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Q99L43

- CDS2_MOUSE

UniProt

Q99L43 - CDS2_MOUSE

Protein

Phosphatidate cytidylyltransferase 2

Gene

Cds2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: BHF-UCL

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
    2. glycosylation Source: BHF-UCL
    3. phototransduction Source: BHF-UCL

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BRENDAi2.7.7.41. 3474.
    ReactomeiREACT_199032. Synthesis of PG.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase 2
    CDP-DG synthase 2
    CDP-diacylglycerol synthase 2
    Short name:
    CDS 2
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthase 2
    CTP:phosphatidate cytidylyltransferase 2
    Gene namesi
    Name:Cds2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1332236. Cds2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Phosphatidate cytidylyltransferase 2PRO_0000090717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201PhosphoserineBy similarity
    Modified residuei32 – 321Phosphoserine2 Publications
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei36 – 361PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99L43.
    PaxDbiQ99L43.
    PRIDEiQ99L43.

    PTM databases

    PhosphoSiteiQ99L43.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99L43.
    BgeeiQ99L43.
    GenevestigatoriQ99L43.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99L43. 1 interaction.
    MINTiMINT-4124036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99L43.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    GeneTreeiENSGT00390000016175.
    HOGENOMiHOG000209582.
    HOVERGENiHBG002485.
    InParanoidiQ99L43.
    KOiK00981.
    OMAiRILTYFV.
    PhylomeDBiQ99L43.
    TreeFamiTF313464.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99L43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTELRQRVVR EDAPPEDKES ESEAKLDGET ASDSESRAET APLPTSVDDT    50
    PEVLNRALSN LSSRWKNWWV RGILTLAMIA FFFIIIYLGP MVLMMIVMCV 100
    QIKCFHEIIT IGYNVYHSYD LPWFRTLSWY FLLCVNYFFY GETVTDYFFT 150
    LVQREEPLRI LSKYHRFISF ALYLTGFCMF VLSLVKKHYR LQFYMFGWTH 200
    VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM FGFFFGRTPL 250
    IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT 300
    VDCEPSDLFR LQEYNIPGVI QSAIGWKTVR MYPFQIHSIA LSTFASLIGP 350
    FGGFFASGFK RAFKIKDFAN TIPGHGGIMD RFDCQYLMAT FVNVYIASFI 400
    RGPNPSKLIQ QFLTLRPDQQ LHIFNTLKSH LTDKGILTSA LEDE 444
    Length:444
    Mass (Da):51,314
    Last modified:June 1, 2001 - v1
    Checksum:i6A3568A7E90A6C53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431L → P in AAH69879. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY159802 mRNA. Translation: AAO17790.1.
    AK036328 mRNA. Translation: BAC29384.1.
    AK147541 mRNA. Translation: BAE27984.1.
    AK166001 mRNA. Translation: BAE38511.1.
    BC003852 mRNA. Translation: AAH03852.1.
    BC069879 mRNA. Translation: AAH69879.1.
    CCDSiCCDS16772.1.
    RefSeqiNP_001277968.1. NM_001291039.1.
    NP_619592.1. NM_138651.7.
    UniGeneiMm.284503.

    Genome annotation databases

    EnsembliENSMUST00000103181; ENSMUSP00000099470; ENSMUSG00000058793.
    GeneIDi110911.
    KEGGimmu:110911.
    UCSCiuc008mmo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY159802 mRNA. Translation: AAO17790.1 .
    AK036328 mRNA. Translation: BAC29384.1 .
    AK147541 mRNA. Translation: BAE27984.1 .
    AK166001 mRNA. Translation: BAE38511.1 .
    BC003852 mRNA. Translation: AAH03852.1 .
    BC069879 mRNA. Translation: AAH69879.1 .
    CCDSi CCDS16772.1.
    RefSeqi NP_001277968.1. NM_001291039.1.
    NP_619592.1. NM_138651.7.
    UniGenei Mm.284503.

    3D structure databases

    ProteinModelPortali Q99L43.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99L43. 1 interaction.
    MINTi MINT-4124036.

    PTM databases

    PhosphoSitei Q99L43.

    Proteomic databases

    MaxQBi Q99L43.
    PaxDbi Q99L43.
    PRIDEi Q99L43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103181 ; ENSMUSP00000099470 ; ENSMUSG00000058793 .
    GeneIDi 110911.
    KEGGi mmu:110911.
    UCSCi uc008mmo.1. mouse.

    Organism-specific databases

    CTDi 8760.
    MGIi MGI:1332236. Cds2.

    Phylogenomic databases

    eggNOGi COG0575.
    GeneTreei ENSGT00390000016175.
    HOGENOMi HOG000209582.
    HOVERGENi HBG002485.
    InParanoidi Q99L43.
    KOi K00981.
    OMAi RILTYFV.
    PhylomeDBi Q99L43.
    TreeFami TF313464.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    BRENDAi 2.7.7.41. 3474.
    Reactomei REACT_199032. Synthesis of PG.

    Miscellaneous databases

    NextBioi 364917.
    PROi Q99L43.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99L43.
    Bgeei Q99L43.
    Genevestigatori Q99L43.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2."
      Inglis S.L., Hunt D.M., Halford S.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Embryonic stem cell and Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Embryo and Mammary tumor.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCDS2_MOUSE
    AccessioniPrimary (citable) accession number: Q99L43
    Secondary accession number(s): Q3TMD1, Q6NSU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3