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Protein

Tubulointerstitial nephritis antigen-like

Gene

Tinagl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulointerstitial nephritis antigen-like
Alternative name(s):
Adrenocortical zonation factor 1
Short name:
AZ-1
Androgen-regulated gene 1 protein
Tubulointerstitial nephritis antigen-related protein
Short name:
TARP
Gene namesi
Name:Tinagl1
Synonyms:Arg1, Lcn7, Tinagl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2137617. Tinagl1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: Ensembl
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 466445Tubulointerstitial nephritis antigen-likePRO_0000026483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 72AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 84AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 72PROSITE-ProRule annotation
Disulfide bondi76 ↔ 83PROSITE-ProRule annotation
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi84 ↔ 91PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99JR5.
PaxDbiQ99JR5.
PRIDEiQ99JR5.

PTM databases

PhosphoSiteiQ99JR5.

Expressioni

Tissue specificityi

Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level).2 Publications

Inductioni

Down-regulated in prostate after castration.1 Publication

Gene expression databases

BgeeiQ99JR5.
CleanExiMM_ARG1.
ExpressionAtlasiQ99JR5. baseline and differential.
GenevisibleiQ99JR5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030560.

Structurei

3D structure databases

ProteinModelPortaliQ99JR5.
SMRiQ99JR5. Positions 144-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 9648SMBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Contains 1 SMB (somatomedin-B) domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG310046.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ99JR5.
OMAiIQSMGHM.
OrthoDBiEOG7SV0V1.
PhylomeDBiQ99JR5.
TreeFamiTF313765.

Family and domain databases

InterProiIPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
SM00201. SO. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGCWLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ
60 70 80 90 100
DMCCRGRADE CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP
110 120 130 140 150
VQGCMHGGRI YPVFGTYWDN CNRCTCHEGG HWECDQEPCL VDPDMIKAIN
160 170 180 190 200
RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI RPSSTVMNMN EIYTVLGQGE
210 220 230 240 250
VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR VSIHSLGHMT
260 270 280 290 300
PILSPQNLLS CDTHHQQGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN
310 320 330 340 350
EASPTPRCMM HSRAMGRGKR QATSRCPNGQ VDSNDIYQVT PAYRLGSDEK
360 370 380 390 400
EIMKELMENG PVQALMEVHE DFFLYQRGIY SHTPVSQGRP EQYRRHGTHS
410 420 430 440 450
VKITGWGEET LPDGRTIKYW TAANSWGPWW GERGHFRIVR GTNECDIETF
460
VLGVWGRVGM EDMGHH
Length:466
Mass (Da):52,665
Last modified:June 1, 2001 - v1
Checksum:iD12ABDCC8F63F36D
GO

Sequence cautioni

The sequence BAB20596.1 differs from that shown. Reason: Frameshift at position 43. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047402 mRNA. Translation: BAB20596.1. Sequence problems.
AB050626 mRNA. Translation: BAC76038.1.
BC005738 mRNA. Translation: AAH05738.1.
BC018539 mRNA. Translation: AAH18539.1.
CCDSiCCDS18708.2.
RefSeqiNP_001161805.1. NM_001168333.1.
NP_075965.2. NM_023476.3.
UniGeneiMm.15801.

Genome annotation databases

EnsembliENSMUST00000030560; ENSMUSP00000030560; ENSMUSG00000028776.
ENSMUST00000105998; ENSMUSP00000101620; ENSMUSG00000028776.
ENSMUST00000105999; ENSMUSP00000101621; ENSMUSG00000028776.
GeneIDi94242.
KEGGimmu:94242.
UCSCiuc008uyz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047402 mRNA. Translation: BAB20596.1. Sequence problems.
AB050626 mRNA. Translation: BAC76038.1.
BC005738 mRNA. Translation: AAH05738.1.
BC018539 mRNA. Translation: AAH18539.1.
CCDSiCCDS18708.2.
RefSeqiNP_001161805.1. NM_001168333.1.
NP_075965.2. NM_023476.3.
UniGeneiMm.15801.

3D structure databases

ProteinModelPortaliQ99JR5.
SMRiQ99JR5. Positions 144-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030560.

Protein family/group databases

MEROPSiC01.975.

PTM databases

PhosphoSiteiQ99JR5.

Proteomic databases

MaxQBiQ99JR5.
PaxDbiQ99JR5.
PRIDEiQ99JR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030560; ENSMUSP00000030560; ENSMUSG00000028776.
ENSMUST00000105998; ENSMUSP00000101620; ENSMUSG00000028776.
ENSMUST00000105999; ENSMUSP00000101621; ENSMUSG00000028776.
GeneIDi94242.
KEGGimmu:94242.
UCSCiuc008uyz.2. mouse.

Organism-specific databases

CTDi64129.
MGIiMGI:2137617. Tinagl1.

Phylogenomic databases

eggNOGiNOG310046.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ99JR5.
OMAiIQSMGHM.
OrthoDBiEOG7SV0V1.
PhylomeDBiQ99JR5.
TreeFamiTF313765.

Miscellaneous databases

NextBioi352247.
PROiQ99JR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ99JR5.
CleanExiMM_ARG1.
ExpressionAtlasiQ99JR5. baseline and differential.
GenevisibleiQ99JR5. MM.

Family and domain databases

InterProiIPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
SM00201. SO. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells."
    Kobayashi M., Kinouchi T., Hakamata Y., Kamiakito T., Kuriki K., Suzuki K., Tokue A., Fukayama M., Tanaka A.
    J. Steroid Biochem. Mol. Biol. 77:109-115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
  2. "An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta - hydroxylase in adrenocortical cells."
    Mukai K., Mitani F., Nagasawa H., Suzuki R., Suzuki T., Suematsu M., Ishimura Y.
    J. Biol. Chem. 278:17084-17092(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Adrenal cortex.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTINAL_MOUSE
AccessioniPrimary (citable) accession number: Q99JR5
Secondary accession number(s): Q9EQT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.