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Reviewed, UniProtKB/Swiss-Prot Q99K90 (TAB2_MOUSE)

Last modified December 15, 2009. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Alternative name(s):
    TAK1-binding protein 2
      Short name=TAB2
Gene names
Name: Map3k7ip2
Synonyms: Kiaa0733, Tab2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Ref.1

Subunit structure

Interacts with MAP3K7 and TRAF6. Interacts with NCOR1 and HDAC3 to form a ternary complex.

Subcellular location

Nucleus. Cytoplasm › cytosol. Note: Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol. Ref.1

Tissue specificity

Widely expressed. Ref.1

Post-translational modification

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression By similarity.

Phosphorylated Probable.

Sequence similarities

Contains 1 CUE domain.

Contains 1 RanBP2-type zinc finger.

Sequence caution

The sequence BAC40772.1 differs from that shown. Reason: Frameshift at positions 62, 72, 152 and 275.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
Ubl conjugation
Gene Ontology (GO)
   Cellular componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Map3k7Q620734EBI-1775124,EBI-1775345

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
PRO_0000225696

Regions

Domain8 – 5144CUE
Zinc finger663 – 69331RanBP2-type
Coiled coil532 – 61988 Potential

Amino acid modifications

Modified residue3721Phosphoserine By similarity
Modified residue4501Phosphoserine Ref.5

Experimental info

Sequence conflict1831P → T in BAE28166. Ref.3
Sequence conflict4761V → F in BAC40772. Ref.3
Sequence conflict5801S → L in BAE28166. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q99K90-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 810F17CBE6F80BA8

FASTA69376,442
        10         20         30         40         50         60 
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL 

        70         80         90        100        110        120 
NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS RTLTHSVSDG QLHGGQSNNE 

       130        140        150        160        170        180 
LFQQEPQTAP AQVPQGFNVF GMPSTSGASN STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT 

       190        200        210        220        230        240 
LAPNIQTGRS TPTSLHIHGV PPPVLNSPQG NSIYIRPYIT TPSGTARQTQ QHSGWVSQFN 

       250        260        270        280        290        300 
PMNPQQAYQP SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTIHS 

       310        320        330        340        350        360 
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS TSSLVNSQTL 

       370        380        390        400        410        420 
NRNQPTVYIA ASPPNTDEMI SRSQPKVYIS ANATAGDEQG MRNQPTLFIS TNSGPSAASR 

       430        440        450        460        470        480 
NMSGQVSMGP AFIHHHPPKS RVLGGNSATS PRVVVTQPNT KYTFKITVSP NKPPAVSPGV 

       490        500        510        520        530        540 
VSPTFELTNL LNHPDHYVET ENIQHLTDPA LAHVDRISEA RKLSMGSDDA AYTQALLVHQ 

       550        560        570        580        590        600 
KARMERLQRE LEMQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR 

       610        620        630        640        650        660 
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS TIKAPKTQDA 

       670        680        690 
EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF

« Hide

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References

« Hide 'large scale' references
[1]"Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein."
Baek S.H., Ohgi K.A., Rose D.W., Koo E.H., Glass C.K., Rosenfeld M.G.
Cell 110:55-67(2002) [PubMed: 12150997] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PHOSPHORYLATION, SUBCELLULAR LOCATION, FUNCTION.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II and FVB/N.
Tissue: Mammary tumor.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-595.
Strain: C57BL/6J and NOD.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed: 12465718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-693.
Tissue: Embryonic tail.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AY093701 mRNA. Translation: AAM10487.1.
BC004072 mRNA. Translation: AAH04072.1.
BC004813 mRNA. Translation: AAH04813.1.
AK089164 mRNA. Translation: BAC40772.1. Frameshift.
AK147830 mRNA. Translation: BAE28166.1.
AB093262 mRNA. Translation: BAC41446.1.
IPIIPI00115639.
RefSeqNP_619608.1.
UniGeneMm.193041

3D structure databases

SMRQ99K90. Positions 5-70.
ModBaseSearch...

Protein-protein interaction databases

IntActQ99K90. 1 interaction.
STRINGQ99K90.

PTM databases

PhosphoSiteQ99K90.

Proteomic databases

PRIDEQ99K90.

Genome annotation databases

EnsemblENSMUST00000015899; ENSMUSP00000015899; ENSMUSG00000015755; Mus musculus. [Genome view]
GeneID68652.
KEGGmmu:68652.
UCSCuc007eir.1. mouse.

Organism-specific databases

CTD68652.
MGIMGI:1915902. Map3k7ip2.
RougeSearch...

Phylogenomic databases

HOGENOMHBG714653.
HOVERGENQ99K90.
InParanoidQ99K90.
OMAVYHHGRE.
OrthoDBEOG9HX7KQ.

Gene expression databases

ArrayExpressQ99K90.
BgeeQ99K90.
GenevestigatorQ99K90.
GermOnlineENSMUSG00000015755. Mus musculus.

Family and domain databases

InterProIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamPF02845. CUE. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio327630.
SOURCESearch...

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Entry information

Entry nameTAB2_MOUSE
AccessionPrimary (citable) accession number: Q99K90
Secondary accession number(s): Q3UGP1 expand/collapse secondary AC list , Q8BTP4, Q8CHD3, Q99KP4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: December 15, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents