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Protein

Dipeptidyl peptidase 3

Gene

Dpp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).By similarity

Catalytic activityi

Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi450Zinc; catalyticBy similarity1
Active sitei451By similarity1
Metal bindingi455Zinc; catalyticBy similarity1
Metal bindingi508Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM49.001

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 3 (EC:3.4.14.4By similarity)
Alternative name(s):
Dipeptidyl aminopeptidase III
Dipeptidyl arylamidase III
Dipeptidyl peptidase III
Short name:
DPP III
Enkephalinase B
Gene namesi
Name:Dpp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1922471 Dpp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000782392 – 738Dipeptidyl peptidase 3Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99KK7
MaxQBiQ99KK7
PaxDbiQ99KK7
PRIDEiQ99KK7

PTM databases

iPTMnetiQ99KK7
PhosphoSitePlusiQ99KK7

Expressioni

Gene expression databases

BgeeiENSMUSG00000063904
CleanExiMM_DPP3
GenevisibleiQ99KK7 MM

Interactioni

Protein-protein interaction databases

IntActiQ99KK7, 2 interactors
MINTiQ99KK7
STRINGi10090.ENSMUSP00000025851

Structurei

3D structure databases

ProteinModelPortaliQ99KK7
SMRiQ99KK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M49 family.Curated

Phylogenomic databases

eggNOGiKOG3675 Eukaryota
ENOG410XRK4 LUCA
GeneTreeiENSGT00390000007335
HOGENOMiHOG000187784
HOVERGENiHBG025680
InParanoidiQ99KK7
KOiK01277
OMAiGEWEGFA
OrthoDBiEOG091G0KUS
TreeFamiTF300598

Family and domain databases

InterProiView protein in InterPro
IPR005317 Dipeptidyl-peptase3
PIRSFiPIRSF007828 Dipeptidyl-peptidase_III, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99KK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAHHLSRA AWYGGLAVLL
60 70 80 90 100
QTSPEAPYIY ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY
110 120 130 140 150
SNMGNYKSFG DTKFVPNLPK DKLGRVILGS KAAQQRPEEV RDLWQTCGDL
160 170 180 190 200
MFSLEPRLRH LGLGKEGVTT YFSGDCTMED AKLAQDFLDS QNLSAYNTRL
210 220 230 240 250
FKVVGQEGKS HYEVRLASVL NTDPALDSEL TSKLKRYEFQ GNHFQVTRGD
260 270 280 290 300
YAPILQKVVE HLEKAKAYAA NSHQEQMLAQ YVESFTQGSI EAHKRGSRFW
310 320 330 340 350
IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAMVNKAMS AKFERLVASA
360 370 380 390 400
EQLLKELPWP LAFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ
410 420 430 440 450
TEGFKNVSLG NVLAVAYAAK REKLTFLEEE DKDLYIRWKG PSFDVQVGLH
460 470 480 490 500
ELLGHGSGKL FVQDEKGAFN FDKETVINPE TGEQIQSWYR SGETWDSKFS
510 520 530 540 550
TIASSYEECR AESVGLYLCL NPQVLEIFGF EGADAEDVIY VNWLNMVRAG
560 570 580 590 600
LLALEFYTPE AANWRQAHMQ ARFVILRVLL EAGEGLVTVT PTTGSDGRPD
610 620 630 640 650
ARVRLDRSKI RSVGRPALER FLRRLQVLKS TGDVVAGRAL YEGYAAVTDA
660 670 680 690 700
PPECFLTLRD TVLLRKESRK LIVQPNTRLE GSEVQLVEYE ASAAGLIRSF
710 720 730
CERFPEDGPE LEEVLIQLAA ADARFWRNQA QEAPPGQA
Length:738
Mass (Da):82,898
Last modified:July 27, 2011 - v2
Checksum:iE2B6BD91AE9C81EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348A → V in AAH04600 (PubMed:15489334).Curated1
Sequence conflicti361L → P in AAH04600 (PubMed:15489334).Curated1
Sequence conflicti728N → D in AAH04600 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031020 mRNA Translation: BAC27216.1
AK166842 mRNA Translation: BAE39063.1
BC004600 mRNA Translation: AAH04600.1
CCDSiCCDS29443.1
RefSeqiNP_598564.2, NM_133803.2
XP_006531917.1, XM_006531854.3
UniGeneiMm.234769

Genome annotation databases

EnsembliENSMUST00000025851; ENSMUSP00000025851; ENSMUSG00000063904
GeneIDi75221
KEGGimmu:75221
UCSCiuc008gbo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDPP3_MOUSE
AccessioniPrimary (citable) accession number: Q99KK7
Secondary accession number(s): Q8C0I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health