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Q99L88

- SNTB1_MOUSE

UniProt

Q99L88 - SNTB1_MOUSE

Protein

Beta-1-syntrophin

Gene

Sntb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

    GO - Molecular functioni

    1. protein binding Source: MGI

    Keywords - Ligandi

    Actin-binding, Calcium, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1-syntrophin
    Alternative name(s):
    59 kDa dystrophin-associated protein A1 basic component 1
    Short name:
    DAPA1B
    Syntrophin-2
    Gene namesi
    Name:Sntb1
    Synonyms:Snt2b1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:101781. Sntb1.

    Subcellular locationi

    Cell membranesarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cell junction 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. protein complex Source: MGI
    5. sarcolemma Source: UniProtKB-SubCell
    6. synapse Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 537536Beta-1-syntrophinPRO_0000184010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei86 – 861Phosphoserine1 Publication
    Modified residuei213 – 2131Phosphothreonine1 Publication
    Modified residuei218 – 2181Phosphoserine1 Publication
    Modified residuei388 – 3881PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by CaM-kinase II.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ99L88.
    PaxDbiQ99L88.
    PRIDEiQ99L88.

    PTM databases

    PhosphoSiteiQ99L88.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed at high levels in the liver.

    Gene expression databases

    BgeeiQ99L88.
    CleanExiMM_SNTB1.
    GenevestigatoriQ99L88.

    Interactioni

    Subunit structurei

    Monomer and homodimer Probable. Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 By similarity. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A.By similarity2 PublicationsCurated

    Protein-protein interaction databases

    BioGridi203383. 1 interaction.
    IntActiQ99L88. 5 interactions.
    MINTiMINT-1846430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99L88.
    SMRiQ99L88. Positions 16-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 297280PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 19484PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini321 – 432112PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 53757SUAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni517 – 53721Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 1211Poly-AlaAdd
    BLAST
    Compositional biasi13 – 164Poly-Gly

    Domaini

    The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
    The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.By similarity
    The SU domain binds calmodulin in a calcium-dependent manner.By similarity

    Sequence similaritiesi

    Belongs to the syntrophin family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG318350.
    GeneTreeiENSGT00550000074581.
    HOGENOMiHOG000231596.
    HOVERGENiHBG054204.
    InParanoidiQ99L88.
    OMAiDAKHTVV.
    OrthoDBiEOG7R56VZ.
    PhylomeDBiQ99L88.
    TreeFamiTF317932.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    [Graphical view]
    PANTHERiPTHR10554. PTHR10554. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99L88-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE    50
    EGAAAYNGIG AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ 100
    VPESISNQKR GVKVLKQELG GLGISIKGGK ENKMPILISK IFKGLAADQT 150
    QALYVGDAIL SVNGADLRDA THDEAVQALK RAGKEVLLEV KYMREATPYV 200
    KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR KSIPLKMCYV 250
    TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL 300
    TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK 350
    DLLIYDSMPR RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR 400
    TGTKQGIETH LFRAEISRDL SHWTRSIVQG CHNSAELTAE ITTACTYRNQ 450
    ECRLTIHYDN GFSISTEPQD GAFPKTIIQS PYEKLKMSSD DGIRMLYLDF 500
    GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA 537
    Length:537
    Mass (Da):58,081
    Last modified:January 23, 2007 - v4
    Checksum:i91A5E4DD0A97A665
    GO
    Isoform 2 (identifier: Q99L88-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         262-276: RQLEIHSPDAKHTVI → STHPSDLIPIQGWAA
         277-537: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:276
    Mass (Da):28,944
    Checksum:i59ED70FAE4122803
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei262 – 27615RQLEI…KHTVI → STHPSDLIPIQGWAA in isoform 2. 1 PublicationVSP_006356Add
    BLAST
    Alternative sequencei277 – 537261Missing in isoform 2. 1 PublicationVSP_006357Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89997 mRNA. Translation: AAB66697.1.
    BC003748 mRNA. Translation: AAH03748.1.
    CCDSiCCDS27479.1. [Q99L88-1]
    RefSeqiNP_057876.1. NM_016667.3. [Q99L88-1]
    XP_006520734.1. XM_006520671.1. [Q99L88-1]
    UniGeneiMm.309425.

    Genome annotation databases

    EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429. [Q99L88-1]
    ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429. [Q99L88-2]
    GeneIDi20649.
    KEGGimmu:20649.
    UCSCiuc007vsk.1. mouse. [Q99L88-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89997 mRNA. Translation: AAB66697.1 .
    BC003748 mRNA. Translation: AAH03748.1 .
    CCDSi CCDS27479.1. [Q99L88-1 ]
    RefSeqi NP_057876.1. NM_016667.3. [Q99L88-1 ]
    XP_006520734.1. XM_006520671.1. [Q99L88-1 ]
    UniGenei Mm.309425.

    3D structure databases

    ProteinModelPortali Q99L88.
    SMRi Q99L88. Positions 16-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203383. 1 interaction.
    IntActi Q99L88. 5 interactions.
    MINTi MINT-1846430.

    PTM databases

    PhosphoSitei Q99L88.

    Proteomic databases

    MaxQBi Q99L88.
    PaxDbi Q99L88.
    PRIDEi Q99L88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039769 ; ENSMUSP00000041294 ; ENSMUSG00000060429 . [Q99L88-1 ]
    ENSMUST00000110200 ; ENSMUSP00000105829 ; ENSMUSG00000060429 . [Q99L88-2 ]
    GeneIDi 20649.
    KEGGi mmu:20649.
    UCSCi uc007vsk.1. mouse. [Q99L88-1 ]

    Organism-specific databases

    CTDi 6641.
    MGIi MGI:101781. Sntb1.

    Phylogenomic databases

    eggNOGi NOG318350.
    GeneTreei ENSGT00550000074581.
    HOGENOMi HOG000231596.
    HOVERGENi HBG054204.
    InParanoidi Q99L88.
    OMAi DAKHTVV.
    OrthoDBi EOG7R56VZ.
    PhylomeDBi Q99L88.
    TreeFami TF317932.

    Miscellaneous databases

    ChiTaRSi SNTB1. mouse.
    NextBioi 299067.
    PROi Q99L88.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99L88.
    CleanExi MM_SNTB1.
    Genevestigatori Q99L88.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    [Graphical view ]
    PANTHERi PTHR10554. PTHR10554. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential association of syntrophin pairs with the dystrophin complex."
      Peters M.F., Adams M.E., Froehner S.C.
      J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH DMD; DTNA AND UTRN.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Mammary tumor.
    3. "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins."
      Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C.
      J. Neurosci. 18:128-137(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCN4A AND SCN5A.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; THR-213 AND SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSNTB1_MOUSE
    AccessioniPrimary (citable) accession number: Q99L88
    Secondary accession number(s): O35925
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3