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Q99K20 (Q99K20_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase RuleBase RU000496
EC=1.1.1.27 RuleBase RU000496
Gene names
Name:Ldha EMBL AAH05509.1 MGI 96759
Synonyms:Ldh1 MGI 96759
OrganismMus musculus (Mouse) EMBL AAH05509.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length315 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. RuleBase RU000496

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. RuleBase RU000496

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family. RuleBase RU004149

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAH05509.1

Sequences

Sequence LengthMass (Da)Tools
Q99K20 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 492A6561499E9854

FASTA31534,503
        10         20         30         40         50         60 
APQNKITVVG VGAVGMACAI SILMKDLADE LALVDVMEDK LKGEMMDLQH GSLFLKTPKI 

        70         80         90        100        110        120 
VSSKDYCVTA NSKLVIITAG ARQQEGESRL NLVQRSVNIF KFIIPNIVKY SPHCKLLIVS 

       130        140        150        160        170        180 
NPVDILTYVA WKISGFPKNR VIGSGCNLDS ARFRYLMGER LGVHALSCHG WVLGEHGDSS 

       190        200        210        220        230        240 
VPVWSGVNVA GVSLKSLNPE LGTDADKEQW KEVHKQVVDS AYEVIKLKGY TSWAIGLSVA 

       250        260        270        280        290        300 
DLAESIMKNL RRVHPISTMI KGLYGINEDV FLSVPCILGQ NGISDVVKVT LTPEEEARLK 

       310 
KSADTLWGIQ KELQF

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II EMBL AAH05509.1.
Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneously EMBL AAH05509.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC005509 mRNA. Translation: AAH05509.1.
IPIIPI00319994.
UniGeneMm.29324.

3D structure databases

ProteinModelPortalQ99K20.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000103267.

Proteomic databases

PRIDEQ99K20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96759. Ldha.

Phylogenomic databases

HOVERGENHBG000462.
InParanoidQ99K20.

Enzyme and pathway databases

UniPathwayUPA00554; UER00611.

Gene expression databases

ArrayExpressQ99K20.
GenevestigatorQ99K20.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00488. Lactate_dehydrog.
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLDHA. mouse.
SOURCESearch...

Entry information

Entry nameQ99K20_MOUSE
AccessionPrimary (citable) accession number: Q99K20
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info