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Protein

Vacuole membrane protein 1

Gene

Vmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
NF-E2-inducible protein 2
Short name:
Protein ni-2
Transmembrane protein 49
Gene namesi
Name:Vmp1
Synonyms:Tmem49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923159. Vmp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 7776CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 10911ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 250120CytoplasmicSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 2732ExtracellularSequence analysis
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Topological domaini295 – 30511CytoplasmicSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Topological domaini327 – 36337ExtracellularSequence analysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Topological domaini385 – 40622CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 406405Vacuole membrane protein 1PRO_0000284547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99KU0.
MaxQBiQ99KU0.
PaxDbiQ99KU0.
PeptideAtlasiQ99KU0.
PRIDEiQ99KU0.
TopDownProteomicsiQ99KU0.

PTM databases

iPTMnetiQ99KU0.
PhosphoSiteiQ99KU0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018171.
CleanExiMM_TMEM49.
ExpressionAtlasiQ99KU0. baseline and differential.
GenevisibleiQ99KU0. MM.

Interactioni

Subunit structurei

Interacts with BECN1. Interacts with TJP1 (By similarity). Interacts with TP53INP2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018315.

Structurei

3D structure databases

ProteinModelPortaliQ99KU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ99KU0.
OMAiQRIKLHH.
OrthoDBiEOG091G0AKM.
PhylomeDBiQ99KU0.
TreeFamiTF313699.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGKNCDQ RRIAMSKDQH NGSLTDPSSV HEKKRRDREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE TLVVLKEWTS KLWHRQSIVV SFLLLLAALV ATYYVEGAHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPE EEGAEGAISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAEAAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVIV TFSKHIVEQM VTFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HRSEAGTPQG ENWLSWMFEK LVVAMVCYFV LSIINSMAQN YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):45,960
Last modified:April 17, 2007 - v2
Checksum:i2EFE789F29E2CF5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131I → V in BAD06453 (Ref. 2) Curated
Sequence conflicti13 – 131I → V in AAH04013 (PubMed:15489334).Curated
Sequence conflicti228 – 2281E → K in BAE35109 (PubMed:16141072).Curated
Sequence conflicti347 – 3471Q → H in BAF47367 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047550 mRNA. Translation: BAF47367.1.
AB076609 mRNA. Translation: BAD06453.1.
AK043091 mRNA. Translation: BAC31456.1.
AK077443 mRNA. Translation: BAC36803.1.
AK159468 mRNA. Translation: BAE35109.1.
AL592222, AL604063 Genomic DNA. Translation: CAI25358.1.
AL604063, AL592222 Genomic DNA. Translation: CAI25797.1.
BC004013 mRNA. Translation: AAH04013.1.
CCDSiCCDS25203.1.
RefSeqiNP_083754.2. NM_029478.3.
XP_006534466.1. XM_006534403.2.
UniGeneiMm.390398.
Mm.491180.

Genome annotation databases

EnsembliENSMUST00000018315; ENSMUSP00000018315; ENSMUSG00000018171.
GeneIDi75909.
KEGGimmu:75909.
UCSCiuc007ksv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047550 mRNA. Translation: BAF47367.1.
AB076609 mRNA. Translation: BAD06453.1.
AK043091 mRNA. Translation: BAC31456.1.
AK077443 mRNA. Translation: BAC36803.1.
AK159468 mRNA. Translation: BAE35109.1.
AL592222, AL604063 Genomic DNA. Translation: CAI25358.1.
AL604063, AL592222 Genomic DNA. Translation: CAI25797.1.
BC004013 mRNA. Translation: AAH04013.1.
CCDSiCCDS25203.1.
RefSeqiNP_083754.2. NM_029478.3.
XP_006534466.1. XM_006534403.2.
UniGeneiMm.390398.
Mm.491180.

3D structure databases

ProteinModelPortaliQ99KU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018315.

PTM databases

iPTMnetiQ99KU0.
PhosphoSiteiQ99KU0.

Proteomic databases

EPDiQ99KU0.
MaxQBiQ99KU0.
PaxDbiQ99KU0.
PeptideAtlasiQ99KU0.
PRIDEiQ99KU0.
TopDownProteomicsiQ99KU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018315; ENSMUSP00000018315; ENSMUSG00000018171.
GeneIDi75909.
KEGGimmu:75909.
UCSCiuc007ksv.1. mouse.

Organism-specific databases

CTDi81671.
MGIiMGI:1923159. Vmp1.

Phylogenomic databases

eggNOGiKOG1109. Eukaryota.
ENOG410XQHA. LUCA.
GeneTreeiENSGT00390000007230.
HOVERGENiHBG057290.
InParanoidiQ99KU0.
OMAiQRIKLHH.
OrthoDBiEOG091G0AKM.
PhylomeDBiQ99KU0.
TreeFamiTF313699.

Miscellaneous databases

PROiQ99KU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018171.
CleanExiMM_TMEM49.
ExpressionAtlasiQ99KU0. baseline and differential.
GenevisibleiQ99KU0. MM.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
[Graphical view]
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMP1_MOUSE
AccessioniPrimary (citable) accession number: Q99KU0
Secondary accession number(s): A2V655, Q3TX07, Q8BHD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.