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Protein

Receptor expression-enhancing protein 3

Gene

Reep3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 3
Gene namesi
Name:Reep3
Synonyms:D10Ucla1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88930. Reep3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Receptor expression-enhancing protein 3PRO_0000101827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei200 – 2001PhosphothreonineCombined sources
Modified residuei209 – 2091PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99KK1.
MaxQBiQ99KK1.
PaxDbiQ99KK1.
PeptideAtlasiQ99KK1.
PRIDEiQ99KK1.

PTM databases

iPTMnetiQ99KK1.
PhosphoSiteiQ99KK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019873.
CleanExiMM_REEP3.
GenevisibleiQ99KK1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99KK1. 2 interactions.
MINTiMINT-4123875.
STRINGi10090.ENSMUSP00000020023.

Structurei

3D structure databases

ProteinModelPortaliQ99KK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1726. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000007472.
HOVERGENiHBG056861.
InParanoidiQ99KK1.
KOiK17338.
OMAiWMISRAV.
OrthoDBiEOG091G0X58.
PhylomeDBiQ99KK1.
TreeFamiTF314177.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV
60 70 80 90 100
IETVADQTLA WFPLYYELKI AFVIWLLSPY TRGASLIYRK FLHPLLSSKE
110 120 130 140 150
REIDDYIVQA KERGYETMVN FGRQGLNLAA AAAVTAAVKS QGAITERLRS
160 170 180 190 200
FSMHDLTAIQ GDEPVGHRPY QTLPEAKRKG KQATESPAYG IPLKDGSEQT
210 220 230 240 250
DEEAEGPFSD DEMVTHKALR RSQSMKSVKT IKGRKEVRYG SLKYKVKKRP

QVYF
Length:254
Mass (Da):29,214
Last modified:June 1, 2001 - v1
Checksum:i2F211016F4256EA2
GO

Sequence cautioni

The sequence BAB25434 differs from that shown. Reason: Erroneous termination at position 182. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501V → I in BAB28218 (PubMed:16141072).Curated
Sequence conflicti179 – 1791K → E in BAB28218 (PubMed:16141072).Curated
Sequence conflicti222 – 2221S → F in BAB28218 (PubMed:16141072).Curated
Sequence conflicti234 – 2352RK → PQ in BAB28218 (PubMed:16141072).Curated
Sequence conflicti249 – 2502RP → TT in BAB28218 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562231 mRNA. Translation: AAT70676.1.
AK008058 mRNA. Translation: BAB25434.1. Sequence problems.
AK012403 mRNA. Translation: BAB28218.1.
AK047728 mRNA. Translation: BAC33141.1.
AK079649 mRNA. Translation: BAC37714.1.
BC004607 mRNA. Translation: AAH04607.1.
CCDSiCCDS35926.1.
RefSeqiNP_848721.1. NM_178606.5.
UniGeneiMm.41272.

Genome annotation databases

EnsembliENSMUST00000020023; ENSMUSP00000020023; ENSMUSG00000019873.
GeneIDi28193.
KEGGimmu:28193.
UCSCiuc007flq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562231 mRNA. Translation: AAT70676.1.
AK008058 mRNA. Translation: BAB25434.1. Sequence problems.
AK012403 mRNA. Translation: BAB28218.1.
AK047728 mRNA. Translation: BAC33141.1.
AK079649 mRNA. Translation: BAC37714.1.
BC004607 mRNA. Translation: AAH04607.1.
CCDSiCCDS35926.1.
RefSeqiNP_848721.1. NM_178606.5.
UniGeneiMm.41272.

3D structure databases

ProteinModelPortaliQ99KK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99KK1. 2 interactions.
MINTiMINT-4123875.
STRINGi10090.ENSMUSP00000020023.

PTM databases

iPTMnetiQ99KK1.
PhosphoSiteiQ99KK1.

Proteomic databases

EPDiQ99KK1.
MaxQBiQ99KK1.
PaxDbiQ99KK1.
PeptideAtlasiQ99KK1.
PRIDEiQ99KK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020023; ENSMUSP00000020023; ENSMUSG00000019873.
GeneIDi28193.
KEGGimmu:28193.
UCSCiuc007flq.2. mouse.

Organism-specific databases

CTDi221035.
MGIiMGI:88930. Reep3.

Phylogenomic databases

eggNOGiKOG1726. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000007472.
HOVERGENiHBG056861.
InParanoidiQ99KK1.
KOiK17338.
OMAiWMISRAV.
OrthoDBiEOG091G0X58.
PhylomeDBiQ99KK1.
TreeFamiTF314177.

Miscellaneous databases

PROiQ99KK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019873.
CleanExiMM_REEP3.
GenevisibleiQ99KK1. MM.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREEP3_MOUSE
AccessioniPrimary (citable) accession number: Q99KK1
Secondary accession number(s): Q9CZM8, Q9D8G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.