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Q99JY3

- GIMA4_MOUSE

UniProt

Q99JY3 - GIMA4_MOUSE

Protein

GTPase IMAP family member 4

Gene

Gimap4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium By similarity. May play a role in regulating lymphocyte apoptosis.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei58 – 581GTPBy similarity
    Binding sitei191 – 1911GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 459GTPBy similarity
    Nucleotide bindingi155 – 1573GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase IMAP family member 4
    Alternative name(s):
    Immunity-associated nucleotide 1 protein
    Short name:
    IAN-1
    Immunity-associated protein 4
    Gene namesi
    Name:Gimap4
    Synonyms:Ian1, Imap4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1349656. Gimap4.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Increased apoptosis in mature T-cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219GTPase IMAP family member 4PRO_0000190988Add
    BLAST

    Post-translational modificationi

    Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99JY3.
    PaxDbiQ99JY3.
    PRIDEiQ99JY3.

    PTM databases

    PhosphoSiteiQ99JY3.

    Expressioni

    Tissue specificityi

    Detected on splenocytes, B-cells and T-cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ99JY3.
    BgeeiQ99JY3.
    CleanExiMM_GIMAP4.
    GenevestigatoriQ99JY3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99JY3. 2 interactions.
    MINTiMINT-4096095.
    STRINGi10090.ENSMUSP00000087524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JY3.
    SMRiQ99JY3. Positions 30-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 219192AIG1-type GAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG76898.
    GeneTreeiENSGT00750000117514.
    HOGENOMiHOG000115747.
    HOVERGENiHBG004016.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006703. AIG1.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF04548. AIG1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51720. G_AIG1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99JY3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVQCGGAGF IPESSRSSHE LGNQDQGIPQ LRIVLLGKTG AGKSSTGNSI    50
    LGEKVFNSGI CAKSITKVCE KRVSTWDGKE LVVVDTPGIF DTEVPDADTQ 100
    REITRYVALT SPGPHALLLV VPLGRYTVEE HKATQKILDM FGKQARRFMI 150
    LLLTRKDDLE DTDIHEYLEK APKFFQEVMH EFQNRYCLFN NRASGAEKEE 200
    QKMQLLTLVQ SMFLSSRMK 219
    Length:219
    Mass (Da):24,554
    Last modified:June 1, 2001 - v1
    Checksum:iEDA63F448531A93C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005577 mRNA. Translation: AAH05577.1.
    CCDSiCCDS57423.1.
    RefSeqiNP_001230128.1. NM_001243199.1.
    UniGeneiMm.333048.
    Mm.486676.
    Mm.490512.

    Genome annotation databases

    EnsembliENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435.
    GeneIDi107526.
    KEGGimmu:107526.
    UCSCiuc009bvi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005577 mRNA. Translation: AAH05577.1 .
    CCDSi CCDS57423.1.
    RefSeqi NP_001230128.1. NM_001243199.1.
    UniGenei Mm.333048.
    Mm.486676.
    Mm.490512.

    3D structure databases

    ProteinModelPortali Q99JY3.
    SMRi Q99JY3. Positions 30-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99JY3. 2 interactions.
    MINTi MINT-4096095.
    STRINGi 10090.ENSMUSP00000087524.

    PTM databases

    PhosphoSitei Q99JY3.

    Proteomic databases

    MaxQBi Q99JY3.
    PaxDbi Q99JY3.
    PRIDEi Q99JY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067506 ; ENSMUSP00000068398 ; ENSMUSG00000054435 .
    GeneIDi 107526.
    KEGGi mmu:107526.
    UCSCi uc009bvi.2. mouse.

    Organism-specific databases

    CTDi 55303.
    MGIi MGI:1349656. Gimap4.

    Phylogenomic databases

    eggNOGi NOG76898.
    GeneTreei ENSGT00750000117514.
    HOGENOMi HOG000115747.
    HOVERGENi HBG004016.

    Miscellaneous databases

    NextBioi 358978.
    PROi Q99JY3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JY3.
    Bgeei Q99JY3.
    CleanExi MM_GIMAP4.
    Genevestigatori Q99JY3.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006703. AIG1.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF04548. AIG1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51720. G_AIG1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    2. Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.

    Entry informationi

    Entry nameiGIMA4_MOUSE
    AccessioniPrimary (citable) accession number: Q99JY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3