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Q99K85

- SERC_MOUSE

UniProt

Q99K85 - SERC_MOUSE

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Protein

Phosphoserine aminotransferase

Gene

Psat1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451L-glutamateBy similarity
Binding sitei107 – 1071Pyridoxal phosphateBy similarity
Binding sitei156 – 1561Pyridoxal phosphateBy similarity
Binding sitei176 – 1761Pyridoxal phosphateBy similarity
Binding sitei199 – 1991Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. L-serine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Serine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_199119. Serine biosynthesis.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferase (EC:2.6.1.52)
Short name:
PSAT
Alternative name(s):
Endometrial progesterone-induced protein
Short name:
EPIP
Phosphohydroxythreonine aminotransferase
Gene namesi
Name:Psat1
Synonyms:Psa, Psat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2183441. Psat1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Phosphoserine aminotransferasePRO_0000150136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei51 – 511N6-acetyllysineBy similarity
Modified residuei127 – 1271N6-acetyllysine1 Publication
Modified residuei200 – 2001N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei269 – 2691N6-acetyllysineBy similarity
Modified residuei318 – 3181N6-acetyllysineBy similarity
Modified residuei323 – 3231N6-acetyllysineBy similarity
Modified residuei333 – 3331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99K85.
PaxDbiQ99K85.
PRIDEiQ99K85.

PTM databases

PhosphoSiteiQ99K85.

Expressioni

Gene expression databases

BgeeiQ99K85.
CleanExiMM_PSAT1.
ExpressionAtlasiQ99K85. baseline and differential.
GenevestigatoriQ99K85.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi223231. 1 interaction.
IntActiQ99K85. 2 interactions.
MINTiMINT-4134236.

Structurei

3D structure databases

ProteinModelPortaliQ99K85.
SMRiQ99K85. Positions 17-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 802Pyridoxal phosphate bindingBy similarity
Regioni241 – 2422Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1932.
GeneTreeiENSGT00390000015177.
HOGENOMiHOG000088965.
HOVERGENiHBG001218.
InParanoidiQ99K85.
KOiK00831.
OMAiFAAIPMN.
OrthoDBiEOG7KQ220.
PhylomeDBiQ99K85.
TreeFamiTF312975.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEATKQVVNF GPGPAKLPHS VLLEIQKQLL DYRGLGISVL EMSHRSSDFA
60 70 80 90 100
KIIGNTENLV RELLAVPNNY KVIFVQGGGS GQFSAVPLNL IGLKAGRSAD
110 120 130 140 150
YVVTGAWSAK AAEEAKKFGT VNIVHPKLGS YTKIPDPSTW NLNPDASYVY
160 170 180 190 200
FCANETVHGV EFDFVPDVKG AVLVCDMSSN FLSRPVDVSK FGVIFAGAQK
210 220 230 240 250
NVGSAGVTVV IVRDDLLGFS LRECPSVLDY KVQAGNNSLY NTPPCFSIYV
260 270 280 290 300
MGMVLEWIKN NGGAAAMEKL SSIKSQMIYE IIDNSQGFYV CPVERQNRSR
310 320 330 340 350
MNIPFRIGNA KGDEALEKRF LDKAVELNMI SLKGHRSVGG IRASLYNAVT
360 370
TEDVEKLAAF MKNFLEMHQL
Length:370
Mass (Da):40,473
Last modified:June 1, 2001 - v1
Checksum:i6CF6B80CFDA1974B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259674 mRNA. Translation: AAK69389.1.
BC004827 mRNA. Translation: AAH04827.1.
CCDSiCCDS29681.1.
RefSeqiNP_803155.1. NM_177420.2.
UniGeneiMm.289936.

Genome annotation databases

EnsembliENSMUST00000025542; ENSMUSP00000025542; ENSMUSG00000024640.
GeneIDi107272.
KEGGimmu:107272.
UCSCiuc008gwp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259674 mRNA. Translation: AAK69389.1 .
BC004827 mRNA. Translation: AAH04827.1 .
CCDSi CCDS29681.1.
RefSeqi NP_803155.1. NM_177420.2.
UniGenei Mm.289936.

3D structure databases

ProteinModelPortali Q99K85.
SMRi Q99K85. Positions 17-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223231. 1 interaction.
IntActi Q99K85. 2 interactions.
MINTi MINT-4134236.

PTM databases

PhosphoSitei Q99K85.

Proteomic databases

MaxQBi Q99K85.
PaxDbi Q99K85.
PRIDEi Q99K85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025542 ; ENSMUSP00000025542 ; ENSMUSG00000024640 .
GeneIDi 107272.
KEGGi mmu:107272.
UCSCi uc008gwp.2. mouse.

Organism-specific databases

CTDi 29968.
MGIi MGI:2183441. Psat1.

Phylogenomic databases

eggNOGi COG1932.
GeneTreei ENSGT00390000015177.
HOGENOMi HOG000088965.
HOVERGENi HBG001218.
InParanoidi Q99K85.
KOi K00831.
OMAi FAAIPMN.
OrthoDBi EOG7KQ220.
PhylomeDBi Q99K85.
TreeFami TF312975.

Enzyme and pathway databases

UniPathwayi UPA00135 ; UER00197 .
UPA00244 ; UER00311 .
Reactomei REACT_199119. Serine biosynthesis.

Miscellaneous databases

ChiTaRSi Psat1. mouse.
NextBioi 358656.
PROi Q99K85.
SOURCEi Search...

Gene expression databases

Bgeei Q99K85.
CleanExi MM_PSAT1.
ExpressionAtlasi Q99K85. baseline and differential.
Genevestigatori Q99K85.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00160. SerC_aminotrans_5.
InterProi IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000525. SerC. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01364. serC_1. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Sato M., Oguma T., Tsujimoto K., Tadakuma T.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 17-27; 52-94; 191-200; 223-231 AND 343-356, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSERC_MOUSE
AccessioniPrimary (citable) accession number: Q99K85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3