Q99JT6 (TLCD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TLC domain-containing protein 1

Gene names

Name:

Tlcd1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99JT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99JT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     170-196: Missing.

Isoform 3 (identifier: Q99JT6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MPLLFHPAWP...IVSGIWALLC → MRWPWDLSRG...QPRTAVGNPS

Isoform 4 (identifier: Q99JT6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     121-127: AMGAFFS → VRENPVK
     128-247: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 247	220	TLC domain-containing protein 1		PRO_0000285678
Regions
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	110 – 129	20	Helical; Potential
	Transmembrane	134 – 153	20	Helical; Potential
	Transmembrane	173 – 190	18	Helical; Potential
	Transmembrane	202 – 222	21	Helical; Potential
	Domain	40 – 234	195	TLC
Natural variations
	Alternative sequence	1 – 65	65	MPLLF…WALLC → MRWPWDLSRGARTGLPLAIP ITGEQTPRISPDSVWKTTQP RTAVGNPS in isoform 3.		VSP_024887
	Alternative sequence	121 – 127	7	AMGAFFS → VRENPVK in isoform 4.		VSP_024888
	Alternative sequence	128 – 247	120	Missing in isoform 4.		VSP_024889
	Alternative sequence	170 – 196	27	Missing in isoform 2.		VSP_024890
Experimental info
	Sequence conflict	28	1	R → H in BAE20654. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 84AEA3CBE8BE4093	FASTA	247	28,787
	10 20 30 40 50 60 MPLLFHPAWP LLLGATLTFR ALRRVLCRLP QPAHVQTDPL RTWRWHNLLV SFTHSIVSGI 70 80 90 100 110 120 WALLCLWQTP EMLVEIETAW SASGYLLVCF SAGYFIHDTV DIVVSKQTRA SWEYLVHHVM 130 140 150 160 170 180 AMGAFFSGIF WKRFVGGGVL TLLVEVSNIF LTLRMMMKIN NAQDLLLYKV NKYINLVMYF 190 200 210 220 230 240 LFRLAPQAYL TKFFLQYAGQ RTLGTFLLAI LLMLDLMIII YFSRLLRSDF CPERAPRRQQ KDKFLTE
	Isoform 2 [UniParc]. Checksum: 4B79D9A43DEEFF4F	FASTA	220	25,463
	10 20 30 40 50 60 MPLLFHPAWP LLLGATLTFR ALRRVLCRLP QPAHVQTDPL RTWRWHNLLV SFTHSIVSGI 70 80 90 100 110 120 WALLCLWQTP EMLVEIETAW SASGYLLVCF SAGYFIHDTV DIVVSKQTRA SWEYLVHHVM 130 140 150 160 170 180 AMGAFFSGIF WKRFVGGGVL TLLVEVSNIF LTLRMMMKIN NAQDLLLYKY AGQRTLGTFL 190 200 210 220 LAILLMLDLM IIIYFSRLLR SDFCPERAPR RQQKDKFLTE
	Isoform 3 [UniParc]. Checksum: 4C6FA50D091D0D29	FASTA	230	26,548
	10 20 30 40 50 60 MRWPWDLSRG ARTGLPLAIP ITGEQTPRIS PDSVWKTTQP RTAVGNPSLW QTPEMLVEIE 70 80 90 100 110 120 TAWSASGYLL VCFSAGYFIH DTVDIVVSKQ TRASWEYLVH HVMAMGAFFS GIFWKRFVGG 130 140 150 160 170 180 GVLTLLVEVS NIFLTLRMMM KINNAQDLLL YKVNKYINLV MYFLFRLAPQ AYLTKFFLQY 190 200 210 220 230 AGQRTLGTFL LAILLMLDLM IIIYFSRLLR SDFCPERAPR RQQKDKFLTE
	Isoform 4 [UniParc]. Checksum: A8E256D59F585165	FASTA	127	14,703
	10 20 30 40 50 60 MPLLFHPAWP LLLGATLTFR ALRRVLCRLP QPAHVQTDPL RTWRWHNLLV SFTHSIVSGI 70 80 90 100 110 120 WALLCLWQTP EMLVEIETAW SASGYLLVCF SAGYFIHDTV DIVVSKQTRA SWEYLVHHVM VRENPVK

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Strain: C57BL/6J. Tissue: Adipose tissue, Kidney and Thymus.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Strain: Czech II and FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002703 mRNA. Translation: BAB22297.1. AK046577 mRNA. Translation: BAE20654.1. AK161721 mRNA. Translation: BAE36548.1. AK165432 mRNA. Translation: BAE38185.1. AL591070 Genomic DNA. Translation: CAI24331.1. AL591070 Genomic DNA. Translation: CAI24332.1. AL591070 Genomic DNA. Translation: CAI24333.1. AL591070 Genomic DNA. Translation: CAI24334.1. BC005702 mRNA. Translation: AAH05702.1. BC039182 mRNA. Translation: AAH39182.1.
IPI	IPI00162802. IPI00407672. IPI00515431. IPI00648398.
RefSeq	NP_080984.1. NM_026708.1.
UniGene	Mm.390375.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q99JT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092880; ENSMUSP00000090556; ENSMUSG00000019437. ENSMUST00000098545; ENSMUSP00000096145; ENSMUSG00000019437. ENSMUST00000108338; ENSMUSP00000103975; ENSMUSG00000019437. ENSMUST00000127587; ENSMUSP00000114202; ENSMUSG00000019437.
GeneID	68385.
KEGG	mmu:68385.
UCSC	uc007kij.1. mouse. uc007kik.1. mouse.
Organism-specific databases
CTD	116238.
MGI	MGI:1915572. Tlcd1.
Phylogenomic databases
eggNOG	NOG258821.
GeneTree	ENSGT00520000055611.
HOGENOM	HOG000015396.
HOVERGEN	HBG100100.
InParanoid	Q99JT6.
OMA	GIWALLC.
OrthoDB	EOG4K6G57.
Gene expression databases
ArrayExpress	Q99JT6.
Bgee	Q99JT6.
CleanEx	MM_TLCD1.
Genevestigator	Q99JT6.
Family and domain databases
InterPro	IPR006634. TLC-dom. [Graphical view]
Pfam	PF03798. TRAM_LAG1_CLN8. 1 hit. [Graphical view]
SMART	SM00724. TLC. 1 hit. [Graphical view]
PROSITE	PS50922. TLC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	327098.
SOURCE	Search...

Entry information

Entry name

TLCD1_MOUSE

Accession

Primary (citable) accession number: Q99JT6
Secondary accession number(s): Q3V372 , Q5SYM9, Q8CHT9, Q9DCK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program