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Protein

Caspase recruitment domain-containing protein 14

Gene

Card14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Stimulates the phosphorylation of BCL10 (By similarity). Activates NF-kappa-B via BCL10 and IKK.By similarity

GO - Molecular functioni

  1. CARD domain binding Source: MGI

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: UniProtKB
  3. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  4. positive regulation of protein phosphorylation Source: MGI
  5. tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 14
Alternative name(s):
Bcl10-interacting MAGUK protein 2
Short name:
Bimp2
Gene namesi
Name:Card14
Synonyms:Bimp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2386258. Card14.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 999999Caspase recruitment domain-containing protein 14PRO_0000144089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei541 – 5411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99KF0.
PaxDbiQ99KF0.
PRIDEiQ99KF0.

PTM databases

PhosphoSiteiQ99KF0.

Expressioni

Gene expression databases

BgeeiQ99KF0.
CleanExiMM_CARD14.
GenevestigatoriQ99KF0.

Interactioni

Subunit structurei

Interacts with BCL10 by CARD-CARD interaction. Interacts with TRAF2, TRAF3 and TRAF6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi228392. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99KF0.
SMRiQ99KF0. Positions 584-746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 10793CARDPROSITE-ProRule annotationAdd
BLAST
Domaini572 – 65584PDZPROSITE-ProRule annotationAdd
BLAST
Domaini803 – 986184Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 411287Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG314915.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000049174.
HOVERGENiHBG106927.
InParanoidiQ99KF0.
OMAiMEKNTHA.
OrthoDBiEOG747PH5.
PhylomeDBiQ99KF0.
TreeFamiTF315606.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG
60 70 80 90 100
QLDEEEILHS SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY
110 120 130 140 150
TLVTGLQSDI DFSTFSGLME TSKLTECLAG AISSLQEELA QEKAQKEVLL
160 170 180 190 200
RRCQQLKERL GLAEAHAEGL RQLEVDHSRM KREVSTHFHE VLKLKDEMLN
210 220 230 240 250
LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS SCERESRERS
260 270 280 290 300
LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE
310 320 330 340 350
LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML
360 370 380 390 400
QGQVAELQKE RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR
410 420 430 440 450
TQLRRLQAEA PGGPKQEAGA RELCLRGKQR LVRMHAVCPP DDSDCSLLSS
460 470 480 490 500
TESRLWWDLN STSSREQMDS FRSSSPMPPS QQSLYKRVAE DFLEDPESLS
510 520 530 540 550
FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG SSRSLNVSES
560 570 580 590 600
SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA
610 620 630 640 650
ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS
660 670 680 690 700
VKINTEGYKN LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL
710 720 730 740 750
HVTDTMFQGR SCWHAHHVNP YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ
760 770 780 790 800
RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT SSFDQSQWDS GKEEGGPSVC
810 820 830 840 850
FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK LCLLQGFKQC
860 870 880 890 900
SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD
910 920 930 940 950
VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR
960 970 980 990
QEEGELDRVP CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC
Length:999
Mass (Da):113,497
Last modified:January 31, 2002 - v2
Checksum:iD18350DA12430255
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti736 – 7438QAQQQLLA → HLLEDHRS in AAH04692. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363457 mRNA. Translation: AAK60137.1.
BC004692 mRNA. Translation: AAH04692.1.
BC029102 mRNA. Translation: AAH29102.1.
CCDSiCCDS25715.1.
RefSeqiNP_570956.1. NM_130886.3.
XP_006532439.1. XM_006532376.1.
UniGeneiMm.130832.

Genome annotation databases

EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483.
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483.
GeneIDi170720.
KEGGimmu:170720.
UCSCiuc007mqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363457 mRNA. Translation: AAK60137.1.
BC004692 mRNA. Translation: AAH04692.1.
BC029102 mRNA. Translation: AAH29102.1.
CCDSiCCDS25715.1.
RefSeqiNP_570956.1. NM_130886.3.
XP_006532439.1. XM_006532376.1.
UniGeneiMm.130832.

3D structure databases

ProteinModelPortaliQ99KF0.
SMRiQ99KF0. Positions 584-746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228392. 1 interaction.

PTM databases

PhosphoSiteiQ99KF0.

Proteomic databases

MaxQBiQ99KF0.
PaxDbiQ99KF0.
PRIDEiQ99KF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053245; ENSMUSP00000053665; ENSMUSG00000013483.
ENSMUST00000106250; ENSMUSP00000101857; ENSMUSG00000013483.
GeneIDi170720.
KEGGimmu:170720.
UCSCiuc007mqk.1. mouse.

Organism-specific databases

CTDi79092.
MGIiMGI:2386258. Card14.

Phylogenomic databases

eggNOGiNOG314915.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000049174.
HOVERGENiHBG106927.
InParanoidiQ99KF0.
OMAiMEKNTHA.
OrthoDBiEOG747PH5.
PhylomeDBiQ99KF0.
TreeFamiTF315606.

Miscellaneous databases

ChiTaRSiCard14. mouse.
NextBioi370238.
PROiQ99KF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ99KF0.
CleanExiMM_CARD14.
GenevestigatoriQ99KF0.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappa B induction."
    McAllister-Lucas L.M., Inohara N., Lucas P.C., Ruland J., Benito A., Li Q., Chen S., Chen F.F., Yamaoka S., Verma I.M., Mak T.W., Nunez G.
    J. Biol. Chem. 276:30589-30597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCAR14_MOUSE
AccessioniPrimary (citable) accession number: Q99KF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.