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Protein

EMILIN-1

Gene

Emilin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue.By similarity

GO - Molecular functioni

  • extracellular matrix constituent conferring elasticity Source: MGI
  • identical protein binding Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • extracellular matrix organization Source: MGI
  • positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
EMILIN-1
Alternative name(s):
Elastin microfibril interface-located protein 1
Short name:
Elastin microfibril interfacer 1
Gene namesi
Name:Emilin1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926189. Emilin1.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • extracellular matrix Source: UniProtKB
  • extracellular region Source: Reactome
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000781624 – 1017EMILIN-1Add BLAST994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 123PROSITE-ProRule annotation
Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
Disulfide bondi122 ↔ 131PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi562N-linked (GlcNAc...)Sequence analysis1
Glycosylationi659N-linked (GlcNAc...)Sequence analysis1
Glycosylationi767N-linked (GlcNAc...)Sequence analysis1
Glycosylationi795N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ99K41.
MaxQBiQ99K41.
PaxDbiQ99K41.
PeptideAtlasiQ99K41.
PRIDEiQ99K41.

PTM databases

iPTMnetiQ99K41.
PhosphoSitePlusiQ99K41.

Expressioni

Developmental stagei

Detectable in morula and blastocyst. First expressed in ectoplacental cone in embryos of 6.5 days and in extraembryonic visceral endoderm at 7.5 days. Expressed also in the allantois. Expression in the ectoplacental cone-derived secondary trophoblast giant cells and spongiotrophoblast is strong up to 11.5 days and then declines. In the embryo, high levels are initially expressed in blood vessels, perineural mesenchyme and somites at 8.5 days. Later on, intense expression is identified in the mesenchymal component of organs anlage (ie lung and liver) and different mesenchymal condensations (ie limb bud and branchial arches). At late gestation expression is widely distributed in interstitial connective tissue and smooth muscle cell-rich tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000029163.
CleanExiMM_EMILIN1.
GenevisibleiQ99K41. MM.

Interactioni

Subunit structurei

Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds. Interacts with EMILIN2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TGFB1P072002EBI-906561,EBI-907660From a different organism.

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

BioGridi221560. 1 interactor.
IntActiQ99K41. 5 interactors.
MINTiMINT-4094392.
STRINGi10090.ENSMUSP00000031055.

Structurei

3D structure databases

ProteinModelPortaliQ99K41.
SMRiQ99K41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 133EMIPROSITE-ProRule annotationAdd BLAST78
Domaini815 – 865Collagen-likeAdd BLAST51
Domaini867 – 1014C1qPROSITE-ProRule annotationAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili171 – 211Sequence analysisAdd BLAST41
Coiled coili237 – 266Sequence analysisAdd BLAST30
Coiled coili310 – 374Sequence analysisAdd BLAST65
Coiled coili519 – 573Sequence analysisAdd BLAST55
Coiled coili676 – 697Sequence analysisAdd BLAST22
Coiled coili789 – 809Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 275Poly-Gly7

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKJ2. Eukaryota.
ENOG4111F2M. LUCA.
GeneTreeiENSGT00660000095314.
HOGENOMiHOG000112364.
HOVERGENiHBG051473.
InParanoidiQ99K41.
OMAiERCSCPL.
OrthoDBiEOG091G0C3E.
PhylomeDBiQ99K41.
TreeFamiTF331033.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR011489. EMI_domain.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99K41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRALWSCY LCCLLTIATE AASYPPRGYS LYTGGTGALS PGGPQAQNSP
60 70 80 90 100
RPASRHRNWC AYVVTRTVSC VLEDGVETIV KPDYQPCGWG QPHCSRSIMY
110 120 130 140 150
RSFLRPRYRV AYKTVTDMEW RCCQGYGGDD CGEGPASVLG PAPSTPLPRP
160 170 180 190 200
RPVRPNLSGS SAGSHLSGLG GEGPVESEKV QQLERQVKSL TKELQGLRGV
210 220 230 240 250
LQGMNGRLAE DVQRAVDTVF NGRQQPADAA ARPGVHETLS EIQQQLQLLD
260 270 280 290 300
NRVSTHDQEL GHLNNHHNGG PGGGGRASGP VPVPSGPSEE LLRQLERQLQ
310 320 330 340 350
ESCSVCLTGL DGFRQQQQED RERLRTLEKL MSSMEERQQQ LVGPAMARRP
360 370 380 390 400
PQECCPPELG RRVSELERRL DVVTGSLTVL SGRRGSELGG AAGQGGHPPG
410 420 430 440 450
YTSLASRLSR LEDRFNSTLG PSEEQEKNWP GGPGRLGHWL PAAPGRLEKL
460 470 480 490 500
EGLLANVSRE LGGRMDLLEE QVAGAVRTCG QICSGAPGEQ DSRVNEILSA
510 520 530 540 550
LERRVLDSEG RLQLVGSGLH EAEAAGEAQQ AVLEGLQGLL SRLRERMDAQ
560 570 580 590 600
EETAAEILLR LNLTAAQLSQ LEGLLQARGD EGCGACGGVQ EELGRLRDGV
610 620 630 640 650
ERCSCPLLPP RGPGAGPGVG GPSRGPLDGF SVFGGSSGSA LQALQGELSE
660 670 680 690 700
VILTFSSLND SLHELQTTVE GQGADLADLG ATKDSIISEI NRLQQEATEH
710 720 730 740 750
VTESEERFRG LEEGQAQAGQ CPSLEGRLGR LEGVCERLDT VAGGLQGLRE
760 770 780 790 800
GLSRHVAGLW AAVRESNSTS LTQAALLEKL LGGQAGLGRR LGALNNSLLL
810 820 830 840 850
LEDRLQQLSL KDFTGPSGKA GPPGPPGLQG PSGPAGPPGP PGKDGQQGAI
860 870 880 890 900
GPPGPQGEQG AEGAPAAPVP RVAFSAALSL PRSEPGTVPF DRVLLNDGGY
910 920 930 940 950
YDPETGVFTA PLAGRYLLSA VLTGHRHEKV EAVLSRSNLG VARIDSGGYE
960 970 980 990 1000
PEGLENKPVA ESQPSPGALG VFSLILPLQV GDTVCIDLVM GQLAHSEEPL
1010
TIFSGALLYE DTELEQV
Length:1,017
Mass (Da):107,585
Last modified:June 1, 2001 - v1
Checksum:i2EF903204DB9C88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029337 mRNA. Translation: BAC26403.1.
BC005481 mRNA. Translation: AAH05481.1.
CCDSiCCDS19167.1.
RefSeqiNP_598679.1. NM_133918.2.
UniGeneiMm.286375.

Genome annotation databases

EnsembliENSMUST00000031055; ENSMUSP00000031055; ENSMUSG00000029163.
GeneIDi100952.
KEGGimmu:100952.
UCSCiuc008wwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029337 mRNA. Translation: BAC26403.1.
BC005481 mRNA. Translation: AAH05481.1.
CCDSiCCDS19167.1.
RefSeqiNP_598679.1. NM_133918.2.
UniGeneiMm.286375.

3D structure databases

ProteinModelPortaliQ99K41.
SMRiQ99K41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221560. 1 interactor.
IntActiQ99K41. 5 interactors.
MINTiMINT-4094392.
STRINGi10090.ENSMUSP00000031055.

PTM databases

iPTMnetiQ99K41.
PhosphoSitePlusiQ99K41.

Proteomic databases

EPDiQ99K41.
MaxQBiQ99K41.
PaxDbiQ99K41.
PeptideAtlasiQ99K41.
PRIDEiQ99K41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031055; ENSMUSP00000031055; ENSMUSG00000029163.
GeneIDi100952.
KEGGimmu:100952.
UCSCiuc008wwm.1. mouse.

Organism-specific databases

CTDi11117.
MGIiMGI:1926189. Emilin1.

Phylogenomic databases

eggNOGiENOG410IKJ2. Eukaryota.
ENOG4111F2M. LUCA.
GeneTreeiENSGT00660000095314.
HOGENOMiHOG000112364.
HOVERGENiHBG051473.
InParanoidiQ99K41.
OMAiERCSCPL.
OrthoDBiEOG091G0C3E.
PhylomeDBiQ99K41.
TreeFamiTF331033.

Miscellaneous databases

PROiQ99K41.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029163.
CleanExiMM_EMILIN1.
GenevisibleiQ99K41. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR011489. EMI_domain.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMIL1_MOUSE
AccessioniPrimary (citable) accession number: Q99K41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.