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Protein

Glutathione hydrolase 7

Gene

Ggt7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-174403 Glutathione synthesis and recycling
R-MMU-5423646 Aflatoxin activation and detoxification
UniPathwayiUPA00204

Protein family/group databases

MEROPSiT03.017

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 7 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 7 (EC:2.3.2.2)
Short name:
GGT 7
Gamma-glutamyltransferase-like 3
Gamma-glutamyltranspeptidase 7
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt7
Synonyms:Ggtl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913385 Ggt7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini128 – 662ExtracellularSequence analysisAdd BLAST535

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000110681 – 472Glutathione hydrolase 7 heavy chainBy similarityAdd BLAST472
ChainiPRO_0000011069473 – 662Glutathione hydrolase 7 light chainBy similarityAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

MaxQBiQ99JP7
PaxDbiQ99JP7
PeptideAtlasiQ99JP7
PRIDEiQ99JP7

PTM databases

iPTMnetiQ99JP7
PhosphoSitePlusiQ99JP7
SwissPalmiQ99JP7

Expressioni

Gene expression databases

BgeeiENSMUSG00000027603
CleanExiMM_GGT7
ExpressionAtlasiQ99JP7 baseline and differential
GenevisibleiQ99JP7 MM

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A (By similarity).By similarity

Protein-protein interaction databases

IntActiQ99JP7, 1 interactor
MINTiQ99JP7
STRINGi10090.ENSMUSP00000029131

Structurei

3D structure databases

ProteinModelPortaliQ99JP7
SMRiQ99JP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00550000074591
HOGENOMiHOG000231793
HOVERGENiHBG039468
InParanoidiQ99JP7
KOiK00681
OMAiFNVTHDL
OrthoDBiEOG091G030G
TreeFamiTF333329

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF
60 70 80 90 100
LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC
110 120 130 140 150
SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDASSCT
160 170 180 190 200
ALGMEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES
210 220 230 240 250
HLIDFRESAP GALREEALQR SWDTKPGLLV GVPGMVKGLH EAHQLYGRLP
260 270 280 290 300
WSQVLAFAAA VAQDGFNVTH DLAHALAEQL PPNASDRFLD TFLPLGHPPL
310 320 330 340 350
PGSLLRRPDL AEVLDILGTS GPAAFYNGGN LTLEMVAEAQ HAGGVITEED
360 370 380 390 400
FSNYSALTEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS
410 420 430 440 450
REQALHWVAE TLKIALALAS RLGDPVYDST ITESMDDMLS KVEAANFRGH
460 470 480 490 500
ISDSQAAPAP LLPVYELDGA PTAAQVLVMG PDDFIVAMVS SLNRPFGSGL
510 520 530 540 550
LTPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP
560 570 580 590 600
AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
610 620 630 640 650
QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNTFIIGVKD
660
PRSPDAAGAT IL
Length:662
Mass (Da):70,251
Last modified:July 27, 2011 - v2
Checksum:iBA7F3413D694F381
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148S → H in AAH05772 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032051 mRNA Translation: BAC27672.1
AL844852 Genomic DNA No translation available.
BC005772 mRNA Translation: AAH05772.1
AF332053 mRNA Translation: AAK56082.1
AF332054 mRNA Translation: AAK56083.1
CCDSiCCDS16949.1
RefSeqiNP_659035.2, NM_144786.2
UniGeneiMm.41757

Genome annotation databases

EnsembliENSMUST00000029131; ENSMUSP00000029131; ENSMUSG00000027603
GeneIDi207182
KEGGimmu:207182
UCSCiuc012chc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGGT7_MOUSE
AccessioniPrimary (citable) accession number: Q99JP7
Secondary accession number(s): A2AQN1, Q91V91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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