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Protein

Protein unc-45 homolog A

Gene

Unc45a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.By similarityCurated2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • Hsp90 protein binding Source: MGI

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • chaperone-mediated protein folding Source: MGI
  • muscle organ development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
Stromal membrane-associated protein 1
Short name:
SMAP-1
Gene namesi
Name:Unc45a
Synonyms:Smap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142246. Unc45a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498891 – 944Protein unc-45 homolog AAdd BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-acetyllysineBy similarity1
Modified residuei483N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99KD5.
MaxQBiQ99KD5.
PaxDbiQ99KD5.
PeptideAtlasiQ99KD5.
PRIDEiQ99KD5.

PTM databases

iPTMnetiQ99KD5.
PhosphoSitePlusiQ99KD5.

Expressioni

Tissue specificityi

Detected in spleen, bone marrow, lung and ovary, and at lower levels in testis, kidney, heart and brain (at protein level). Ubiquitous. Detected in uterus, large intestine, kidney, spleen, lung, brain, liver and ovary.2 Publications

Gene expression databases

BgeeiENSMUSG00000030533.
CleanExiMM_SMAP1.
MM_UNC45A.
ExpressionAtlasiQ99KD5. baseline and differential.
GenevisibleiQ99KD5. MM.

Interactioni

Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: MGI
  • Hsp90 protein binding Source: MGI

Protein-protein interaction databases

BioGridi221742. 1 interactor.
STRINGi10090.ENSMUSP00000032748.

Structurei

3D structure databases

ProteinModelPortaliQ99KD5.
SMRiQ99KD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 54TPR 1Add BLAST34
Repeati58 – 91TPR 2Add BLAST34
Repeati92 – 125TPR 3Add BLAST34

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00860000133805.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ99KD5.
OMAiTFPGERI.
OrthoDBiEOG091G02FM.
PhylomeDBiQ99KD5.
TreeFamiTF314096.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99KD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSGPETPE PRPSDPGASS AEQLRKEGNE LFKCGDYEGA LTAYTQALSL
60 70 80 90 100
GATPQDQAIL HRNRAACHLK LEDYSKAESE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLKRCVS LEPKNKVFQE SLRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPKEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDTEETD LMLAALRTLV GICSEHQSRT VATLSVLGTR RVVSILGVEN
260 270 280 290 300
QAVSLAACHL LQVIFDALKE GVKKGFRGKE GAIIVDPARE LKVLINSLLE
310 320 330 340 350
LLTEVGVSGQ GRDNALTLLI KMVPRKSPKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSLQDAAGE LTVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIR
410 420 430 440 450
NWFEGHGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASER
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVS LLKDLYKGSE RDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDEAA LKALFQLSRS EERSVLFAVG SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMTC
660 670 680 690 700
MVKTESPVLT NSCRELLSRV FLALVEEVED RGTVVAQGGG KALLPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLSCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLRRAAAG GLAMLTSMRP
860 870 880 890 900
ALCSRIPQVT THWLEILQAL LLSPNQELQH RGTVVVLNMM QSSKEIAGTL
910 920 930 940
MESEVLEILS VLAKGEESPV TRAAAACLEK AVEYRLIQPN QDGE
Length:944
Mass (Da):103,447
Last modified:September 19, 2006 - v2
Checksum:i61E15C6DE421242D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86E → G in BAC26192 (PubMed:16141072).Curated1
Sequence conflicti401N → S in AAH04717 (PubMed:15489334).Curated1
Sequence conflicti492D → G in BAC33017 (PubMed:16141072).Curated1
Sequence conflicti492D → G in BAC33070 (PubMed:16141072).Curated1
Sequence conflicti851A → T in AAH04717 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028912 mRNA. Translation: BAC26192.1.
AK047292 mRNA. Translation: BAC33017.1.
AK047476 mRNA. Translation: BAC33070.1.
AK166809 mRNA. Translation: BAE39037.1.
BC004717 mRNA. Translation: AAH04717.1.
CCDSiCCDS21395.1.
RefSeqiNP_598713.2. NM_133952.2.
XP_011249076.1. XM_011250774.1.
UniGeneiMm.243024.

Genome annotation databases

EnsembliENSMUST00000032748; ENSMUSP00000032748; ENSMUSG00000030533.
ENSMUST00000107368; ENSMUSP00000102991; ENSMUSG00000030533.
GeneIDi101869.
KEGGimmu:101869.
UCSCiuc009iam.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028912 mRNA. Translation: BAC26192.1.
AK047292 mRNA. Translation: BAC33017.1.
AK047476 mRNA. Translation: BAC33070.1.
AK166809 mRNA. Translation: BAE39037.1.
BC004717 mRNA. Translation: AAH04717.1.
CCDSiCCDS21395.1.
RefSeqiNP_598713.2. NM_133952.2.
XP_011249076.1. XM_011250774.1.
UniGeneiMm.243024.

3D structure databases

ProteinModelPortaliQ99KD5.
SMRiQ99KD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221742. 1 interactor.
STRINGi10090.ENSMUSP00000032748.

PTM databases

iPTMnetiQ99KD5.
PhosphoSitePlusiQ99KD5.

Proteomic databases

EPDiQ99KD5.
MaxQBiQ99KD5.
PaxDbiQ99KD5.
PeptideAtlasiQ99KD5.
PRIDEiQ99KD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032748; ENSMUSP00000032748; ENSMUSG00000030533.
ENSMUST00000107368; ENSMUSP00000102991; ENSMUSG00000030533.
GeneIDi101869.
KEGGimmu:101869.
UCSCiuc009iam.3. mouse.

Organism-specific databases

CTDi55898.
MGIiMGI:2142246. Unc45a.

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00860000133805.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ99KD5.
OMAiTFPGERI.
OrthoDBiEOG091G02FM.
PhylomeDBiQ99KD5.
TreeFamiTF314096.

Miscellaneous databases

PROiQ99KD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030533.
CleanExiMM_SMAP1.
MM_UNC45A.
ExpressionAtlasiQ99KD5. baseline and differential.
GenevisibleiQ99KD5. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
PF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUN45A_MOUSE
AccessioniPrimary (citable) accession number: Q99KD5
Secondary accession number(s): Q3TKV6, Q8BFT3, Q8C157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.