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Q99K41

- EMIL1_MOUSE

UniProt

Q99K41 - EMIL1_MOUSE

Protein

EMILIN-1

Gene

Emilin1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity By similarity. May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue.By similarity

    GO - Molecular functioni

    1. extracellular matrix constituent conferring elasticity Source: MGI
    2. identical protein binding Source: MGI
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. extracellular matrix organization Source: MGI
    3. positive regulation of cell-substrate adhesion Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EMILIN-1
    Alternative name(s):
    Elastin microfibril interface-located protein 1
    Short name:
    Elastin microfibril interfacer 1
    Gene namesi
    Name:Emilin1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1926189. Emilin1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix
    Note: Found mainly at the interface between amorphous elastin and microfibrils.

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: Reactome
    3. extracellular vesicular exosome Source: Ensembl
    4. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 1017994EMILIN-1PRO_0000007816Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi122 ↔ 131PROSITE-ProRule annotation
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi767 – 7671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ99K41.
    PRIDEiQ99K41.

    PTM databases

    PhosphoSiteiQ99K41.

    Expressioni

    Developmental stagei

    Detectable in morula and blastocyst. First expressed in ectoplacental cone in embryos of 6.5 days and in extraembryonic visceral endoderm at 7.5 days. Expressed also in the allantois. Expression in the ectoplacental cone-derived secondary trophoblast giant cells and spongiotrophoblast is strong up to 11.5 days and then declines. In the embryo, high levels are initially expressed in blood vessels, perineural mesenchyme and somites at 8.5 days. Later on, intense expression is identified in the mesenchymal component of organs anlage (ie lung and liver) and different mesenchymal condensations (ie limb bud and branchial arches). At late gestation expression is widely distributed in interstitial connective tissue and smooth muscle cell-rich tissues.1 Publication

    Gene expression databases

    BgeeiQ99K41.
    CleanExiMM_EMILIN1.
    GenevestigatoriQ99K41.

    Interactioni

    Subunit structurei

    Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TGFB1P072002EBI-906561,EBI-907660From a different organism.

    Protein-protein interaction databases

    BioGridi221560. 1 interaction.
    IntActiQ99K41. 5 interactions.
    MINTiMINT-4094392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99K41.
    SMRiQ99K41. Positions 868-1016.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 13378EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini815 – 86551Collagen-likeAdd
    BLAST
    Domaini867 – 1014148C1qPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili171 – 21141Sequence AnalysisAdd
    BLAST
    Coiled coili237 – 26630Sequence AnalysisAdd
    BLAST
    Coiled coili310 – 37465Sequence AnalysisAdd
    BLAST
    Coiled coili519 – 57355Sequence AnalysisAdd
    BLAST
    Coiled coili676 – 69722Sequence AnalysisAdd
    BLAST
    Coiled coili789 – 80921Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 2757Poly-Gly

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated
    Contains 1 EMI domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG244192.
    GeneTreeiENSGT00660000095314.
    HOGENOMiHOG000112364.
    HOVERGENiHBG051473.
    InParanoidiQ99K41.
    OMAiQQEATEH.
    OrthoDBiEOG74R1RX.
    PhylomeDBiQ99K41.
    TreeFamiTF331033.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR011489. EMI_domain.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    PF07546. EMI. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    PS51041. EMI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99K41-1 [UniParc]FASTAAdd to Basket

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    MAPRALWSCY LCCLLTIATE AASYPPRGYS LYTGGTGALS PGGPQAQNSP     50
    RPASRHRNWC AYVVTRTVSC VLEDGVETIV KPDYQPCGWG QPHCSRSIMY 100
    RSFLRPRYRV AYKTVTDMEW RCCQGYGGDD CGEGPASVLG PAPSTPLPRP 150
    RPVRPNLSGS SAGSHLSGLG GEGPVESEKV QQLERQVKSL TKELQGLRGV 200
    LQGMNGRLAE DVQRAVDTVF NGRQQPADAA ARPGVHETLS EIQQQLQLLD 250
    NRVSTHDQEL GHLNNHHNGG PGGGGRASGP VPVPSGPSEE LLRQLERQLQ 300
    ESCSVCLTGL DGFRQQQQED RERLRTLEKL MSSMEERQQQ LVGPAMARRP 350
    PQECCPPELG RRVSELERRL DVVTGSLTVL SGRRGSELGG AAGQGGHPPG 400
    YTSLASRLSR LEDRFNSTLG PSEEQEKNWP GGPGRLGHWL PAAPGRLEKL 450
    EGLLANVSRE LGGRMDLLEE QVAGAVRTCG QICSGAPGEQ DSRVNEILSA 500
    LERRVLDSEG RLQLVGSGLH EAEAAGEAQQ AVLEGLQGLL SRLRERMDAQ 550
    EETAAEILLR LNLTAAQLSQ LEGLLQARGD EGCGACGGVQ EELGRLRDGV 600
    ERCSCPLLPP RGPGAGPGVG GPSRGPLDGF SVFGGSSGSA LQALQGELSE 650
    VILTFSSLND SLHELQTTVE GQGADLADLG ATKDSIISEI NRLQQEATEH 700
    VTESEERFRG LEEGQAQAGQ CPSLEGRLGR LEGVCERLDT VAGGLQGLRE 750
    GLSRHVAGLW AAVRESNSTS LTQAALLEKL LGGQAGLGRR LGALNNSLLL 800
    LEDRLQQLSL KDFTGPSGKA GPPGPPGLQG PSGPAGPPGP PGKDGQQGAI 850
    GPPGPQGEQG AEGAPAAPVP RVAFSAALSL PRSEPGTVPF DRVLLNDGGY 900
    YDPETGVFTA PLAGRYLLSA VLTGHRHEKV EAVLSRSNLG VARIDSGGYE 950
    PEGLENKPVA ESQPSPGALG VFSLILPLQV GDTVCIDLVM GQLAHSEEPL 1000
    TIFSGALLYE DTELEQV 1017
    Length:1,017
    Mass (Da):107,585
    Last modified:June 1, 2001 - v1
    Checksum:i2EF903204DB9C88F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029337 mRNA. Translation: BAC26403.1.
    BC005481 mRNA. Translation: AAH05481.1.
    CCDSiCCDS19167.1.
    RefSeqiNP_598679.1. NM_133918.2.
    UniGeneiMm.286375.

    Genome annotation databases

    EnsembliENSMUST00000031055; ENSMUSP00000031055; ENSMUSG00000029163.
    GeneIDi100952.
    KEGGimmu:100952.
    UCSCiuc008wwm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029337 mRNA. Translation: BAC26403.1 .
    BC005481 mRNA. Translation: AAH05481.1 .
    CCDSi CCDS19167.1.
    RefSeqi NP_598679.1. NM_133918.2.
    UniGenei Mm.286375.

    3D structure databases

    ProteinModelPortali Q99K41.
    SMRi Q99K41. Positions 868-1016.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221560. 1 interaction.
    IntActi Q99K41. 5 interactions.
    MINTi MINT-4094392.

    PTM databases

    PhosphoSitei Q99K41.

    Proteomic databases

    PaxDbi Q99K41.
    PRIDEi Q99K41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031055 ; ENSMUSP00000031055 ; ENSMUSG00000029163 .
    GeneIDi 100952.
    KEGGi mmu:100952.
    UCSCi uc008wwm.1. mouse.

    Organism-specific databases

    CTDi 11117.
    MGIi MGI:1926189. Emilin1.

    Phylogenomic databases

    eggNOGi NOG244192.
    GeneTreei ENSGT00660000095314.
    HOGENOMi HOG000112364.
    HOVERGENi HBG051473.
    InParanoidi Q99K41.
    OMAi QQEATEH.
    OrthoDBi EOG74R1RX.
    PhylomeDBi Q99K41.
    TreeFami TF331033.

    Enzyme and pathway databases

    Reactomei REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    NextBioi 354704.
    PROi Q99K41.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99K41.
    CleanExi MM_EMILIN1.
    Genevestigatori Q99K41.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR011489. EMI_domain.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    PF07546. EMI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    PS51041. EMI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiEMIL1_MOUSE
    AccessioniPrimary (citable) accession number: Q99K41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3