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Q99L60 (VATC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit C 2
Short name=V-ATPase subunit C 2
Alternative name(s):
Vacuolar proton pump subunit C 2
Gene names
Name:Atp6v1c2
Synonyms:Atp6c2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Tissue specificity

Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney-specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells. Ref.1 Ref.2

Developmental stage

Significant expression seen at 17 dpc and not earlier. Ref.1

Sequence similarities

Belongs to the V-ATPase C subunit family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q99L60-1)

Also known as: C2-a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q99L60-2)

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: V → GLKEKMKCLKI
Isoform 3 (identifier: Q99L60-3)

Also known as: C2-b;

The sequence of this isoform differs from the canonical sequence as follows:
     276-321: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427V-type proton ATPase subunit C 2
PRO_0000285670

Natural variations

Alternative sequence951V → GLKEKMKCLKI in isoform 2.
VSP_024884
Alternative sequence276 – 32146Missing in isoform 3.
VSP_024885

Experimental info

Sequence conflict1251A → T in AAH56636. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (C2-a) [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5D7146D9BC7F03F7

FASTA42748,350
        10         20         30         40         50         60 
MSEFWLISAP GDKENLQALE RMNNVTSKSN LSHNTKFAIP DFKVGTLDSL VGLSDELGKL 

        70         80         90        100        110        120 
DTFAESLIKR MAQSVVEVME DSKGKAHETL LANGVDLTSF VTHFEWDMAK YPAKQPLVSV 

       130        140        150        160        170        180 
VDTLAKQLAQ IETDLKSRTA AYSVLKANLE NLEKRSTGNL FTRTLSDIVS KEDFVLDSEY 

       190        200        210        220        230        240 
LITLLVIVPK SSFAQWQKTY ESLSDMVVPR STKLIAEDNE GGLFTVTLFR KVIEDFKVKA 

       250        260        270        280        290        300 
KENKFIVREF YYDEKEIKRE REEMTRLLSD KKQQYPTSCV ALKKGSATYR DHKVKVAPLG 

       310        320        330        340        350        360 
NPARPAAGQT DRDRESEGEG EGPLLRWLKV NFSEAFIAWI HIKALRVFVE SVLRYGLPVN 

       370        380        390        400        410        420 
FQAVLLQPHK KSATKRLREV LNSVFRHLDE VAAASILDAS VEIPGLQLSN QDYFPYVYFH 


IDLSLLD

« Hide

Isoform 2 [UniParc].

Checksum: 2DAE84F4DB6006EC
Show »

FASTA43749,524
Isoform 3 (C2-b) [UniParc].

Checksum: EEC1EB557D239F62
Show »

FASTA38143,517

References

« Hide 'large scale' references
[1]"Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[2]"Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung."
Sun-Wada G.H., Murata Y., Namba M., Yamamoto A., Wada Y., Futai M.
J. Biol. Chem. 278:44843-44851(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB088357 mRNA. Translation: BAC57950.1.
BC003810 mRNA. Translation: AAH03810.1.
BC056636 mRNA. Translation: AAH56636.1.
IPIIPI00453992.
IPI00762447.
IPI00845614.
RefSeqNP_001153104.1. NM_001159632.1.
NP_598460.1. NM_133699.2.
UniGeneMm.178798.

3D structure databases

HSSPHSSP built from PDB template 1U7L based on UniProtKB P31412.
ProteinModelPortalQ99L60.
SMRQ99L60. Positions 2-383.
ModBaseSearch...

Protein-protein interaction databases

IntActQ99L60. 1 interaction.

PTM databases

PhosphoSiteQ99L60.

Proteomic databases

PaxDbQ99L60.
PRIDEQ99L60.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020884; ENSMUSP00000020884; ENSMUSG00000020566.
ENSMUST00000095820; ENSMUSP00000093500; ENSMUSG00000020566.
GeneID68775.
KEGGmmu:68775.
UCSCuc007ncr.2. mouse.
uc007ncs.2. mouse.

Organism-specific databases

CTD245973.
MGIMGI:1916025. Atp6v1c2.

Phylogenomic databases

eggNOGCOG5127.
GeneTreeENSGT00390000004263.
HOGENOMHOG000207528.
HOVERGENHBG002470.
KOK02148.
OMADNEGGLF.
OrthoDBEOG4X3H1C.

Gene expression databases

ArrayExpressQ99L60.
BgeeQ99L60.
CleanExMM_ATP6V1C2.
GenevestigatorQ99L60.

Family and domain databases

InterProIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERPTHR10137. PTHR10137. 1 hit.
PfamPF03223. V-ATPase_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP6V1C2. mouse.
NextBio327902.
SOURCESearch...

Entry information

Entry nameVATC2_MOUSE
AccessionPrimary (citable) accession number: Q99L60
Secondary accession number(s): Q6PHA4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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