Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99JR5

- TINAL_MOUSE

UniProt

Q99JR5 - TINAL_MOUSE

Protein

Tubulointerstitial nephritis antigen-like

Gene

Tinagl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein.1 Publication

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: InterPro
    2. laminin binding Source: MGI
    3. polysaccharide binding Source: InterPro
    4. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. immune response Source: InterPro

    Protein family/group databases

    MEROPSiC01.975.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulointerstitial nephritis antigen-like
    Alternative name(s):
    Adrenocortical zonation factor 1
    Short name:
    AZ-1
    Androgen-regulated gene 1 protein
    Tubulointerstitial nephritis antigen-related protein
    Short name:
    TARP
    Gene namesi
    Name:Tinagl1
    Synonyms:Arg1, Lcn7, Tinagl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2137617. Tinagl1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular matrix Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 466445Tubulointerstitial nephritis antigen-likePRO_0000026483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 72AlternatePROSITE-ProRule annotation
    Disulfide bondi70 ↔ 84AlternatePROSITE-ProRule annotation
    Disulfide bondi70 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi76 ↔ 83PROSITE-ProRule annotation
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi84 ↔ 91PROSITE-ProRule annotation
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ99JR5.
    PaxDbiQ99JR5.
    PRIDEiQ99JR5.

    PTM databases

    PhosphoSiteiQ99JR5.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level).2 Publications

    Inductioni

    Down-regulated in prostate after castration.1 Publication

    Gene expression databases

    ArrayExpressiQ99JR5.
    BgeeiQ99JR5.
    CleanExiMM_ARG1.
    GenevestigatoriQ99JR5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JR5.
    SMRiQ99JR5. Positions 144-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 9648SMBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation
    Contains 1 SMB (somatomedin-B) domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG310046.
    GeneTreeiENSGT00730000110701.
    HOGENOMiHOG000241342.
    HOVERGENiHBG053961.
    InParanoidiQ99JR5.
    OMAiDNCNRCT.
    OrthoDBiEOG7SV0V1.
    PhylomeDBiQ99JR5.
    TreeFamiTF313765.

    Family and domain databases

    InterProiIPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR001212. Somatomedin_B_dom.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    SMARTiSM00645. Pept_C1. 1 hit.
    SM00201. SO. 1 hit.
    [Graphical view]
    PROSITEiPS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99JR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGCWLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ    50
    DMCCRGRADE CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP 100
    VQGCMHGGRI YPVFGTYWDN CNRCTCHEGG HWECDQEPCL VDPDMIKAIN 150
    RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI RPSSTVMNMN EIYTVLGQGE 200
    VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR VSIHSLGHMT 250
    PILSPQNLLS CDTHHQQGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN 300
    EASPTPRCMM HSRAMGRGKR QATSRCPNGQ VDSNDIYQVT PAYRLGSDEK 350
    EIMKELMENG PVQALMEVHE DFFLYQRGIY SHTPVSQGRP EQYRRHGTHS 400
    VKITGWGEET LPDGRTIKYW TAANSWGPWW GERGHFRIVR GTNECDIETF 450
    VLGVWGRVGM EDMGHH 466
    Length:466
    Mass (Da):52,665
    Last modified:June 1, 2001 - v1
    Checksum:iD12ABDCC8F63F36D
    GO

    Sequence cautioni

    The sequence BAB20596.1 differs from that shown. Reason: Frameshift at position 43.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047402 mRNA. Translation: BAB20596.1. Sequence problems.
    AB050626 mRNA. Translation: BAC76038.1.
    BC005738 mRNA. Translation: AAH05738.1.
    BC018539 mRNA. Translation: AAH18539.1.
    CCDSiCCDS18708.2.
    RefSeqiNP_001161805.1. NM_001168333.1.
    NP_075965.2. NM_023476.3.
    UniGeneiMm.15801.

    Genome annotation databases

    EnsembliENSMUST00000030560; ENSMUSP00000030560; ENSMUSG00000028776.
    ENSMUST00000105998; ENSMUSP00000101620; ENSMUSG00000028776.
    ENSMUST00000105999; ENSMUSP00000101621; ENSMUSG00000028776.
    GeneIDi94242.
    KEGGimmu:94242.
    UCSCiuc008uyz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047402 mRNA. Translation: BAB20596.1 . Sequence problems.
    AB050626 mRNA. Translation: BAC76038.1 .
    BC005738 mRNA. Translation: AAH05738.1 .
    BC018539 mRNA. Translation: AAH18539.1 .
    CCDSi CCDS18708.2.
    RefSeqi NP_001161805.1. NM_001168333.1.
    NP_075965.2. NM_023476.3.
    UniGenei Mm.15801.

    3D structure databases

    ProteinModelPortali Q99JR5.
    SMRi Q99JR5. Positions 144-453.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C01.975.

    PTM databases

    PhosphoSitei Q99JR5.

    Proteomic databases

    MaxQBi Q99JR5.
    PaxDbi Q99JR5.
    PRIDEi Q99JR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030560 ; ENSMUSP00000030560 ; ENSMUSG00000028776 .
    ENSMUST00000105998 ; ENSMUSP00000101620 ; ENSMUSG00000028776 .
    ENSMUST00000105999 ; ENSMUSP00000101621 ; ENSMUSG00000028776 .
    GeneIDi 94242.
    KEGGi mmu:94242.
    UCSCi uc008uyz.2. mouse.

    Organism-specific databases

    CTDi 64129.
    MGIi MGI:2137617. Tinagl1.

    Phylogenomic databases

    eggNOGi NOG310046.
    GeneTreei ENSGT00730000110701.
    HOGENOMi HOG000241342.
    HOVERGENi HBG053961.
    InParanoidi Q99JR5.
    OMAi DNCNRCT.
    OrthoDBi EOG7SV0V1.
    PhylomeDBi Q99JR5.
    TreeFami TF313765.

    Miscellaneous databases

    NextBioi 352247.
    PROi Q99JR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99JR5.
    Bgeei Q99JR5.
    CleanExi MM_ARG1.
    Genevestigatori Q99JR5.

    Family and domain databases

    InterProi IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR001212. Somatomedin_B_dom.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    SMARTi SM00645. Pept_C1. 1 hit.
    SM00201. SO. 1 hit.
    [Graphical view ]
    PROSITEi PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells."
      Kobayashi M., Kinouchi T., Hakamata Y., Kamiakito T., Kuriki K., Suzuki K., Tokue A., Fukayama M., Tanaka A.
      J. Steroid Biochem. Mol. Biol. 77:109-115(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
    2. "An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta - hydroxylase in adrenocortical cells."
      Mukai K., Mitani F., Nagasawa H., Suzuki R., Suzuki T., Suematsu M., Ishimura Y.
      J. Biol. Chem. 278:17084-17092(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Adrenal cortex.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTINAL_MOUSE
    AccessioniPrimary (citable) accession number: Q99JR5
    Secondary accession number(s): Q9EQT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3