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Protein

Dehydrogenase/reductase SDR family member 1

Gene

Dhrs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151SubstrateBy similarity1
Active sitei163Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)
Gene namesi
Name:Dhrs1
Synonyms:D14ertd484e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1196314. Dhrs1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546411 – 313Dehydrogenase/reductase SDR family member 1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ99L04.
MaxQBiQ99L04.
PaxDbiQ99L04.
PeptideAtlasiQ99L04.
PRIDEiQ99L04.

PTM databases

iPTMnetiQ99L04.
PhosphoSitePlusiQ99L04.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002332.
CleanExiMM_DHRS1.
GenevisibleiQ99L04. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99L04. 1 interactor.
MINTiMINT-1863592.
STRINGi10090.ENSMUSP00000002403.

Structurei

3D structure databases

ProteinModelPortaliQ99L04.
SMRiQ99L04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00900000140982.
HOVERGENiHBG051351.
InParanoidiQ99L04.
KOiK11163.
OMAiPADVTGY.
OrthoDBiEOG091G0CL5.
PhylomeDBiQ99L04.
TreeFamiTF314146.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99L04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPMKGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRATAQE
60 70 80 90 100
AQSLGGRCVP VVCDSSQESE VKSLFEQVDR EQKGRLDVLV NNAYAGVQAI
110 120 130 140 150
LNTTNKSFWE VPASIWDDIN NVGLRGHYLC SVYGARLMVP AGKGLIVIVS
160 170 180 190 200
SPGGLQHMFN VPYGVGKAAC DRLAADCAHE LRRHGVSYVS LWPGLVQTEM
210 220 230 240 250
VKEFMAKEDT PEDPLFKKMK PDFSSAESPE MSGKCVVALA TDPNILNLSG
260 270 280 290 300
KVLPSCDLAR RYGLKDIDGR PVKDYFSLGY ALSQVSSLGW LNSFLPGFLR
310
VPKWVVTLYN SKF
Length:313
Mass (Da):34,005
Last modified:June 1, 2001 - v1
Checksum:i60E05BD7911BDC0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194G → R in BAB23093 (PubMed:16141072).Curated1
Sequence conflicti304W → L in BAB23093 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003958 mRNA. Translation: BAB23093.1.
AK146317 mRNA. Translation: BAE27072.1.
AK168115 mRNA. Translation: BAE40086.1.
AK168147 mRNA. Translation: BAE40112.1.
BC003930 mRNA. Translation: AAH03930.1.
CCDSiCCDS36934.1.
RefSeqiNP_081095.2. NM_026819.3.
UniGeneiMm.21623.

Genome annotation databases

EnsembliENSMUST00000002403; ENSMUSP00000002403; ENSMUSG00000002332.
GeneIDi52585.
KEGGimmu:52585.
UCSCiuc007uan.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDHRS1_MOUSE
AccessioniPrimary (citable) accession number: Q99L04
Secondary accession number(s): Q3THW0, Q9D148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families