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Protein

Protein Mdm4

Gene

Mdm4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mdm4UniRule annotation
Gene namesi
Name:Mdm4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107934 Mdm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ99L86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 329RanBP2-typeInterPro annotationAdd BLAST30
Domaini437 – 478RING-typeInterPro annotationAdd BLAST42

Sequence similaritiesi

Belongs to the MDM2/MDM4 family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IE9V Eukaryota
ENOG410XSWN LUCA
HOVERGENiHBG013472

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015458 MDM4
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF20 PTHR13844:SF20, 1 hit
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500699 MDM4, 1 hit
PIRSF006748 p53_MDM_2/4, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99L86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSHSTSAQC SASDSACRIS SEQISQQVRP KLQLLKILHA AGAQGEVFTM
60 70 80 90 100
KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGDLLGCQS FSVKDPSPLY
110 120 130 140 150
DMLRKNLVTS ASNNTDAAQT LALAQDHTMD FPSQDRLKHG ATEYSNPRKR
160 170 180 190 200
TEEEDTHTLP TSRHKCRDSR ADEDLIEHLS QDETSRLDLD FEEWDVAGLP
210 220 230 240 250
WWFLGNLRNN CIPKSNGSTD LQTNQDIGTA IVSDTTDDLW FLNETVSEQL
260 270 280 290 300
GVGIKVEAAN SEQTSEVGKT SNKKTVEVGK DDDLEDSRSL SDDTDVELTS
310 320 330 340 350
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSNITAIP
360 370 380 390 400
EKKDNEGIDV PDCRRTISAP VVRPKDGYLK EEKPRFDPCN SVGFLDLAHS
410 420 430 440 450
SESQEIISSA REQTDIFSEQ KAETESMEDF QNVLKPCSLC EKRPRDGNII
460 470 480 490
HGKTSHLTTC FHCARRLKKS GASCPVCKKE IQLVIKVFIA
Length:490
Mass (Da):55,120
Last modified:June 1, 2001 - v1
Checksum:i58B171C5B8C37577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003750 mRNA Translation: AAH03750.1
UniGeneiMm.426531
Mm.476028

Similar proteinsi

Entry informationi

Entry nameiQ99L86_MOUSE
AccessioniPrimary (citable) accession number: Q99L86
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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