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Protein

Tetraspanin

Gene

Tspan6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
TetraspaninUniRule annotation
Gene namesi
Name:Tspan6Imported
Synonyms:Tm4sf6Imported
ORF Names:mCG_9501Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1926264. Tspan6.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 42HelicalUniRule annotationAdd BLAST22
Transmembranei62 – 80HelicalUniRule annotationAdd BLAST19
Transmembranei92 – 114HelicalUniRule annotationAdd BLAST23
Transmembranei211 – 233HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000067377.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084838.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOVERGENiHBG107306.
KOiK17295.
OMAiEDCSPQR.
OrthoDBiEOG091G0NJA.
TreeFamiTF352891.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99L96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSRRLQT KPVITCLKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIGTGTV IILLGTFGCF ATCRASAWML KLYAMFLTLI
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKSNYENAL KEYNSTGDYR SEAVDKIQST
160 170 180 190 200
LHCCGVTNYG DWKGTNYYSE TGFPKSCCKL EGCYPQRDAD KVNEEGCFIK
210 220 230 240
VMTTIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,303
Last modified:June 1, 2001 - v1
Checksum:i895142C6381037A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691421 Genomic DNA. No translation available.
BC003733 mRNA. Translation: AAH03733.1.
BC110314 mRNA. Translation: AAI10315.1.
AK146673 mRNA. Translation: BAE27349.1.
AK149204 mRNA. Translation: BAE28764.1.
AK167384 mRNA. Translation: BAE39476.1.
CH466598 Genomic DNA. Translation: EDL20414.1.
RefSeqiNP_062630.2. NM_019656.3.
UniGeneiMm.46701.

Genome annotation databases

EnsembliENSMUST00000087557; ENSMUSP00000084838; ENSMUSG00000067377.
GeneIDi56496.
KEGGimmu:56496.
UCSCiuc009ufa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691421 Genomic DNA. No translation available.
BC003733 mRNA. Translation: AAH03733.1.
BC110314 mRNA. Translation: AAI10315.1.
AK146673 mRNA. Translation: BAE27349.1.
AK149204 mRNA. Translation: BAE28764.1.
AK167384 mRNA. Translation: BAE39476.1.
CH466598 Genomic DNA. Translation: EDL20414.1.
RefSeqiNP_062630.2. NM_019656.3.
UniGeneiMm.46701.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087557; ENSMUSP00000084838; ENSMUSG00000067377.
GeneIDi56496.
KEGGimmu:56496.
UCSCiuc009ufa.1. mouse.

Organism-specific databases

CTDi7105.
MGIiMGI:1926264. Tspan6.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOVERGENiHBG107306.
KOiK17295.
OMAiEDCSPQR.
OrthoDBiEOG091G0NJA.
TreeFamiTF352891.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067377.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ99L96_MOUSE
AccessioniPrimary (citable) accession number: Q99L96
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.