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Protein

Signal transducer and activator of transcription

Gene

Stat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. double-stranded DNA binding Source: MGI
  2. enzyme binding Source: MGI
  3. identical protein binding Source: MGI
  4. protein homodimerization activity Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  7. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. signal transducer activity Source: InterPro
  10. tumor necrosis factor receptor binding Source: MGI

GO - Biological processi

  1. blood circulation Source: Ensembl
  2. cellular response to insulin stimulus Source: Ensembl
  3. cellular response to interferon-beta Source: MGI
  4. cellular response to lipopolysaccharide Source: MGI
  5. cytokine-mediated signaling pathway Source: MGI
  6. interferon-gamma-mediated signaling pathway Source: MGI
  7. JAK-STAT cascade Source: MGI
  8. lipopolysaccharide-mediated signaling pathway Source: MGI
  9. negative regulation by virus of viral protein levels in host cell Source: MGI
  10. negative regulation of angiogenesis Source: MGI
  11. negative regulation of endothelial cell proliferation Source: MGI
  12. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  13. negative regulation of macrophage fusion Source: MGI
  14. positive regulation of smooth muscle cell proliferation Source: Ensembl
  15. positive regulation of transcription, DNA-templated Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. renal tubule development Source: MGI
  18. response to bacterium Source: MGI
  19. response to cAMP Source: Ensembl
  20. response to drug Source: Ensembl
  21. response to exogenous dsRNA Source: MGI
  22. response to hydrogen peroxide Source: Ensembl
  23. response to lipopolysaccharide Source: MGI
  24. response to mechanical stimulus Source: Ensembl
  25. response to nutrient Source: Ensembl
  26. transcription, DNA-templated Source: MGI
  27. transcription from RNA polymerase II promoter Source: MGI
  28. tumor necrosis factor-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_188578. Signaling by SCF-KIT.
REACT_196460. Signaling by FGFR1 fusion mutants.
REACT_198533. ISG15 antiviral mechanism.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198645. Regulation of IFNG signaling.
REACT_198660. Interferon gamma signaling.
REACT_199118. Interleukin-6 signaling.
REACT_230639. Downstream signal transduction.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:103063. Stat1.

Subcellular locationi

Cytoplasm UniRule annotation
Nucleus UniRule annotation

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: MGI
  3. dendrite Source: Ensembl
  4. nuclear chromatin Source: MGI
  5. nucleolus Source: MGI
  6. nucleoplasm Source: MGI
  7. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ99K94.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11220.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQWFELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV
60 70 80 90 100
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ
110 120 130 140 150
MSMIIYNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK
160 170 180 190 200
DQVMCIEQEI KTLEELQDEY DFKCKTSQNR EGEANGVAKS DQKQEQLLLH
210 220 230 240 250
KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK RRQQSACIGG
260 270 280 290 300
PPNACLDQLQ SWFTIVAETL QQIRQQLKKL EELEQKFTYE PDPITKNKQV
310 320 330 340 350
LSDRTFLLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
360 370 380 390 400
LQELNYNLKV KVSFDKDVNE KNTVKGFRKF NILGTHTKVM NMEESTNGSL
410 420 430 440 450
AAEFRHLQLK EQKNAGNRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET
460 470 480 490 500
TSLPVVVISN VSQLPSGWAS ILWYNMLVTE PRNLSFFLNP PCAWWSQLSE
510 520 530 540 550
VLSWQFSSVT KRGLNADQLS MLGEKLLGPN AGPDGLIPWT RFCKENINDK
560 570 580 590 600
NFSFWPWIDT ILELIKKHLL CLWNDGCIMG FISKERERAL LKDQQPGTFL
610 620 630 640 650
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN
660 670 680 690 700
YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDDPKRTG
710
YIKTELISVS EV
Length:712
Mass (Da):83,107
Last modified:June 1, 2001 - v1
Checksum:iD62081709638CDA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA. No translation available.
BC004808 mRNA. Translation: AAH04808.1.
AK039458 mRNA. Translation: BAC30355.1.
AK157263 mRNA. Translation: BAE34017.1.
RefSeqiNP_001192243.1. NM_001205314.1.
NP_033309.3. NM_009283.4.
UniGeneiMm.277406.
Mm.487336.

Genome annotation databases

EnsembliENSMUST00000186574; ENSMUSP00000140518; ENSMUSG00000026104.
ENSMUST00000189347; ENSMUSP00000141125; ENSMUSG00000026104.
ENSMUST00000191435; ENSMUSP00000139746; ENSMUSG00000026104.
GeneIDi20846.
KEGGimmu:20846.
UCSCiuc007axz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA. No translation available.
BC004808 mRNA. Translation: AAH04808.1.
AK039458 mRNA. Translation: BAC30355.1.
AK157263 mRNA. Translation: BAE34017.1.
RefSeqiNP_001192243.1. NM_001205314.1.
NP_033309.3. NM_009283.4.
UniGeneiMm.277406.
Mm.487336.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000186574; ENSMUSP00000140518; ENSMUSG00000026104.
ENSMUST00000189347; ENSMUSP00000141125; ENSMUSG00000026104.
ENSMUST00000191435; ENSMUSP00000139746; ENSMUSG00000026104.
GeneIDi20846.
KEGGimmu:20846.
UCSCiuc007axz.1. mouse.

Organism-specific databases

CTDi6772.
MGIiMGI:103063. Stat1.

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11220.

Enzyme and pathway databases

ReactomeiREACT_188578. Signaling by SCF-KIT.
REACT_196460. Signaling by FGFR1 fusion mutants.
REACT_198533. ISG15 antiviral mechanism.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198645. Regulation of IFNG signaling.
REACT_198660. Interferon gamma signaling.
REACT_199118. Interleukin-6 signaling.
REACT_230639. Downstream signal transduction.

Miscellaneous databases

ChiTaRSiStat1. mouse.
NextBioi299615.
PROiQ99K94.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ99K94.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CZECH IIImported.
    Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Spinal cordImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ99K94_MOUSE
AccessioniPrimary (citable) accession number: Q99K94
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.