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Q99KL7

- RAB28_MOUSE

UniProt

Q99KL7 - RAB28_MOUSE

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Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi129 – 1324GTPBy similarity
Nucleotide bindingi159 – 1613GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1917285. Rab28.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmcytoskeletoncilium basal body
Note: Expressed in the basal body and ciliary rootlet of the photoreceptors.By similarity

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. ciliary rootlet Source: UniProtKB
  3. cytoplasm Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 218217Ras-related protein Rab-28PRO_0000121228Add
BLAST
Propeptidei219 – 2213Removed in mature formBy similarityPRO_0000396722

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei218 – 2181Cysteine methyl esterBy similarity
Lipidationi218 – 2181S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ99KL7.
PaxDbiQ99KL7.
PRIDEiQ99KL7.

PTM databases

PhosphoSiteiQ99KL7.

Expressioni

Gene expression databases

BgeeiQ99KL7.
CleanExiMM_RAB28.
ExpressionAtlasiQ99KL7. baseline and differential.
GenevestigatoriQ99KL7.

Structurei

3D structure databases

ProteinModelPortaliQ99KL7.
SMRiQ99KL7. Positions 8-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000111076.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiQ99KL7.
KOiK07915.
OMAiCFQRIAA.
OrthoDBiEOG74FF1S.
PhylomeDBiQ99KL7.
TreeFamiTF313852.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KL7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK ADKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPLSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,728
Last modified:June 1, 2001 - v1
Checksum:i5520BD9CC0F78FB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004580 mRNA. Translation: AAH04580.1.
CCDSiCCDS19258.1.
RefSeqiNP_081571.1. NM_027295.2.
UniGeneiMm.41555.

Genome annotation databases

EnsembliENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
GeneIDi100972.
KEGGimmu:100972.
UCSCiuc008xha.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004580 mRNA. Translation: AAH04580.1 .
CCDSi CCDS19258.1.
RefSeqi NP_081571.1. NM_027295.2.
UniGenei Mm.41555.

3D structure databases

ProteinModelPortali Q99KL7.
SMRi Q99KL7. Positions 8-184.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99KL7.

Proteomic databases

MaxQBi Q99KL7.
PaxDbi Q99KL7.
PRIDEi Q99KL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031011 ; ENSMUSP00000031011 ; ENSMUSG00000029128 .
GeneIDi 100972.
KEGGi mmu:100972.
UCSCi uc008xha.1. mouse.

Organism-specific databases

CTDi 9364.
MGIi MGI:1917285. Rab28.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00730000111076.
HOGENOMi HOG000233968.
HOVERGENi HBG101090.
InParanoidi Q99KL7.
KOi K07915.
OMAi CFQRIAA.
OrthoDBi EOG74FF1S.
PhylomeDBi Q99KL7.
TreeFami TF313852.

Miscellaneous databases

ChiTaRSi RAB28. mouse.
NextBioi 354708.
PROi Q99KL7.
SOURCEi Search...

Gene expression databases

Bgeei Q99KL7.
CleanExi MM_RAB28.
ExpressionAtlasi Q99KL7. baseline and differential.
Genevestigatori Q99KL7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRAB28_MOUSE
AccessioniPrimary (citable) accession number: Q99KL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3