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Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi129 – 1324GTPBy similarity
Nucleotide bindingi159 – 1613GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
  2. toxin transport Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917285. Rab28.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmcytoskeletoncilium basal body
Note: Expressed in the basal body and ciliary rootlet of the photoreceptors.By similarity

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. ciliary rootlet Source: UniProtKB
  3. cytoplasm Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 218217Ras-related protein Rab-28PRO_0000121228Add
BLAST
Propeptidei219 – 2213Removed in mature formBy similarityPRO_0000396722

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei218 – 2181Cysteine methyl esterBy similarity
Lipidationi218 – 2181S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ99KL7.
PaxDbiQ99KL7.
PRIDEiQ99KL7.

PTM databases

PhosphoSiteiQ99KL7.

Expressioni

Gene expression databases

BgeeiQ99KL7.
CleanExiMM_RAB28.
ExpressionAtlasiQ99KL7. baseline and differential.
GenevestigatoriQ99KL7.

Structurei

3D structure databases

ProteinModelPortaliQ99KL7.
SMRiQ99KL7. Positions 8-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000111076.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiQ99KL7.
KOiK07915.
OMAiCFQRIAA.
OrthoDBiEOG74FF1S.
PhylomeDBiQ99KL7.
TreeFamiTF313852.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK ADKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPLSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,728
Last modified:May 31, 2001 - v1
Checksum:i5520BD9CC0F78FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004580 mRNA. Translation: AAH04580.1.
CCDSiCCDS19258.1.
RefSeqiNP_081571.1. NM_027295.2.
UniGeneiMm.41555.

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
GeneIDi100972.
KEGGimmu:100972.
UCSCiuc008xha.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004580 mRNA. Translation: AAH04580.1.
CCDSiCCDS19258.1.
RefSeqiNP_081571.1. NM_027295.2.
UniGeneiMm.41555.

3D structure databases

ProteinModelPortaliQ99KL7.
SMRiQ99KL7. Positions 8-184.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ99KL7.

Proteomic databases

MaxQBiQ99KL7.
PaxDbiQ99KL7.
PRIDEiQ99KL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
GeneIDi100972.
KEGGimmu:100972.
UCSCiuc008xha.1. mouse.

Organism-specific databases

CTDi9364.
MGIiMGI:1917285. Rab28.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000111076.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiQ99KL7.
KOiK07915.
OMAiCFQRIAA.
OrthoDBiEOG74FF1S.
PhylomeDBiQ99KL7.
TreeFamiTF313852.

Miscellaneous databases

NextBioi354708.
PROiQ99KL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ99KL7.
CleanExiMM_RAB28.
ExpressionAtlasiQ99KL7. baseline and differential.
GenevestigatoriQ99KL7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRAB28_MOUSE
AccessioniPrimary (citable) accession number: Q99KL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2004
Last sequence update: May 31, 2001
Last modified: March 3, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.