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Q99KU1

- DHDDS_MOUSE

UniProt

Q99KU1 - DHDDS_MOUSE

Protein

Dehydrodolichyl diphosphate synthase

Gene

Dhdds

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.

    Pathwayi

    GO - Molecular functioni

    1. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_202113. Synthesis of Dolichyl-phosphate.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrodolichyl diphosphate synthase (EC:2.5.1.-)
    Short name:
    Dedol-PP synthase
    Alternative name(s):
    Cis-isoprenyltransferase
    Short name:
    CIT
    Short name:
    Cis-IPTase
    Gene namesi
    Name:Dhdds
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1914672. Dhdds.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
    Note: colocalizes with calnexin.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Dehydrodolichyl diphosphate synthasePRO_0000123750Add
    BLAST

    Proteomic databases

    PRIDEiQ99KU1.

    PTM databases

    PhosphoSiteiQ99KU1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99KU1.
    BgeeiQ99KU1.
    CleanExiMM_DHDDS.
    GenevestigatoriQ99KU1.

    Interactioni

    Subunit structurei

    Interacts with NUS1/NgBR, the interaction is required for efficient activity. Interacts with NPC2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000101511.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99KU1.
    SMRiQ99KU1. Positions 27-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0020.
    GeneTreeiENSGT00390000007879.
    HOGENOMiHOG000006053.
    HOVERGENiHBG051350.
    InParanoidiA3KGL4.
    KOiK11778.
    OMAiRIEGHKR.
    OrthoDBiEOG7HTHHB.
    PhylomeDBiQ99KU1.
    TreeFamiTF323753.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99KU1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWIKEGELS LWERFCANII KAGPVPKHIA FIMDGNRRYA KKCQVERQEG    50
    HTQGFNKLAE TLRWCLNLGI LEVTVYAFSI ENFKRSKSEV DGLLDLARQK 100
    FSCLMEEQEK LQKHGVCIRV LGDLHLLPLD LQEKIAHAIQ ATKNYNKCFL 150
    NVCFAYTSRH EIANAVREMA WGVEQGLLEP SDVSESLLDK CLYSNHSPHP 200
    DILIRTSGEV RLSDFLLWQT SHSCLVFQPV LWPEYTFWNL CEAILQFQRN 250
    HGALQKARDM YAEERKRRQL ERDQAAVTEQ LLREGLQASG DAQLRRTRLH 300
    KLSTKREERV QGFLKALELK RANWLALWGT ASA 333
    Length:333
    Mass (Da):38,509
    Last modified:June 1, 2001 - v1
    Checksum:i53992F5E92D3F2C9
    GO
    Isoform 2 (identifier: Q99KU1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-255: Q → QQ

    Show »
    Length:334
    Mass (Da):38,637
    Checksum:iB4574B527D0D8C1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301A → L in BAC29643. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 2551Q → QQ in isoform 2. 1 PublicationVSP_010032

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034277 mRNA. Translation: BAC28657.1.
    AK036929 mRNA. Translation: BAC29643.1.
    AK049991 mRNA. Translation: BAC34020.1.
    AK135087 mRNA. Translation: BAE22416.1.
    AK149138 mRNA. Translation: BAE28748.1.
    AK171207 mRNA. Translation: BAE42313.1.
    AL837508, AL670680 Genomic DNA. Translation: CAM46083.1.
    BC004011 mRNA. Translation: AAH04011.1.
    CCDSiCCDS18760.1. [Q99KU1-1]
    RefSeqiNP_080420.2. NM_026144.4. [Q99KU1-1]
    UniGeneiMm.100290.

    Genome annotation databases

    EnsembliENSMUST00000012262; ENSMUSP00000012262; ENSMUSG00000012117. [Q99KU1-1]
    ENSMUST00000105887; ENSMUSP00000101511; ENSMUSG00000012117. [Q99KU1-2]
    ENSMUST00000144668; ENSMUSP00000116098; ENSMUSG00000012117. [Q99KU1-1]
    GeneIDi67422.
    KEGGimmu:67422.
    UCSCiuc008vds.1. mouse. [Q99KU1-1]
    uc008vdv.1. mouse. [Q99KU1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034277 mRNA. Translation: BAC28657.1 .
    AK036929 mRNA. Translation: BAC29643.1 .
    AK049991 mRNA. Translation: BAC34020.1 .
    AK135087 mRNA. Translation: BAE22416.1 .
    AK149138 mRNA. Translation: BAE28748.1 .
    AK171207 mRNA. Translation: BAE42313.1 .
    AL837508 , AL670680 Genomic DNA. Translation: CAM46083.1 .
    BC004011 mRNA. Translation: AAH04011.1 .
    CCDSi CCDS18760.1. [Q99KU1-1 ]
    RefSeqi NP_080420.2. NM_026144.4. [Q99KU1-1 ]
    UniGenei Mm.100290.

    3D structure databases

    ProteinModelPortali Q99KU1.
    SMRi Q99KU1. Positions 27-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000101511.

    PTM databases

    PhosphoSitei Q99KU1.

    Proteomic databases

    PRIDEi Q99KU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012262 ; ENSMUSP00000012262 ; ENSMUSG00000012117 . [Q99KU1-1 ]
    ENSMUST00000105887 ; ENSMUSP00000101511 ; ENSMUSG00000012117 . [Q99KU1-2 ]
    ENSMUST00000144668 ; ENSMUSP00000116098 ; ENSMUSG00000012117 . [Q99KU1-1 ]
    GeneIDi 67422.
    KEGGi mmu:67422.
    UCSCi uc008vds.1. mouse. [Q99KU1-1 ]
    uc008vdv.1. mouse. [Q99KU1-2 ]

    Organism-specific databases

    CTDi 79947.
    MGIi MGI:1914672. Dhdds.

    Phylogenomic databases

    eggNOGi COG0020.
    GeneTreei ENSGT00390000007879.
    HOGENOMi HOG000006053.
    HOVERGENi HBG051350.
    InParanoidi A3KGL4.
    KOi K11778.
    OMAi RIEGHKR.
    OrthoDBi EOG7HTHHB.
    PhylomeDBi Q99KU1.
    TreeFami TF323753.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_202113. Synthesis of Dolichyl-phosphate.

    Miscellaneous databases

    NextBioi 324524.
    PROi Q99KU1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99KU1.
    Bgeei Q99KU1.
    CleanExi MM_DHDDS.
    Genevestigatori Q99KU1.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Diencephalon, Hippocampus, Olfactory bulb, Sympathetic ganglion and Vagina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiDHDDS_MOUSE
    AccessioniPrimary (citable) accession number: Q99KU1
    Secondary accession number(s): A3KGL4
    , Q3UF13, Q8BZ16, Q8BZK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3