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Protein

V-type proton ATPase subunit C 2

Gene

Atp6v1c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI
  2. protein dimerization activity Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. positive regulation of Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.
REACT_233181. Insulin receptor recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 2
Short name:
V-ATPase subunit C 2
Alternative name(s):
Vacuolar proton pump subunit C 2
Gene namesi
Name:Atp6v1c2
Synonyms:Atp6c2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1916025. Atp6v1c2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. lysosomal membrane Source: MGI
  3. proton-transporting V-type ATPase, V1 domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427V-type proton ATPase subunit C 2PRO_0000285670Add
BLAST

Proteomic databases

MaxQBiQ99L60.
PaxDbiQ99L60.
PRIDEiQ99L60.

PTM databases

PhosphoSiteiQ99L60.

Expressioni

Tissue specificityi

Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney-specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells.2 Publications

Developmental stagei

Significant expression seen at 17 dpc and not earlier.1 Publication

Gene expression databases

BgeeiQ99L60.
CleanExiMM_ATP6V1C2.
ExpressionAtlasiQ99L60. baseline and differential.
GenevestigatoriQ99L60.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

IntActiQ99L60. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99L60.
SMRiQ99L60. Positions 2-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiCOG5127.
GeneTreeiENSGT00390000004263.
HOGENOMiHOG000207528.
HOVERGENiHBG002470.
InParanoidiQ99L60.
KOiK02148.
OMAiNSEYLIT.
OrthoDBiEOG7QNVKX.
PhylomeDBiQ99L60.
TreeFamiTF314912.

Family and domain databases

InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 1 hit.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99L60-1) [UniParc]FASTAAdd to Basket

Also known as: C2-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEFWLISAP GDKENLQALE RMNNVTSKSN LSHNTKFAIP DFKVGTLDSL
60 70 80 90 100
VGLSDELGKL DTFAESLIKR MAQSVVEVME DSKGKAHETL LANGVDLTSF
110 120 130 140 150
VTHFEWDMAK YPAKQPLVSV VDTLAKQLAQ IETDLKSRTA AYSVLKANLE
160 170 180 190 200
NLEKRSTGNL FTRTLSDIVS KEDFVLDSEY LITLLVIVPK SSFAQWQKTY
210 220 230 240 250
ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA KENKFIVREF
260 270 280 290 300
YYDEKEIKRE REEMTRLLSD KKQQYPTSCV ALKKGSATYR DHKVKVAPLG
310 320 330 340 350
NPARPAAGQT DRDRESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE
360 370 380 390 400
SVLRYGLPVN FQAVLLQPHK KSATKRLREV LNSVFRHLDE VAAASILDAS
410 420
VEIPGLQLSN QDYFPYVYFH IDLSLLD
Length:427
Mass (Da):48,350
Last modified:June 1, 2001 - v1
Checksum:i5D7146D9BC7F03F7
GO
Isoform 2 (identifier: Q99L60-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: V → GLKEKMKCLKI

Show »
Length:437
Mass (Da):49,524
Checksum:i2DAE84F4DB6006EC
GO
Isoform 3 (identifier: Q99L60-3) [UniParc]FASTAAdd to Basket

Also known as: C2-b

The sequence of this isoform differs from the canonical sequence as follows:
     276-321: Missing.

Show »
Length:381
Mass (Da):43,517
Checksum:iEEC1EB557D239F62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251A → T in AAH56636. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 951V → GLKEKMKCLKI in isoform 2. 1 PublicationVSP_024884
Alternative sequencei276 – 32146Missing in isoform 3. 2 PublicationsVSP_024885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088357 mRNA. Translation: BAC57950.1.
BC003810 mRNA. Translation: AAH03810.1.
BC056636 mRNA. Translation: AAH56636.1.
CCDSiCCDS25827.1. [Q99L60-1]
CCDS49034.1. [Q99L60-2]
RefSeqiNP_001153104.1. NM_001159632.1. [Q99L60-2]
NP_598460.1. NM_133699.2. [Q99L60-1]
XP_006515257.1. XM_006515194.1. [Q99L60-2]
XP_006515258.1. XM_006515195.1. [Q99L60-2]
XP_006515259.1. XM_006515196.1. [Q99L60-2]
XP_006515260.1. XM_006515197.1. [Q99L60-1]
XP_006515262.1. XM_006515199.1. [Q99L60-3]
UniGeneiMm.178798.

Genome annotation databases

EnsembliENSMUST00000020884; ENSMUSP00000020884; ENSMUSG00000020566. [Q99L60-2]
ENSMUST00000095820; ENSMUSP00000093500; ENSMUSG00000020566. [Q99L60-1]
GeneIDi68775.
KEGGimmu:68775.
UCSCiuc007ncq.1. mouse. [Q99L60-1]
uc007ncs.2. mouse. [Q99L60-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088357 mRNA. Translation: BAC57950.1.
BC003810 mRNA. Translation: AAH03810.1.
BC056636 mRNA. Translation: AAH56636.1.
CCDSiCCDS25827.1. [Q99L60-1]
CCDS49034.1. [Q99L60-2]
RefSeqiNP_001153104.1. NM_001159632.1. [Q99L60-2]
NP_598460.1. NM_133699.2. [Q99L60-1]
XP_006515257.1. XM_006515194.1. [Q99L60-2]
XP_006515258.1. XM_006515195.1. [Q99L60-2]
XP_006515259.1. XM_006515196.1. [Q99L60-2]
XP_006515260.1. XM_006515197.1. [Q99L60-1]
XP_006515262.1. XM_006515199.1. [Q99L60-3]
UniGeneiMm.178798.

3D structure databases

ProteinModelPortaliQ99L60.
SMRiQ99L60. Positions 2-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99L60. 1 interaction.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteiQ99L60.

Proteomic databases

MaxQBiQ99L60.
PaxDbiQ99L60.
PRIDEiQ99L60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020884; ENSMUSP00000020884; ENSMUSG00000020566. [Q99L60-2]
ENSMUST00000095820; ENSMUSP00000093500; ENSMUSG00000020566. [Q99L60-1]
GeneIDi68775.
KEGGimmu:68775.
UCSCiuc007ncq.1. mouse. [Q99L60-1]
uc007ncs.2. mouse. [Q99L60-2]

Organism-specific databases

CTDi245973.
MGIiMGI:1916025. Atp6v1c2.

Phylogenomic databases

eggNOGiCOG5127.
GeneTreeiENSGT00390000004263.
HOGENOMiHOG000207528.
HOVERGENiHBG002470.
InParanoidiQ99L60.
KOiK02148.
OMAiNSEYLIT.
OrthoDBiEOG7QNVKX.
PhylomeDBiQ99L60.
TreeFamiTF314912.

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.
REACT_233181. Insulin receptor recycling.

Miscellaneous databases

ChiTaRSiAtp6v1c2. mouse.
NextBioi327902.
PROiQ99L60.
SOURCEiSearch...

Gene expression databases

BgeeiQ99L60.
CleanExiMM_ATP6V1C2.
ExpressionAtlasiQ99L60. baseline and differential.
GenevestigatoriQ99L60.

Family and domain databases

InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 1 hit.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
    Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
    Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  2. "Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung."
    Sun-Wada G.H., Murata Y., Namba M., Yamamoto A., Wada Y., Futai M.
    J. Biol. Chem. 278:44843-44851(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiVATC2_MOUSE
AccessioniPrimary (citable) accession number: Q99L60
Secondary accession number(s): Q6PHA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.