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Protein

Docking protein 4

Gene

Dok4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity).By similarity

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: MGI

GO - Biological processi

  • MAPK cascade Source: MGI
  • nervous system development Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 4
Alternative name(s):
Downstream of tyrosine kinase 4
Gene namesi
Name:Dok4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2148865 Dok4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872751 – 325Docking protein 4Add BLAST325

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99KE3
PRIDEiQ99KE3

PTM databases

iPTMnetiQ99KE3
PhosphoSitePlusiQ99KE3

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart, lung and kidney.1 Publication

Developmental stagei

At E12.5 and E13.5, expressed in the central and peripheral nervous system and in endothelia. In the nervous system, expression localized to the ventral portion of the neural tube and the dorsal root and cranial sensory ganglia. Expression confined to neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000040631
CleanExiMM_DOK4
ExpressionAtlasiQ99KE3 baseline and differential
GenevisibleiQ99KE3 MM

Interactioni

Subunit structurei

Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062'.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043554

Structurei

3D structure databases

ProteinModelPortaliQ99KE3
SMRiQ99KE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 112PHAdd BLAST106
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 275DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ99KE3
OMAiMMQITHE
OrthoDBiEOG091G0M38
PhylomeDBiQ99KE3
TreeFamiTF324994

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q99KE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNFNDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS
60 70 80 90 100
VCLRGCPKVT EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA
110 120 130 140 150
EEWYKTLSVE CLGSRLNDIS LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD
160 170 180 190 200
VYGECKLQIT HENIYLWDIH NPRVKLVSWP LCSLRRYGRD ATRFTFEAGR
210 220 230 240 250
MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE MEKNVRLLNK
260 270 280 290 300
GTEHYSYPCT PTAMLPRSAY WHHITGSQNI AEASSYGESY GAAQASSETD
310 320
LLNRFILLKP KPSQEDSSEA KTPAQ
Length:325
Mass (Da):37,040
Last modified:June 1, 2001 - v1
Checksum:iB925D9F11BA7093A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418207 mRNA Translation: AAL14626.1
AK032352 mRNA Translation: BAC27829.1
AK043670 mRNA Translation: BAC31613.1
AK142621 mRNA Translation: BAE25134.1
AK156485 mRNA Translation: BAE33728.1
BC004705 mRNA Translation: AAH04705.1
CCDSiCCDS40443.1
RefSeqiNP_444476.1, NM_053246.3
XP_006530642.1, XM_006530579.3
UniGeneiMm.203949

Genome annotation databases

EnsembliENSMUST00000046461; ENSMUSP00000043554; ENSMUSG00000040631
ENSMUST00000212810; ENSMUSP00000148355; ENSMUSG00000040631
GeneIDi114255
KEGGimmu:114255
UCSCiuc009mxf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDOK4_MOUSE
AccessioniPrimary (citable) accession number: Q99KE3
Secondary accession number(s): Q3U0X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health