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Protein

RNA-binding protein 10

Gene

Rbm10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 242RanBP2-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri759 – 784C2H2-type; atypicalPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of mRNA splicing, via spliceosome Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of smooth muscle cell apoptotic process Source: MGI
  • regulation of alternative mRNA splicing, via spliceosome Source: InterPro
  • regulation of smooth muscle cell apoptotic process Source: MGI
  • RNA splicing Source: InterPro

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 10Curated
Alternative name(s):
RNA-binding motif protein 10
Gene namesi
Name:Rbm10Imported
Synonyms:Kiaa0122
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2384310 Rbm10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450171 – 930RNA-binding protein 10Add BLAST930

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei383N6-acetyllysineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei723PhosphoserineBy similarity1
Modified residuei733PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei781PhosphoserineBy similarity1
Modified residuei797PhosphoserineCombined sources1
Modified residuei845PhosphoserineBy similarity1
Modified residuei902Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ99KG3
PeptideAtlasiQ99KG3
PRIDEiQ99KG3

PTM databases

iPTMnetiQ99KG3
PhosphoSitePlusiQ99KG3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031060
GenevisibleiQ99KG3 MM

Interactioni

Subunit structurei

Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2317852 interactors.
IntActiQ99KG3 1 interactor.
MINTiQ99KG3
STRINGi10090.ENSMUSP00000068188

Structurei

3D structure databases

ProteinModelPortaliQ99KG3
SMRiQ99KG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 209RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini300 – 384RRM 2PROSITE-ProRule annotationAdd BLAST85
Domaini858 – 904G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 87Poly-Arg8
Compositional biasi113 – 125Poly-GluAdd BLAST13

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 242RanBP2-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri759 – 784C2H2-type; atypicalPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0154 Eukaryota
ENOG410YNFQ LUCA
GeneTreeiENSGT00510000046476
HOGENOMiHOG000046285
HOVERGENiHBG000318
InParanoidiQ99KG3
KOiK13094
OMAiQDMEYER
OrthoDBiEOG091G01UT
TreeFamiTF315789

Family and domain databases

CDDicd16167 OCRE_RBM10, 1 hit
cd12754 RRM2_RBM10, 1 hit
Gene3Di3.30.70.3302 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR033095 RBM10
IPR035618 RBM10_OCRE
IPR034992 RBM10_RRM2
IPR000504 RRM_dom
IPR013087 Znf_C2H2_type
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR13948:SF4 PTHR13948:SF4, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00076 RRM_1, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00360 RRM, 2 hits
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF54928 SSF54928, 3 hits
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50102 RRM, 2 hits
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99KG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEYERRGGRG DRTGRYGATD RSQDDSGENR SRDHDYRDMD YRSYPREYGS
60 70 80 90 100
QEGKHEYDDS SEEQSAEDSY EASPGSETQR RRRRRHRHSP TGPPGFPRDG
110 120 130 140 150
DYRDQDYRTE QGEEEEEEDE EEEEEKASNI VMLRMLPQAA TEDDIRGQLQ
160 170 180 190 200
SHGVQAREVR LMRNKSSGQS RGFAFVEFSH LQDATRWMEA NQHSLNILGQ
210 220 230 240 250
KVSMHYSDPK PKINEDWLCN KCGVQNFKRR EKCFKCGVPK SEAEQKLPLG
260 270 280 290 300
TRLDQQALPL GGRELSQGLL PLPQPYQAQG VLTSQALSQG SEPSSENAND
310 320 330 340 350
TIILRNLNPH STMDSILGAL APYAVLSSSN VRVIKDKQTQ LNRGFAFIQL
360 370 380 390 400
STIVEAAQLL QILQALHPPL TIDGKTINVE FAKGSKRDMA SNEGSRINAA
410 420 430 440 450
SVASTAIAAA QWAISQASQG GESAWAAPEE PPVDYSYYQQ DEGYGSSQGT
460 470 480 490 500
DSLYAHGYLK NSKGPGMTGT KGDPAGTGPE ASLEAGADSV SLQAFSRAQP
510 520 530 540 550
GAAPGLYQQS AEGSSGQSTA TNSQSYTIIS PAVLKAELQS PTQPSSSAFP
560 570 580 590 600
PATSPTAPEA YSQYPVPDVS TYQYDETSGY YYDPQTGLYY DPNSQYYYNA
610 620 630 640 650
QSQQYLYWDG ERRTYIPALE QSADGHKDTG ASSKEGKEKK EKHKTKTAQQ
660 670 680 690 700
IAKDMERWAR SLNKQKENFK NSFQPISALR DDERRESATA DAGYAILEKK
710 720 730 740 750
GALAERQHTS MDLPKLASDD RPSPPRGLVA AYSGESDSEE EQERGGPERE
760 770 780 790 800
EKLTDWQKLA CLLCRRQFPS KEALIRHQQL SGLHKQNLEI HRRAHLSENE
810 820 830 840 850
LEALEKNDME QMKYRDRAAE RREKYGIPEP PEPKRRKYGG ISTASVDFEQ
860 870 880 890 900
PTRDGLGSDN IGSRMLQAMG WKEGSGLGRK KQGIVTPIEA QTRVRGSGLG
910 920 930
ARGSSYGVTS TESYKETLHK TMVTRFNEAQ
Length:930
Mass (Da):103,494
Last modified:June 1, 2001 - v1
Checksum:iE59A2AB20AF1C08C
GO
Isoform 2 (identifier: Q99KG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-144: Missing.

Show »
Length:853
Mass (Da):94,430
Checksum:iD936DA91736681FD
GO
Isoform 3 (identifier: Q99KG3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: Missing.

Show »
Length:929
Mass (Da):103,394
Checksum:i78506A1D7A81C1B9
GO

Sequence cautioni

The sequence BAC65490 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188M → V in BAE26813 (PubMed:16141072).Curated1
Sequence conflicti355E → VR in BAC65490 (PubMed:12693553).Curated1
Sequence conflicti428P → H in BAE39715 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03490568 – 144Missing in isoform 2. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_034906354Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122208 Transcribed RNA Translation: BAC65490.3 Different initiation.
AK089105 mRNA Translation: BAC40753.1
AK145991 mRNA Translation: BAE26813.1
AK153736 mRNA Translation: BAE32161.1
AK167666 mRNA Translation: BAE39715.1
AL672073, AL807240 Genomic DNA Translation: CAM21277.1
AL807240, AL672073 Genomic DNA Translation: CAM23098.1
AL672073, AL807240 Genomic DNA Translation: CAM21279.1
AL807240, AL672073 Genomic DNA Translation: CAM23096.1
AL672073, AL807240 Genomic DNA Translation: CAM21278.1
AL807240, AL672073 Genomic DNA Translation: CAM23097.1
BC004674 mRNA Translation: AAH04674.1
CCDSiCCDS40885.1 [Q99KG3-1]
CCDS53013.1 [Q99KG3-3]
CCDS53014.1 [Q99KG3-2]
RefSeqiNP_001161247.1, NM_001167775.1 [Q99KG3-3]
NP_001161248.1, NM_001167776.1 [Q99KG3-2]
NP_663602.1, NM_145627.2 [Q99KG3-1]
XP_006527681.1, XM_006527618.3
UniGeneiMm.279194
Mm.383632
Mm.475412

Genome annotation databases

EnsembliENSMUST00000064911; ENSMUSP00000068188; ENSMUSG00000031060 [Q99KG3-1]
ENSMUST00000082089; ENSMUSP00000080738; ENSMUSG00000031060 [Q99KG3-2]
ENSMUST00000084383; ENSMUSP00000111031; ENSMUSG00000031060 [Q99KG3-2]
ENSMUST00000115374; ENSMUSP00000111032; ENSMUSG00000031060 [Q99KG3-1]
ENSMUST00000115375; ENSMUSP00000111033; ENSMUSG00000031060 [Q99KG3-3]
ENSMUST00000177738; ENSMUSP00000136209; ENSMUSG00000031060 [Q99KG3-3]
GeneIDi236732
KEGGimmu:236732
UCSCiuc009stf.2 mouse [Q99KG3-3]
uc009sth.2 mouse [Q99KG3-1]
uc009sti.2 mouse [Q99KG3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBM10_MOUSE
AccessioniPrimary (citable) accession number: Q99KG3
Secondary accession number(s): Q3TIY0
, Q3U5B8, Q3UKI8, Q80U75, Q8BTP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome