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Protein

Zinc transporter ZIP3

Gene

Slc39a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a zinc-influx transporter.Curated

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. embryonic cranial skeleton morphogenesis Source: MGI
  3. in utero embryonic development Source: MGI
  4. limb development Source: MGI
  5. T cell homeostasis Source: MGI
  6. zinc ion transmembrane transport Source: GOC
  7. zinc ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP3
Alternative name(s):
Solute carrier family 39 member 3
Zrt- and Irt-like protein 3
Short name:
ZIP-3
Gene namesi
Name:Slc39a3
Synonyms:Zip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2147269. Slc39a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33ExtracellularSequence Analysis
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 4218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Topological domaini64 – 8522ExtracellularSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 17266CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 1996ExtracellularSequence Analysis
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Topological domaini221 – 23212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Topological domaini254 – 26512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 2948CytoplasmicSequence Analysis
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST
Topological domaini316 – 3172ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Zinc transporter ZIP3PRO_0000312869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99K24.
PRIDEiQ99K24.

PTM databases

PhosphoSiteiQ99K24.

Expressioni

Gene expression databases

BgeeiQ99K24.
GenevestigatoriQ99K24.

Interactioni

Protein-protein interaction databases

IntActiQ99K24. 1 interaction.
MINTiMINT-4123595.
STRINGi10090.ENSMUSP00000057094.

Structurei

3D structure databases

ProteinModelPortaliQ99K24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG108447.
InParanoidiQ99K24.
KOiK14709.
OMAiRGSAMMA.
OrthoDBiEOG7CRTQS.
PhylomeDBiQ99K24.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF
60 70 80 90 100
GGGVFLATCF NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF
110 120 130 140 150
VEQLVLTFRR ERPPFIDLET FNAGSDAGSD SEYESPFVGV GNRSHSLYPE
160 170 180 190 200
PTAHTHGAGL RLRELGRPGP LRLLSLVFAL SAHSVFEGLA LGLQEEGERV
210 220 230 240 250
VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS AMIPVGIGLG
260 270 280 290 300
LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL
310
FLVLGYAVLA GMVFLKW
Length:317
Mass (Da):34,002
Last modified:June 1, 2001 - v1
Checksum:iE6F72B1783F99B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005502 mRNA. Translation: AAH05502.1.
CCDSiCCDS24041.1.
RefSeqiNP_598896.1. NM_134135.1.
UniGeneiMm.5353.

Genome annotation databases

EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
GeneIDi106947.
KEGGimmu:106947.
UCSCiuc007gfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005502 mRNA. Translation: AAH05502.1.
CCDSiCCDS24041.1.
RefSeqiNP_598896.1. NM_134135.1.
UniGeneiMm.5353.

3D structure databases

ProteinModelPortaliQ99K24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99K24. 1 interaction.
MINTiMINT-4123595.
STRINGi10090.ENSMUSP00000057094.

PTM databases

PhosphoSiteiQ99K24.

Proteomic databases

PaxDbiQ99K24.
PRIDEiQ99K24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
GeneIDi106947.
KEGGimmu:106947.
UCSCiuc007gfq.1. mouse.

Organism-specific databases

CTDi29985.
MGIiMGI:2147269. Slc39a3.

Phylogenomic databases

eggNOGiKOG1558.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG108447.
InParanoidiQ99K24.
KOiK14709.
OMAiRGSAMMA.
OrthoDBiEOG7CRTQS.
PhylomeDBiQ99K24.
TreeFamiTF317098.

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSlc39a3. mouse.
NextBioi358478.
PROiQ99K24.
SOURCEiSearch...

Gene expression databases

BgeeiQ99K24.
GenevestigatoriQ99K24.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS39A3_MOUSE
AccessioniPrimary (citable) accession number: Q99K24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.