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Protein

Zinc transporter ZIP3

Gene

Slc39a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a zinc-influx transporter.Curated

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cell morphogenesis Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • limb development Source: MGI
  • T cell homeostasis Source: MGI
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP3
Alternative name(s):
Solute carrier family 39 member 3
Zrt- and Irt-like protein 3
Short name:
ZIP-3
Gene namesi
Name:Slc39a3
Synonyms:Zip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2147269. Slc39a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3ExtracellularSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 42CytoplasmicSequence analysisAdd BLAST18
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 85ExtracellularSequence analysisAdd BLAST22
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 172CytoplasmicSequence analysisAdd BLAST66
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 199ExtracellularSequence analysis6
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 232CytoplasmicSequence analysisAdd BLAST12
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 265ExtracellularSequence analysisAdd BLAST12
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 294CytoplasmicSequence analysis8
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 317ExtracellularSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128691 – 317Zinc transporter ZIP3Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99K24.
PRIDEiQ99K24.

PTM databases

iPTMnetiQ99K24.
PhosphoSitePlusiQ99K24.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046822.
GenevisibleiQ99K24. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99K24. 1 interactor.
MINTiMINT-4123595.
STRINGi10090.ENSMUSP00000057094.

Structurei

3D structure databases

ProteinModelPortaliQ99K24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG108447.
InParanoidiQ99K24.
KOiK14709.
OMAiMRAHAEH.
OrthoDBiEOG091G0EFA.
PhylomeDBiQ99K24.
TreeFamiTF317098.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99K24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF
60 70 80 90 100
GGGVFLATCF NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF
110 120 130 140 150
VEQLVLTFRR ERPPFIDLET FNAGSDAGSD SEYESPFVGV GNRSHSLYPE
160 170 180 190 200
PTAHTHGAGL RLRELGRPGP LRLLSLVFAL SAHSVFEGLA LGLQEEGERV
210 220 230 240 250
VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS AMIPVGIGLG
260 270 280 290 300
LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL
310
FLVLGYAVLA GMVFLKW
Length:317
Mass (Da):34,002
Last modified:June 1, 2001 - v1
Checksum:iE6F72B1783F99B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005502 mRNA. Translation: AAH05502.1.
CCDSiCCDS24041.1.
RefSeqiNP_598896.1. NM_134135.1.
UniGeneiMm.5353.

Genome annotation databases

EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
GeneIDi106947.
KEGGimmu:106947.
UCSCiuc007gfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005502 mRNA. Translation: AAH05502.1.
CCDSiCCDS24041.1.
RefSeqiNP_598896.1. NM_134135.1.
UniGeneiMm.5353.

3D structure databases

ProteinModelPortaliQ99K24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99K24. 1 interactor.
MINTiMINT-4123595.
STRINGi10090.ENSMUSP00000057094.

PTM databases

iPTMnetiQ99K24.
PhosphoSitePlusiQ99K24.

Proteomic databases

PaxDbiQ99K24.
PRIDEiQ99K24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
GeneIDi106947.
KEGGimmu:106947.
UCSCiuc007gfq.1. mouse.

Organism-specific databases

CTDi29985.
MGIiMGI:2147269. Slc39a3.

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
GeneTreeiENSGT00530000063242.
HOGENOMiHOG000236331.
HOVERGENiHBG108447.
InParanoidiQ99K24.
KOiK14709.
OMAiMRAHAEH.
OrthoDBiEOG091G0EFA.
PhylomeDBiQ99K24.
TreeFamiTF317098.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSlc39a3. mouse.
PROiQ99K24.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046822.
GenevisibleiQ99K24. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A3_MOUSE
AccessioniPrimary (citable) accession number: Q99K24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.