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Protein

Transcription initiation factor TFIID subunit 11

Gene

Taf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein N-terminus binding Source: MGI
  3. thyroid hormone receptor binding Source: MGI
  4. transcription coactivator activity Source: MGI
  5. vitamin D receptor binding Source: MGI

GO - Biological processi

  1. positive regulation by host of viral transcription Source: MGI
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription initiation from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 11
Alternative name(s):
TFIID subunit p30-beta
Transcription initiation factor TFIID 28 kDa subunit
Short name:
TAF(II)28
Short name:
TAFII-28
Short name:
TAFII28
Gene namesi
Name:Taf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1916026. Taf11.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. nucleoplasm Source: MGI
  3. nucleus Source: MGI
  4. transcription factor TFIID complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Transcription initiation factor TFIID subunit 11PRO_0000118903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99JX1.
PRIDEiQ99JX1.

PTM databases

PhosphoSiteiQ99JX1.

Expressioni

Gene expression databases

BgeeiQ99JX1.
GenevestigatoriQ99JX1.

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).By similarity

Protein-protein interaction databases

IntActiQ99JX1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99JX1.
SMRiQ99JX1. Positions 113-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

TBP and TAFII18 bind to distinct domains of TAFII28.By similarity

Sequence similaritiesi

Belongs to the TAF11 family.Curated

Phylogenomic databases

eggNOGiCOG5251.
GeneTreeiENSGT00390000013228.
HOGENOMiHOG000006355.
HOVERGENiHBG079228.
InParanoidiQ99JX1.
KOiK03135.
OMAiMDDAHES.
OrthoDBiEOG7VDXQT.
PhylomeDBiQ99JX1.
TreeFamiTF315132.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR006809. TAFII28.
[Graphical view]
PANTHERiPTHR13218. PTHR13218. 1 hit.
PfamiPF04719. TAFII28. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99JX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLGESPTD KGGEPGESEE TRATPGALVA ADTEGIPEET DRDGDADLKE
60 70 80 90 100
AAAEESELKS QDVSDVTAAE RENSSLLTPA AKKLKLDIKD KKEKKQKVDE
110 120 130 140 150
DEIQKMQILV SSFSEEQLNR YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV
160 170 180 190 200
VIAMSGISKV FVGEVVEEAL DVCEKWGETP PLQPKHMREA VRRLKSKGQI
210
PNSKHKKITF F
Length:211
Mass (Da):23,333
Last modified:June 1, 2001 - v1
Checksum:iA19D3778C07513E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004168 mRNA. Translation: BAB23203.1.
AK050689 mRNA. Translation: BAC34381.1.
AK133851 mRNA. Translation: BAE21886.1.
BC005603 mRNA. Translation: AAH05603.1.
CCDSiCCDS28571.1.
RefSeqiNP_081112.1. NM_026836.2.
XP_006524924.1. XM_006524861.1.
XP_006524925.1. XM_006524862.1.
XP_006536847.1. XM_006536784.1.
XP_006536848.1. XM_006536785.1.
UniGeneiMm.267998.

Genome annotation databases

EnsembliENSMUST00000025057; ENSMUSP00000025057; ENSMUSG00000024218.
ENSMUST00000114848; ENSMUSP00000110498; ENSMUSG00000024218.
GeneIDi68776.
KEGGimmu:68776.
UCSCiuc008bpu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004168 mRNA. Translation: BAB23203.1.
AK050689 mRNA. Translation: BAC34381.1.
AK133851 mRNA. Translation: BAE21886.1.
BC005603 mRNA. Translation: AAH05603.1.
CCDSiCCDS28571.1.
RefSeqiNP_081112.1. NM_026836.2.
XP_006524924.1. XM_006524861.1.
XP_006524925.1. XM_006524862.1.
XP_006536847.1. XM_006536784.1.
XP_006536848.1. XM_006536785.1.
UniGeneiMm.267998.

3D structure databases

ProteinModelPortaliQ99JX1.
SMRiQ99JX1. Positions 113-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99JX1. 1 interaction.

PTM databases

PhosphoSiteiQ99JX1.

Proteomic databases

MaxQBiQ99JX1.
PRIDEiQ99JX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025057; ENSMUSP00000025057; ENSMUSG00000024218.
ENSMUST00000114848; ENSMUSP00000110498; ENSMUSG00000024218.
GeneIDi68776.
KEGGimmu:68776.
UCSCiuc008bpu.1. mouse.

Organism-specific databases

CTDi6882.
MGIiMGI:1916026. Taf11.

Phylogenomic databases

eggNOGiCOG5251.
GeneTreeiENSGT00390000013228.
HOGENOMiHOG000006355.
HOVERGENiHBG079228.
InParanoidiQ99JX1.
KOiK03135.
OMAiMDDAHES.
OrthoDBiEOG7VDXQT.
PhylomeDBiQ99JX1.
TreeFamiTF315132.

Enzyme and pathway databases

ReactomeiREACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.

Miscellaneous databases

ChiTaRSiTaf11. mouse.
NextBioi327906.
PROiQ99JX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ99JX1.
GenevestigatoriQ99JX1.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR006809. TAFII28.
[Graphical view]
PANTHERiPTHR13218. PTHR13218. 1 hit.
PfamiPF04719. TAFII28. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTAF11_MOUSE
AccessioniPrimary (citable) accession number: Q99JX1
Secondary accession number(s): Q3UZH1, Q9CT98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.