Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

Ciao1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.UniRule annotation

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:Ciao1UniRule annotation
Synonyms:Wdr39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1346998. Ciao1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Probable cytosolic iron-sulfur protein assembly protein CIAO1PRO_0000281106Add
BLAST

Proteomic databases

EPDiQ99KN2.
MaxQBiQ99KN2.
PaxDbiQ99KN2.
PRIDEiQ99KN2.

PTM databases

iPTMnetiQ99KN2.
PhosphoSiteiQ99KN2.

Expressioni

Gene expression databases

BgeeiQ99KN2.
ExpressionAtlasiQ99KN2. baseline and differential.
GenevisibleiQ99KN2. MM.

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.UniRule annotation

Protein-protein interaction databases

BioGridi204931. 1 interaction.
IntActiQ99KN2. 4 interactions.
MINTiMINT-4123916.
STRINGi10090.ENSMUSP00000003759.

Structurei

3D structure databases

ProteinModelPortaliQ99KN2.
SMRiQ99KN2. Positions 4-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 5340WD 1Add
BLAST
Repeati59 – 9840WD 2Add
BLAST
Repeati103 – 14240WD 3Add
BLAST
Repeati148 – 18740WD 4Add
BLAST
Repeati192 – 23140WD 5Add
BLAST
Repeati250 – 28940WD 6Add
BLAST
Repeati301 – 33939WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00820000127115.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiQ99KN2.
OMAiWEVAGDD.
OrthoDBiEOG7XH6Q1.
PhylomeDBiQ99KN2.
TreeFamiTF318181.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSLVLQSR VPAHPDSRCW FLAWNPSGTL LASCGGDRKI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLSSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYQEE GDDWVCCATL EGHESTVWSI
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCICTLSGF
260 270 280 290 300
HTRTIYDVAW CQLTGALATA CGDDAIRVFE EDPGSDPQQP TFSLTAHLRQ
310 320 330
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WEYHQPAGL
Length:339
Mass (Da):37,633
Last modified:June 1, 2001 - v1
Checksum:i302A9FCD8E110FC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651R → M in BAB22008 (PubMed:16141072).Curated
Sequence conflicti213 – 2131S → N in BAB22008 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002314 mRNA. Translation: BAB22008.1.
AK028376 mRNA. Translation: BAC25915.1.
AL845368 Genomic DNA. Translation: CAM17441.1.
BC004089 mRNA. Translation: AAH04089.1.
CCDSiCCDS16696.1.
RefSeqiNP_079572.2. NM_025296.4.
UniGeneiMm.45179.

Genome annotation databases

EnsembliENSMUST00000003759; ENSMUSP00000003759; ENSMUSG00000003662.
GeneIDi26371.
KEGGimmu:26371.
UCSCiuc008mfb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002314 mRNA. Translation: BAB22008.1.
AK028376 mRNA. Translation: BAC25915.1.
AL845368 Genomic DNA. Translation: CAM17441.1.
BC004089 mRNA. Translation: AAH04089.1.
CCDSiCCDS16696.1.
RefSeqiNP_079572.2. NM_025296.4.
UniGeneiMm.45179.

3D structure databases

ProteinModelPortaliQ99KN2.
SMRiQ99KN2. Positions 4-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204931. 1 interaction.
IntActiQ99KN2. 4 interactions.
MINTiMINT-4123916.
STRINGi10090.ENSMUSP00000003759.

PTM databases

iPTMnetiQ99KN2.
PhosphoSiteiQ99KN2.

Proteomic databases

EPDiQ99KN2.
MaxQBiQ99KN2.
PaxDbiQ99KN2.
PRIDEiQ99KN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003759; ENSMUSP00000003759; ENSMUSG00000003662.
GeneIDi26371.
KEGGimmu:26371.
UCSCiuc008mfb.2. mouse.

Organism-specific databases

CTDi9391.
MGIiMGI:1346998. Ciao1.

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00820000127115.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiQ99KN2.
OMAiWEVAGDD.
OrthoDBiEOG7XH6Q1.
PhylomeDBiQ99KN2.
TreeFamiTF318181.

Miscellaneous databases

ChiTaRSiCiao1. mouse.
PROiQ99KN2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99KN2.
ExpressionAtlasiQ99KN2. baseline and differential.
GenevisibleiQ99KN2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiCIAO1_MOUSE
AccessioniPrimary (citable) accession number: Q99KN2
Secondary accession number(s): Q9DCZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.