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Q99JY3

- GIMA4_MOUSE

UniProt

Q99JY3 - GIMA4_MOUSE

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Protein

GTPase IMAP family member 4

Gene

Gimap4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium (By similarity). May play a role in regulating lymphocyte apoptosis.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581GTPBy similarity
Binding sitei191 – 1911GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 459GTPBy similarity
Nucleotide bindingi155 – 1573GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 4
Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name:
IAN-1
Immunity-associated protein 4
Gene namesi
Name:Gimap4
Synonyms:Ian1, Imap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1349656. Gimap4.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Increased apoptosis in mature T-cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219GTPase IMAP family member 4PRO_0000190988Add
BLAST

Post-translational modificationi

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99JY3.
PaxDbiQ99JY3.
PRIDEiQ99JY3.

PTM databases

PhosphoSiteiQ99JY3.

Expressioni

Tissue specificityi

Detected on splenocytes, B-cells and T-cells (at protein level).1 Publication

Gene expression databases

BgeeiQ99JY3.
CleanExiMM_GIMAP4.
ExpressionAtlasiQ99JY3. baseline and differential.
GenevestigatoriQ99JY3.

Interactioni

Protein-protein interaction databases

IntActiQ99JY3. 2 interactions.
MINTiMINT-4096095.
STRINGi10090.ENSMUSP00000087524.

Structurei

3D structure databases

ProteinModelPortaliQ99JY3.
SMRiQ99JY3. Positions 30-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 219192AIG1-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG76898.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ99JY3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JY3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVQCGGAGF IPESSRSSHE LGNQDQGIPQ LRIVLLGKTG AGKSSTGNSI
60 70 80 90 100
LGEKVFNSGI CAKSITKVCE KRVSTWDGKE LVVVDTPGIF DTEVPDADTQ
110 120 130 140 150
REITRYVALT SPGPHALLLV VPLGRYTVEE HKATQKILDM FGKQARRFMI
160 170 180 190 200
LLLTRKDDLE DTDIHEYLEK APKFFQEVMH EFQNRYCLFN NRASGAEKEE
210
QKMQLLTLVQ SMFLSSRMK
Length:219
Mass (Da):24,554
Last modified:June 1, 2001 - v1
Checksum:iEDA63F448531A93C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005577 mRNA. Translation: AAH05577.1.
CCDSiCCDS57423.1.
RefSeqiNP_001230128.1. NM_001243199.1.
UniGeneiMm.333048.
Mm.486676.
Mm.490512.

Genome annotation databases

EnsembliENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435.
GeneIDi107526.
KEGGimmu:107526.
UCSCiuc009bvi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005577 mRNA. Translation: AAH05577.1 .
CCDSi CCDS57423.1.
RefSeqi NP_001230128.1. NM_001243199.1.
UniGenei Mm.333048.
Mm.486676.
Mm.490512.

3D structure databases

ProteinModelPortali Q99JY3.
SMRi Q99JY3. Positions 30-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99JY3. 2 interactions.
MINTi MINT-4096095.
STRINGi 10090.ENSMUSP00000087524.

PTM databases

PhosphoSitei Q99JY3.

Proteomic databases

MaxQBi Q99JY3.
PaxDbi Q99JY3.
PRIDEi Q99JY3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067506 ; ENSMUSP00000068398 ; ENSMUSG00000054435 .
GeneIDi 107526.
KEGGi mmu:107526.
UCSCi uc009bvi.2. mouse.

Organism-specific databases

CTDi 55303.
MGIi MGI:1349656. Gimap4.

Phylogenomic databases

eggNOGi NOG76898.
GeneTreei ENSGT00760000118989.
HOGENOMi HOG000115747.
HOVERGENi HBG004016.
InParanoidi Q99JY3.

Miscellaneous databases

NextBioi 358978.
PROi Q99JY3.
SOURCEi Search...

Gene expression databases

Bgeei Q99JY3.
CleanExi MM_GIMAP4.
ExpressionAtlasi Q99JY3. baseline and differential.
Genevestigatori Q99JY3.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006703. AIG1.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF04548. AIG1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51720. G_AIG1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  2. Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.

Entry informationi

Entry nameiGIMA4_MOUSE
AccessioniPrimary (citable) accession number: Q99JY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3