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Q99KF0 (CAR14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
Bcl10-interacting MAGUK protein 2
Short name=Bimp2
Gene names
Name:Card14
Synonyms:Bimp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length999 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Stimulates the phosphorylation of BCL10 By similarity. Activates NF-kappa-B via BCL10 and IKK.

Subunit structure

Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6 By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 CARD domain.

Contains 1 guanylate kinase-like domain.

Contains 1 PDZ (DHR) domain.

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 999999Caspase recruitment domain-containing protein 14
PRO_0000144089

Regions

Domain15 – 10793CARD
Domain572 – 65584PDZ
Domain803 – 986184Guanylate kinase-like
Coiled coil125 – 411287 Potential

Amino acid modifications

Modified residue5411Phosphoserine By similarity

Experimental info

Sequence conflict736 – 7438QAQQQLLA → HLLEDHRS in AAH04692. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99KF0 [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: D18350DA12430255

FASTA999113,497
        10         20         30         40         50         60 
MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG QLDEEEILHS 

        70         80         90        100        110        120 
SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY TLVTGLQSDI DFSTFSGLME 

       130        140        150        160        170        180 
TSKLTECLAG AISSLQEELA QEKAQKEVLL RRCQQLKERL GLAEAHAEGL RQLEVDHSRM 

       190        200        210        220        230        240 
KREVSTHFHE VLKLKDEMLN LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS 

       250        260        270        280        290        300 
SCERESRERS LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE 

       310        320        330        340        350        360 
LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML QGQVAELQKE 

       370        380        390        400        410        420 
RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR TQLRRLQAEA PGGPKQEAGA 

       430        440        450        460        470        480 
RELCLRGKQR LVRMHAVCPP DDSDCSLLSS TESRLWWDLN STSSREQMDS FRSSSPMPPS 

       490        500        510        520        530        540 
QQSLYKRVAE DFLEDPESLS FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG 

       550        560        570        580        590        600 
SSRSLNVSES SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA 

       610        620        630        640        650        660 
ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS VKINTEGYKN 

       670        680        690        700        710        720 
LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL HVTDTMFQGR SCWHAHHVNP 

       730        740        750        760        770        780 
YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT 

       790        800        810        820        830        840 
SSFDQSQWDS GKEEGGPSVC FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK 

       850        860        870        880        890        900 
LCLLQGFKQC SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD 

       910        920        930        940        950        960 
VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR QEEGELDRVP 

       970        980        990 
CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC 

« Hide

References

« Hide 'large scale' references
[1]"Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa B induction."
McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., Mak T.W., Nunez G.
J. Biol. Chem. 276:30589-30597(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF363457 mRNA. Translation: AAK60137.1.
BC004692 mRNA. Translation: AAH04692.1.
BC029102 mRNA. Translation: AAH29102.1.
RefSeqNP_570956.1. NM_130886.3.
XP_006532439.1. XM_006532376.1.
UniGeneMm.130832.

3D structure databases

ProteinModelPortalQ99KF0.
SMRQ99KF0. Positions 19-105, 128-160, 574-746.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ99KF0.

Proteomic databases

PaxDbQ99KF0.
PRIDEQ99KF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483.
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483.
GeneID170720.
KEGGmmu:170720.
UCSCuc007mqk.1. mouse.

Organism-specific databases

CTD79092.
MGIMGI:2386258. Card14.

Phylogenomic databases

eggNOGNOG314915.
GeneTreeENSGT00530000063108.
HOGENOMHOG000049174.
HOVERGENHBG106927.
InParanoidQ99KF0.
OMAMEKNTHA.
OrthoDBEOG747PH5.
PhylomeDBQ99KF0.
TreeFamTF315606.

Gene expression databases

BgeeQ99KF0.
CleanExMM_CARD14.
GenevestigatorQ99KF0.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamPF00619. CARD. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCARD14. mouse.
NextBio370238.
PROQ99KF0.
SOURCESearch...

Entry information

Entry nameCAR14_MOUSE
AccessionPrimary (citable) accession number: Q99KF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot