Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99L86

- Q99L86_MOUSE

UniProt

Q99L86 - Q99L86_MOUSE

Protein
Submitted name:

Mdm4 protein

Gene

Mdm4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
    3. G0 to G1 transition Source: UniProtKB
    4. negative regulation of apoptotic process Source: InterPro
    5. negative regulation of cell cycle arrest Source: InterPro
    6. negative regulation of protein catabolic process Source: UniProtKB
    7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. positive regulation of cell proliferation Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mdm4 proteinImported
    Gene namesi
    Name:Mdm4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:107934. Mdm4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ99L86.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000068661.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99L86.
    SMRiQ99L86. Positions 27-108, 301-344, 428-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Zinc-fingerUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG013472.
    InParanoidiQ99L86.

    Family and domain databases

    Gene3Di1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR015458. MDM4.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10360:SF10. PTHR10360:SF10. 1 hit.
    PfamiPF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500699. MDM4. 1 hit.
    PIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTiSM00184. RING. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47592. SSF47592. 1 hit.
    PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99L86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSHSTSAQC SASDSACRIS SEQISQQVRP KLQLLKILHA AGAQGEVFTM    50
    KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGDLLGCQS FSVKDPSPLY 100
    DMLRKNLVTS ASNNTDAAQT LALAQDHTMD FPSQDRLKHG ATEYSNPRKR 150
    TEEEDTHTLP TSRHKCRDSR ADEDLIEHLS QDETSRLDLD FEEWDVAGLP 200
    WWFLGNLRNN CIPKSNGSTD LQTNQDIGTA IVSDTTDDLW FLNETVSEQL 250
    GVGIKVEAAN SEQTSEVGKT SNKKTVEVGK DDDLEDSRSL SDDTDVELTS 300
    EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSNITAIP 350
    EKKDNEGIDV PDCRRTISAP VVRPKDGYLK EEKPRFDPCN SVGFLDLAHS 400
    SESQEIISSA REQTDIFSEQ KAETESMEDF QNVLKPCSLC EKRPRDGNII 450
    HGKTSHLTTC FHCARRLKKS GASCPVCKKE IQLVIKVFIA 490
    Length:490
    Mass (Da):55,120
    Last modified:June 1, 2001 - v1
    Checksum:i58B171C5B8C37577
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC003750 mRNA. Translation: AAH03750.1.
    UniGeneiMm.426531.
    Mm.476028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC003750 mRNA. Translation: AAH03750.1 .
    UniGenei Mm.426531.
    Mm.476028.

    3D structure databases

    ProteinModelPortali Q99L86.
    SMRi Q99L86. Positions 27-108, 301-344, 428-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000068661.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:107934. Mdm4.

    Phylogenomic databases

    HOVERGENi HBG013472.
    InParanoidi Q99L86.

    Miscellaneous databases

    PROi Q99L86.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q99L86.

    Family and domain databases

    Gene3Di 1.10.245.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR015458. MDM4.
    IPR016495. p53_neg-reg_MDM_2/4.
    IPR003121. SWIB_MDM2_domain.
    IPR001876. Znf_RanBP2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10360:SF10. PTHR10360:SF10. 1 hit.
    Pfami PF02201. SWIB. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500699. MDM4. 1 hit.
    PIRSF006748. p53_MDM_2/4. 1 hit.
    SMARTi SM00184. RING. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47592. SSF47592. 1 hit.
    PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ99L86_MOUSE
    AccessioniPrimary (citable) accession number: Q99L86
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)