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Protein

Vacuole membrane protein 1

Gene

Vmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.By similarity1 Publication

GO - Biological processi

  • autophagy Source: GO_Central
  • cell-cell adhesion Source: UniProtKB
  • cell junction assembly Source: UniProtKB
  • embryo implantation Source: MGI
  • endoplasmic reticulum organization Source: GO_Central
  • exocytosis Source: GO_Central
  • Golgi organization Source: GO_Central

Keywordsi

Biological processAutophagy, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
NF-E2-inducible protein 2
Short name:
Protein ni-2
Transmembrane protein 49
Gene namesi
Name:Vmp1
Synonyms:Tmem49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923159 Vmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 77CytoplasmicSequence analysisAdd BLAST76
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 109ExtracellularSequence analysisAdd BLAST11
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 250CytoplasmicSequence analysisAdd BLAST120
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 273ExtracellularSequence analysis2
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305CytoplasmicSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 363ExtracellularSequence analysisAdd BLAST37
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 406CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002845472 – 406Vacuole membrane protein 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99KU0
MaxQBiQ99KU0
PaxDbiQ99KU0
PeptideAtlasiQ99KU0
PRIDEiQ99KU0
TopDownProteomicsiQ99KU0

PTM databases

iPTMnetiQ99KU0
PhosphoSitePlusiQ99KU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000018171
CleanExiMM_TMEM49
ExpressionAtlasiQ99KU0 baseline and differential
GenevisibleiQ99KU0 MM

Interactioni

Subunit structurei

Interacts with BECN1. Interacts with TJP1 (By similarity). Interacts with TP53INP2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018315

Structurei

3D structure databases

ProteinModelPortaliQ99KU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109 Eukaryota
ENOG410XQHA LUCA
GeneTreeiENSGT00390000007230
HOVERGENiHBG057290
InParanoidiQ99KU0
KOiK21248
OMAiMDKGKLF
OrthoDBiEOG091G0AKM
PhylomeDBiQ99KU0
TreeFamiTF313699

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGKNCDQ RRIAMSKDQH NGSLTDPSSV HEKKRRDREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE TLVVLKEWTS KLWHRQSIVV SFLLLLAALV ATYYVEGAHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPE EEGAEGAISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAEAAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVIV TFSKHIVEQM VTFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HRSEAGTPQG ENWLSWMFEK LVVAMVCYFV LSIINSMAQN YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):45,960
Last modified:April 17, 2007 - v2
Checksum:i2EFE789F29E2CF5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13I → V in BAD06453 (Ref. 2) Curated1
Sequence conflicti13I → V in AAH04013 (PubMed:15489334).Curated1
Sequence conflicti228E → K in BAE35109 (PubMed:16141072).Curated1
Sequence conflicti347Q → H in BAF47367 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047550 mRNA Translation: BAF47367.1
AB076609 mRNA Translation: BAD06453.1
AK043091 mRNA Translation: BAC31456.1
AK077443 mRNA Translation: BAC36803.1
AK159468 mRNA Translation: BAE35109.1
AL592222, AL604063 Genomic DNA Translation: CAI25358.1
AL604063, AL592222 Genomic DNA Translation: CAI25797.1
BC004013 mRNA Translation: AAH04013.1
CCDSiCCDS25203.1
RefSeqiNP_083754.2, NM_029478.3
XP_006534466.1, XM_006534403.3
UniGeneiMm.390398
Mm.491180

Genome annotation databases

EnsembliENSMUST00000018315; ENSMUSP00000018315; ENSMUSG00000018171
GeneIDi75909
KEGGimmu:75909
UCSCiuc007ksv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVMP1_MOUSE
AccessioniPrimary (citable) accession number: Q99KU0
Secondary accession number(s): A2V655, Q3TX07, Q8BHD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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