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Protein

Beta-1-syntrophin

Gene

Sntb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 1
Short name:
DAPA1B
Syntrophin-2
Gene namesi
Name:Sntb1
Synonyms:Snt2b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:101781. Sntb1.

Subcellular locationi

  • Cell membranesarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cell junction 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: MGI
  • protein complex Source: MGI
  • sarcolemma Source: UniProtKB-SubCell
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001840102 – 537Beta-1-syntrophinAdd BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei125PhosphoserineBy similarity1
Modified residuei204PhosphoserineCombined sources1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei231PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CaM-kinase II.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ99L88.
PeptideAtlasiQ99L88.
PRIDEiQ99L88.

PTM databases

iPTMnetiQ99L88.
PhosphoSitePlusiQ99L88.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the liver.

Gene expression databases

BgeeiENSMUSG00000060429.
CleanExiMM_SNTB1.
GenevisibleiQ99L88. MM.

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A.By similarityCurated2 Publications

Protein-protein interaction databases

BioGridi203383. 1 interactor.
IntActiQ99L88. 5 interactors.
MINTiMINT-1846430.
STRINGi10090.ENSMUSP00000041294.

Structurei

3D structure databases

ProteinModelPortaliQ99L88.
SMRiQ99L88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 297PH 1PROSITE-ProRule annotationAdd BLAST280
Domaini111 – 194PDZPROSITE-ProRule annotationAdd BLAST84
Domaini321 – 432PH 2PROSITE-ProRule annotationAdd BLAST112
Domaini481 – 537SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni517 – 537Calmodulin-bindingBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 12Poly-AlaAdd BLAST11
Compositional biasi13 – 16Poly-Gly4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3551. Eukaryota.
ENOG410XSII. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ99L88.
OMAiQGDRRCI.
OrthoDBiEOG091G0O31.
PhylomeDBiQ99L88.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 2 hits.
PfamiPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99L88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE
60 70 80 90 100
EGAAAYNGIG AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ
110 120 130 140 150
VPESISNQKR GVKVLKQELG GLGISIKGGK ENKMPILISK IFKGLAADQT
160 170 180 190 200
QALYVGDAIL SVNGADLRDA THDEAVQALK RAGKEVLLEV KYMREATPYV
210 220 230 240 250
KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR KSIPLKMCYV
260 270 280 290 300
TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL
310 320 330 340 350
TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK
360 370 380 390 400
DLLIYDSMPR RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR
410 420 430 440 450
TGTKQGIETH LFRAEISRDL SHWTRSIVQG CHNSAELTAE ITTACTYRNQ
460 470 480 490 500
ECRLTIHYDN GFSISTEPQD GAFPKTIIQS PYEKLKMSSD DGIRMLYLDF
510 520 530
GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA
Length:537
Mass (Da):58,081
Last modified:January 23, 2007 - v4
Checksum:i91A5E4DD0A97A665
GO
Isoform 2 (identifier: Q99L88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-276: RQLEIHSPDAKHTVI → STHPSDLIPIQGWAA
     277-537: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):28,944
Checksum:i59ED70FAE4122803
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006356262 – 276RQLEI…KHTVI → STHPSDLIPIQGWAA in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_006357277 – 537Missing in isoform 2. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA. Translation: AAB66697.1.
BC003748 mRNA. Translation: AAH03748.1.
CCDSiCCDS27479.1. [Q99L88-1]
RefSeqiNP_057876.1. NM_016667.3. [Q99L88-1]
XP_006520734.1. XM_006520671.3. [Q99L88-1]
UniGeneiMm.309425.

Genome annotation databases

EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429. [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429. [Q99L88-2]
GeneIDi20649.
KEGGimmu:20649.
UCSCiuc007vsk.1. mouse. [Q99L88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA. Translation: AAB66697.1.
BC003748 mRNA. Translation: AAH03748.1.
CCDSiCCDS27479.1. [Q99L88-1]
RefSeqiNP_057876.1. NM_016667.3. [Q99L88-1]
XP_006520734.1. XM_006520671.3. [Q99L88-1]
UniGeneiMm.309425.

3D structure databases

ProteinModelPortaliQ99L88.
SMRiQ99L88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203383. 1 interactor.
IntActiQ99L88. 5 interactors.
MINTiMINT-1846430.
STRINGi10090.ENSMUSP00000041294.

PTM databases

iPTMnetiQ99L88.
PhosphoSitePlusiQ99L88.

Proteomic databases

PaxDbiQ99L88.
PeptideAtlasiQ99L88.
PRIDEiQ99L88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429. [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429. [Q99L88-2]
GeneIDi20649.
KEGGimmu:20649.
UCSCiuc007vsk.1. mouse. [Q99L88-1]

Organism-specific databases

CTDi6641.
MGIiMGI:101781. Sntb1.

Phylogenomic databases

eggNOGiKOG3551. Eukaryota.
ENOG410XSII. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ99L88.
OMAiQGDRRCI.
OrthoDBiEOG091G0O31.
PhylomeDBiQ99L88.
TreeFamiTF317932.

Miscellaneous databases

ChiTaRSiSntb1. mouse.
PROiQ99L88.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060429.
CleanExiMM_SNTB1.
GenevisibleiQ99L88. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 2 hits.
PfamiPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB1_MOUSE
AccessioniPrimary (citable) accession number: Q99L88
Secondary accession number(s): O35925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.