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Protein

Lambda-crystallin homolog

Gene

Cryl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei97NADBy similarity1
Binding sitei102NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:Cryl1
Synonyms:Cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915881. Cryl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093211 – 319Lambda-crystallin homologAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99KP3.
PaxDbiQ99KP3.
PRIDEiQ99KP3.

2D gel databases

REPRODUCTION-2DPAGEiQ99KP3.

PTM databases

iPTMnetiQ99KP3.
PhosphoSitePlusiQ99KP3.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver. Undetectable in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000021947.
CleanExiMM_CRYL1.
ExpressionAtlasiQ99KP3. baseline and differential.
GenevisibleiQ99KP3. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99KP3. 2 interactors.
MINTiMINT-4092037.
STRINGi10090.ENSMUSP00000022517.

Structurei

3D structure databases

ProteinModelPortaliQ99KP3.
SMRiQ99KP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ99KP3.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ99KP3.
TreeFamiTF313501.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiView protein in InterPro
IPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00067. 3HCDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99KP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IVGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITDALENIR
60 70 80 90 100
KEMKSLEQSG SLKGSLSAER QLSLISGCGN LAEAVEGAVH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDRVILS SSSSCLLPSK LFSGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIG QSPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AVISEAWRLV EEEIVSPSDL DLVMSDGLGM RYAFIGPLET MHLNAEGVIS
260 270 280 290 300
YCERYSEGMK HVLSTFGPVP EFSGATVERV SEDMCMKVPD DPEHLAARRQ
310
WRDDCLMKLS ILKYQMQPK
Length:319
Mass (Da):35,209
Last modified:January 23, 2007 - v3
Checksum:i590EC278F5C83A9D
GO

Sequence cautioni

Q99KP3: The sequence AAM13398 differs from that shown. Reason: Frameshift at position 227.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351609 mRNA. Translation: AAM13398.1. Frameshift.
AK043569 mRNA. Translation: BAC31583.1.
AK080625 mRNA. Translation: BAC37964.1.
AK135834 mRNA. Translation: BAE22682.1.
BC004074 mRNA. Translation: AAH04074.1.
BC027064 mRNA. Translation: AAH27064.1.
CCDSiCCDS27155.1.
RefSeqiNP_084280.2. NM_030004.3.
UniGeneiMm.25539.

Genome annotation databases

EnsembliENSMUST00000022517; ENSMUSP00000022517; ENSMUSG00000021947.
GeneIDi68631.
KEGGimmu:68631.
UCSCiuc007ucz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCRYL1_MOUSE
AccessioniPrimary (citable) accession number: Q99KP3
Secondary accession number(s): Q542R9, Q8R4W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families