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Q99K24 (S39A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP3
Alternative name(s):
Solute carrier family 39 member 3
Zrt- and Irt-like protein 3
Short name=ZIP-3
Gene names
Name:Slc39a3
Synonyms:Zip3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a zinc-influx transporter Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Zinc transporter ZIP3
PRO_0000312869

Regions

Topological domain1 – 33Extracellular Potential
Transmembrane4 – 2421Helical; Potential
Topological domain25 – 4218Cytoplasmic Potential
Transmembrane43 – 6321Helical; Potential
Topological domain64 – 8522Extracellular Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 17266Cytoplasmic Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 1996Extracellular Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 23212Cytoplasmic Potential
Transmembrane233 – 25321Helical; Potential
Topological domain254 – 26512Extracellular Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 2948Cytoplasmic Potential
Transmembrane295 – 31521Helical; Potential
Topological domain316 – 3172Extracellular Potential

Amino acid modifications

Modified residue1251Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99K24 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E6F72B1783F99B63

FASTA31734,002
        10         20         30         40         50         60 
MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF GGGVFLATCF 

        70         80         90        100        110        120 
NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF VEQLVLTFRR ERPPFIDLET 

       130        140        150        160        170        180 
FNAGSDAGSD SEYESPFVGV GNRSHSLYPE PTAHTHGAGL RLRELGRPGP LRLLSLVFAL 

       190        200        210        220        230        240 
SAHSVFEGLA LGLQEEGERV VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS 

       250        260        270        280        290        300 
AMIPVGIGLG LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL 

       310 
FLVLGYAVLA GMVFLKW 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC005502 mRNA. Translation: AAH05502.1.
CCDSCCDS24041.1.
RefSeqNP_598896.1. NM_134135.1.
UniGeneMm.5353.

3D structure databases

ProteinModelPortalQ99K24.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99K24. 1 interaction.
MINTMINT-4123595.
STRING10090.ENSMUSP00000057094.

PTM databases

PhosphoSiteQ99K24.

Proteomic databases

PaxDbQ99K24.
PRIDEQ99K24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
GeneID106947.
KEGGmmu:106947.
UCSCuc007gfq.1. mouse.

Organism-specific databases

CTD29985.
MGIMGI:2147269. Slc39a3.

Phylogenomic databases

eggNOGKOG1558.
GeneTreeENSGT00530000063242.
HOGENOMHOG000236331.
HOVERGENHBG108447.
InParanoidQ99K24.
KOK14709.
OMARGSAMMA.
OrthoDBEOG7CRTQS.
PhylomeDBQ99K24.
TreeFamTF317098.

Gene expression databases

BgeeQ99K24.
GenevestigatorQ99K24.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC39A3. mouse.
NextBio358478.
PROQ99K24.
SOURCESearch...

Entry information

Entry nameS39A3_MOUSE
AccessionPrimary (citable) accession number: Q99K24
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot