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Protein

Myeloid leukemia factor 2

Gene

Mlf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid leukemia factor 2
Alternative name(s):
Myelodysplasia-myeloid leukemia factor 2
Gene namesi
Name:Mlf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1353554. Mlf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Myeloid leukemia factor 2PRO_0000220755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineCombined sources
Modified residuei239 – 2391PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99KX1.
MaxQBiQ99KX1.
PaxDbiQ99KX1.
PRIDEiQ99KX1.

PTM databases

iPTMnetiQ99KX1.
PhosphoSiteiQ99KX1.

Expressioni

Gene expression databases

BgeeiQ99KX1.
CleanExiMM_MLF2.
ExpressionAtlasiQ99KX1. baseline and differential.
GenevisibleiQ99KX1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99KX1. 3 interactions.
MINTiMINT-4102144.
STRINGi10090.ENSMUSP00000032214.

Structurei

3D structure databases

ProteinModelPortaliQ99KX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MLF family.Curated

Phylogenomic databases

eggNOGiKOG4049. Eukaryota.
ENOG4111J7M. LUCA.
GeneTreeiENSGT00390000005023.
HOGENOMiHOG000045671.
HOVERGENiHBG019060.
InParanoidiQ99KX1.
OMAiMTGGFMD.
OrthoDBiEOG7H1JN6.
PhylomeDBiQ99KX1.
TreeFamiTF317561.

Family and domain databases

InterProiIPR019376. Myeloid_leukemia_factor.
[Graphical view]
PfamiPF10248. Mlf1IP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPA
60 70 80 90 100
TRPASRRMQA GAVSPFGMLG MSGGFMDMFG MMNDMIGNME HMAAGGNCQT
110 120 130 140 150
FSSSTVISYS NTGDGAPKVY QETSEMRSAP GGIRETRRTV RDSDSGLEQM
160 170 180 190 200
SIGHHIRDRA HILQRSRNHR TGDQEERQDY INLDESEAAA FDDEWRRETS
210 220 230 240
RYRQQRPLEF RRHEASVGGG RRAEGPPRLA IQGPEDSPSR QSRRYDW
Length:247
Mass (Da):28,055
Last modified:June 1, 2001 - v1
Checksum:i00097529ECAB0123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003975 mRNA. Translation: AAH03975.1.
CCDSiCCDS20538.1.
RefSeqiNP_001163812.1. NM_001170341.1.
NP_663360.1. NM_145385.2.
UniGeneiMm.29737.
Mm.490270.

Genome annotation databases

EnsembliENSMUST00000032214; ENSMUSP00000032214; ENSMUSG00000030120.
ENSMUST00000180095; ENSMUSP00000135920; ENSMUSG00000030120.
GeneIDi30853.
KEGGimmu:30853.
UCSCiuc009dso.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003975 mRNA. Translation: AAH03975.1.
CCDSiCCDS20538.1.
RefSeqiNP_001163812.1. NM_001170341.1.
NP_663360.1. NM_145385.2.
UniGeneiMm.29737.
Mm.490270.

3D structure databases

ProteinModelPortaliQ99KX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KX1. 3 interactions.
MINTiMINT-4102144.
STRINGi10090.ENSMUSP00000032214.

PTM databases

iPTMnetiQ99KX1.
PhosphoSiteiQ99KX1.

Proteomic databases

EPDiQ99KX1.
MaxQBiQ99KX1.
PaxDbiQ99KX1.
PRIDEiQ99KX1.

Protocols and materials databases

DNASUi30853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032214; ENSMUSP00000032214; ENSMUSG00000030120.
ENSMUST00000180095; ENSMUSP00000135920; ENSMUSG00000030120.
GeneIDi30853.
KEGGimmu:30853.
UCSCiuc009dso.2. mouse.

Organism-specific databases

CTDi8079.
MGIiMGI:1353554. Mlf2.

Phylogenomic databases

eggNOGiKOG4049. Eukaryota.
ENOG4111J7M. LUCA.
GeneTreeiENSGT00390000005023.
HOGENOMiHOG000045671.
HOVERGENiHBG019060.
InParanoidiQ99KX1.
OMAiMTGGFMD.
OrthoDBiEOG7H1JN6.
PhylomeDBiQ99KX1.
TreeFamiTF317561.

Miscellaneous databases

ChiTaRSiMlf2. mouse.
PROiQ99KX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99KX1.
CleanExiMM_MLF2.
ExpressionAtlasiQ99KX1. baseline and differential.
GenevisibleiQ99KX1. MM.

Family and domain databases

InterProiIPR019376. Myeloid_leukemia_factor.
[Graphical view]
PfamiPF10248. Mlf1IP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung, Spleen and Testis.

Entry informationi

Entry nameiMLF2_MOUSE
AccessioniPrimary (citable) accession number: Q99KX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.