Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99L60

- VATC2_MOUSE

UniProt

Q99L60 - VATC2_MOUSE

Protein

V-type proton ATPase subunit C 2

Gene

Atp6v1c2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit C 2
    Short name:
    V-ATPase subunit C 2
    Alternative name(s):
    Vacuolar proton pump subunit C 2
    Gene namesi
    Name:Atp6v1c2
    Synonyms:Atp6c2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1916025. Atp6v1c2.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. proton-transporting V-type ATPase, V1 domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427V-type proton ATPase subunit C 2PRO_0000285670Add
    BLAST

    Proteomic databases

    MaxQBiQ99L60.
    PaxDbiQ99L60.
    PRIDEiQ99L60.

    PTM databases

    PhosphoSiteiQ99L60.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney-specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells.2 Publications

    Developmental stagei

    Significant expression seen at 17 dpc and not earlier.1 Publication

    Gene expression databases

    ArrayExpressiQ99L60.
    BgeeiQ99L60.
    CleanExiMM_ATP6V1C2.
    GenevestigatoriQ99L60.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Protein-protein interaction databases

    IntActiQ99L60. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99L60.
    SMRiQ99L60. Positions 2-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase C subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG5127.
    GeneTreeiENSGT00390000004263.
    HOGENOMiHOG000207528.
    HOVERGENiHBG002470.
    KOiK02148.
    OMAiFMVREFY.
    OrthoDBiEOG7QNVKX.
    PhylomeDBiQ99L60.
    TreeFamiTF314912.

    Family and domain databases

    InterProiIPR004907. ATPase_V1-cplx_csu.
    [Graphical view]
    PANTHERiPTHR10137. PTHR10137. 1 hit.
    PfamiPF03223. V-ATPase_C. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99L60-1) [UniParc]FASTAAdd to Basket

    Also known as: C2-a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEFWLISAP GDKENLQALE RMNNVTSKSN LSHNTKFAIP DFKVGTLDSL    50
    VGLSDELGKL DTFAESLIKR MAQSVVEVME DSKGKAHETL LANGVDLTSF 100
    VTHFEWDMAK YPAKQPLVSV VDTLAKQLAQ IETDLKSRTA AYSVLKANLE 150
    NLEKRSTGNL FTRTLSDIVS KEDFVLDSEY LITLLVIVPK SSFAQWQKTY 200
    ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA KENKFIVREF 250
    YYDEKEIKRE REEMTRLLSD KKQQYPTSCV ALKKGSATYR DHKVKVAPLG 300
    NPARPAAGQT DRDRESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE 350
    SVLRYGLPVN FQAVLLQPHK KSATKRLREV LNSVFRHLDE VAAASILDAS 400
    VEIPGLQLSN QDYFPYVYFH IDLSLLD 427
    Length:427
    Mass (Da):48,350
    Last modified:June 1, 2001 - v1
    Checksum:i5D7146D9BC7F03F7
    GO
    Isoform 2 (identifier: Q99L60-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-95: V → GLKEKMKCLKI

    Show »
    Length:437
    Mass (Da):49,524
    Checksum:i2DAE84F4DB6006EC
    GO
    Isoform 3 (identifier: Q99L60-3) [UniParc]FASTAAdd to Basket

    Also known as: C2-b

    The sequence of this isoform differs from the canonical sequence as follows:
         276-321: Missing.

    Show »
    Length:381
    Mass (Da):43,517
    Checksum:iEEC1EB557D239F62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251A → T in AAH56636. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei95 – 951V → GLKEKMKCLKI in isoform 2. 1 PublicationVSP_024884
    Alternative sequencei276 – 32146Missing in isoform 3. 2 PublicationsVSP_024885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088357 mRNA. Translation: BAC57950.1.
    BC003810 mRNA. Translation: AAH03810.1.
    BC056636 mRNA. Translation: AAH56636.1.
    CCDSiCCDS25827.1. [Q99L60-1]
    CCDS49034.1. [Q99L60-2]
    RefSeqiNP_001153104.1. NM_001159632.1. [Q99L60-2]
    NP_598460.1. NM_133699.2. [Q99L60-1]
    XP_006515257.1. XM_006515194.1. [Q99L60-2]
    XP_006515258.1. XM_006515195.1. [Q99L60-2]
    XP_006515259.1. XM_006515196.1. [Q99L60-2]
    XP_006515260.1. XM_006515197.1. [Q99L60-1]
    XP_006515262.1. XM_006515199.1. [Q99L60-3]
    UniGeneiMm.178798.

    Genome annotation databases

    EnsembliENSMUST00000020884; ENSMUSP00000020884; ENSMUSG00000020566. [Q99L60-2]
    ENSMUST00000095820; ENSMUSP00000093500; ENSMUSG00000020566. [Q99L60-1]
    GeneIDi68775.
    KEGGimmu:68775.
    UCSCiuc007ncq.1. mouse. [Q99L60-1]
    uc007ncs.2. mouse. [Q99L60-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088357 mRNA. Translation: BAC57950.1 .
    BC003810 mRNA. Translation: AAH03810.1 .
    BC056636 mRNA. Translation: AAH56636.1 .
    CCDSi CCDS25827.1. [Q99L60-1 ]
    CCDS49034.1. [Q99L60-2 ]
    RefSeqi NP_001153104.1. NM_001159632.1. [Q99L60-2 ]
    NP_598460.1. NM_133699.2. [Q99L60-1 ]
    XP_006515257.1. XM_006515194.1. [Q99L60-2 ]
    XP_006515258.1. XM_006515195.1. [Q99L60-2 ]
    XP_006515259.1. XM_006515196.1. [Q99L60-2 ]
    XP_006515260.1. XM_006515197.1. [Q99L60-1 ]
    XP_006515262.1. XM_006515199.1. [Q99L60-3 ]
    UniGenei Mm.178798.

    3D structure databases

    ProteinModelPortali Q99L60.
    SMRi Q99L60. Positions 2-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99L60. 1 interaction.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q99L60.

    Proteomic databases

    MaxQBi Q99L60.
    PaxDbi Q99L60.
    PRIDEi Q99L60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020884 ; ENSMUSP00000020884 ; ENSMUSG00000020566 . [Q99L60-2 ]
    ENSMUST00000095820 ; ENSMUSP00000093500 ; ENSMUSG00000020566 . [Q99L60-1 ]
    GeneIDi 68775.
    KEGGi mmu:68775.
    UCSCi uc007ncq.1. mouse. [Q99L60-1 ]
    uc007ncs.2. mouse. [Q99L60-2 ]

    Organism-specific databases

    CTDi 245973.
    MGIi MGI:1916025. Atp6v1c2.

    Phylogenomic databases

    eggNOGi COG5127.
    GeneTreei ENSGT00390000004263.
    HOGENOMi HOG000207528.
    HOVERGENi HBG002470.
    KOi K02148.
    OMAi FMVREFY.
    OrthoDBi EOG7QNVKX.
    PhylomeDBi Q99L60.
    TreeFami TF314912.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V1C2. mouse.
    NextBioi 327902.
    PROi Q99L60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99L60.
    Bgeei Q99L60.
    CleanExi MM_ATP6V1C2.
    Genevestigatori Q99L60.

    Family and domain databases

    InterProi IPR004907. ATPase_V1-cplx_csu.
    [Graphical view ]
    PANTHERi PTHR10137. PTHR10137. 1 hit.
    Pfami PF03223. V-ATPase_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
      Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
      Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    2. "Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung."
      Sun-Wada G.H., Murata Y., Namba M., Yamamoto A., Wada Y., Futai M.
      J. Biol. Chem. 278:44843-44851(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiVATC2_MOUSE
    AccessioniPrimary (citable) accession number: Q99L60
    Secondary accession number(s): Q6PHA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3