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Protein

LIM and senescent cell antigen-like-containing domain protein 1

Gene

Lims1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

GO - Molecular functioni

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • cell-cell junction organization Source: MGI
  • cell-matrix adhesion Source: MGI
  • chordate embryonic development Source: MGI
  • establishment of protein localization Source: MGI
  • establishment or maintenance of cell polarity Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of hepatocyte proliferation Source: MGI
  • negative regulation of neural precursor cell proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of cell-substrate adhesion Source: MGI
  • positive regulation of focal adhesion assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of integrin-mediated signaling pathway Source: MGI
  • positive regulation of NIK/NF-kappaB signaling Source: MGI
  • positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain protein 1
Alternative name(s):
Particularly interesting new Cys-His protein 1
Short name:
PINCH-1
Gene namesi
Name:Lims1
Synonyms:Pinch1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1195263. Lims1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002660092 – 325LIM and senescent cell antigen-like-containing domain protein 1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99JW4.
MaxQBiQ99JW4.
PaxDbiQ99JW4.
PRIDEiQ99JW4.

PTM databases

iPTMnetiQ99JW4.
PhosphoSitePlusiQ99JW4.

Expressioni

Gene expression databases

CleanExiMM_LIMS1.

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors (By similarity). Interacts (via LIM zinc-binding 5) with TGFB1I1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225940. 7 interactors.
CORUMiQ99JW4.
DIPiDIP-59289N.
IntActiQ99JW4. 2 interactors.
STRINGi10090.ENSMUSP00000020077.

Structurei

3D structure databases

ProteinModelPortaliQ99JW4.
SMRiQ99JW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 62LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini71 – 121LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST51
Domaini135 – 184LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST50
Domaini193 – 243LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST51
Domaini252 – 303LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG2272. Eukaryota.
ENOG410XP46. LUCA.
HOVERGENiHBG000053.
InParanoidiQ99JW4.
PhylomeDBiQ99JW4.
TreeFamiTF314113.

Family and domain databases

InterProiView protein in InterPro
IPR017351. PINCH.
IPR001781. Znf_LIM.
PANTHERiPTHR24210. PTHR24210. 1 hit.
PfamiView protein in Pfam
PF00412. LIM. 5 hits.
PIRSFiPIRSF038003. PINCH. 1 hit.
SMARTiView protein in SMART
SM00132. LIM. 5 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF
60 70 80 90 100
YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC
110 120 130 140 150
QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK
160 170 180 190 200
NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI
210 220 230 240 250
EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD
260 270 280 290 300
VCFHCNRVIE GDVVSALNKA WCVSCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KKCYEKFPLE LKKRLKKLSE TLGRK
Length:325
Mass (Da):37,240
Last modified:January 23, 2007 - v3
Checksum:iE665FEA59B5FFDFE
GO

Sequence cautioni

The sequence AAH05621 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29637 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38699 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC40663 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE30227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE30814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE31411 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE31922 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59C → S in BAE30227 (PubMed:16141072).Curated1
Sequence conflicti123N → D in BAB29637 (PubMed:16141072).Curated1
Sequence conflicti148I → T in BAB29637 (PubMed:16141072).Curated1
Sequence conflicti170A → V in BAC40663 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014954 mRNA. Translation: BAB29637.1. Different initiation.
AK082932 mRNA. Translation: BAC38699.1. Different initiation.
AK088939 mRNA. Translation: BAC40663.1. Different initiation.
AK151235 mRNA. Translation: BAE30227.1. Different initiation.
AK151938 mRNA. Translation: BAE30814.1. Different initiation.
AK152679 mRNA. Translation: BAE31411.1. Different initiation.
AK153346 mRNA. Translation: BAE31922.1. Different initiation.
BC005621 mRNA. Translation: AAH05621.1. Different initiation.
RefSeqiNP_080424.2. NM_026148.3.
XP_006513136.1. XM_006513073.2.
UniGeneiMm.402697.
Mm.482932.
Mm.57734.

Genome annotation databases

GeneIDi110829.
KEGGimmu:110829.
UCSCiuc011xeb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLIMS1_MOUSE
AccessioniPrimary (citable) accession number: Q99JW4
Secondary accession number(s): Q3UAT7, Q8BTR6, Q9D5T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot