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Q99JP7

- GGT7_MOUSE

UniProt

Q99JP7 - GGT7_MOUSE

Protein

Gamma-glutamyltransferase 7

Gene

Ggt7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cleaves glutathione conjugates.By similarity

    Catalytic activityi

    A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
    Glutathione + H2O = L-cysteinylglycine + L-glutamate.

    Pathwayi

    GO - Molecular functioni

    1. gamma-glutamyltransferase activity Source: UniProtKB-EC
    2. glutathione hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutathione biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Hydrolase, Transferase

    Keywords - Biological processi

    Glutathione biosynthesis

    Enzyme and pathway databases

    SABIO-RKQ99JP7.
    UniPathwayiUPA00204.

    Protein family/group databases

    MEROPSiT03.017.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyltransferase 7 (EC:2.3.2.2)
    Short name:
    GGT 7
    Alternative name(s):
    Gamma-glutamyltransferase-like 3
    Gamma-glutamyltranspeptidase 7
    Glutathione hydrolase 7 (EC:3.4.19.13)
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Ggt7
    Synonyms:Ggtl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1913385. Ggt7.

    Subcellular locationi

    Membrane By similarity; Single-pass type II membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Gamma-glutamyltransferase 7 heavy chainBy similarityPRO_0000011068Add
    BLAST
    Chaini473 – 662190Gamma-glutamyltransferase 7 light chainBy similarityPRO_0000011069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ99JP7.
    PaxDbiQ99JP7.
    PRIDEiQ99JP7.

    PTM databases

    PhosphoSiteiQ99JP7.

    Expressioni

    Gene expression databases

    BgeeiQ99JP7.
    CleanExiMM_GGT7.
    GenevestigatoriQ99JP7.

    Interactioni

    Subunit structurei

    Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ99JP7. 1 interaction.
    MINTiMINT-4096072.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99JP7.
    SMRiQ99JP7. Positions 133-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 106106CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini128 – 662535ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei107 – 12721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyltransferase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0405.
    GeneTreeiENSGT00550000074591.
    HOGENOMiHOG000231793.
    HOVERGENiHBG039468.
    InParanoidiA2AQN1.
    KOiK00681.
    OMAiMLVHDIR.
    OrthoDBiEOG7DNNTR.
    TreeFamiTF333329.

    Family and domain databases

    InterProiIPR000101. GGT_peptidase.
    IPR029055. Ntn_hydrolases_N.
    [Graphical view]
    PANTHERiPTHR11686. PTHR11686. 1 hit.
    PfamiPF01019. G_glu_transpept. 1 hit.
    [Graphical view]
    PRINTSiPR01210. GGTRANSPTASE.
    SUPFAMiSSF56235. SSF56235. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99JP7-1 [UniParc]FASTAAdd to Basket

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    MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF    50
    LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC 100
    SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDASSCT 150
    ALGMEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES 200
    HLIDFRESAP GALREEALQR SWDTKPGLLV GVPGMVKGLH EAHQLYGRLP 250
    WSQVLAFAAA VAQDGFNVTH DLAHALAEQL PPNASDRFLD TFLPLGHPPL 300
    PGSLLRRPDL AEVLDILGTS GPAAFYNGGN LTLEMVAEAQ HAGGVITEED 350
    FSNYSALTEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS 400
    REQALHWVAE TLKIALALAS RLGDPVYDST ITESMDDMLS KVEAANFRGH 450
    ISDSQAAPAP LLPVYELDGA PTAAQVLVMG PDDFIVAMVS SLNRPFGSGL 500
    LTPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP 550
    AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL 600
    QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNTFIIGVKD 650
    PRSPDAAGAT IL 662
    Length:662
    Mass (Da):70,251
    Last modified:July 27, 2011 - v2
    Checksum:iBA7F3413D694F381
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481S → H in AAH05772. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032051 mRNA. Translation: BAC27672.1.
    AL844852 Genomic DNA. Translation: CAM18929.1.
    BC005772 mRNA. Translation: AAH05772.1.
    AF332053 mRNA. Translation: AAK56082.1.
    AF332054 mRNA. Translation: AAK56083.1.
    CCDSiCCDS16949.1.
    RefSeqiNP_659035.2. NM_144786.2.
    UniGeneiMm.41757.

    Genome annotation databases

    EnsembliENSMUST00000029131; ENSMUSP00000029131; ENSMUSG00000027603.
    GeneIDi207182.
    KEGGimmu:207182.
    UCSCiuc012chc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032051 mRNA. Translation: BAC27672.1 .
    AL844852 Genomic DNA. Translation: CAM18929.1 .
    BC005772 mRNA. Translation: AAH05772.1 .
    AF332053 mRNA. Translation: AAK56082.1 .
    AF332054 mRNA. Translation: AAK56083.1 .
    CCDSi CCDS16949.1.
    RefSeqi NP_659035.2. NM_144786.2.
    UniGenei Mm.41757.

    3D structure databases

    ProteinModelPortali Q99JP7.
    SMRi Q99JP7. Positions 133-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99JP7. 1 interaction.
    MINTi MINT-4096072.

    Protein family/group databases

    MEROPSi T03.017.

    PTM databases

    PhosphoSitei Q99JP7.

    Proteomic databases

    MaxQBi Q99JP7.
    PaxDbi Q99JP7.
    PRIDEi Q99JP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029131 ; ENSMUSP00000029131 ; ENSMUSG00000027603 .
    GeneIDi 207182.
    KEGGi mmu:207182.
    UCSCi uc012chc.1. mouse.

    Organism-specific databases

    CTDi 2686.
    MGIi MGI:1913385. Ggt7.

    Phylogenomic databases

    eggNOGi COG0405.
    GeneTreei ENSGT00550000074591.
    HOGENOMi HOG000231793.
    HOVERGENi HBG039468.
    InParanoidi A2AQN1.
    KOi K00681.
    OMAi MLVHDIR.
    OrthoDBi EOG7DNNTR.
    TreeFami TF333329.

    Enzyme and pathway databases

    UniPathwayi UPA00204 .
    SABIO-RK Q99JP7.

    Miscellaneous databases

    NextBioi 371879.
    PROi Q99JP7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99JP7.
    CleanExi MM_GGT7.
    Genevestigatori Q99JP7.

    Family and domain databases

    InterProi IPR000101. GGT_peptidase.
    IPR029055. Ntn_hydrolases_N.
    [Graphical view ]
    PANTHERi PTHR11686. PTHR11686. 1 hit.
    Pfami PF01019. G_glu_transpept. 1 hit.
    [Graphical view ]
    PRINTSi PR01210. GGTRANSPTASE.
    SUPFAMi SSF56235. SSF56235. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary cancer.
    4. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 552-662.
      Strain: ILS and ISS.

    Entry informationi

    Entry nameiGGT7_MOUSE
    AccessioniPrimary (citable) accession number: Q99JP7
    Secondary accession number(s): A2AQN1, Q91V91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3