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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene

Tab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1251985. Nuclear signaling by ERBB4.
R-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-450302. activated TAK1 mediates p38 MAPK activation.
R-MMU-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-937042. IRAK2 mediated activation of TAK1 complex.
R-MMU-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TAK1-binding protein 2
Short name:
TAB-2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:Tab2
Synonyms:Kiaa0733, Map3k7ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1915902. Tab2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasmcytosol 1 Publication

  • Note: Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi674T → A: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi675F → A: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi678H → Q: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi681L → T: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi685E → V: Loss of interaction with 'Lys-63'-linked ubiquitin. 1 Publication1
Mutagenesisi686Q → I or M: Confers ability to bind monoubiquitin and polyubiquitin, irrespective of the type of linkage. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256961 – 693TGF-beta-activated kinase 1 and MAP3K7-binding protein 2Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Asymmetric dimethylarginineCombined sources1
Modified residuei372PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei524PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to7 proteasomal degradation (By similarity).By similarity
Phosphorylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99K90.
MaxQBiQ99K90.
PaxDbiQ99K90.
PRIDEiQ99K90.

PTM databases

iPTMnetiQ99K90.
PhosphoSitePlusiQ99K90.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000015755.
ExpressionAtlasiQ99K90. baseline and differential.
GenevisibleiQ99K90. MM.

Interactioni

Subunit structurei

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with TRIM5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Map3k7Q620738EBI-1775124,EBI-1775345
UbcP629919EBI-1775124,EBI-413074

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212973. 8 interactors.
IntActiQ99K90. 4 interactors.
STRINGi10090.ENSMUSP00000121266.

Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni671 – 673Combined sources3
Turni685 – 687Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9JX-ray1.18C665-693[»]
ProteinModelPortaliQ99K90.
SMRiQ99K90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99K90.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUEPROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni675 – 685Interaction with polyubiquitinAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili532 – 619Sequence analysisAdd BLAST88

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.

Sequence similaritiesi

Contains 1 CUE domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ99K90.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ99K90.
TreeFamiTF332021.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES
60 70 80 90 100
TRYLYGEGDL NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS
110 120 130 140 150
RTLTHSVSDG QLHGGQSNNE LFQQEPQTAP AQVPQGFNVF GMPSTSGASN
160 170 180 190 200
STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT LAPNIQTGRS TPTSLHIHGV
210 220 230 240 250
PPPVLNSPQG NSIYIRPYIT TPSGTARQTQ QHSGWVSQFN PMNPQQAYQP
260 270 280 290 300
SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTIHS
310 320 330 340 350
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS
360 370 380 390 400
TSSLVNSQTL NRNQPTVYIA ASPPNTDEMI SRSQPKVYIS ANATAGDEQG
410 420 430 440 450
MRNQPTLFIS TNSGPSAASR NMSGQVSMGP AFIHHHPPKS RVLGGNSATS
460 470 480 490 500
PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET
510 520 530 540 550
ENIQHLTDPA LAHVDRISEA RKLSMGSDDA AYTQALLVHQ KARMERLQRE
560 570 580 590 600
LEMQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR
610 620 630 640 650
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS
660 670 680 690
TIKAPKTQDA EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF
Length:693
Mass (Da):76,442
Last modified:June 1, 2001 - v1
Checksum:i810F17CBE6F80BA8
GO

Sequence cautioni

The sequence BAC40772 differs from that shown. Reason: Frameshift at positions 62, 72, 152 and 275.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183P → T in BAE28166 (PubMed:16141072).Curated1
Sequence conflicti476V → F in BAC40772 (PubMed:16141072).Curated1
Sequence conflicti580S → L in BAE28166 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093701 mRNA. Translation: AAM10487.1.
BC004072 mRNA. Translation: AAH04072.1.
BC004813 mRNA. Translation: AAH04813.1.
AK089164 mRNA. Translation: BAC40772.1. Frameshift.
AK147830 mRNA. Translation: BAE28166.1.
AB093262 mRNA. Translation: BAC41446.1.
CCDSiCCDS23691.1.
RefSeqiNP_619608.1. NM_138667.3.
XP_017169562.1. XM_017314073.1.
UniGeneiMm.193041.

Genome annotation databases

EnsembliENSMUST00000146444; ENSMUSP00000121266; ENSMUSG00000015755.
GeneIDi68652.
KEGGimmu:68652.
UCSCiuc007eir.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093701 mRNA. Translation: AAM10487.1.
BC004072 mRNA. Translation: AAH04072.1.
BC004813 mRNA. Translation: AAH04813.1.
AK089164 mRNA. Translation: BAC40772.1. Frameshift.
AK147830 mRNA. Translation: BAE28166.1.
AB093262 mRNA. Translation: BAC41446.1.
CCDSiCCDS23691.1.
RefSeqiNP_619608.1. NM_138667.3.
XP_017169562.1. XM_017314073.1.
UniGeneiMm.193041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9JX-ray1.18C665-693[»]
ProteinModelPortaliQ99K90.
SMRiQ99K90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212973. 8 interactors.
IntActiQ99K90. 4 interactors.
STRINGi10090.ENSMUSP00000121266.

PTM databases

iPTMnetiQ99K90.
PhosphoSitePlusiQ99K90.

Proteomic databases

EPDiQ99K90.
MaxQBiQ99K90.
PaxDbiQ99K90.
PRIDEiQ99K90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146444; ENSMUSP00000121266; ENSMUSG00000015755.
GeneIDi68652.
KEGGimmu:68652.
UCSCiuc007eir.2. mouse.

Organism-specific databases

CTDi23118.
MGIiMGI:1915902. Tab2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ99K90.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ99K90.
TreeFamiTF332021.

Enzyme and pathway databases

ReactomeiR-MMU-1251985. Nuclear signaling by ERBB4.
R-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-450302. activated TAK1 mediates p38 MAPK activation.
R-MMU-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-937042. IRAK2 mediated activation of TAK1 complex.
R-MMU-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Miscellaneous databases

ChiTaRSiTab2. mouse.
EvolutionaryTraceiQ99K90.
PROiQ99K90.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015755.
ExpressionAtlasiQ99K90. baseline and differential.
GenevisibleiQ99K90. MM.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAB2_MOUSE
AccessioniPrimary (citable) accession number: Q99K90
Secondary accession number(s): Q3UGP1
, Q8BTP4, Q8CHD3, Q99KP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.