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Protein

Deoxynucleotidyltransferase terminal-interacting protein 1

Gene

Dnttip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi158 – 172A.T hookCuratedAdd BLAST15
DNA bindingi215 – 236H-T-H motifCuratedAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 1
Alternative name(s):
Terminal deoxynucleotidyltransferase-interacting factor 1
Short name:
TdIF1
Short name:
TdT-interacting factor 1
Gene namesi
Name:Dnttip1
Synonyms:Tdif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923483. Dnttip1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724741 – 328Deoxynucleotidyltransferase terminal-interacting protein 1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99LB0.
MaxQBiQ99LB0.
PaxDbiQ99LB0.
PRIDEiQ99LB0.

PTM databases

iPTMnetiQ99LB0.
PhosphoSitePlusiQ99LB0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017299.
ExpressionAtlasiQ99LB0. baseline and differential.
GenevisibleiQ99LB0. MM.

Interactioni

Subunit structurei

Monomer and homodimer (By similarity). A minor proportion may form homotrimers (By similarity). Interacts with ZNF541 (PubMed:18849567). Interacts with the terminal deoxynucleotidyltransferase DNTT (By similarity). Interacts with TRERF1 (By similarity). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (By similarity). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218041. 1 interactor.
IntActiQ99LB0. 2 interactors.
MINTiMINT-4137321.
STRINGi10090.ENSMUSP00000017443.

Structurei

3D structure databases

ProteinModelPortaliQ99LB0.
SMRiQ99LB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 147Important for dimerizationBy similarityAdd BLAST92
Regioni196 – 315Important for DNA and nucleosome bindingBy similarityAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 169Nuclear localization signalSequence analysis7

Domaini

The N-terminal domain mediates dimerization.By similarity
The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4801. Eukaryota.
ENOG410XPIX. LUCA.
GeneTreeiENSGT00510000047836.
HOGENOMiHOG000059597.
HOVERGENiHBG057022.
InParanoidiQ99LB0.
KOiK08707.
OMAiLAERHHM.
OrthoDBiEOG091G0E9R.
PhylomeDBiQ99LB0.
TreeFamiTF329275.

Family and domain databases

InterProiIPR026064. TdIF1.
[Graphical view]
PANTHERiPTHR23399. PTHR23399. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGATGDTEQP RGPGGAERGG LELGDAGAAG QPVLTNPWNI MIKHRQVQRR
60 70 80 90 100
GRRSQMTTSF TDPAISMDLL RAVLQPSINE EIQGVFNKYM KFFQKAALNV
110 120 130 140 150
RDNVGEEVDA EQLIQEACRS CLEQAKLLFS DGEKVIPRLA HELPGIKRGR
160 170 180 190 200
QAEEESHRGS PIPKKRKGRP PGHVLSNDRA AAGMVWKQKS CEPIRREGPK
210 220 230 240 250
WDPARLNEST TFVLGSRANK ALGMGGTRGR IYIKHPHLFK YAADPQDKHW
260 270 280 290 300
LAEQHHMRAT GGKMAYLLIE EDIRDLAASD DYRGCLDLKL EELKSFVLPS
310 320
WMVEKMRKYM ETLRTENEHR AAEAPPQT
Length:328
Mass (Da):36,852
Last modified:June 1, 2001 - v1
Checksum:i221D334D832F9AB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045974 mRNA. Translation: BAB82521.1.
BC003486 mRNA. Translation: AAH03486.1.
CCDSiCCDS17054.1.
RefSeqiNP_598524.1. NM_133763.1.
UniGeneiMm.440009.

Genome annotation databases

EnsembliENSMUST00000017443; ENSMUSP00000017443; ENSMUSG00000017299.
GeneIDi76233.
KEGGimmu:76233.
UCSCiuc008nvx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045974 mRNA. Translation: BAB82521.1.
BC003486 mRNA. Translation: AAH03486.1.
CCDSiCCDS17054.1.
RefSeqiNP_598524.1. NM_133763.1.
UniGeneiMm.440009.

3D structure databases

ProteinModelPortaliQ99LB0.
SMRiQ99LB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218041. 1 interactor.
IntActiQ99LB0. 2 interactors.
MINTiMINT-4137321.
STRINGi10090.ENSMUSP00000017443.

PTM databases

iPTMnetiQ99LB0.
PhosphoSitePlusiQ99LB0.

Proteomic databases

EPDiQ99LB0.
MaxQBiQ99LB0.
PaxDbiQ99LB0.
PRIDEiQ99LB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017443; ENSMUSP00000017443; ENSMUSG00000017299.
GeneIDi76233.
KEGGimmu:76233.
UCSCiuc008nvx.1. mouse.

Organism-specific databases

CTDi116092.
MGIiMGI:1923483. Dnttip1.

Phylogenomic databases

eggNOGiKOG4801. Eukaryota.
ENOG410XPIX. LUCA.
GeneTreeiENSGT00510000047836.
HOGENOMiHOG000059597.
HOVERGENiHBG057022.
InParanoidiQ99LB0.
KOiK08707.
OMAiLAERHHM.
OrthoDBiEOG091G0E9R.
PhylomeDBiQ99LB0.
TreeFamiTF329275.

Miscellaneous databases

ChiTaRSiDnttip1. mouse.
PROiQ99LB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017299.
ExpressionAtlasiQ99LB0. baseline and differential.
GenevisibleiQ99LB0. MM.

Family and domain databases

InterProiIPR026064. TdIF1.
[Graphical view]
PANTHERiPTHR23399. PTHR23399. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTDIF1_MOUSE
AccessioniPrimary (citable) accession number: Q99LB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.