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Q99JT6

- TLCD1_MOUSE

UniProt

Q99JT6 - TLCD1_MOUSE

Protein

Calfacilitin

Gene

Tlcd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation By similarity.By similarity

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calfacilitin
    Alternative name(s):
    TLC domain-containing protein 1
    Gene namesi
    Name:Tlcd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1915572. Tlcd1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 247220CalfacilitinPRO_0000285678Add
    BLAST

    Proteomic databases

    PRIDEiQ99JT6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99JT6.
    BgeeiQ99JT6.
    CleanExiMM_TLCD1.
    GenevestigatoriQ99JT6.

    Interactioni

    Subunit structurei

    Interacts with CACNA1C.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 4619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 12319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 17329ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini195 – 2017CytoplasmicSequence Analysis
    Topological domaini223 – 24725ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 234195TLCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258821.
    GeneTreeiENSGT00520000055611.
    HOGENOMiHOG000015396.
    HOVERGENiHBG100100.
    InParanoidiQ99JT6.
    OMAiCVERNIS.
    OrthoDBiEOG725DJM.
    PhylomeDBiQ99JT6.
    TreeFamiTF315115.

    Family and domain databases

    InterProiIPR006634. TLC-dom.
    [Graphical view]
    PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view]
    SMARTiSM00724. TLC. 1 hit.
    [Graphical view]
    PROSITEiPS50922. TLC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99JT6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLLFHPAWP LLLGATLTFR ALRRVLCRLP QPAHVQTDPL RTWRWHNLLV    50
    SFTHSIVSGI WALLCLWQTP EMLVEIETAW SASGYLLVCF SAGYFIHDTV 100
    DIVVSKQTRA SWEYLVHHVM AMGAFFSGIF WKRFVGGGVL TLLVEVSNIF 150
    LTLRMMMKIN NAQDLLLYKV NKYINLVMYF LFRLAPQAYL TKFFLQYAGQ 200
    RTLGTFLLAI LLMLDLMIII YFSRLLRSDF CPERAPRRQQ KDKFLTE 247
    Length:247
    Mass (Da):28,787
    Last modified:June 1, 2001 - v1
    Checksum:i84AEA3CBE8BE4093
    GO
    Isoform 2 (identifier: Q99JT6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         170-196: Missing.

    Show »
    Length:220
    Mass (Da):25,463
    Checksum:i4B79D9A43DEEFF4F
    GO
    Isoform 3 (identifier: Q99JT6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: MPLLFHPAWP...IVSGIWALLC → MRWPWDLSRG...QPRTAVGNPS

    Show »
    Length:230
    Mass (Da):26,548
    Checksum:i4C6FA50D091D0D29
    GO
    Isoform 4 (identifier: Q99JT6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-127: AMGAFFS → VRENPVK
         128-247: Missing.

    Show »
    Length:127
    Mass (Da):14,703
    Checksum:iA8E256D59F585165
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281R → H in BAE20654. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565MPLLF…WALLC → MRWPWDLSRGARTGLPLAIP ITGEQTPRISPDSVWKTTQP RTAVGNPS in isoform 3. 2 PublicationsVSP_024887Add
    BLAST
    Alternative sequencei121 – 1277AMGAFFS → VRENPVK in isoform 4. 1 PublicationVSP_024888
    Alternative sequencei128 – 247120Missing in isoform 4. 1 PublicationVSP_024889Add
    BLAST
    Alternative sequencei170 – 19627Missing in isoform 2. 1 PublicationVSP_024890Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002703 mRNA. Translation: BAB22297.1.
    AK046577 mRNA. Translation: BAE20654.1.
    AK161721 mRNA. Translation: BAE36548.1.
    AK165432 mRNA. Translation: BAE38185.1.
    AL591070 Genomic DNA. Translation: CAI24331.1.
    AL591070 Genomic DNA. Translation: CAI24332.1.
    AL591070 Genomic DNA. Translation: CAI24333.1.
    AL591070 Genomic DNA. Translation: CAI24334.1.
    BC005702 mRNA. Translation: AAH05702.1.
    BC039182 mRNA. Translation: AAH39182.1.
    CCDSiCCDS25092.1. [Q99JT6-1]
    CCDS70257.1. [Q99JT6-3]
    RefSeqiNP_001278165.1. NM_001291236.1. [Q99JT6-3]
    NP_001278166.1. NM_001291237.1. [Q99JT6-3]
    NP_080984.1. NM_026708.2. [Q99JT6-1]
    XP_006534117.1. XM_006534054.1. [Q99JT6-1]
    UniGeneiMm.390375.

    Genome annotation databases

    EnsembliENSMUST00000092880; ENSMUSP00000090556; ENSMUSG00000019437. [Q99JT6-3]
    ENSMUST00000098545; ENSMUSP00000096145; ENSMUSG00000019437. [Q99JT6-2]
    ENSMUST00000108338; ENSMUSP00000103975; ENSMUSG00000019437. [Q99JT6-4]
    ENSMUST00000127587; ENSMUSP00000114202; ENSMUSG00000019437. [Q99JT6-1]
    GeneIDi68385.
    KEGGimmu:68385.
    UCSCiuc007kij.1. mouse. [Q99JT6-1]
    uc007kik.1. mouse. [Q99JT6-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002703 mRNA. Translation: BAB22297.1 .
    AK046577 mRNA. Translation: BAE20654.1 .
    AK161721 mRNA. Translation: BAE36548.1 .
    AK165432 mRNA. Translation: BAE38185.1 .
    AL591070 Genomic DNA. Translation: CAI24331.1 .
    AL591070 Genomic DNA. Translation: CAI24332.1 .
    AL591070 Genomic DNA. Translation: CAI24333.1 .
    AL591070 Genomic DNA. Translation: CAI24334.1 .
    BC005702 mRNA. Translation: AAH05702.1 .
    BC039182 mRNA. Translation: AAH39182.1 .
    CCDSi CCDS25092.1. [Q99JT6-1 ]
    CCDS70257.1. [Q99JT6-3 ]
    RefSeqi NP_001278165.1. NM_001291236.1. [Q99JT6-3 ]
    NP_001278166.1. NM_001291237.1. [Q99JT6-3 ]
    NP_080984.1. NM_026708.2. [Q99JT6-1 ]
    XP_006534117.1. XM_006534054.1. [Q99JT6-1 ]
    UniGenei Mm.390375.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q99JT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092880 ; ENSMUSP00000090556 ; ENSMUSG00000019437 . [Q99JT6-3 ]
    ENSMUST00000098545 ; ENSMUSP00000096145 ; ENSMUSG00000019437 . [Q99JT6-2 ]
    ENSMUST00000108338 ; ENSMUSP00000103975 ; ENSMUSG00000019437 . [Q99JT6-4 ]
    ENSMUST00000127587 ; ENSMUSP00000114202 ; ENSMUSG00000019437 . [Q99JT6-1 ]
    GeneIDi 68385.
    KEGGi mmu:68385.
    UCSCi uc007kij.1. mouse. [Q99JT6-1 ]
    uc007kik.1. mouse. [Q99JT6-3 ]

    Organism-specific databases

    CTDi 116238.
    MGIi MGI:1915572. Tlcd1.

    Phylogenomic databases

    eggNOGi NOG258821.
    GeneTreei ENSGT00520000055611.
    HOGENOMi HOG000015396.
    HOVERGENi HBG100100.
    InParanoidi Q99JT6.
    OMAi CVERNIS.
    OrthoDBi EOG725DJM.
    PhylomeDBi Q99JT6.
    TreeFami TF315115.

    Miscellaneous databases

    NextBioi 327098.
    PROi Q99JT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JT6.
    Bgeei Q99JT6.
    CleanExi MM_TLCD1.
    Genevestigatori Q99JT6.

    Family and domain databases

    InterProi IPR006634. TLC-dom.
    [Graphical view ]
    Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view ]
    SMARTi SM00724. TLC. 1 hit.
    [Graphical view ]
    PROSITEi PS50922. TLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Strain: C57BL/6J.
      Tissue: Adipose tissue, Kidney and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTLCD1_MOUSE
    AccessioniPrimary (citable) accession number: Q99JT6
    Secondary accession number(s): Q3V372
    , Q5SYM9, Q8CHT9, Q9DCK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3