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Protein

Serine/threonine-protein kinase 26

Gene

Stk26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediator of cell growth. Modulates apoptosis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531ATPPROSITE-ProRule annotationBy similarity
Active sitei144 – 1441Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 389ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_277640. Apoptotic cleavage of cellular proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 26Curated (EC:2.7.11.1By similarity)
Alternative name(s):
Mammalian STE20-like protein kinase 4Curated
Short name:
MST-4Curated
STE20-like kinase MST4Curated
Serine/threonine-protein kinase MST4Curated
Gene namesi
Name:Stk26Imported
Synonyms:Mst4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917665. Stk26.

Subcellular locationi

  • Cytoplasm By similarity
  • Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Localizes to the Golgi apparatus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Serine/threonine-protein kinase 26PRO_0000086405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99JT2.
PaxDbiQ99JT2.
PRIDEiQ99JT2.

PTM databases

PhosphoSiteiQ99JT2.

Expressioni

Gene expression databases

BgeeiQ99JT2.
CleanExiMM_2610018G03RIK.
ExpressionAtlasiQ99JT2. baseline and differential.
GenevisibleiQ99JT2. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL.By similarity

Protein-protein interaction databases

BioGridi214035. 1 interaction.
IntActiQ99JT2. 17 interactions.
STRINGi10090.ENSMUSP00000033444.

Structurei

3D structure databases

ProteinModelPortaliQ99JT2.
SMRiQ99JT2. Positions 17-297, 344-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 274251Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091192.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ99JT2.
KOiK08838.
OMAiMEKFQKF.
OrthoDBiEOG77T14Q.
PhylomeDBiQ99JT2.
TreeFamiTF354217.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV
60 70 80 90 100
AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME
110 120 130 140 150
YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV
160 170 180 190 200
LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA
210 220 230 240 250
DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLI GDFTKSFKEF
260 270 280 290 300
IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS
310 320 330 340 350
DEESDSEGSD SESSSRESNP HPEWSFTTVR KKPDPKKLQN GEEQDLVQTL
360 370 380 390 400
SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAET ACPGITDKMV
410
KKLIEKFQKC SADESP
Length:416
Mass (Da):46,614
Last modified:June 1, 2001 - v1
Checksum:i87EF04547F8BE681
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034609 mRNA. Translation: BAC28768.1.
BC005708 mRNA. Translation: AAH05708.1.
CCDSiCCDS40968.1.
RefSeqiNP_598490.1. NM_133729.1.
UniGeneiMm.391246.

Genome annotation databases

EnsembliENSMUST00000033444; ENSMUSP00000033444; ENSMUSG00000031112.
GeneIDi70415.
KEGGimmu:70415.
UCSCiuc009tdr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034609 mRNA. Translation: BAC28768.1.
BC005708 mRNA. Translation: AAH05708.1.
CCDSiCCDS40968.1.
RefSeqiNP_598490.1. NM_133729.1.
UniGeneiMm.391246.

3D structure databases

ProteinModelPortaliQ99JT2.
SMRiQ99JT2. Positions 17-297, 344-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214035. 1 interaction.
IntActiQ99JT2. 17 interactions.
STRINGi10090.ENSMUSP00000033444.

PTM databases

PhosphoSiteiQ99JT2.

Proteomic databases

MaxQBiQ99JT2.
PaxDbiQ99JT2.
PRIDEiQ99JT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033444; ENSMUSP00000033444; ENSMUSG00000031112.
GeneIDi70415.
KEGGimmu:70415.
UCSCiuc009tdr.1. mouse.

Organism-specific databases

CTDi51765.
MGIiMGI:1917665. Stk26.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091192.
HOGENOMiHOG000234203.
HOVERGENiHBG108518.
InParanoidiQ99JT2.
KOiK08838.
OMAiMEKFQKF.
OrthoDBiEOG77T14Q.
PhylomeDBiQ99JT2.
TreeFamiTF354217.

Enzyme and pathway databases

ReactomeiREACT_277640. Apoptotic cleavage of cellular proteins.

Miscellaneous databases

NextBioi331563.
PROiQ99JT2.
SOURCEiSearch...

Gene expression databases

BgeeiQ99JT2.
CleanExiMM_2610018G03RIK.
ExpressionAtlasiQ99JT2. baseline and differential.
GenevisibleiQ99JT2. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiSTK26_MOUSE
AccessioniPrimary (citable) accession number: Q99JT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.