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Q99KF0

- CAR14_MOUSE

UniProt

Q99KF0 - CAR14_MOUSE

Protein

Caspase recruitment domain-containing protein 14

Gene

Card14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
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    Functioni

    Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Stimulates the phosphorylation of BCL10 By similarity. Activates NF-kappa-B via BCL10 and IKK.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: UniProtKB
    3. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    4. positive regulation of protein phosphorylation Source: Ensembl
    5. tumor necrosis factor-mediated signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 14
    Alternative name(s):
    Bcl10-interacting MAGUK protein 2
    Short name:
    Bimp2
    Gene namesi
    Name:Card14
    Synonyms:Bimp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2386258. Card14.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. aggresome Source: Ensembl
    2. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 999999Caspase recruitment domain-containing protein 14PRO_0000144089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei541 – 5411PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99KF0.
    PaxDbiQ99KF0.
    PRIDEiQ99KF0.

    PTM databases

    PhosphoSiteiQ99KF0.

    Expressioni

    Gene expression databases

    BgeeiQ99KF0.
    CleanExiMM_CARD14.
    GenevestigatoriQ99KF0.

    Interactioni

    Subunit structurei

    Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ99KF0.
    SMRiQ99KF0. Positions 19-105, 584-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10793CARDPROSITE-ProRule annotationAdd
    BLAST
    Domaini572 – 65584PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini803 – 986184Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili125 – 411287Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG314915.
    GeneTreeiENSGT00530000063108.
    HOGENOMiHOG000049174.
    HOVERGENiHBG106927.
    InParanoidiQ99KF0.
    OMAiMEKNTHA.
    OrthoDBiEOG747PH5.
    PhylomeDBiQ99KF0.
    TreeFamiTF315606.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99KF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG    50
    QLDEEEILHS SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY 100
    TLVTGLQSDI DFSTFSGLME TSKLTECLAG AISSLQEELA QEKAQKEVLL 150
    RRCQQLKERL GLAEAHAEGL RQLEVDHSRM KREVSTHFHE VLKLKDEMLN 200
    LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS SCERESRERS 250
    LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE 300
    LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML 350
    QGQVAELQKE RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR 400
    TQLRRLQAEA PGGPKQEAGA RELCLRGKQR LVRMHAVCPP DDSDCSLLSS 450
    TESRLWWDLN STSSREQMDS FRSSSPMPPS QQSLYKRVAE DFLEDPESLS 500
    FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG SSRSLNVSES 550
    SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA 600
    ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS 650
    VKINTEGYKN LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL 700
    HVTDTMFQGR SCWHAHHVNP YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ 750
    RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT SSFDQSQWDS GKEEGGPSVC 800
    FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK LCLLQGFKQC 850
    SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD 900
    VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR 950
    QEEGELDRVP CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC 999
    Length:999
    Mass (Da):113,497
    Last modified:January 31, 2002 - v2
    Checksum:iD18350DA12430255
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti736 – 7438QAQQQLLA → HLLEDHRS in AAH04692. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF363457 mRNA. Translation: AAK60137.1.
    BC004692 mRNA. Translation: AAH04692.1.
    BC029102 mRNA. Translation: AAH29102.1.
    CCDSiCCDS25715.1.
    RefSeqiNP_570956.1. NM_130886.3.
    XP_006532439.1. XM_006532376.1.
    UniGeneiMm.130832.

    Genome annotation databases

    EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483.
    ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483.
    GeneIDi170720.
    KEGGimmu:170720.
    UCSCiuc007mqk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF363457 mRNA. Translation: AAK60137.1 .
    BC004692 mRNA. Translation: AAH04692.1 .
    BC029102 mRNA. Translation: AAH29102.1 .
    CCDSi CCDS25715.1.
    RefSeqi NP_570956.1. NM_130886.3.
    XP_006532439.1. XM_006532376.1.
    UniGenei Mm.130832.

    3D structure databases

    ProteinModelPortali Q99KF0.
    SMRi Q99KF0. Positions 19-105, 584-746.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q99KF0.

    Proteomic databases

    MaxQBi Q99KF0.
    PaxDbi Q99KF0.
    PRIDEi Q99KF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053245 ; ENSMUSP00000053665 ; ENSMUSG00000013483 .
    ENSMUST00000106250 ; ENSMUSP00000101857 ; ENSMUSG00000013483 .
    GeneIDi 170720.
    KEGGi mmu:170720.
    UCSCi uc007mqk.1. mouse.

    Organism-specific databases

    CTDi 79092.
    MGIi MGI:2386258. Card14.

    Phylogenomic databases

    eggNOGi NOG314915.
    GeneTreei ENSGT00530000063108.
    HOGENOMi HOG000049174.
    HOVERGENi HBG106927.
    InParanoidi Q99KF0.
    OMAi MEKNTHA.
    OrthoDBi EOG747PH5.
    PhylomeDBi Q99KF0.
    TreeFami TF315606.

    Miscellaneous databases

    ChiTaRSi CARD14. mouse.
    NextBioi 370238.
    PROi Q99KF0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99KF0.
    CleanExi MM_CARD14.
    Genevestigatori Q99KF0.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa B induction."
      McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., Mak T.W., Nunez G.
      J. Biol. Chem. 276:30589-30597(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCAR14_MOUSE
    AccessioniPrimary (citable) accession number: Q99KF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3