Q99KL7 (RAB28_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-28

Gene names

Name:

Rab28

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GDP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 218	217	Ras-related protein Rab-28		PRO_0000121228
	Propeptide	219 – 221	3	Removed in mature form By similarity		PRO_0000396722
Regions
	Nucleotide binding	19 – 27	9	GTP By similarity
	Nucleotide binding	68 – 72	5	GTP By similarity
	Nucleotide binding	129 – 132	4	GTP By similarity
	Nucleotide binding	159 – 161	3	GTP By similarity
	Motif	41 – 49	9	Effector region By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	8	1	Phosphoserine By similarity
	Modified residue	218	1	Cysteine methyl ester By similarity
	Lipidation	218	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99KL7 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5520BD9CC0F78FB9	FASTA	221	24,728
	10 20 30 40 50 60 MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF LRRITLPGNL 70 80 90 100 110 120 NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS FENLEDWYSV VKTVSEESET 130 140 150 160 170 180 QPLVALVGNK IDLEHMRTVK ADKHLRFCQE NGFSSHFVSA KTGDSVFLCF QKVAAEILGI 190 200 210 220 KLNKAEIEQS QRVVKADIVN YNQEPLSRTV NPPRSSMCAV Q

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC004580 mRNA. Translation: AAH04580.1.
IPI	IPI00281538.
RefSeq	NP_081571.1. NM_027295.2.
UniGene	Mm.41555.
3D structure databases
ProteinModelPortal	Q99KL7.
SMR	Q99KL7. Positions 8-184.
ModBase	Search...
PTM databases
PhosphoSite	Q99KL7.
Proteomic databases
PaxDb	Q99KL7.
PRIDE	Q99KL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
GeneID	100972.
KEGG	mmu:100972.
Organism-specific databases
CTD	9364.
MGI	MGI:1917285. Rab28.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00600000084341.
HOGENOM	HOG000233968.
HOVERGEN	HBG101090.
InParanoid	Q99KL7.
KO	K07915.
OMA	CFQRIAA.
OrthoDB	EOG43R3NJ.
Gene expression databases
ArrayExpress	Q99KL7.
Bgee	Q99KL7.
CleanEx	MM_RAB28.
Genevestigator	Q99KL7.
GermOnline	ENSMUSG00000029128. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RAB28. mouse.
NextBio	354708.
SOURCE	Search...

Entry information

Entry name

RAB28_MOUSE

Accession

Primary (citable) accession number: Q99KL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program