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Protein

Transcription factor 19-like protein

Gene

Tcf19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: MGI
  • regulation of gene expression Source: MGI
  • type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 19-like protein
Short name:
TCF-19
Alternative name(s):
SC1 protein homolog
Gene namesi
Name:Tcf19
Synonyms:Sc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103180. Tcf19.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Transcription factor 19-like proteinPRO_0000059330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99KJ5.
PRIDEiQ99KJ5.

PTM databases

PhosphoSiteiQ99KJ5.

Expressioni

Gene expression databases

CleanExiMM_TCF19.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125167.

Structurei

3D structure databases

ProteinModelPortaliQ99KJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8858FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXZZ. Eukaryota.
ENOG4111J5W. LUCA.
HOGENOMiHOG000261618.
HOVERGENiHBG054343.
InParanoidiQ99KJ5.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPCFQLLRI GGGRGGDLYT FHPPSKSGCT YGLGCRADLC DVALRPQQEP
60 70 80 90 100
GLISGVHAEL HAELQGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD
110 120 130 140 150
LLTFGPQGQA GTSSSSEFYF MFQQVRVKPQ DFAAITVPRS KGEAGGGFQP
160 170 180 190 200
MLPPQGAPQR PLSTLSSAPK ATLILNSIGS LSKLQAQPLT FSRGGGRPQG
210 220 230 240 250
LAIPSQHGEA QVSPAPPTRN RRKSAHKVLA ELDDEVSPGP LSVLTEPRKR
260
LRVEKAALIA SGE
Length:263
Mass (Da):28,068
Last modified:June 1, 2001 - v1
Checksum:iF210FECDD614E62A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321G → R in BAC36789 (PubMed:16141072).Curated
Sequence conflicti130 – 1301Q → E in BAB23229 (PubMed:16141072).Curated
Sequence conflicti252 – 2521R → W in BAC36789 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077414 mRNA. Translation: BAC36789.1.
AK088479 mRNA. Translation: BAC40380.1.
AK004231 mRNA. Translation: BAB23229.1.
BC004617 mRNA. Translation: AAH04617.1.
CCDSiCCDS50089.1.
PIRiB61188.
RefSeqiNP_001157235.1. NM_001163763.1.
NP_001157236.1. NM_001163764.1.
NP_079950.2. NM_025674.2.
XP_011249580.1. XM_011251278.1.
UniGeneiMm.11434.
Mm.475434.

Genome annotation databases

GeneIDi106795.
KEGGimmu:106795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077414 mRNA. Translation: BAC36789.1.
AK088479 mRNA. Translation: BAC40380.1.
AK004231 mRNA. Translation: BAB23229.1.
BC004617 mRNA. Translation: AAH04617.1.
CCDSiCCDS50089.1.
PIRiB61188.
RefSeqiNP_001157235.1. NM_001163763.1.
NP_001157236.1. NM_001163764.1.
NP_079950.2. NM_025674.2.
XP_011249580.1. XM_011251278.1.
UniGeneiMm.11434.
Mm.475434.

3D structure databases

ProteinModelPortaliQ99KJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125167.

PTM databases

PhosphoSiteiQ99KJ5.

Proteomic databases

PaxDbiQ99KJ5.
PRIDEiQ99KJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106795.
KEGGimmu:106795.

Organism-specific databases

CTDi6941.
MGIiMGI:103180. Tcf19.

Phylogenomic databases

eggNOGiENOG410IXZZ. Eukaryota.
ENOG4111J5W. LUCA.
HOGENOMiHOG000261618.
HOVERGENiHBG054343.
InParanoidiQ99KJ5.

Miscellaneous databases

PROiQ99KJ5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TCF19.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCF19_MOUSE
AccessioniPrimary (citable) accession number: Q99KJ5
Secondary accession number(s): Q8BPA3, Q9CT93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This sequence is very similar to other orthologs but it lacks the PHD-type zinc finger domain which may be important for the trans-activation function.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.