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Protein

T-cell immunomodulatory protein

Gene

Itfg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Modulator of T-cell function. Has a protective effect in graft versus host disease model.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell immunomodulatory protein
Short name:
Protein TIP
Alternative name(s):
Integrin-alpha FG-GAP repeat-containing protein 1
LinkinBy similarity
Gene namesi
Name:Itfg1Imported
Synonyms:D8Wsu49eImported, Lnkn-1By similarity, TipBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106419. Itfg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000003435533 – 610T-cell immunomodulatory proteinAdd BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi351N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ99KW9.
MaxQBiQ99KW9.
PaxDbiQ99KW9.
PeptideAtlasiQ99KW9.
PRIDEiQ99KW9.

PTM databases

PhosphoSitePlusiQ99KW9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031703.
CleanExiMM_ITFG1.
GenevisibleiQ99KW9. MM.

Interactioni

Subunit structurei

Interacts with RUVBL1, RUVBL2 and alpha-tubulin.By similarity

Protein-protein interaction databases

IntActiQ99KW9. 3 interactors.
MINTiMINT-217156.
STRINGi10090.ENSMUSP00000034140.

Structurei

3D structure databases

ProteinModelPortaliQ99KW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati98 – 135FG-GAP 1; atypicalAdd BLAST38
Repeati153 – 183FG-GAP 2; atypicalAdd BLAST31
Repeati256 – 291FG-GAP 3; atypicalAdd BLAST36

Sequence similaritiesi

Belongs to the TIP family.Curated
Contains 3 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4550. Eukaryota.
ENOG410XPFB. LUCA.
GeneTreeiENSGT00390000013367.
HOGENOMiHOG000045462.
HOVERGENiHBG050269.
InParanoidiQ99KW9.
KOiK17257.
OMAiFYDFYQD.
OrthoDBiEOG091G05G7.
TreeFamiTF105620.

Family and domain databases

InterProiIPR024881. Tip.
[Graphical view]
PANTHERiPTHR13412. PTHR13412. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGRLPSAR AVLAPLFLGL ALLSVGPAPA RALHNVTAEL FGAEAWGTLA
60 70 80 90 100
AFGDLNSDKQ TDLFVLRERN DLIVFLADQS APYFKPKVKV SLKTLSALVT
110 120 130 140 150
SVVPGDYDGD SQMDVLLTYF PQNHTNSELG AVIFWGQNQT LDPKNMTILN
160 170 180 190 200
RTFHDQPLIM DFNGDLIPDV FGITNESSQP QILLGGDLSW HPALTTKSKM
210 220 230 240 250
RDPHSHAFID LTEDFTADLF LTTLTASNAF QFEIWENLGG NFSIHSVFEK
260 270 280 290 300
PKNLVVVGQS AFADFDGDGH MDHLLPGCED KDCQKSAIYL MRSGTGQWVP
310 320 330 340 350
VLQDFSNKGT LWGFVPFVHE EQPTTIPIPL TLHIGDYNMD GYPDALAILK
360 370 380 390 400
NTSGSNQQAF LLENVPCNNA SCEEVHRMFK VYWDLAGLNL IKDAIVATFF
410 420 430 440 450
DIYEDGILDI IVLSKGYTKN DVAIHTLKNN FEADAYFVKV IVLSGLCSND
460 470 480 490 500
CPRKITPFGV NQPGPYIMYT TVDANGYLKN GSAGQLSQSA HLALQLPYNV
510 520 530 540 550
LGLGRSANFL DHLFVGIPRP SGEKSIRKQE WTAIIPNSQL IVIPYPHNVP
560 570 580 590 600
RSWSAKLYLT PSNIVLLTAV ALIGVCIFIL AIIAILHWQE KKADDREKRQ
610
EAHRFHFDAM
Length:610
Mass (Da):67,465
Last modified:July 27, 2011 - v2
Checksum:i123667168AB22BE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269G → V in BAB26552 (PubMed:16141072).Curated1
Sequence conflicti521S → P in AAH03977 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009867 mRNA. Translation: BAB26552.1.
AC117185 Genomic DNA. No translation available.
AC158357 Genomic DNA. No translation available.
BC003977 mRNA. Translation: AAH03977.1.
CCDSiCCDS40424.1.
RefSeqiNP_082283.2. NM_028007.3.
UniGeneiMm.61018.

Genome annotation databases

EnsembliENSMUST00000034140; ENSMUSP00000034140; ENSMUSG00000031703.
GeneIDi71927.
KEGGimmu:71927.
UCSCiuc009mqf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009867 mRNA. Translation: BAB26552.1.
AC117185 Genomic DNA. No translation available.
AC158357 Genomic DNA. No translation available.
BC003977 mRNA. Translation: AAH03977.1.
CCDSiCCDS40424.1.
RefSeqiNP_082283.2. NM_028007.3.
UniGeneiMm.61018.

3D structure databases

ProteinModelPortaliQ99KW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KW9. 3 interactors.
MINTiMINT-217156.
STRINGi10090.ENSMUSP00000034140.

PTM databases

PhosphoSitePlusiQ99KW9.

Proteomic databases

EPDiQ99KW9.
MaxQBiQ99KW9.
PaxDbiQ99KW9.
PeptideAtlasiQ99KW9.
PRIDEiQ99KW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034140; ENSMUSP00000034140; ENSMUSG00000031703.
GeneIDi71927.
KEGGimmu:71927.
UCSCiuc009mqf.2. mouse.

Organism-specific databases

CTDi81533.
MGIiMGI:106419. Itfg1.

Phylogenomic databases

eggNOGiKOG4550. Eukaryota.
ENOG410XPFB. LUCA.
GeneTreeiENSGT00390000013367.
HOGENOMiHOG000045462.
HOVERGENiHBG050269.
InParanoidiQ99KW9.
KOiK17257.
OMAiFYDFYQD.
OrthoDBiEOG091G05G7.
TreeFamiTF105620.

Miscellaneous databases

ChiTaRSiItfg1. mouse.
PROiQ99KW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031703.
CleanExiMM_ITFG1.
GenevisibleiQ99KW9. MM.

Family and domain databases

InterProiIPR024881. Tip.
[Graphical view]
PANTHERiPTHR13412. PTHR13412. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTIP_MOUSE
AccessioniPrimary (citable) accession number: Q99KW9
Secondary accession number(s): E9QQ11, Q9D6X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.