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Q99K20

- Q99K20_MOUSE

UniProt

Q99K20 - Q99K20_MOUSE

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Protein

L-lactate dehydrogenase

Gene

Ldha

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: MGI

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. cellular response to extracellular stimulus Source: MGI
  3. glycolytic process Source: UniProtKB-KW
  4. lactate biosynthetic process from pyruvate Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:LdhaImported
Synonyms:Ldh1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96759. Ldha.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. mitochondrion Source: MGI
  3. sperm fibrous sheath Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ99K20.

Expressioni

Gene expression databases

GenevestigatoriQ99K20.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103267.

Structurei

3D structure databases

ProteinModelPortaliQ99K20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000462.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99K20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
APQNKITVVG VGAVGMACAI SILMKDLADE LALVDVMEDK LKGEMMDLQH
60 70 80 90 100
GSLFLKTPKI VSSKDYCVTA NSKLVIITAG ARQQEGESRL NLVQRSVNIF
110 120 130 140 150
KFIIPNIVKY SPHCKLLIVS NPVDILTYVA WKISGFPKNR VIGSGCNLDS
160 170 180 190 200
ARFRYLMGER LGVHALSCHG WVLGEHGDSS VPVWSGVNVA GVSLKSLNPE
210 220 230 240 250
LGTDADKEQW KEVHKQVVDS AYEVIKLKGY TSWAIGLSVA DLAESIMKNL
260 270 280 290 300
RRVHPISTMI KGLYGINEDV FLSVPCILGQ NGISDVVKVT LTPEEEARLK
310
KSADTLWGIQ KELQF
Length:315
Mass (Da):34,503
Last modified:June 1, 2001 - v1
Checksum:i492A6561499E9854
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005509 mRNA. Translation: AAH05509.1.
UniGeneiMm.29324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005509 mRNA. Translation: AAH05509.1 .
UniGenei Mm.29324.

3D structure databases

ProteinModelPortali Q99K20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000103267.

Proteomic databases

PRIDEi Q99K20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96759. Ldha.

Phylogenomic databases

HOVERGENi HBG000462.

Enzyme and pathway databases

UniPathwayi UPA00554 ; UER00611 .

Miscellaneous databases

ChiTaRSi LDHA. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q99K20.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00488. Lactate_dehydrog.
InterProi IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01771. L-LDH-NAD. 1 hit.
PROSITEi PS00064. L_LDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.

Entry informationi

Entry nameiQ99K20_MOUSE
AccessioniPrimary (citable) accession number: Q99K20
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)