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Q99KF0

- CAR14_MOUSE

UniProt

Q99KF0 - CAR14_MOUSE

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Protein

Caspase recruitment domain-containing protein 14

Gene
Card14, Bimp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Stimulates the phosphorylation of BCL10 By similarity. Activates NF-kappa-B via BCL10 and IKK.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: UniProtKB
  3. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  4. positive regulation of protein phosphorylation Source: Ensembl
  5. tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
Bcl10-interacting MAGUK protein 2
Short name:
Bimp2
Gene namesi
Name:Card14
Synonyms:Bimp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2386258. Card14.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 999999Caspase recruitment domain-containing protein 14PRO_0000144089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei541 – 5411Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99KF0.
PaxDbiQ99KF0.
PRIDEiQ99KF0.

PTM databases

PhosphoSiteiQ99KF0.

Expressioni

Gene expression databases

BgeeiQ99KF0.
CleanExiMM_CARD14.
GenevestigatoriQ99KF0.

Interactioni

Subunit structurei

Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99KF0.
SMRiQ99KF0. Positions 19-105, 584-746.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 10793CARDAdd
BLAST
Domaini572 – 65584PDZAdd
BLAST
Domaini803 – 986184Guanylate kinase-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 411287 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG314915.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000049174.
HOVERGENiHBG106927.
InParanoidiQ99KF0.
OMAiMEKNTHA.
OrthoDBiEOG747PH5.
PhylomeDBiQ99KF0.
TreeFamiTF315606.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KF0-1 [UniParc]FASTAAdd to Basket

« Hide

MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG    50
QLDEEEILHS SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY 100
TLVTGLQSDI DFSTFSGLME TSKLTECLAG AISSLQEELA QEKAQKEVLL 150
RRCQQLKERL GLAEAHAEGL RQLEVDHSRM KREVSTHFHE VLKLKDEMLN 200
LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS SCERESRERS 250
LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE 300
LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML 350
QGQVAELQKE RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR 400
TQLRRLQAEA PGGPKQEAGA RELCLRGKQR LVRMHAVCPP DDSDCSLLSS 450
TESRLWWDLN STSSREQMDS FRSSSPMPPS QQSLYKRVAE DFLEDPESLS 500
FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG SSRSLNVSES 550
SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA 600
ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS 650
VKINTEGYKN LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL 700
HVTDTMFQGR SCWHAHHVNP YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ 750
RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT SSFDQSQWDS GKEEGGPSVC 800
FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK LCLLQGFKQC 850
SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD 900
VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR 950
QEEGELDRVP CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC 999
Length:999
Mass (Da):113,497
Last modified:January 31, 2002 - v2
Checksum:iD18350DA12430255
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti736 – 7438QAQQQLLA → HLLEDHRS in AAH04692. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363457 mRNA. Translation: AAK60137.1.
BC004692 mRNA. Translation: AAH04692.1.
BC029102 mRNA. Translation: AAH29102.1.
CCDSiCCDS25715.1.
RefSeqiNP_570956.1. NM_130886.3.
XP_006532439.1. XM_006532376.1.
UniGeneiMm.130832.

Genome annotation databases

EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483.
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483.
GeneIDi170720.
KEGGimmu:170720.
UCSCiuc007mqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363457 mRNA. Translation: AAK60137.1 .
BC004692 mRNA. Translation: AAH04692.1 .
BC029102 mRNA. Translation: AAH29102.1 .
CCDSi CCDS25715.1.
RefSeqi NP_570956.1. NM_130886.3.
XP_006532439.1. XM_006532376.1.
UniGenei Mm.130832.

3D structure databases

ProteinModelPortali Q99KF0.
SMRi Q99KF0. Positions 19-105, 584-746.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q99KF0.

Proteomic databases

MaxQBi Q99KF0.
PaxDbi Q99KF0.
PRIDEi Q99KF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053245 ; ENSMUSP00000053665 ; ENSMUSG00000013483 .
ENSMUST00000106250 ; ENSMUSP00000101857 ; ENSMUSG00000013483 .
GeneIDi 170720.
KEGGi mmu:170720.
UCSCi uc007mqk.1. mouse.

Organism-specific databases

CTDi 79092.
MGIi MGI:2386258. Card14.

Phylogenomic databases

eggNOGi NOG314915.
GeneTreei ENSGT00530000063108.
HOGENOMi HOG000049174.
HOVERGENi HBG106927.
InParanoidi Q99KF0.
OMAi MEKNTHA.
OrthoDBi EOG747PH5.
PhylomeDBi Q99KF0.
TreeFami TF315606.

Miscellaneous databases

ChiTaRSi CARD14. mouse.
NextBioi 370238.
PROi Q99KF0.
SOURCEi Search...

Gene expression databases

Bgeei Q99KF0.
CleanExi MM_CARD14.
Genevestigatori Q99KF0.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa B induction."
    McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., Mak T.W., Nunez G.
    J. Biol. Chem. 276:30589-30597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCAR14_MOUSE
AccessioniPrimary (citable) accession number: Q99KF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi