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Q99JR5 (TINAL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tubulointerstitial nephritis antigen-like
Alternative name(s):
Adrenocortical zonation factor 1
Short name=AZ-1
Androgen-regulated gene 1 protein
Tubulointerstitial nephritis antigen-related protein
Short name=TARP
Gene names
Name:Tinagl1
Synonyms:Arg1, Lcn7, Tinagl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. Ref.2

Subcellular location

Secreted.

Tissue specificity

Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level). Ref.1 Ref.2

Induction

Down-regulated in prostate after castration. Ref.1

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Contains 1 SMB (somatomedin-B) domain.

Sequence caution

The sequence BAB20596.1 differs from that shown. Reason: Frameshift at position 43.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 466445Tubulointerstitial nephritis antigen-like
PRO_0000026483

Regions

Domain49 – 9648SMB

Amino acid modifications

Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 72Alternate By similarity
Disulfide bond70 ↔ 84Alternate By similarity
Disulfide bond70 ↔ 72 By similarity
Disulfide bond76 ↔ 83 By similarity
Disulfide bond84 ↔ 91 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99JR5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D12ABDCC8F63F36D

FASTA46652,665
        10         20         30         40         50         60 
MWGCWLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ DMCCRGRADE 

        70         80         90        100        110        120 
CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP VQGCMHGGRI YPVFGTYWDN 

       130        140        150        160        170        180 
CNRCTCHEGG HWECDQEPCL VDPDMIKAIN RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI 

       190        200        210        220        230        240 
RPSSTVMNMN EIYTVLGQGE VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR 

       250        260        270        280        290        300 
VSIHSLGHMT PILSPQNLLS CDTHHQQGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN 

       310        320        330        340        350        360 
EASPTPRCMM HSRAMGRGKR QATSRCPNGQ VDSNDIYQVT PAYRLGSDEK EIMKELMENG 

       370        380        390        400        410        420 
PVQALMEVHE DFFLYQRGIY SHTPVSQGRP EQYRRHGTHS VKITGWGEET LPDGRTIKYW 

       430        440        450        460 
TAANSWGPWW GERGHFRIVR GTNECDIETF VLGVWGRVGM EDMGHH 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells."
Kobayashi M., Kinouchi T., Hakamata Y., Kamiakito T., Kuriki K., Suzuki K., Tokue A., Fukayama M., Tanaka A.
J. Steroid Biochem. Mol. Biol. 77:109-115(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
[2]"An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta - hydroxylase in adrenocortical cells."
Mukai K., Mitani F., Nagasawa H., Suzuki R., Suzuki T., Suematsu M., Ishimura Y.
J. Biol. Chem. 278:17084-17092(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
Tissue: Adrenal cortex.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II and FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB047402 mRNA. Translation: BAB20596.1. Sequence problems.
AB050626 mRNA. Translation: BAC76038.1.
BC005738 mRNA. Translation: AAH05738.1.
BC018539 mRNA. Translation: AAH18539.1.
RefSeqNP_001161805.1. NM_001168333.1.
NP_075965.2. NM_023476.3.
UniGeneMm.15801.

3D structure databases

ProteinModelPortalQ99JR5.
SMRQ99JR5. Positions 144-457.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.975.

PTM databases

PhosphoSiteQ99JR5.

Proteomic databases

PaxDbQ99JR5.
PRIDEQ99JR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030560; ENSMUSP00000030560; ENSMUSG00000028776.
ENSMUST00000105998; ENSMUSP00000101620; ENSMUSG00000028776.
ENSMUST00000105999; ENSMUSP00000101621; ENSMUSG00000028776.
GeneID94242.
KEGGmmu:94242.
UCSCuc008uyz.2. mouse.

Organism-specific databases

CTD64129.
MGIMGI:2137617. Tinagl1.

Phylogenomic databases

eggNOGNOG310046.
GeneTreeENSGT00730000110701.
HOGENOMHOG000241342.
HOVERGENHBG053961.
InParanoidQ99JR5.
OMADNCNRCT.
OrthoDBEOG7SV0V1.
PhylomeDBQ99JR5.
TreeFamTF313765.

Gene expression databases

ArrayExpressQ99JR5.
BgeeQ99JR5.
CleanExMM_ARG1.
GenevestigatorQ99JR5.

Family and domain databases

InterProIPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTSM00645. Pept_C1. 1 hit.
SM00201. SO. 1 hit.
[Graphical view]
PROSITEPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio352247.
PROQ99JR5.
SOURCESearch...

Entry information

Entry nameTINAL_MOUSE
AccessionPrimary (citable) accession number: Q99JR5
Secondary accession number(s): Q9EQT9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot