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Protein

Dehydrogenase/reductase SDR family member 1

Gene

Dhrs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511SubstrateBy similarity
Active sitei163 – 1631Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)
Gene namesi
Name:Dhrs1
Synonyms:D14ertd484e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1196314. Dhrs1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 313312Dehydrogenase/reductase SDR family member 1PRO_0000054641Add
BLAST

Proteomic databases

EPDiQ99L04.
MaxQBiQ99L04.
PaxDbiQ99L04.
PeptideAtlasiQ99L04.
PRIDEiQ99L04.

PTM databases

iPTMnetiQ99L04.
PhosphoSiteiQ99L04.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002332.
CleanExiMM_DHRS1.
GenevisibleiQ99L04. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99L04. 1 interaction.
MINTiMINT-1863592.
STRINGi10090.ENSMUSP00000002403.

Structurei

3D structure databases

ProteinModelPortaliQ99L04.
SMRiQ99L04. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ99L04.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG091G0CL5.
PhylomeDBiQ99L04.
TreeFamiTF314146.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99L04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPMKGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRATAQE
60 70 80 90 100
AQSLGGRCVP VVCDSSQESE VKSLFEQVDR EQKGRLDVLV NNAYAGVQAI
110 120 130 140 150
LNTTNKSFWE VPASIWDDIN NVGLRGHYLC SVYGARLMVP AGKGLIVIVS
160 170 180 190 200
SPGGLQHMFN VPYGVGKAAC DRLAADCAHE LRRHGVSYVS LWPGLVQTEM
210 220 230 240 250
VKEFMAKEDT PEDPLFKKMK PDFSSAESPE MSGKCVVALA TDPNILNLSG
260 270 280 290 300
KVLPSCDLAR RYGLKDIDGR PVKDYFSLGY ALSQVSSLGW LNSFLPGFLR
310
VPKWVVTLYN SKF
Length:313
Mass (Da):34,005
Last modified:June 1, 2001 - v1
Checksum:i60E05BD7911BDC0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941G → R in BAB23093 (PubMed:16141072).Curated
Sequence conflicti304 – 3041W → L in BAB23093 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003958 mRNA. Translation: BAB23093.1.
AK146317 mRNA. Translation: BAE27072.1.
AK168115 mRNA. Translation: BAE40086.1.
AK168147 mRNA. Translation: BAE40112.1.
BC003930 mRNA. Translation: AAH03930.1.
CCDSiCCDS36934.1.
RefSeqiNP_081095.2. NM_026819.3.
XP_006519322.1. XM_006519259.2.
UniGeneiMm.21623.

Genome annotation databases

EnsembliENSMUST00000002403; ENSMUSP00000002403; ENSMUSG00000002332.
GeneIDi52585.
KEGGimmu:52585.
UCSCiuc007uan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003958 mRNA. Translation: BAB23093.1.
AK146317 mRNA. Translation: BAE27072.1.
AK168115 mRNA. Translation: BAE40086.1.
AK168147 mRNA. Translation: BAE40112.1.
BC003930 mRNA. Translation: AAH03930.1.
CCDSiCCDS36934.1.
RefSeqiNP_081095.2. NM_026819.3.
XP_006519322.1. XM_006519259.2.
UniGeneiMm.21623.

3D structure databases

ProteinModelPortaliQ99L04.
SMRiQ99L04. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99L04. 1 interaction.
MINTiMINT-1863592.
STRINGi10090.ENSMUSP00000002403.

PTM databases

iPTMnetiQ99L04.
PhosphoSiteiQ99L04.

Proteomic databases

EPDiQ99L04.
MaxQBiQ99L04.
PaxDbiQ99L04.
PeptideAtlasiQ99L04.
PRIDEiQ99L04.

Protocols and materials databases

DNASUi52585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002403; ENSMUSP00000002403; ENSMUSG00000002332.
GeneIDi52585.
KEGGimmu:52585.
UCSCiuc007uan.2. mouse.

Organism-specific databases

CTDi115817.
MGIiMGI:1196314. Dhrs1.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ99L04.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG091G0CL5.
PhylomeDBiQ99L04.
TreeFamiTF314146.

Miscellaneous databases

ChiTaRSiDhrs1. mouse.
PROiQ99L04.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002332.
CleanExiMM_DHRS1.
GenevisibleiQ99L04. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS1_MOUSE
AccessioniPrimary (citable) accession number: Q99L04
Secondary accession number(s): Q3THW0, Q9D148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.