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Protein

Zinc transporter ZIP3

Gene

Slc39a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a zinc-influx transporter.Curated

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cell morphogenesis Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • limb development Source: MGI
  • T cell homeostasis Source: MGI
  • zinc ion transport Source: MGI

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-MMU-442380 Zinc influx into cells by the SLC39 gene family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP3
Alternative name(s):
Solute carrier family 39 member 3
Zrt- and Irt-like protein 3
Short name:
ZIP-3
Gene namesi
Name:Slc39a3
Synonyms:Zip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2147269 Slc39a3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3ExtracellularSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 42CytoplasmicSequence analysisAdd BLAST18
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 85ExtracellularSequence analysisAdd BLAST22
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 172CytoplasmicSequence analysisAdd BLAST66
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 199ExtracellularSequence analysis6
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 232CytoplasmicSequence analysisAdd BLAST12
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 265ExtracellularSequence analysisAdd BLAST12
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 294CytoplasmicSequence analysis8
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 317ExtracellularSequence analysis2

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128691 – 317Zinc transporter ZIP3Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99K24
PRIDEiQ99K24

PTM databases

iPTMnetiQ99K24
PhosphoSitePlusiQ99K24

Expressioni

Gene expression databases

BgeeiENSMUSG00000046822
GenevisibleiQ99K24 MM

Interactioni

Protein-protein interaction databases

IntActiQ99K24, 1 interactor
MINTiQ99K24
STRINGi10090.ENSMUSP00000057094

Structurei

3D structure databases

ProteinModelPortaliQ99K24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00530000063242
HOGENOMiHOG000236331
HOVERGENiHBG108447
InParanoidiQ99K24
KOiK14709
OMAiEYESPFI
OrthoDBiEOG091G0EFA
PhylomeDBiQ99K24
TreeFamiTF317098

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequencei

Sequence statusi: Complete.

Q99K24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF
60 70 80 90 100
GGGVFLATCF NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF
110 120 130 140 150
VEQLVLTFRR ERPPFIDLET FNAGSDAGSD SEYESPFVGV GNRSHSLYPE
160 170 180 190 200
PTAHTHGAGL RLRELGRPGP LRLLSLVFAL SAHSVFEGLA LGLQEEGERV
210 220 230 240 250
VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS AMIPVGIGLG
260 270 280 290 300
LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL
310
FLVLGYAVLA GMVFLKW
Length:317
Mass (Da):34,002
Last modified:June 1, 2001 - v1
Checksum:iE6F72B1783F99B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005502 mRNA Translation: AAH05502.1
RefSeqiNP_598896.1, NM_134135.1
UniGeneiMm.449443
Mm.5353

Genome annotation databases

EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822
GeneIDi106947
KEGGimmu:106947
UCSCiuc007gfq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS39A3_MOUSE
AccessioniPrimary (citable) accession number: Q99K24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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