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Protein

Hsc70-interacting protein

Gene

St13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Hsc70-interacting protein
Short name:
Hip
Alternative name(s):
Protein FAM10A1
Protein ST13 homolog
Gene namesi
Name:St13
Synonyms:Fam10a1, Hip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1917606 St13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001908121 – 371Hsc70-interacting proteinAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei348Phosphoserine; by GRK5By similarity1
Modified residuei355N6-acetyllysineCombined sources1
Modified residuei362N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99L47
MaxQBiQ99L47
PaxDbiQ99L47
PeptideAtlasiQ99L47
PRIDEiQ99L47

2D gel databases

REPRODUCTION-2DPAGEiQ99L47

PTM databases

iPTMnetiQ99L47
PhosphoSitePlusiQ99L47

Expressioni

Gene expression databases

BgeeiENSMUSG00000022403
CleanExiMM_ST13
ExpressionAtlasiQ99L47 baseline and differential
GenevisibleiQ99L47 MM

Interactioni

Subunit structurei

Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213997, 1 interactor
IntActiQ99L47, 5 interactors
MINTiQ99L47
STRINGi10090.ENSMUSP00000130195

Structurei

3D structure databases

ProteinModelPortaliQ99L47
SMRiQ99L47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 146TPR 1Add BLAST34
Repeati147 – 180TPR 2Add BLAST34
Repeati181 – 214TPR 3Add BLAST34
Domaini321 – 360STI1Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 314Gly/Met/Pro-richAdd BLAST37

Sequence similaritiesi

Belongs to the FAM10 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1308 Eukaryota
ENOG410XR19 LUCA
GeneTreeiENSGT00390000001347
HOGENOMiHOG000001586
HOVERGENiHBG002482
InParanoidiQ99L47
KOiK09560
OMAiTVLNMPQ
OrthoDBiEOG091G0KXF
TreeFamiTF313244

Family and domain databases

CDDicd14438 Hip_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034649 Hip_N
IPR006636 STI1_HS-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q99L47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRKVSELR AFVKMCRQDP SVLHTEEMRF LREWVESMGG KVPPATHKAK
60 70 80 90 100
SEENTKEEKR DKTTEENIKT EELSSEESDL EIDNEGVIEP DTDAPQEMGD
110 120 130 140 150
ENAEITEEMM DEANEKKGAA IEALNDGELQ KAIDLFTDAI KLNPRLAILY
160 170 180 190 200
AKRASVFVKL QKPNAAIRDC DRAIEINPDS AQPYKWRGKA HRLLGHWEEA
210 220 230 240 250
AHDLALACKL DYDEDASAML REVQPRAQKI AEHRRKYERK REEREIKERI
260 270 280 290 300
ERVKKAREEH ERAQREEEAR RQSGSQYGSF PGGFPGGMPG NFPGGMPGMG
310 320 330 340 350
GAMPGMAGMA GMPGLNEILS DPEVLAAMQD PEVMVAFQDV AQNPSNMSKY
360 370
QSNPKVMNLI SKLSAKFGGQ S
Length:371
Mass (Da):41,656
Last modified:June 1, 2001 - v1
Checksum:i7F9417F251B99F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010318 mRNA Translation: CAJ18526.1
AK146528 mRNA Translation: BAE27237.1
AK147169 mRNA Translation: BAE27733.1
AK159149 mRNA Translation: BAE34856.1
BC003843 mRNA Translation: AAH03843.1
CCDSiCCDS27667.1
RefSeqiNP_598487.1, NM_133726.2
UniGeneiMm.180337

Genome annotation databases

EnsembliENSMUST00000172107; ENSMUSP00000130195; ENSMUSG00000022403
GeneIDi70356
KEGGimmu:70356
UCSCiuc007wwl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiF10A1_MOUSE
AccessioniPrimary (citable) accession number: Q99L47
Secondary accession number(s): Q4FJT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health