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Protein

TRIO and F-actin-binding protein

Gene

Triobp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
Gene namesi
Name:Triobp
Synonyms:Kiaa1662, Tara
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1349410. Triobp.

Subcellular locationi

Isoform 1 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20142014TRIO and F-actin-binding proteinPRO_0000072434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1598 – 15981PhosphoserineBy similarity
Modified residuei1604 – 16041PhosphoserineBy similarity
Modified residuei1879 – 18791Phosphothreonine; by PLK1By similarity

Post-translational modificationi

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.By similarity
Isoform 1: Phosphorylation at Thr-445 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99KW3.
MaxQBiQ99KW3.
PaxDbiQ99KW3.
PRIDEiQ99KW3.

PTM databases

iPTMnetiQ99KW3.
PhosphoSiteiQ99KW3.

Expressioni

Gene expression databases

BgeeiQ99KW3.
CleanExiMM_TRIOBP.
ExpressionAtlasiQ99KW3. baseline and differential.
GenevisibleiQ99KW3. MM.

Interactioni

Subunit structurei

Binds to TRIO and F-actin. May also interact with myosin II (By similarity). Interacts with HECTD3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99KW3. 1 interaction.
MINTiMINT-4136918.
STRINGi10090.ENSMUSP00000105312.

Structurei

3D structure databases

ProteinModelPortaliQ99KW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1440 – 153697PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1711 – 2010300Sequence analysisAdd
BLAST

Domaini

Contains at least 2 actin-binding sites per coiled-coil dimer.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4807. Eukaryota.
ENOG410ZA8F. LUCA.
GeneTreeiENSGT00530000063678.
HOVERGENiHBG094025.
InParanoidiQ99KW3.
OMAiPYCDLPR.
OrthoDBiEOG773XKP.
PhylomeDBiQ99KW3.
TreeFamiTF343361.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR029908. Tara.
[Graphical view]
PANTHERiPTHR17271:SF10. PTHR17271:SF10. 1 hit.
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q99KW3-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEQDTRAL LPTQGTAWAT ASAPVARLQG PQGDSHQACS QEPHSPSSAE
60 70 80 90 100
APYCDLPRCP PALQNPLRTT TCVGQSVHSL GLGLGQEPQR VWSPTTALPA
110 120 130 140 150
EGPAAAPKNR HQDSEGIPYL EGLARSSCTD DNDNKDEDED PNSNTSSSQD
160 170 180 190 200
SNTPHDTSNS SSVDWDTTER PGVVPSRNRL TEMIPRRPQE GLRADSARKA
210 220 230 240 250
TRSPARGDTA GQRKENSGSG GQSAGQHWAK LRSESGYFSL ERQRSGQTQA
260 270 280 290 300
SSGTPPSGPR GTTQASSAQR DVFQAAPAQE APQTSSLPRN TQRDTQRSTP
310 320 330 340 350
RTSSPSRVSQ RDTPRVMSTQ RKNTPLSSPL RATPETLKIS APEDGTHVTP
360 370 380 390 400
SPCVQDSSLN RTSQRDSSRT PCIQWDNPRA SSPNRTTQRD NPRTPCTQRD
410 420 430 440 450
NPRASSPNRT TQRDNPRTPC TQRDNPRASS PNRTTQRDNP RTPCAQRDNP
460 470 480 490 500
RAASPNRSTQ RDSPRTPCAQ RDNPRASSPN RTAQRDNPRT PCAQRDNPRT
510 520 530 540 550
SCTSQNTPRT PSTQADKTTA SCSKWEHLRS ACTQRDNPRT FSQGCTQKDN
560 570 580 590 600
PGPPSPRRAT QGSNSRNPSP HRTNKDIPWA SFPLRPTQSD SPRTSSPSRT
610 620 630 640 650
KQNQVPWASI SLRPTQGDKP QTSAPTRLAH NDPPQQYSPS LATTSSSSHN
660 670 680 690 700
PGHSSASRTS SPLHAAPRGA PQTSLESSQP PCTVCIGHRD APRASSPPRY
710 720 730 740 750
FQYDPFPFFP DPRSSESESP HHEPPYMPPA VCIGHRDAPR ATSPPRHTQF
760 770 780 790 800
DPFPFLPDTS DADNESPQHD PPQFPPPVCI GYRDAPRASS PPRQFPEPSF
810 820 830 840 850
FQDLPRASTE SLVPSTDSMH EPPHIPTPVC IGHRDAPSFS SPPRQAPEPS
860 870 880 890 900
LFFQDPPGTS MESLAPSIDS LHGCPLLPPQ VCIGHRDAPR ASSPPRHPPS
910 920 930 940 950
DIGLLAPSPP PGSSGSRGSA PPGETRHNLE REEYTMLADL PPPRRLAQRG
960 970 980 990 1000
PEPQAQGSNE GRTRSPGRAE VERLFGQERR KSEAPGAFQT RDEGRSQRPS
1010 1020 1030 1040 1050
QAQSQLRRQS SPAPSRQVTK PSAKQAEPTR QSRTGPPHPK SPDKRPEGDR
1060 1070 1080 1090 1100
QLQRTSPPAR TPARPPERKA QIERHLESGH TGPRQSLGGW QSQERLSGPQ
1110 1120 1130 1140 1150
SPNRHPEKSW GSQKEGPSLG GWPELEGPSL EGIWRGPPQE HREQWGHSEA
1160 1170 1180 1190 1200
WEEPPSNGIQ GAPPRGQGRL QELSRPHQPT PSSENSWAGP AECSCALQPE
1210 1220 1230 1240 1250
ASTAVGWRAE GTSPHQRSAE RPPDLDWRDL LGLLRAPEDG AWTRLPRLDW
1260 1270 1280 1290 1300
EGLLELLQAR LPQKDPARHW HDPAKASGPE QGSSGTEDTL KTEPQTQPEG
1310 1320 1330 1340 1350
RAKATLANGH RPGQQSESPA QLPSPACTST QWPTTKVTSG PETSPLAALE
1360 1370 1380 1390 1400
QIDHLESHSP PDLEFQPEEP EASEPSRGED SRAVQKQADS ADKRPAEGKA
1410 1420 1430 1440 1450
GSPLKGRLVT SWRMPGDRPA LFNPYLLSLG VLRWQRPDLL NFKKGWMSIL
1460 1470 1480 1490 1500
DEPGEWKKHW FVLTDSSLKY YRDSTAEEAD ELDGEIDLRS CTDVTEYAVQ
1510 1520 1530 1540 1550
RNYGFQIHTK DAVYTLSAMT SGIRRNWIEA LRKTVRPTSA PDVTKLSDCN
1560 1570 1580 1590 1600
KENTLHGYGT QKSSLKIGEQ RTGSEVIGRG GPRKADGPRP SLDYVELSPL
1610 1620 1630 1640 1650
APSSPQRMRT LSRSTPERPT KQEDLERDLA QRSEERRKWF ESTDGRTPET
1660 1670 1680 1690 1700
PSGDGSRRGL GAPLTDDQQS RLSEEIEKKW QELEKLPLRE NKRVPLTALL
1710 1720 1730 1740 1750
NQAHNDRRGP TSDSHEALEK EVQSLRAQLE AWRLRGEAPQ NAPRLQEDSH
1760 1770 1780 1790 1800
IPPGYISQEA CERSLAEMES SHQQVMEQLQ RHHERELQRL QQEKEWLLAE
1810 1820 1830 1840 1850
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPESLRKQ HQLDMEALKQ
1860 1870 1880 1890 1900
ELQVLSERYS QKCLEIGALT RQAEEREHTL RRCQQEGQEL LRHNQELHSH
1910 1920 1930 1940 1950
LSEEIDRLRS FIASQGTGNS CGRSNERSSC ELEVLLRVKE NELQYLKKEV
1960 1970 1980 1990 2000
QCLRDELQVI QKDKRFTGKY QDVYVELNHI KTRSEREIEQ LKEHLRLAMA
2010
ALQEKEAVRN SLAE
Length:2,014
Mass (Da):223,368
Last modified:March 21, 2006 - v3
Checksum:iABDF0F8C3AC4C476
GO
Isoform 4 (identifier: Q99KW3-4) [UniParc]FASTAAdd to basket

Also known as: TRIOBP isoform 5

The sequence of this isoform differs from the canonical sequence as follows:
     1391-1436: Missing.

Show »
Length:1,968
Mass (Da):218,223
Checksum:i88AD93F9AC4F8DBE
GO
Isoform 5 (identifier: Q99KW3-5) [UniParc]FASTAAdd to basket

Also known as: TRIOBP isoform 4

The sequence of this isoform differs from the canonical sequence as follows:
     981-2014: Missing.

Show »
Length:980
Mass (Da):106,587
Checksum:iFB0D255E4B593D28
GO
Isoform 1 (identifier: Q99KW3-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1434: Missing.
     1435-1436: QR → MT

Show »
Length:580
Mass (Da):66,980
Checksum:iC3E3CFE534CD1A13
GO
Isoform 2 (identifier: Q99KW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1508-1508: H → HVRLR

Note: No experimental confirmation available.
Show »
Length:2,018
Mass (Da):223,892
Checksum:i003FDD11DB74BC2D
GO

Sequence cautioni

The sequence BAC98227.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651N → D in ABB77203 (PubMed:16385458).Curated
Sequence conflicti1036 – 10361P → S in ABB77203 (PubMed:16385458).Curated
Sequence conflicti1464 – 14641T → A in ABB77203 (PubMed:16385458).Curated
Sequence conflicti1674 – 16741E → V in AAH42760 (PubMed:15489334).Curated
Sequence conflicti1708 – 17081R → RR in ABB77203 (PubMed:16385458).Curated
Sequence conflicti1771 – 17711S → P in ABB77203 (PubMed:16385458).Curated
Sequence conflicti1889 – 18891E → K in ABB77203 (PubMed:16385458).Curated
Sequence conflicti2014 – 20141E → V in ABB77203 (PubMed:16385458).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14341434Missing in isoform 1. 2 PublicationsVSP_017718Add
BLAST
Alternative sequencei981 – 20141034Missing in isoform 5. 1 PublicationVSP_017721Add
BLAST
Alternative sequencei1391 – 143646Missing in isoform 4. 2 PublicationsVSP_017719Add
BLAST
Alternative sequencei1435 – 14362QR → MT in isoform 1. 2 PublicationsVSP_017720
Alternative sequencei1508 – 15081H → HVRLR in isoform 2. 1 PublicationVSP_016762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129417 Transcribed RNA. Translation: BAC98227.2. Different initiation.
DQ278602 mRNA. Translation: ABB77203.1.
DQ228000 mRNA. Translation: ABB59556.1.
DQ228001 mRNA. Translation: ABB59557.2.
DQ228002 mRNA. Translation: ABB59558.2.
AK053194 mRNA. Translation: BAC35308.1.
AK170390 mRNA. Translation: BAE41764.1.
BC003984 mRNA. Translation: AAH03984.1.
BC042760 mRNA. Translation: AAH42760.1.
BC053329 mRNA. Translation: AAH53329.1.
CCDSiCCDS37136.1. [Q99KW3-3]
CCDS37137.1. [Q99KW3-4]
RefSeqiNP_001034244.1. NM_001039155.1. [Q99KW3-5]
NP_001034245.1. NM_001039156.1. [Q99KW3-3]
NP_613045.3. NM_138579.4. [Q99KW3-4]
UniGeneiMm.123714.

Genome annotation databases

EnsembliENSMUST00000109687; ENSMUSP00000105309; ENSMUSG00000033088. [Q99KW3-1]
ENSMUST00000109689; ENSMUSP00000105311; ENSMUSG00000033088. [Q99KW3-4]
ENSMUST00000109690; ENSMUSP00000105312; ENSMUSG00000033088. [Q99KW3-3]
GeneIDi110253.
KEGGimmu:110253.
UCSCiuc007wrx.1. mouse. [Q99KW3-5]
uc007wry.1. mouse. [Q99KW3-3]
uc007wrz.1. mouse. [Q99KW3-4]
uc029sth.1. mouse. [Q99KW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129417 Transcribed RNA. Translation: BAC98227.2. Different initiation.
DQ278602 mRNA. Translation: ABB77203.1.
DQ228000 mRNA. Translation: ABB59556.1.
DQ228001 mRNA. Translation: ABB59557.2.
DQ228002 mRNA. Translation: ABB59558.2.
AK053194 mRNA. Translation: BAC35308.1.
AK170390 mRNA. Translation: BAE41764.1.
BC003984 mRNA. Translation: AAH03984.1.
BC042760 mRNA. Translation: AAH42760.1.
BC053329 mRNA. Translation: AAH53329.1.
CCDSiCCDS37136.1. [Q99KW3-3]
CCDS37137.1. [Q99KW3-4]
RefSeqiNP_001034244.1. NM_001039155.1. [Q99KW3-5]
NP_001034245.1. NM_001039156.1. [Q99KW3-3]
NP_613045.3. NM_138579.4. [Q99KW3-4]
UniGeneiMm.123714.

3D structure databases

ProteinModelPortaliQ99KW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KW3. 1 interaction.
MINTiMINT-4136918.
STRINGi10090.ENSMUSP00000105312.

PTM databases

iPTMnetiQ99KW3.
PhosphoSiteiQ99KW3.

Proteomic databases

EPDiQ99KW3.
MaxQBiQ99KW3.
PaxDbiQ99KW3.
PRIDEiQ99KW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109687; ENSMUSP00000105309; ENSMUSG00000033088. [Q99KW3-1]
ENSMUST00000109689; ENSMUSP00000105311; ENSMUSG00000033088. [Q99KW3-4]
ENSMUST00000109690; ENSMUSP00000105312; ENSMUSG00000033088. [Q99KW3-3]
GeneIDi110253.
KEGGimmu:110253.
UCSCiuc007wrx.1. mouse. [Q99KW3-5]
uc007wry.1. mouse. [Q99KW3-3]
uc007wrz.1. mouse. [Q99KW3-4]
uc029sth.1. mouse. [Q99KW3-1]

Organism-specific databases

CTDi11078.
MGIiMGI:1349410. Triobp.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4807. Eukaryota.
ENOG410ZA8F. LUCA.
GeneTreeiENSGT00530000063678.
HOVERGENiHBG094025.
InParanoidiQ99KW3.
OMAiPYCDLPR.
OrthoDBiEOG773XKP.
PhylomeDBiQ99KW3.
TreeFamiTF343361.

Miscellaneous databases

ChiTaRSiTriobp. mouse.
NextBioi363625.
PROiQ99KW3.
SOURCEiSearch...

Gene expression databases

BgeeiQ99KW3.
CleanExiMM_TRIOBP.
ExpressionAtlasiQ99KW3. baseline and differential.
GenevisibleiQ99KW3. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR029908. Tara.
[Graphical view]
PANTHERiPTHR17271:SF10. PTHR17271:SF10. 1 hit.
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  2. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss."
    Shahin H., Walsh T., Sobe T., Abu Sa'ed J., Abu Rayan A., Lynch E.D., Lee M.K., Avraham K.B., King M.-C., Kanaan M.
    Am. J. Hum. Genet. 78:144-152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Cochlea.
  4. "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness."
    Riazuddin S., Khan S.N., Ahmed Z.M., Ghosh M., Caution K., Nazli S., Kabra M., Zafar A.U., Chen K., Naz S., Antonellis A., Pavan W.J., Green E.D., Wilcox E.R., Friedman P.L., Morell R.J., Riazuddin S., Friedman T.B.
    Am. J. Hum. Genet. 78:137-143(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Inner ear.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Lung.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiTARA_MOUSE
AccessioniPrimary (citable) accession number: Q99KW3
Secondary accession number(s): Q2PZW9
, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.