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Protein

Plastin-3

Gene

Pls3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi25 – 361PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi65 – 762PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-3
Alternative name(s):
T-plastin
Gene namesi
Name:Pls3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104807. Pls3.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: GO_Central
  • actin filament bundle Source: GO_Central
  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737481 – 630Plastin-3Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei293PhosphoserineBy similarity1
Modified residuei297N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei364N6-acetyllysineBy similarity1
Modified residuei391PhosphothreonineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei475N6-acetyllysineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei545N6-acetyllysineBy similarity1
Modified residuei582N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99K51.
MaxQBiQ99K51.
PaxDbiQ99K51.
PeptideAtlasiQ99K51.
PRIDEiQ99K51.

PTM databases

iPTMnetiQ99K51.
PhosphoSitePlusiQ99K51.
SwissPalmiQ99K51.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016382.
CleanExiMM_PLS3.
ExpressionAtlasiQ99K51. baseline and differential.
GenevisibleiQ99K51. MM.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221967. 3 interactors.
IntActiQ99K51. 4 interactors.
MINTiMINT-1868840.
STRINGi10090.ENSMUSP00000033547.

Structurei

3D structure databases

ProteinModelPortaliQ99K51.
SMRiQ99K51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini109 – 382Actin-binding 1Add BLAST274
Domaini123 – 239CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini267 – 378CH 2PROSITE-ProRule annotationAdd BLAST112
Domaini383 – 627Actin-binding 2Add BLAST245
Domaini397 – 506CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini518 – 627CH 4PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOVERGENiHBG003082.
InParanoidiQ99K51.
KOiK17336.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG
60 70 80 90 100
YKVREIIQKL MVDGDRNKDG KISFNEFVYI FQEVKSSDIA KTFRKAINRK
110 120 130 140 150
EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN
160 170 180 190 200
PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA
210 220 230 240 250
LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF ADIELSRNEA
260 270 280 290 300
LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK
310 320 330 340 350
AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR
360 370 380 390 400
QFVTPADVVS GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE
410 420 430 440 450
RTFRNWMNSL GVNPHVNHLY ADLQDALVIL QLYERIKVPV DWSKVNKPPY
460 470 480 490 500
PKLGANMKKL ENCNYAVELG KNPAKFSLVG IGGQDLNDGN PTLTLAVVWQ
510 520 530 540 550
LMRRYTLNVL EDLGEGQKAN DDIIVNWVNR TLSEAGKSTS IQSFKDKTIS
560 570 580 590 600
SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV
610 620 630
YALPEDLVEV KPKMVMTVFA CLMGRGMKRV
Length:630
Mass (Da):70,742
Last modified:April 14, 2009 - v3
Checksum:iFEC5AA91DB963286
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti391T → A in BAE35826 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182243 mRNA. Translation: BAD23918.1.
AK160501 mRNA. Translation: BAE35826.1.
AL805920 Genomic DNA. Translation: CAM15949.1.
AL805920 Genomic DNA. Translation: CAM15950.1.
CH466576 Genomic DNA. Translation: EDL29216.1.
BC005459 mRNA. Translation: AAH05459.1.
CCDSiCCDS30243.1.
RefSeqiNP_001159925.1. NM_001166453.1.
NP_001159926.1. NM_001166454.2.
NP_663604.1. NM_145629.2.
UniGeneiMm.28777.
Mm.448352.

Genome annotation databases

EnsembliENSMUST00000033547; ENSMUSP00000033547; ENSMUSG00000016382.
ENSMUST00000114057; ENSMUSP00000109691; ENSMUSG00000016382.
ENSMUST00000114059; ENSMUSP00000109693; ENSMUSG00000016382.
GeneIDi102866.
KEGGimmu:102866.
UCSCiuc009tqi.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182243 mRNA. Translation: BAD23918.1.
AK160501 mRNA. Translation: BAE35826.1.
AL805920 Genomic DNA. Translation: CAM15949.1.
AL805920 Genomic DNA. Translation: CAM15950.1.
CH466576 Genomic DNA. Translation: EDL29216.1.
BC005459 mRNA. Translation: AAH05459.1.
CCDSiCCDS30243.1.
RefSeqiNP_001159925.1. NM_001166453.1.
NP_001159926.1. NM_001166454.2.
NP_663604.1. NM_145629.2.
UniGeneiMm.28777.
Mm.448352.

3D structure databases

ProteinModelPortaliQ99K51.
SMRiQ99K51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221967. 3 interactors.
IntActiQ99K51. 4 interactors.
MINTiMINT-1868840.
STRINGi10090.ENSMUSP00000033547.

PTM databases

iPTMnetiQ99K51.
PhosphoSitePlusiQ99K51.
SwissPalmiQ99K51.

Proteomic databases

EPDiQ99K51.
MaxQBiQ99K51.
PaxDbiQ99K51.
PeptideAtlasiQ99K51.
PRIDEiQ99K51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033547; ENSMUSP00000033547; ENSMUSG00000016382.
ENSMUST00000114057; ENSMUSP00000109691; ENSMUSG00000016382.
ENSMUST00000114059; ENSMUSP00000109693; ENSMUSG00000016382.
GeneIDi102866.
KEGGimmu:102866.
UCSCiuc009tqi.3. mouse.

Organism-specific databases

CTDi5358.
MGIiMGI:104807. Pls3.

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOVERGENiHBG003082.
InParanoidiQ99K51.
KOiK17336.
TreeFamiTF300680.

Miscellaneous databases

ChiTaRSiPls3. mouse.
PROiQ99K51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016382.
CleanExiMM_PLS3.
ExpressionAtlasiQ99K51. baseline and differential.
GenevisibleiQ99K51. MM.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLST_MOUSE
AccessioniPrimary (citable) accession number: Q99K51
Secondary accession number(s): B1AX56, Q3TUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.