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Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4
Nucleotide bindingi159 – 161GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • toxin transport Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917285. Rab28.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212282 – 218Ras-related protein Rab-28Add BLAST217
PropeptideiPRO_0000396722219 – 221Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ99KL7.
MaxQBiQ99KL7.
PaxDbiQ99KL7.
PRIDEiQ99KL7.

PTM databases

iPTMnetiQ99KL7.
PhosphoSitePlusiQ99KL7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029128.
CleanExiMM_RAB28.
ExpressionAtlasiQ99KL7. baseline and differential.
GenevisibleiQ99KL7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99KL7. 3 interactors.
STRINGi10090.ENSMUSP00000031011.

Structurei

3D structure databases

ProteinModelPortaliQ99KL7.
SMRiQ99KL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00800000124173.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiQ99KL7.
KOiK07915.
OMAiYKQTIGV.
OrthoDBiEOG091G11JJ.
PhylomeDBiQ99KL7.
TreeFamiTF313852.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK ADKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPLSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,728
Last modified:June 1, 2001 - v1
Checksum:i5520BD9CC0F78FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004580 mRNA. Translation: AAH04580.1.
CCDSiCCDS19258.1.
RefSeqiNP_081571.1. NM_027295.3.
UniGeneiMm.41555.

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
GeneIDi100972.
KEGGimmu:100972.
UCSCiuc008xha.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRAB28_MOUSE
AccessioniPrimary (citable) accession number: Q99KL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families