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Protein

Lambda-crystallin homolog

Gene

Cryl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADBy similarity
Binding sitei97 – 971NADBy similarity
Binding sitei102 – 1021NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 172NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-MMU-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:Cryl1
Synonyms:Cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915881. Cryl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 319318Lambda-crystallin homologPRO_0000109321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99KP3.
PaxDbiQ99KP3.
PRIDEiQ99KP3.

2D gel databases

REPRODUCTION-2DPAGEQ99KP3.

PTM databases

iPTMnetiQ99KP3.
PhosphoSiteiQ99KP3.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver. Undetectable in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000021947.
CleanExiMM_CRYL1.
ExpressionAtlasiQ99KP3. baseline and differential.
GenevisibleiQ99KP3. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99KP3. 2 interactions.
MINTiMINT-4092037.
STRINGi10090.ENSMUSP00000022517.

Structurei

3D structure databases

ProteinModelPortaliQ99KP3.
SMRiQ99KP3. Positions 7-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ99KP3.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ99KP3.
TreeFamiTF313501.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IVGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITDALENIR
60 70 80 90 100
KEMKSLEQSG SLKGSLSAER QLSLISGCGN LAEAVEGAVH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDRVILS SSSSCLLPSK LFSGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIG QSPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AVISEAWRLV EEEIVSPSDL DLVMSDGLGM RYAFIGPLET MHLNAEGVIS
260 270 280 290 300
YCERYSEGMK HVLSTFGPVP EFSGATVERV SEDMCMKVPD DPEHLAARRQ
310
WRDDCLMKLS ILKYQMQPK
Length:319
Mass (Da):35,209
Last modified:January 23, 2007 - v3
Checksum:i590EC278F5C83A9D
GO

Sequence cautioni

The sequence AAM13398 differs from that shown. Reason: Frameshift at position 227. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351609 mRNA. Translation: AAM13398.1. Frameshift.
AK043569 mRNA. Translation: BAC31583.1.
AK080625 mRNA. Translation: BAC37964.1.
AK135834 mRNA. Translation: BAE22682.1.
BC004074 mRNA. Translation: AAH04074.1.
BC027064 mRNA. Translation: AAH27064.1.
CCDSiCCDS27155.1.
RefSeqiNP_084280.2. NM_030004.3.
UniGeneiMm.25539.

Genome annotation databases

EnsembliENSMUST00000022517; ENSMUSP00000022517; ENSMUSG00000021947.
GeneIDi68631.
KEGGimmu:68631.
UCSCiuc007ucz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351609 mRNA. Translation: AAM13398.1. Frameshift.
AK043569 mRNA. Translation: BAC31583.1.
AK080625 mRNA. Translation: BAC37964.1.
AK135834 mRNA. Translation: BAE22682.1.
BC004074 mRNA. Translation: AAH04074.1.
BC027064 mRNA. Translation: AAH27064.1.
CCDSiCCDS27155.1.
RefSeqiNP_084280.2. NM_030004.3.
UniGeneiMm.25539.

3D structure databases

ProteinModelPortaliQ99KP3.
SMRiQ99KP3. Positions 7-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KP3. 2 interactions.
MINTiMINT-4092037.
STRINGi10090.ENSMUSP00000022517.

PTM databases

iPTMnetiQ99KP3.
PhosphoSiteiQ99KP3.

2D gel databases

REPRODUCTION-2DPAGEQ99KP3.

Proteomic databases

MaxQBiQ99KP3.
PaxDbiQ99KP3.
PRIDEiQ99KP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022517; ENSMUSP00000022517; ENSMUSG00000021947.
GeneIDi68631.
KEGGimmu:68631.
UCSCiuc007ucz.1. mouse.

Organism-specific databases

CTDi51084.
MGIiMGI:1915881. Cryl1.

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ99KP3.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ99KP3.
TreeFamiTF313501.

Enzyme and pathway databases

ReactomeiR-MMU-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

ChiTaRSiCryl1. mouse.
PROiQ99KP3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021947.
CleanExiMM_CRYL1.
ExpressionAtlasiQ99KP3. baseline and differential.
GenevisibleiQ99KP3. MM.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRYL1_MOUSE
AccessioniPrimary (citable) accession number: Q99KP3
Secondary accession number(s): Q542R9, Q8R4W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.