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Q99JY3 (GIMA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase IMAP family member 4
Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name=IAN-1
Immunity-associated protein 4
Gene names
Name:Gimap4
Synonyms:Ian1, Imap4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium By similarity. May play a role in regulating lymphocyte apoptosis. Ref.2

Subcellular location

Cytoplasmcytosol Ref.2.

Tissue specificity

Detected on splenocytes, B-cells and T-cells (at protein level). Ref.2

Post-translational modification

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis. Ref.2

Disruption phenotype

No visible phenotype. Increased apoptosis in mature T-cells. Ref.2

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

Contains 1 AIG1-type G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219GTPase IMAP family member 4
PRO_0000190988

Regions

Domain28 – 219192AIG1-type G
Nucleotide binding37 – 459GTP By similarity
Nucleotide binding155 – 1573GTP By similarity

Sites

Binding site581GTP By similarity
Binding site1911GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99JY3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: EDA63F448531A93C

FASTA21924,554
        10         20         30         40         50         60 
MEVQCGGAGF IPESSRSSHE LGNQDQGIPQ LRIVLLGKTG AGKSSTGNSI LGEKVFNSGI 

        70         80         90        100        110        120 
CAKSITKVCE KRVSTWDGKE LVVVDTPGIF DTEVPDADTQ REITRYVALT SPGPHALLLV 

       130        140        150        160        170        180 
VPLGRYTVEE HKATQKILDM FGKQARRFMI LLLTRKDDLE DTDIHEYLEK APKFFQEVMH 

       190        200        210 
EFQNRYCLFN NRASGAEKEE QKMQLLTLVQ SMFLSSRMK 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[2]"Gimap4 accelerates T-cell death."
Schnell S., Demolliere C., van den Berk P., Jacobs H.
Blood 108:591-599(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC005577 mRNA. Translation: AAH05577.1.
CCDSCCDS57423.1.
RefSeqNP_001230128.1. NM_001243199.1.
UniGeneMm.333048.
Mm.486676.
Mm.490512.

3D structure databases

ProteinModelPortalQ99JY3.
SMRQ99JY3. Positions 30-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99JY3. 2 interactions.
MINTMINT-4096095.
STRING10090.ENSMUSP00000087524.

PTM databases

PhosphoSiteQ99JY3.

Proteomic databases

MaxQBQ99JY3.
PaxDbQ99JY3.
PRIDEQ99JY3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435.
GeneID107526.
KEGGmmu:107526.
UCSCuc009bvi.2. mouse.

Organism-specific databases

CTD55303.
MGIMGI:1349656. Gimap4.

Phylogenomic databases

eggNOGNOG76898.
GeneTreeENSGT00750000117514.
HOGENOMHOG000115747.
HOVERGENHBG004016.

Gene expression databases

ArrayExpressQ99JY3.
BgeeQ99JY3.
CleanExMM_GIMAP4.
GenevestigatorQ99JY3.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR006703. AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio358978.
PROQ99JY3.
SOURCESearch...

Entry information

Entry nameGIMA4_MOUSE
AccessionPrimary (citable) accession number: Q99JY3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot