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Protein

RNA-binding protein 10

Gene

Rbm10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 242RanBP2-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri759 – 784C2H2-type; atypicalPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of mRNA splicing, via spliceosome Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of smooth muscle cell apoptotic process Source: MGI
  • regulation of alternative mRNA splicing, via spliceosome Source: InterPro
  • regulation of smooth muscle cell apoptotic process Source: MGI
  • RNA splicing Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 10
Alternative name(s):
RNA-binding motif protein 10
Gene namesi
Name:Rbm10
Synonyms:Kiaa0122
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2384310. Rbm10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450171 – 930RNA-binding protein 10Add BLAST930

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei383N6-acetyllysineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei723PhosphoserineBy similarity1
Modified residuei733PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei781PhosphoserineBy similarity1
Modified residuei797PhosphoserineCombined sources1
Modified residuei845PhosphoserineBy similarity1
Modified residuei902Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ99KG3.
PeptideAtlasiQ99KG3.
PRIDEiQ99KG3.

PTM databases

iPTMnetiQ99KG3.
PhosphoSitePlusiQ99KG3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031060.
GenevisibleiQ99KG3. MM.

Interactioni

Subunit structurei

Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231785. 1 interactor.
IntActiQ99KG3. 1 interactor.
MINTiMINT-4123810.
STRINGi10090.ENSMUSP00000068188.

Structurei

3D structure databases

ProteinModelPortaliQ99KG3.
SMRiQ99KG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 209RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini300 – 384RRM 2PROSITE-ProRule annotationAdd BLAST85
Domaini858 – 904G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 87Poly-Arg8
Compositional biasi113 – 125Poly-GluAdd BLAST13

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 242RanBP2-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri759 – 784C2H2-type; atypicalPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0154. Eukaryota.
ENOG410YNFQ. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000046285.
HOVERGENiHBG000318.
InParanoidiQ99KG3.
KOiK13094.
OMAiDSVSMQA.
OrthoDBiEOG091G01UT.
TreeFamiTF315789.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033095. RBM10.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERiPTHR13948:SF4. PTHR13948:SF4. 2 hits.
PfamiPF01585. G-patch. 1 hit.
PF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99KG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYERRGGRG DRTGRYGATD RSQDDSGENR SRDHDYRDMD YRSYPREYGS
60 70 80 90 100
QEGKHEYDDS SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG
110 120 130 140 150
DYRDQDYRTE QGEEEEEEDE EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ
160 170 180 190 200
SHGVQAREVR LMRNKSSGQS RGFAFVEFSH LQDATRWMEA NQHSLNILGQ
210 220 230 240 250
KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK SEAEQKLPLG
260 270 280 290 300
TRLDQQALPL GGRELSQGLL PLPQPYQAQG VLTSQALSQG SEPSSENAND
310 320 330 340 350
TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL
360 370 380 390 400
STIVEAAQLL QILQALHPPL TIDGKTINVE FAKGSKRDMA SNEGSRINAA
410 420 430 440 450
SVASTAIAAA QWAISQASQG GESAWAAPEE PPVDYSYYQQ DEGYGSSQGT
460 470 480 490 500
DSLYAHGYLK NSKGPGMTGT KGDPAGTGPE ASLEAGADSV SLQAFSRAQP
510 520 530 540 550
GAAPGLYQQS AEGSSGQSTA TNSQSYTIIS PAVLKAELQS PTQPSSSAFP
560 570 580 590 600
PATSPTAPEA YSQYPVPDVS TYQYDETSGY YYDPQTGLYY DPNSQYYYNA
610 620 630 640 650
QSQQYLYWDG ERRTYIPALE QSADGHKDTG ASSKEGKEKK EKHKTKTAQQ
660 670 680 690 700
IAKDMERWAR SLNKQKENFK NSFQPISALR DDERRESATA DAGYAILEKK
710 720 730 740 750
GALAERQHTS MDLPKLASDD RPSPPRGLVA AYSGESDSEE EQERGGPERE
760 770 780 790 800
EKLTDWQKLA CLLCRRQFPS KEALIRHQQL SGLHKQNLEI HRRAHLSENE
810 820 830 840 850
LEALEKNDME QMKYRDRAAE RREKYGIPEP PEPKRRKYGG ISTASVDFEQ
860 870 880 890 900
PTRDGLGSDN IGSRMLQAMG WKEGSGLGRK KQGIVTPIEA QTRVRGSGLG
910 920 930
ARGSSYGVTS TESYKETLHK TMVTRFNEAQ
Length:930
Mass (Da):103,494
Last modified:June 1, 2001 - v1
Checksum:iE59A2AB20AF1C08C
GO
Isoform 2 (identifier: Q99KG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.

Show »
Length:853
Mass (Da):94,430
Checksum:iD936DA91736681FD
GO
Isoform 3 (identifier: Q99KG3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: Missing.

Show »
Length:929
Mass (Da):103,394
Checksum:i78506A1D7A81C1B9
GO

Sequence cautioni

The sequence BAC65490 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188M → V in BAE26813 (PubMed:16141072).Curated1
Sequence conflicti355E → VR in BAC65490 (PubMed:12693553).Curated1
Sequence conflicti428P → H in BAE39715 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03490568 – 144Missing in isoform 2. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_034906354Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122208 Transcribed RNA. Translation: BAC65490.3. Different initiation.
AK089105 mRNA. Translation: BAC40753.1.
AK145991 mRNA. Translation: BAE26813.1.
AK153736 mRNA. Translation: BAE32161.1.
AK167666 mRNA. Translation: BAE39715.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21277.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23098.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21279.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23096.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21278.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23097.1.
BC004674 mRNA. Translation: AAH04674.1.
CCDSiCCDS40885.1. [Q99KG3-1]
CCDS53013.1. [Q99KG3-3]
CCDS53014.1. [Q99KG3-2]
RefSeqiNP_001161247.1. NM_001167775.1. [Q99KG3-3]
NP_001161248.1. NM_001167776.1. [Q99KG3-2]
NP_663602.1. NM_145627.2. [Q99KG3-1]
XP_006527681.1. XM_006527618.3. [Q99KG3-3]
UniGeneiMm.279194.
Mm.383632.
Mm.475412.

Genome annotation databases

EnsembliENSMUST00000064911; ENSMUSP00000068188; ENSMUSG00000031060. [Q99KG3-1]
ENSMUST00000082089; ENSMUSP00000080738; ENSMUSG00000031060. [Q99KG3-2]
ENSMUST00000084383; ENSMUSP00000111031; ENSMUSG00000031060. [Q99KG3-2]
ENSMUST00000115374; ENSMUSP00000111032; ENSMUSG00000031060. [Q99KG3-1]
ENSMUST00000115375; ENSMUSP00000111033; ENSMUSG00000031060. [Q99KG3-3]
ENSMUST00000177738; ENSMUSP00000136209; ENSMUSG00000031060. [Q99KG3-3]
GeneIDi236732.
KEGGimmu:236732.
UCSCiuc009stf.2. mouse. [Q99KG3-3]
uc009sth.2. mouse. [Q99KG3-1]
uc009sti.2. mouse. [Q99KG3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122208 Transcribed RNA. Translation: BAC65490.3. Different initiation.
AK089105 mRNA. Translation: BAC40753.1.
AK145991 mRNA. Translation: BAE26813.1.
AK153736 mRNA. Translation: BAE32161.1.
AK167666 mRNA. Translation: BAE39715.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21277.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23098.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21279.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23096.1.
AL672073, AL807240 Genomic DNA. Translation: CAM21278.1.
AL807240, AL672073 Genomic DNA. Translation: CAM23097.1.
BC004674 mRNA. Translation: AAH04674.1.
CCDSiCCDS40885.1. [Q99KG3-1]
CCDS53013.1. [Q99KG3-3]
CCDS53014.1. [Q99KG3-2]
RefSeqiNP_001161247.1. NM_001167775.1. [Q99KG3-3]
NP_001161248.1. NM_001167776.1. [Q99KG3-2]
NP_663602.1. NM_145627.2. [Q99KG3-1]
XP_006527681.1. XM_006527618.3. [Q99KG3-3]
UniGeneiMm.279194.
Mm.383632.
Mm.475412.

3D structure databases

ProteinModelPortaliQ99KG3.
SMRiQ99KG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231785. 1 interactor.
IntActiQ99KG3. 1 interactor.
MINTiMINT-4123810.
STRINGi10090.ENSMUSP00000068188.

PTM databases

iPTMnetiQ99KG3.
PhosphoSitePlusiQ99KG3.

Proteomic databases

PaxDbiQ99KG3.
PeptideAtlasiQ99KG3.
PRIDEiQ99KG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064911; ENSMUSP00000068188; ENSMUSG00000031060. [Q99KG3-1]
ENSMUST00000082089; ENSMUSP00000080738; ENSMUSG00000031060. [Q99KG3-2]
ENSMUST00000084383; ENSMUSP00000111031; ENSMUSG00000031060. [Q99KG3-2]
ENSMUST00000115374; ENSMUSP00000111032; ENSMUSG00000031060. [Q99KG3-1]
ENSMUST00000115375; ENSMUSP00000111033; ENSMUSG00000031060. [Q99KG3-3]
ENSMUST00000177738; ENSMUSP00000136209; ENSMUSG00000031060. [Q99KG3-3]
GeneIDi236732.
KEGGimmu:236732.
UCSCiuc009stf.2. mouse. [Q99KG3-3]
uc009sth.2. mouse. [Q99KG3-1]
uc009sti.2. mouse. [Q99KG3-2]

Organism-specific databases

CTDi8241.
MGIiMGI:2384310. Rbm10.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0154. Eukaryota.
ENOG410YNFQ. LUCA.
GeneTreeiENSGT00510000046476.
HOGENOMiHOG000046285.
HOVERGENiHBG000318.
InParanoidiQ99KG3.
KOiK13094.
OMAiDSVSMQA.
OrthoDBiEOG091G01UT.
TreeFamiTF315789.

Miscellaneous databases

ChiTaRSiRbm10. mouse.
PROiQ99KG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031060.
GenevisibleiQ99KG3. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033095. RBM10.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERiPTHR13948:SF4. PTHR13948:SF4. 2 hits.
PfamiPF01585. G-patch. 1 hit.
PF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM10_MOUSE
AccessioniPrimary (citable) accession number: Q99KG3
Secondary accession number(s): Q3TIY0
, Q3U5B8, Q3UKI8, Q80U75, Q8BTP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.