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Q99JT2

- MST4_MOUSE

UniProt

Q99JT2 - MST4_MOUSE

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Protein
Serine/threonine-protein kinase MST4
Gene
Mst4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediator of cell growth. Modulates apoptosis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531ATP By similarityBy similarity
Active sitei144 – 1441Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 389ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein kinase activity Source: UniProtKB
  4. receptor signaling protein serine/threonine kinase activity Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: RefGenome
  2. intracellular signal transduction Source: RefGenome
  3. protein phosphorylation Source: UniProtKB
  4. regulation of apoptotic process Source: UniProtKB
  5. regulation of cell differentiation Source: RefGenome
  6. signal transduction by phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_224460. Apoptotic cleavage of cellular proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MST4 (EC:2.7.11.1)
Alternative name(s):
Mammalian STE20-like protein kinase 4
Short name:
MST-4
STE20-like kinase MST4
Gene namesi
Name:Mst4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1917665. 2610018G03Rik.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Localizes to the Golgi apparatus By similarity.

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. cytoplasm Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Serine/threonine-protein kinase MST4
PRO_0000086405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphothreonine; by autocatalysis By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99JT2.
PaxDbiQ99JT2.
PRIDEiQ99JT2.

PTM databases

PhosphoSiteiQ99JT2.

Expressioni

Gene expression databases

ArrayExpressiQ99JT2.
BgeeiQ99JT2.
CleanExiMM_2610018G03RIK.
GenevestigatoriQ99JT2.

Interactioni

Subunit structurei

Homodimer. Interacts with PDCD10 and GOLGA2 By similarity. Interacts with CTTNBP2NL By similarity.

Protein-protein interaction databases

BioGridi214035. 1 interaction.
IntActiQ99JT2. 17 interactions.
STRINGi10090.ENSMUSP00000033444.

Structurei

3D structure databases

ProteinModelPortaliQ99JT2.
SMRiQ99JT2. Positions 17-331, 344-412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 274251Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091192.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ99JT2.
KOiK08838.
OMAiMEKFQKF.
OrthoDBiEOG77T14Q.
PhylomeDBiQ99JT2.
TreeFamiTF354217.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JT2-1 [UniParc]FASTAAdd to Basket

« Hide

MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV    50
AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME 100
YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV 150
LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA 200
DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLI GDFTKSFKEF 250
IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS 300
DEESDSEGSD SESSSRESNP HPEWSFTTVR KKPDPKKLQN GEEQDLVQTL 350
SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAET ACPGITDKMV 400
KKLIEKFQKC SADESP 416
Length:416
Mass (Da):46,614
Last modified:June 1, 2001 - v1
Checksum:i87EF04547F8BE681
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034609 mRNA. Translation: BAC28768.1.
BC005708 mRNA. Translation: AAH05708.1.
CCDSiCCDS40968.1.
RefSeqiNP_598490.1. NM_133729.1.
UniGeneiMm.391246.

Genome annotation databases

EnsembliENSMUST00000033444; ENSMUSP00000033444; ENSMUSG00000031112.
GeneIDi70415.
KEGGimmu:70415.
UCSCiuc009tdr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK034609 mRNA. Translation: BAC28768.1 .
BC005708 mRNA. Translation: AAH05708.1 .
CCDSi CCDS40968.1.
RefSeqi NP_598490.1. NM_133729.1.
UniGenei Mm.391246.

3D structure databases

ProteinModelPortali Q99JT2.
SMRi Q99JT2. Positions 17-331, 344-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214035. 1 interaction.
IntActi Q99JT2. 17 interactions.
STRINGi 10090.ENSMUSP00000033444.

PTM databases

PhosphoSitei Q99JT2.

Proteomic databases

MaxQBi Q99JT2.
PaxDbi Q99JT2.
PRIDEi Q99JT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033444 ; ENSMUSP00000033444 ; ENSMUSG00000031112 .
GeneIDi 70415.
KEGGi mmu:70415.
UCSCi uc009tdr.1. mouse.

Organism-specific databases

MGIi MGI:1917665. 2610018G03Rik.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091192.
HOGENOMi HOG000234203.
HOVERGENi HBG108518.
InParanoidi Q99JT2.
KOi K08838.
OMAi MEKFQKF.
OrthoDBi EOG77T14Q.
PhylomeDBi Q99JT2.
TreeFami TF354217.

Enzyme and pathway databases

Reactomei REACT_224460. Apoptotic cleavage of cellular proteins.

Miscellaneous databases

NextBioi 331563.
PROi Q99JT2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99JT2.
Bgeei Q99JT2.
CleanExi MM_2610018G03RIK.
Genevestigatori Q99JT2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMST4_MOUSE
AccessioniPrimary (citable) accession number: Q99JT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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