDKVLS INVTATAMMI
160 170 180 190 200
KAVVPEMEKR GGGSVVIVGS VAGFTRFPSL GPYNVSKTAL LGLTKNFAAE
210 220 230 240 250
LAPKNIRVNC LAPGLIKTRF SSVLWEEKAR EDFIKEAMQI RRLGKPEDCA
260 270
GIVSFLCSED ASYINGETVV VGGGTPSRL
Length:279
Mass (Da):29,885
Last modified:October 3, 2012 - v3
Checksum:i985668BDE2935072
GO

Sequence cautioni

The sequence AAH03484 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB18776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109Q → R in AAH03484 (PubMed:15489334).Curated1
Sequence conflicti109Q → R in AAH54361 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045132 mRNA Translation: BAB18776.1 Different initiation.
AC159002 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL36299.1
BC003484 mRNA Translation: AAH03484.1 Different initiation.
BC054361 mRNA Translation: AAH54361.1
CCDSiCCDS27111.1
RefSeqiNP_001033027.2, NM_001037938.2
UniGeneiMm.27427

Genome annotation databases

EnsembliENSMUST00000022821; ENSMUSP00000022821; ENSMUSG00000022210
GeneIDi28200
KEGGimmu:28200
UCSCiuc007tym.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDHRS4_MOUSE
AccessioniPrimary (citable) accession number: Q99LB2
Secondary accession number(s): G3X8V7, Q9EQU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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