Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase IMAP family member 4

Gene

Gimap4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium (By similarity). May play a role in regulating lymphocyte apoptosis.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58GTPBy similarity1
Binding sitei191GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 45GTPBy similarity9
Nucleotide bindingi155 – 157GTPBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 4
Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name:
IAN-1
Immunity-associated protein 4
Gene namesi
Name:Gimap4
Synonyms:Ian1, Imap4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1349656. Gimap4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Increased apoptosis in mature T-cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909881 – 219GTPase IMAP family member 4Add BLAST219

Post-translational modificationi

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99JY3.
MaxQBiQ99JY3.
PaxDbiQ99JY3.
PeptideAtlasiQ99JY3.
PRIDEiQ99JY3.

Expressioni

Tissue specificityi

Detected on splenocytes, B-cells and T-cells (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000054435.
CleanExiMM_GIMAP4.
ExpressionAtlasiQ99JY3. baseline and differential.
GenevisibleiQ99JY3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ99JY3. 2 interactors.
MINTiMINT-4096095.
STRINGi10090.ENSMUSP00000087524.

Structurei

3D structure databases

ProteinModelPortaliQ99JY3.
SMRiQ99JY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 219AIG1-type GAdd BLAST192

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF8B. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ99JY3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQCGGAGF IPESSRSSHE LGNQDQGIPQ LRIVLLGKTG AGKSSTGNSI
60 70 80 90 100
LGEKVFNSGI CAKSITKVCE KRVSTWDGKE LVVVDTPGIF DTEVPDADTQ
110 120 130 140 150
REITRYVALT SPGPHALLLV VPLGRYTVEE HKATQKILDM FGKQARRFMI
160 170 180 190 200
LLLTRKDDLE DTDIHEYLEK APKFFQEVMH EFQNRYCLFN NRASGAEKEE
210
QKMQLLTLVQ SMFLSSRMK
Length:219
Mass (Da):24,554
Last modified:June 1, 2001 - v1
Checksum:iEDA63F448531A93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005577 mRNA. Translation: AAH05577.1.
CCDSiCCDS57423.1.
RefSeqiNP_001230128.1. NM_001243199.1.
UniGeneiMm.333048.
Mm.486676.
Mm.490512.

Genome annotation databases

EnsembliENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435.
GeneIDi107526.
KEGGimmu:107526.
UCSCiuc009bvi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005577 mRNA. Translation: AAH05577.1.
CCDSiCCDS57423.1.
RefSeqiNP_001230128.1. NM_001243199.1.
UniGeneiMm.333048.
Mm.486676.
Mm.490512.

3D structure databases

ProteinModelPortaliQ99JY3.
SMRiQ99JY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99JY3. 2 interactors.
MINTiMINT-4096095.
STRINGi10090.ENSMUSP00000087524.

Proteomic databases

EPDiQ99JY3.
MaxQBiQ99JY3.
PaxDbiQ99JY3.
PeptideAtlasiQ99JY3.
PRIDEiQ99JY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435.
GeneIDi107526.
KEGGimmu:107526.
UCSCiuc009bvi.2. mouse.

Organism-specific databases

CTDi55303.
MGIiMGI:1349656. Gimap4.

Phylogenomic databases

eggNOGiENOG410IF8B. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ99JY3.

Miscellaneous databases

PROiQ99JY3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054435.
CleanExiMM_GIMAP4.
ExpressionAtlasiQ99JY3. baseline and differential.
GenevisibleiQ99JY3. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA4_MOUSE
AccessioniPrimary (citable) accession number: Q99JY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.