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Q99L88

- SNTB1_MOUSE

UniProt

Q99L88 - SNTB1_MOUSE

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Protein

Beta-1-syntrophin

Gene

Sntb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 1
Short name:
DAPA1B
Syntrophin-2
Gene namesi
Name:Sntb1
Synonyms:Snt2b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:101781. Sntb1.

Subcellular locationi

Cell membranesarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cell junction 1 Publication. Cytoplasmcytoskeleton 1 Publication
Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
  5. protein complex Source: MGI
  6. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 537536Beta-1-syntrophinPRO_0000184010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei86 – 861Phosphoserine1 Publication
Modified residuei213 – 2131Phosphothreonine1 Publication
Modified residuei218 – 2181Phosphoserine1 Publication
Modified residuei388 – 3881PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by CaM-kinase II.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99L88.
PaxDbiQ99L88.
PRIDEiQ99L88.

PTM databases

PhosphoSiteiQ99L88.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the liver.

Gene expression databases

BgeeiQ99L88.
CleanExiMM_SNTB1.
GenevestigatoriQ99L88.

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the viral HTLV-1 TAX protein and other members of the syntrophin family: SNTA1 and SNTB2 (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN and with the sodium channel proteins SCN4A and SCN5A.By similarity2 PublicationsCurated

Protein-protein interaction databases

BioGridi203383. 1 interaction.
IntActiQ99L88. 5 interactions.
MINTiMINT-1846430.

Structurei

3D structure databases

ProteinModelPortaliQ99L88.
SMRiQ99L88. Positions 16-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 297280PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 19484PDZPROSITE-ProRule annotationAdd
BLAST
Domaini321 – 432112PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 53757SUAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni517 – 53721Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 1211Poly-AlaAdd
BLAST
Compositional biasi13 – 164Poly-Gly

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG318350.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ99L88.
OMAiDAKHTVV.
OrthoDBiEOG7R56VZ.
PhylomeDBiQ99L88.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99L88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE
60 70 80 90 100
EGAAAYNGIG AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ
110 120 130 140 150
VPESISNQKR GVKVLKQELG GLGISIKGGK ENKMPILISK IFKGLAADQT
160 170 180 190 200
QALYVGDAIL SVNGADLRDA THDEAVQALK RAGKEVLLEV KYMREATPYV
210 220 230 240 250
KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR KSIPLKMCYV
260 270 280 290 300
TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL
310 320 330 340 350
TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK
360 370 380 390 400
DLLIYDSMPR RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR
410 420 430 440 450
TGTKQGIETH LFRAEISRDL SHWTRSIVQG CHNSAELTAE ITTACTYRNQ
460 470 480 490 500
ECRLTIHYDN GFSISTEPQD GAFPKTIIQS PYEKLKMSSD DGIRMLYLDF
510 520 530
GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA
Length:537
Mass (Da):58,081
Last modified:January 23, 2007 - v4
Checksum:i91A5E4DD0A97A665
GO
Isoform 2 (identifier: Q99L88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-276: RQLEIHSPDAKHTVI → STHPSDLIPIQGWAA
     277-537: Missing.

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):28,944
Checksum:i59ED70FAE4122803
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei262 – 27615RQLEI…KHTVI → STHPSDLIPIQGWAA in isoform 2. 1 PublicationVSP_006356Add
BLAST
Alternative sequencei277 – 537261Missing in isoform 2. 1 PublicationVSP_006357Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA. Translation: AAB66697.1.
BC003748 mRNA. Translation: AAH03748.1.
CCDSiCCDS27479.1. [Q99L88-1]
RefSeqiNP_057876.1. NM_016667.3. [Q99L88-1]
XP_006520734.1. XM_006520671.1. [Q99L88-1]
UniGeneiMm.309425.

Genome annotation databases

EnsembliENSMUST00000039769; ENSMUSP00000041294; ENSMUSG00000060429. [Q99L88-1]
ENSMUST00000110200; ENSMUSP00000105829; ENSMUSG00000060429. [Q99L88-2]
GeneIDi20649.
KEGGimmu:20649.
UCSCiuc007vsk.1. mouse. [Q99L88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89997 mRNA. Translation: AAB66697.1 .
BC003748 mRNA. Translation: AAH03748.1 .
CCDSi CCDS27479.1. [Q99L88-1 ]
RefSeqi NP_057876.1. NM_016667.3. [Q99L88-1 ]
XP_006520734.1. XM_006520671.1. [Q99L88-1 ]
UniGenei Mm.309425.

3D structure databases

ProteinModelPortali Q99L88.
SMRi Q99L88. Positions 16-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203383. 1 interaction.
IntActi Q99L88. 5 interactions.
MINTi MINT-1846430.

PTM databases

PhosphoSitei Q99L88.

Proteomic databases

MaxQBi Q99L88.
PaxDbi Q99L88.
PRIDEi Q99L88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039769 ; ENSMUSP00000041294 ; ENSMUSG00000060429 . [Q99L88-1 ]
ENSMUST00000110200 ; ENSMUSP00000105829 ; ENSMUSG00000060429 . [Q99L88-2 ]
GeneIDi 20649.
KEGGi mmu:20649.
UCSCi uc007vsk.1. mouse. [Q99L88-1 ]

Organism-specific databases

CTDi 6641.
MGIi MGI:101781. Sntb1.

Phylogenomic databases

eggNOGi NOG318350.
GeneTreei ENSGT00550000074581.
HOGENOMi HOG000231596.
HOVERGENi HBG054204.
InParanoidi Q99L88.
OMAi DAKHTVV.
OrthoDBi EOG7R56VZ.
PhylomeDBi Q99L88.
TreeFami TF317932.

Miscellaneous databases

ChiTaRSi Sntb1. mouse.
NextBioi 299067.
PROi Q99L88.
SOURCEi Search...

Gene expression databases

Bgeei Q99L88.
CleanExi MM_SNTB1.
Genevestigatori Q99L88.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015482. Syntrophin.
[Graphical view ]
PANTHERi PTHR10554. PTHR10554. 1 hit.
Pfami PF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential association of syntrophin pairs with the dystrophin complex."
    Peters M.F., Adams M.E., Froehner S.C.
    J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH DMD; DTNA AND UTRN.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary tumor.
  3. "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins."
    Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C.
    J. Neurosci. 18:128-137(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCN4A AND SCN5A.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; THR-213 AND SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSNTB1_MOUSE
AccessioniPrimary (citable) accession number: Q99L88
Secondary accession number(s): O35925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3