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Q99L88 (SNTB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 1
Short name=DAPA1B
Syntrophin-2
Gene names
Name:Sntb1
Synonyms:Snt2b1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

Subunit structure

Monomer and homodimer Probable. Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 By similarity. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A. Ref.1 Ref.3

Subcellular location

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasmcytoskeleton. Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. Ref.1

Tissue specificity

Ubiquitous. Expressed at high levels in the liver.

Domain

The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.

The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.

The SU domain binds calmodulin in a calcium-dependent manner By similarity.

Post-translational modification

Phosphorylated by CaM-kinase II By similarity.

Sequence similarities

Belongs to the syntrophin family.

Contains 1 PDZ (DHR) domain.

Contains 2 PH domains.

Contains 1 SU (syntrophin unique) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99L88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99L88-2)

The sequence of this isoform differs from the canonical sequence as follows:
     262-276: RQLEIHSPDAKHTVI → STHPSDLIPIQGWAA
     277-537: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 537536Beta-1-syntrophin
PRO_0000184010

Regions

Domain18 – 297280PH 1
Domain111 – 19484PDZ
Domain321 – 432112PH 2
Domain481 – 53757SU
Region517 – 53721Calmodulin-binding By similarity
Compositional bias2 – 1211Poly-Ala
Compositional bias13 – 164Poly-Gly

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue861Phosphoserine Ref.4
Modified residue2131Phosphothreonine Ref.4
Modified residue2181Phosphoserine Ref.4
Modified residue3881Phosphoserine By similarity

Natural variations

Alternative sequence262 – 27615RQLEI…KHTVI → STHPSDLIPIQGWAA in isoform 2.
VSP_006356
Alternative sequence277 – 537261Missing in isoform 2.
VSP_006357

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 91A5E4DD0A97A665

FASTA53758,081
        10         20         30         40         50         60 
MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE EGAAAYNGIG 

        70         80         90        100        110        120 
AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ VPESISNQKR GVKVLKQELG 

       130        140        150        160        170        180 
GLGISIKGGK ENKMPILISK IFKGLAADQT QALYVGDAIL SVNGADLRDA THDEAVQALK 

       190        200        210        220        230        240 
RAGKEVLLEV KYMREATPYV KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR 

       250        260        270        280        290        300 
KSIPLKMCYV TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL 

       310        320        330        340        350        360 
TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK DLLIYDSMPR 

       370        380        390        400        410        420 
RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR TGTKQGIETH LFRAEISRDL 

       430        440        450        460        470        480 
SHWTRSIVQG CHNSAELTAE ITTACTYRNQ ECRLTIHYDN GFSISTEPQD GAFPKTIIQS 

       490        500        510        520        530 
PYEKLKMSSD DGIRMLYLDF GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA 

« Hide

Isoform 2 [UniParc].

Checksum: 59ED70FAE4122803
Show »

FASTA27628,944

References

« Hide 'large scale' references
[1]"Differential association of syntrophin pairs with the dystrophin complex."
Peters M.F., Adams M.E., Froehner S.C.
J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH DMD; DTNA AND UTRN.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Mammary tumor.
[3]"Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins."
Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C.
J. Neurosci. 18:128-137(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCN4A AND SCN5A.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; THR-213 AND SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89997 mRNA. Translation: AAB66697.1.
BC003748 mRNA. Translation: AAH03748.1.
RefSeqNP_057876.1. NM_016667.3.
XP_006520734.1. XM_006520671.1.
UniGeneMm.309425.

3D structure databases

ProteinModelPortalQ99L88.
SMRQ99L88. Positions 16-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203383. 1 interaction.
IntActQ99L88. 5 interactions.
MINTMINT-1846430.

PTM databases

PhosphoSiteQ99L88.

Proteomic databases

PaxDbQ99L88.
PRIDEQ99L88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429. [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429. [Q99L88-2]
GeneID20649.
KEGGmmu:20649.
UCSCuc007vsk.1. mouse. [Q99L88-1]

Organism-specific databases

CTD6641.
MGIMGI:101781. Sntb1.

Phylogenomic databases

eggNOGNOG318350.
GeneTreeENSGT00550000074581.
HOGENOMHOG000231596.
HOVERGENHBG054204.
InParanoidQ99L88.
OMADAKHTVV.
OrthoDBEOG7R56VZ.
PhylomeDBQ99L88.
TreeFamTF317932.

Gene expression databases

BgeeQ99L88.
CleanExMM_SNTB1.
GenevestigatorQ99L88.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR015482. Syntrophin.
[Graphical view]
PANTHERPTHR10554. PTHR10554. 1 hit.
PfamPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNTB1. mouse.
NextBio299067.
PROQ99L88.
SOURCESearch...

Entry information

Entry nameSNTB1_MOUSE
AccessionPrimary (citable) accession number: Q99L88
Secondary accession number(s): O35925
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot