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Q99L86

- Q99L86_MOUSE

UniProt

Q99L86 - Q99L86_MOUSE

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Protein
Submitted name:

Mdm4 protein

Gene

Mdm4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  3. G0 to G1 transition Source: UniProtKB
  4. negative regulation of apoptotic process Source: InterPro
  5. negative regulation of cell cycle arrest Source: InterPro
  6. negative regulation of protein catabolic process Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Mdm4 proteinImported
Gene namesi
Name:Mdm4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107934. Mdm4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ99L86.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068661.

Structurei

3D structure databases

ProteinModelPortaliQ99L86.
SMRiQ99L86. Positions 27-108, 301-344, 428-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

HOVERGENiHBG013472.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR015458. MDM4.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10360:SF10. PTHR10360:SF10. 1 hit.
PfamiPF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
PIRSFiPIRSF500699. MDM4. 1 hit.
PIRSF006748. p53_MDM_2/4. 1 hit.
SMARTiSM00184. RING. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99L86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSHSTSAQC SASDSACRIS SEQISQQVRP KLQLLKILHA AGAQGEVFTM
60 70 80 90 100
KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGDLLGCQS FSVKDPSPLY
110 120 130 140 150
DMLRKNLVTS ASNNTDAAQT LALAQDHTMD FPSQDRLKHG ATEYSNPRKR
160 170 180 190 200
TEEEDTHTLP TSRHKCRDSR ADEDLIEHLS QDETSRLDLD FEEWDVAGLP
210 220 230 240 250
WWFLGNLRNN CIPKSNGSTD LQTNQDIGTA IVSDTTDDLW FLNETVSEQL
260 270 280 290 300
GVGIKVEAAN SEQTSEVGKT SNKKTVEVGK DDDLEDSRSL SDDTDVELTS
310 320 330 340 350
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSNITAIP
360 370 380 390 400
EKKDNEGIDV PDCRRTISAP VVRPKDGYLK EEKPRFDPCN SVGFLDLAHS
410 420 430 440 450
SESQEIISSA REQTDIFSEQ KAETESMEDF QNVLKPCSLC EKRPRDGNII
460 470 480 490
HGKTSHLTTC FHCARRLKKS GASCPVCKKE IQLVIKVFIA
Length:490
Mass (Da):55,120
Last modified:June 1, 2001 - v1
Checksum:i58B171C5B8C37577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003750 mRNA. Translation: AAH03750.1.
UniGeneiMm.426531.
Mm.476028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003750 mRNA. Translation: AAH03750.1 .
UniGenei Mm.426531.
Mm.476028.

3D structure databases

ProteinModelPortali Q99L86.
SMRi Q99L86. Positions 27-108, 301-344, 428-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000068661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107934. Mdm4.

Phylogenomic databases

HOVERGENi HBG013472.

Miscellaneous databases

PROi Q99L86.
SOURCEi Search...

Gene expression databases

Genevestigatori Q99L86.

Family and domain databases

Gene3Di 1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR015458. MDM4.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10360:SF10. PTHR10360:SF10. 1 hit.
Pfami PF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
PIRSFi PIRSF500699. MDM4. 1 hit.
PIRSF006748. p53_MDM_2/4. 1 hit.
SMARTi SM00184. RING. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47592. SSF47592. 1 hit.
PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ99L86_MOUSE
AccessioniPrimary (citable) accession number: Q99L86
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)