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Q99K24

- S39A3_MOUSE

UniProt

Q99K24 - S39A3_MOUSE

Protein

Zinc transporter ZIP3

Gene

Slc39a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Acts as a zinc-influx transporter.Curated

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. zinc ion transmembrane transport Source: GOC
    2. zinc ion transport Source: MGI

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP3
    Alternative name(s):
    Solute carrier family 39 member 3
    Zrt- and Irt-like protein 3
    Short name:
    ZIP-3
    Gene namesi
    Name:Slc39a3
    Synonyms:Zip3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2147269. Slc39a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Zinc transporter ZIP3PRO_0000312869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei125 – 1251PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ99K24.
    PRIDEiQ99K24.

    PTM databases

    PhosphoSiteiQ99K24.

    Expressioni

    Gene expression databases

    BgeeiQ99K24.
    GenevestigatoriQ99K24.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99K24. 1 interaction.
    MINTiMINT-4123595.
    STRINGi10090.ENSMUSP00000057094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99K24.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33ExtracellularSequence Analysis
    Topological domaini25 – 4218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 8522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini107 – 17266CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 1996ExtracellularSequence Analysis
    Topological domaini221 – 23212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 2948CytoplasmicSequence Analysis
    Topological domaini316 – 3172ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1558.
    GeneTreeiENSGT00530000063242.
    HOGENOMiHOG000236331.
    HOVERGENiHBG108447.
    InParanoidiQ99K24.
    KOiK14709.
    OMAiRGSAMMA.
    OrthoDBiEOG7CRTQS.
    PhylomeDBiQ99K24.
    TreeFamiTF317098.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99K24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF    50
    GGGVFLATCF NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF 100
    VEQLVLTFRR ERPPFIDLET FNAGSDAGSD SEYESPFVGV GNRSHSLYPE 150
    PTAHTHGAGL RLRELGRPGP LRLLSLVFAL SAHSVFEGLA LGLQEEGERV 200
    VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS AMIPVGIGLG 250
    LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL 300
    FLVLGYAVLA GMVFLKW 317
    Length:317
    Mass (Da):34,002
    Last modified:June 1, 2001 - v1
    Checksum:iE6F72B1783F99B63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005502 mRNA. Translation: AAH05502.1.
    CCDSiCCDS24041.1.
    RefSeqiNP_598896.1. NM_134135.1.
    UniGeneiMm.5353.

    Genome annotation databases

    EnsembliENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
    ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
    ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
    GeneIDi106947.
    KEGGimmu:106947.
    UCSCiuc007gfq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005502 mRNA. Translation: AAH05502.1 .
    CCDSi CCDS24041.1.
    RefSeqi NP_598896.1. NM_134135.1.
    UniGenei Mm.5353.

    3D structure databases

    ProteinModelPortali Q99K24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99K24. 1 interaction.
    MINTi MINT-4123595.
    STRINGi 10090.ENSMUSP00000057094.

    PTM databases

    PhosphoSitei Q99K24.

    Proteomic databases

    PaxDbi Q99K24.
    PRIDEi Q99K24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059551 ; ENSMUSP00000057094 ; ENSMUSG00000046822 .
    ENSMUST00000117276 ; ENSMUSP00000113147 ; ENSMUSG00000046822 .
    ENSMUST00000168076 ; ENSMUSP00000128256 ; ENSMUSG00000046822 .
    GeneIDi 106947.
    KEGGi mmu:106947.
    UCSCi uc007gfq.1. mouse.

    Organism-specific databases

    CTDi 29985.
    MGIi MGI:2147269. Slc39a3.

    Phylogenomic databases

    eggNOGi KOG1558.
    GeneTreei ENSGT00530000063242.
    HOGENOMi HOG000236331.
    HOVERGENi HBG108447.
    InParanoidi Q99K24.
    KOi K14709.
    OMAi RGSAMMA.
    OrthoDBi EOG7CRTQS.
    PhylomeDBi Q99K24.
    TreeFami TF317098.

    Enzyme and pathway databases

    Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A3. mouse.
    NextBioi 358478.
    PROi Q99K24.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99K24.
    Genevestigatori Q99K24.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS39A3_MOUSE
    AccessioniPrimary (citable) accession number: Q99K24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3