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Q99K20

- Q99K20_MOUSE

UniProt

Q99K20 - Q99K20_MOUSE

Protein

L-lactate dehydrogenase

Gene

Ldha

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-lactate + NAD+ = pyruvate + NADH.

    Pathwayi

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: MGI

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. cellular response to extracellular stimulus Source: MGI
    3. glycolytic process Source: UniProtKB-KW
    4. lactate biosynthetic process from pyruvate Source: MGI

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00554; UER00611.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
    Gene namesi
    Name:LdhaImported
    Synonyms:Ldh1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96759. Ldha.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. mitochondrion Source: MGI
    3. sperm fibrous sheath Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ99K20.

    Expressioni

    Gene expression databases

    GenevestigatoriQ99K20.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000103267.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99K20.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000462.
    InParanoidiQ99K20.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00488. Lactate_dehydrog.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR011304. L-lactate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
    PROSITEiPS00064. L_LDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99K20-1 [UniParc]FASTAAdd to Basket

    « Hide

    APQNKITVVG VGAVGMACAI SILMKDLADE LALVDVMEDK LKGEMMDLQH    50
    GSLFLKTPKI VSSKDYCVTA NSKLVIITAG ARQQEGESRL NLVQRSVNIF 100
    KFIIPNIVKY SPHCKLLIVS NPVDILTYVA WKISGFPKNR VIGSGCNLDS 150
    ARFRYLMGER LGVHALSCHG WVLGEHGDSS VPVWSGVNVA GVSLKSLNPE 200
    LGTDADKEQW KEVHKQVVDS AYEVIKLKGY TSWAIGLSVA DLAESIMKNL 250
    RRVHPISTMI KGLYGINEDV FLSVPCILGQ NGISDVVKVT LTPEEEARLK 300
    KSADTLWGIQ KELQF 315
    Length:315
    Mass (Da):34,503
    Last modified:June 1, 2001 - v1
    Checksum:i492A6561499E9854
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005509 mRNA. Translation: AAH05509.1.
    UniGeneiMm.29324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005509 mRNA. Translation: AAH05509.1 .
    UniGenei Mm.29324.

    3D structure databases

    ProteinModelPortali Q99K20.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000103267.

    Proteomic databases

    PRIDEi Q99K20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96759. Ldha.

    Phylogenomic databases

    HOVERGENi HBG000462.
    InParanoidi Q99K20.

    Enzyme and pathway databases

    UniPathwayi UPA00554 ; UER00611 .

    Miscellaneous databases

    ChiTaRSi LDHA. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q99K20.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00488. Lactate_dehydrog.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR011304. L-lactate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01771. L-LDH-NAD. 1 hit.
    PROSITEi PS00064. L_LDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.

    Entry informationi

    Entry nameiQ99K20_MOUSE
    AccessioniPrimary (citable) accession number: Q99K20
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)