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Q99K46

- UBP11_MOUSE

UniProt

Q99K46 - UBP11_MOUSE

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Protein
Ubiquitin carboxyl-terminal hydrolase 11
Gene
Usp11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661Nucleophile By similarity
Active sitei847 – 8471Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.014.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:Usp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2384312. Usp11.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly nuclear. Associates with chromatin By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 921921Ubiquitin carboxyl-terminal hydrolase 11
PRO_0000080633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941N6-acetyllysine By similarity
Modified residuei596 – 5961Phosphoserine By similarity
Modified residuei906 – 9061Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99K46.
PaxDbiQ99K46.
PRIDEiQ99K46.

PTM databases

PhosphoSiteiQ99K46.

Expressioni

Gene expression databases

ArrayExpressiQ99K46.
BgeeiQ99K46.
CleanExiMM_USP11.
GenevestigatoriQ99K46.

Interactioni

Subunit structurei

Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033383.

Structurei

3D structure databases

ProteinModelPortaliQ99K46.
SMRiQ99K46. Positions 29-233, 253-447, 738-890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 133106DUSP
Add
BLAST
Domaini257 – 889633USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 DUSP domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00670000097750.
HOGENOMiHOG000264375.
HOVERGENiHBG000864.
InParanoidiB1AXB2.
KOiK11835.
OMAiNFRNPLG.
OrthoDBiEOG77Q4VW.
TreeFamiTF106276.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028135. Ub_USP-typ.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF14836. Ubiquitin_3. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
PROSITEiPS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K46-1 [UniParc]FASTAAdd to Basket

« Hide

MAAVAADPAA AAVPASAEDR DTQPEAMPDL DEQWRQIGNG RERPLRAGES    50
WFLVEKHWYK QWEVYVKGGD QDASTFPGCI NNAGLFEDQI SWHLRERLLE 100
GDDYVLLPAP AWNYMVSWYG LMDGQPPIER KVIELPGIRK VEVYPLELLL 150
VQHSDMETAL TIQFSYTDSV ELVLQTAREQ FLVEPQEDTR LWTKNSEGSL 200
DRLCNTQITL LDACLETGQL VIMETRNKDG TWPSAQLCGM NNIPDEDEDF 250
QGQPGICGLT NLGNTCFMNS ALQCLSNVPQ LTEYFLNNRY LEELNFRNPL 300
GMKGELAEAY ADLVKQTWSG YHRSIVPNVF KNKVGHFASQ FLGYQQHDSQ 350
ELLSFLLDGL HEDLNRVKKK EYVELCNGAG RPDLEVAQEA WQNHKRRNDS 400
VIVDTFHGLF KSTLVCPDCG NVSVTFDPFC YLSVPLPVCS RRVLEVFFVP 450
MDPRRKPEQH RVVVPKKGNI SDLCVALSTH TSVAPDKMIV ADVFSHRFYK 500
LYQLEDPLSG ILDRDDIFVY EVTGRIEPVE GSRDDIVVPV YLRERTPSRD 550
YNNSYYGLIL FGHPLLVSVP RDRFSWEGLY NILMYRLSRY VTKPTSDEDD 600
GDEKVDEDED EDVEDDSSSE EEKEEMSAPT VNDGTREAEQ EQAGTSSGVT 650
ERCPSLLDNS LRASQWPPRR RRKQLFTLQT VNSNGTSDRT TSPEEMQTQP 700
YIAMDWEPDM KRRYYDEVEA EGYVKHDCVG YMLKKSPVQL KECIKLFTTV 750
ETLEKENPWY CSSCKQHQLA TKKLDLWMLP EVLIIHLKRF SFSKISREKL 800
DTLVQFPIRD LDFSEFVIKP KNESSPDLYK YDLIAVSNHY GGMRDGHYTT 850
FACNKDSGQW HYFDDNSVSP VNENQIESKA AYVLFYQRQD VGRRQSQTSS 900
SDTPASPVSS STPNSDIMDI N 921
Length:921
Mass (Da):105,384
Last modified:July 27, 2011 - v4
Checksum:i269E4A3267B9EE1D
GO

Sequence cautioni

The sequence AAH05470.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti863 – 8631F → L in AAH05470. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK166523 mRNA. Translation: BAE38827.1.
AL807240 Genomic DNA. Translation: CAM23095.1.
CH466625 Genomic DNA. Translation: EDL00740.1.
BC005470 mRNA. Translation: AAH05470.1. Different initiation.
CCDSiCCDS53015.1.
RefSeqiNP_663603.3. NM_145628.4.
UniGeneiMm.34489.

Genome annotation databases

EnsembliENSMUST00000033383; ENSMUSP00000033383; ENSMUSG00000031066.
GeneIDi236733.
KEGGimmu:236733.
UCSCiuc009stq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK166523 mRNA. Translation: BAE38827.1 .
AL807240 Genomic DNA. Translation: CAM23095.1 .
CH466625 Genomic DNA. Translation: EDL00740.1 .
BC005470 mRNA. Translation: AAH05470.1 . Different initiation.
CCDSi CCDS53015.1.
RefSeqi NP_663603.3. NM_145628.4.
UniGenei Mm.34489.

3D structure databases

ProteinModelPortali Q99K46.
SMRi Q99K46. Positions 29-233, 253-447, 738-890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033383.

Protein family/group databases

MEROPSi C19.014.

PTM databases

PhosphoSitei Q99K46.

Proteomic databases

MaxQBi Q99K46.
PaxDbi Q99K46.
PRIDEi Q99K46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033383 ; ENSMUSP00000033383 ; ENSMUSG00000031066 .
GeneIDi 236733.
KEGGi mmu:236733.
UCSCi uc009stq.3. mouse.

Organism-specific databases

CTDi 8237.
MGIi MGI:2384312. Usp11.

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00670000097750.
HOGENOMi HOG000264375.
HOVERGENi HBG000864.
InParanoidi B1AXB2.
KOi K11835.
OMAi NFRNPLG.
OrthoDBi EOG77Q4VW.
TreeFami TF106276.

Miscellaneous databases

NextBioi 383051.
PROi Q99K46.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99K46.
Bgeei Q99K46.
CleanExi MM_USP11.
Genevestigatori Q99K46.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028135. Ub_USP-typ.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 1 hit.
PF14836. Ubiquitin_3. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
PROSITEi PS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-367.
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-921.

Entry informationi

Entry nameiUBP11_MOUSE
AccessioniPrimary (citable) accession number: Q99K46
Secondary accession number(s): B1AXB2, Q3TLG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 105 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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