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Q99KL7

- RAB28_MOUSE

UniProt

Q99KL7 - RAB28_MOUSE

Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi129 – 1324GTPBy similarity
    Nucleotide bindingi159 – 1613GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-28
    Gene namesi
    Name:Rab28
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1917285. Rab28.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmcytoskeletoncilium basal body
    Note: Expressed in the basal body and ciliary rootlet of the photoreceptors.By similarity

    GO - Cellular componenti

    1. ciliary basal body Source: UniProtKB
    2. ciliary rootlet Source: UniProtKB
    3. cytoplasm Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 218217Ras-related protein Rab-28PRO_0000121228Add
    BLAST
    Propeptidei219 – 2213Removed in mature formBy similarityPRO_0000396722

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei218 – 2181Cysteine methyl esterBy similarity
    Lipidationi218 – 2181S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ99KL7.
    PRIDEiQ99KL7.

    PTM databases

    PhosphoSiteiQ99KL7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99KL7.
    BgeeiQ99KL7.
    CleanExiMM_RAB28.
    GenevestigatoriQ99KL7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99KL7.
    SMRiQ99KL7. Positions 8-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00730000111076.
    HOGENOMiHOG000233968.
    HOVERGENiHBG101090.
    InParanoidiQ99KL7.
    KOiK07915.
    OMAiCFQRIAA.
    OrthoDBiEOG74FF1S.
    PhylomeDBiQ99KL7.
    TreeFamiTF313852.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99KL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF    50
    LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS 100
    FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK ADKHLRFCQE 150
    NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN 200
    YNQEPLSRTV NPPRSSMCAV Q 221
    Length:221
    Mass (Da):24,728
    Last modified:June 1, 2001 - v1
    Checksum:i5520BD9CC0F78FB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004580 mRNA. Translation: AAH04580.1.
    CCDSiCCDS19258.1.
    RefSeqiNP_081571.1. NM_027295.2.
    UniGeneiMm.41555.

    Genome annotation databases

    EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
    GeneIDi100972.
    KEGGimmu:100972.
    UCSCiuc008xha.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004580 mRNA. Translation: AAH04580.1 .
    CCDSi CCDS19258.1.
    RefSeqi NP_081571.1. NM_027295.2.
    UniGenei Mm.41555.

    3D structure databases

    ProteinModelPortali Q99KL7.
    SMRi Q99KL7. Positions 8-184.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99KL7.

    Proteomic databases

    PaxDbi Q99KL7.
    PRIDEi Q99KL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031011 ; ENSMUSP00000031011 ; ENSMUSG00000029128 .
    GeneIDi 100972.
    KEGGi mmu:100972.
    UCSCi uc008xha.1. mouse.

    Organism-specific databases

    CTDi 9364.
    MGIi MGI:1917285. Rab28.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00730000111076.
    HOGENOMi HOG000233968.
    HOVERGENi HBG101090.
    InParanoidi Q99KL7.
    KOi K07915.
    OMAi CFQRIAA.
    OrthoDBi EOG74FF1S.
    PhylomeDBi Q99KL7.
    TreeFami TF313852.

    Miscellaneous databases

    ChiTaRSi RAB28. mouse.
    NextBioi 354708.
    PROi Q99KL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99KL7.
    Bgeei Q99KL7.
    CleanExi MM_RAB28.
    Genevestigatori Q99KL7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiRAB28_MOUSE
    AccessioniPrimary (citable) accession number: Q99KL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3