Reviewed, UniProtKB/Swiss-Prot Q99K46 (UBP11_MOUSE)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Deubiquitinating enzyme 11

Gene names

Name:

Usp11

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	921 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
Subunit structure	Interacts with RANBP9/RANBPM By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 DUSP domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 921	921	Ubiquitin carboxyl-terminal hydrolase 11		PRO_0000080633
Regions
	Domain	28 – 133	106	DUSP
Sites
	Active site	266	1	By similarity
	Active site	839	1	By similarity
	Active site	847	1	By similarity
Amino acid modifications
	Modified residue	194	1	N6-acetyllysine By similarity
	Modified residue	906	1	Phosphoserine By similarity
	Modified residue	911	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99K46-1 [UniParc]. Last modified November 28, 2006. Version 3. Checksum: 269E403867B3E41D	FASTA	921	105,350
	10 20 30 40 50 60 MAAVAADPAA AAVPASAEDR DTQPEAMPDL DEQWRQIGNG RERPLRAGES WFLVEKHWYK 70 80 90 100 110 120 QWEVYVKGGD QDASTFPGCI NNAGLFEDQI SWHLRERLLE GDDYVLLPAP AWNYMVSWYG 130 140 150 160 170 180 LMDGQPPIER KVIELPGIRK VEVYPLELLL VQHSDMETAL TIQFSYTDSV ELVLQTAREQ 190 200 210 220 230 240 FLVEPQEDTR LWTKNSEGSL DRLCNTQITL LDACLETGQL VIMETRNKDG TWPSAQLCGM 250 260 270 280 290 300 NNIPDEDEDF QGQPGICGLT NLGNTCFMNS ALQCLSNVPQ LTEYFLNNRY LEELNFRNPL 310 320 330 340 350 360 GMKGELAEAY ADLVKQTWSG YHRSIVPNVF KNKVGHFASQ FLGYQQHDSQ ELLSFLLDGL 370 380 390 400 410 420 HEDLNRVKKK EYVELCNGAG RPDLEVAQEA WQNHKRRNDS VIVDTFHGLF KSTLVCPDCG 430 440 450 460 470 480 NVSVTFDPFC YLSVPLPVCS RRVLEVFFVP MDPRRKPEQH RVVVPKKGNI SDLCVALSTH 490 500 510 520 530 540 TSVAPDKMIV ADVFSHRFYK LYQLEDPLSG ILDRDDIFVY EVTGRIEPVE GSRDDIVVPV 550 560 570 580 590 600 YLRERTPSRD YNNSYYGLIL FGHPLLVSVP RDRFSWEGLY NILMYRLSRY VTKPTSDEDD 610 620 630 640 650 660 GDEKVDEDED EDVEDDSSSE EEKEEMSAPT VNDGTREAEQ EQAGTSSGVT ERCPSLLDNS 670 680 690 700 710 720 LRASQWPPRR RRKQLFTLQT VNSNGTSDRT TSPEEMQTQP YIAMDWEPDM KRRYYDEVEA 730 740 750 760 770 780 EGYVKHDCVG YMLKKSPVQL KECIKLFTTV ETLEKENPWY CSSCKQHQLA TKKLDLWMLP 790 800 810 820 830 840 EVLIIHLKRF SFSKISREKL DTLVQFPIRD LDFSEFVIKP KNESSPDLYK YDLIAVSNHY 850 860 870 880 890 900 GGMRDGHYTT FACNKDSGQW HYLDDNSVSP VNENQIESKA AYVLFYQRQD VGRRQSQTSS 910 920 SDTPASPVSS STPNSDIMDI N

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-367. Tissue: Mammary gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-921.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK166523 mRNA. Translation: BAE38827.1. BC005470 mRNA. Translation: AAH05470.1. Different initiation.
IPI	IPI00378163.
UniGene	Mm.34489
3D structure databases
SMR	Q99K46. Positions 27-134.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99K46.
Protein family/group databases
MEROPS	C19.014.
PTM databases
PhosphoSite	Q99K46.
Proteomic databases
PRIDE	Q99K46.
Genome annotation databases
Ensembl	ENSMUST00000033383; ENSMUSP00000033383; ENSMUSG00000031066; Mus musculus. [Genome view]
UCSC	uc009stq.2. mouse.
Organism-specific databases
MGI	MGI:2384312. Usp11.
Phylogenomic databases
HOGENOM	HBG318284.
HOVERGEN	Q99K46.
InParanoid	Q99K46.
PhylomeDB	Q99K46.
Enzyme and pathway databases
BRENDA	3.1.2.15. 244.
Gene expression databases
ArrayExpress	Q99K46.
Bgee	Q99K46.
CleanEx	MM_USP11.
Genevestigator	Q99K46.
GermOnline	ENSMUSG00000031066. Mus musculus.
Family and domain databases
InterPro	IPR006615. Pept_C19_DUSP. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00695. DUSP. 1 hit. [Graphical view]
PROSITE	PS51283. DUSP. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

UBP11_MOUSE

Accession

Primary (citable) accession number: Q99K46
Secondary accession number(s): Q3TLG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	November 28, 2006
Last modified:	February 9, 2010
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)