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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

Usp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266NucleophilePROSITE-ProRule annotation1
Active sitei847Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.014

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:Usp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2384312 Usp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806331 – 921Ubiquitin carboxyl-terminal hydrolase 11Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194N6-acetyllysineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei906PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99K46
MaxQBiQ99K46
PaxDbiQ99K46
PeptideAtlasiQ99K46
PRIDEiQ99K46

PTM databases

iPTMnetiQ99K46
PhosphoSitePlusiQ99K46

Expressioni

Gene expression databases

BgeeiENSMUSG00000031066
CleanExiMM_USP11
GenevisibleiQ99K46 MM

Interactioni

Subunit structurei

Monomer. Interacts with RANBP9/RANBPM. Interacts with BRCA2. Interacts with CHUK/IKKA. Interacts with NFKBIA. Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex.By similarity

Protein-protein interaction databases

BioGridi2317862 interactors.
STRINGi10090.ENSMUSP00000033383

Structurei

3D structure databases

ProteinModelPortaliQ99K46
SMRiQ99K46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 133DUSPPROSITE-ProRule annotationAdd BLAST106
Domaini257 – 889USPAdd BLAST633

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00670000097750
HOGENOMiHOG000264375
HOVERGENiHBG000864
InParanoidiQ99K46
KOiK11835
OMAiQNHKRRN
OrthoDBiEOG091G0157
TreeFamiTF106276

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028135 Ub_USP-typ
IPR028134 USP4
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 1 hit
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF14836 Ubiquitin_3, 1 hit
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99K46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAADPAA AAVPASAEDR DTQPEAMPDL DEQWRQIGNG RERPLRAGES
60 70 80 90 100
WFLVEKHWYK QWEVYVKGGD QDASTFPGCI NNAGLFEDQI SWHLRERLLE
110 120 130 140 150
GDDYVLLPAP AWNYMVSWYG LMDGQPPIER KVIELPGIRK VEVYPLELLL
160 170 180 190 200
VQHSDMETAL TIQFSYTDSV ELVLQTAREQ FLVEPQEDTR LWTKNSEGSL
210 220 230 240 250
DRLCNTQITL LDACLETGQL VIMETRNKDG TWPSAQLCGM NNIPDEDEDF
260 270 280 290 300
QGQPGICGLT NLGNTCFMNS ALQCLSNVPQ LTEYFLNNRY LEELNFRNPL
310 320 330 340 350
GMKGELAEAY ADLVKQTWSG YHRSIVPNVF KNKVGHFASQ FLGYQQHDSQ
360 370 380 390 400
ELLSFLLDGL HEDLNRVKKK EYVELCNGAG RPDLEVAQEA WQNHKRRNDS
410 420 430 440 450
VIVDTFHGLF KSTLVCPDCG NVSVTFDPFC YLSVPLPVCS RRVLEVFFVP
460 470 480 490 500
MDPRRKPEQH RVVVPKKGNI SDLCVALSTH TSVAPDKMIV ADVFSHRFYK
510 520 530 540 550
LYQLEDPLSG ILDRDDIFVY EVTGRIEPVE GSRDDIVVPV YLRERTPSRD
560 570 580 590 600
YNNSYYGLIL FGHPLLVSVP RDRFSWEGLY NILMYRLSRY VTKPTSDEDD
610 620 630 640 650
GDEKVDEDED EDVEDDSSSE EEKEEMSAPT VNDGTREAEQ EQAGTSSGVT
660 670 680 690 700
ERCPSLLDNS LRASQWPPRR RRKQLFTLQT VNSNGTSDRT TSPEEMQTQP
710 720 730 740 750
YIAMDWEPDM KRRYYDEVEA EGYVKHDCVG YMLKKSPVQL KECIKLFTTV
760 770 780 790 800
ETLEKENPWY CSSCKQHQLA TKKLDLWMLP EVLIIHLKRF SFSKISREKL
810 820 830 840 850
DTLVQFPIRD LDFSEFVIKP KNESSPDLYK YDLIAVSNHY GGMRDGHYTT
860 870 880 890 900
FACNKDSGQW HYFDDNSVSP VNENQIESKA AYVLFYQRQD VGRRQSQTSS
910 920
SDTPASPVSS STPNSDIMDI N
Length:921
Mass (Da):105,384
Last modified:July 27, 2011 - v4
Checksum:i269E4A3267B9EE1D
GO

Sequence cautioni

The sequence AAH05470 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti863F → L in AAH05470 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166523 mRNA Translation: BAE38827.1
AL807240 Genomic DNA Translation: CAM23095.1
CH466625 Genomic DNA Translation: EDL00740.1
BC005470 mRNA Translation: AAH05470.1 Different initiation.
CCDSiCCDS53015.1
RefSeqiNP_663603.3, NM_145628.4
UniGeneiMm.34489

Genome annotation databases

EnsembliENSMUST00000033383; ENSMUSP00000033383; ENSMUSG00000031066
GeneIDi236733
KEGGimmu:236733
UCSCiuc009stq.3 mouse

Similar proteinsi

Entry informationi

Entry nameiUBP11_MOUSE
AccessioniPrimary (citable) accession number: Q99K46
Secondary accession number(s): B1AXB2, Q3TLG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 133 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome