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Protein

Zinc finger protein 639

Gene

Znf639

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and may function as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 639
Alternative name(s):
Zinc finger protein ZASC1
Gene namesi
Name:Znf639
Synonyms:Zasc1, Zfp639
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915028. Zfp639.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003835731 – 485Zinc finger protein 639Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei88PhosphoserineBy similarity1
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99KZ6.
PaxDbiQ99KZ6.
PeptideAtlasiQ99KZ6.
PRIDEiQ99KZ6.

PTM databases

iPTMnetiQ99KZ6.
PhosphoSitePlusiQ99KZ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027667.
ExpressionAtlasiQ99KZ6. baseline and differential.
GenevisibleiQ99KZ6. MM.

Interactioni

Subunit structurei

Interacts with CTNNA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029203.

Structurei

3D structure databases

ProteinModelPortaliQ99KZ6.
SMRiQ99KZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni371 – 455Interaction with CTNNA2By similarityAdd BLAST85

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000285973.
InParanoidiQ99KZ6.
OMAiFPHVCDD.
OrthoDBiEOG091G05F4.
PhylomeDBiQ99KZ6.
TreeFamiTF335557.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Q99KZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEYPKKRKR KTLHPSRYSD SSGISRIADG VSGIFSDHCY SVCSMRQPDL
60 70 80 90 100
KYFDNKDDDS DPETANDLPK FADGTKARNR NQSYLVPSPV LRILDHTVFS
110 120 130 140 150
TEKSTEVEIC DEECASPESV HQHTQEESPI EVHTSEDVPI AVEVHAISED
160 170 180 190 200
YDIEAENNSS ESLQDQADEE PPAKLCKILD KGQALNVTAQ QKWPLLRANS
210 220 230 240 250
SGLYKCELCE FNSKYFSDLK QHVILKHKRT DSNVCRVCKE SFSTNMLLIE
260 270 280 290 300
HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS
310 320 330 340 350
SSELYLHFQE HSRDEQYLCQ FCEHETGDPE DLHSHVVNEH ARRLIELSDK
360 370 380 390 400
CGSGGHGQCS LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI
410 420 430 440 450
FPHVCDDCGK GFSSMLEYCK HLNSHLSEGI YLCQYCEYST GQIDDLKIHL
460 470 480
DFKHSADLPH KCSECLMRFG NERDLLGHLQ VHETT
Length:485
Mass (Da):55,678
Last modified:June 1, 2001 - v1
Checksum:i5242B549C27A2E4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455S → P in BAC33991 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY736186 mRNA. Translation: AAU85844.1.
AK049934 mRNA. Translation: BAC33991.2.
AK076145 mRNA. Translation: BAC36215.1.
AK076837 mRNA. Translation: BAC36501.1.
AK078000 mRNA. Translation: BAC37096.1.
CH466530 Genomic DNA. Translation: EDL34991.1.
CH466530 Genomic DNA. Translation: EDL34994.1.
CH466530 Genomic DNA. Translation: EDL34995.1.
CH466530 Genomic DNA. Translation: EDL34996.1.
DQ323614 mRNA. Translation: ABD27861.1.
BC003941 mRNA. Translation: AAH03941.1.
CCDSiCCDS17295.1.
RefSeqiNP_001155290.1. NM_001161818.1.
NP_653102.1. NM_144519.4.
XP_006535590.1. XM_006535527.3.
XP_006535591.1. XM_006535528.2.
XP_006535592.1. XM_006535529.3.
UniGeneiMm.285620.

Genome annotation databases

EnsembliENSMUST00000029203; ENSMUSP00000029203; ENSMUSG00000027667.
ENSMUST00000191783; ENSMUSP00000141446; ENSMUSG00000027667.
ENSMUST00000193287; ENSMUSP00000141341; ENSMUSG00000027667.
GeneIDi67778.
KEGGimmu:67778.
UCSCiuc008owf.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN639_MOUSE
AccessioniPrimary (citable) accession number: Q99KZ6
Secondary accession number(s): A9X400, Q8BWU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families