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Protein

Homer protein homolog 3

Gene

Homer3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

  • G-protein coupled glutamate receptor signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 3
Short name:
Homer-3
Gene namesi
Name:Homer3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347359. Homer3.

Subcellular locationi

GO - Cellular componenti

  • basal part of cell Source: MGI
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • plasma membrane Source: MGI
  • postsynaptic density Source: MGI
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910121 – 356Homer protein homolog 3Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99JP6.
PeptideAtlasiQ99JP6.
PRIDEiQ99JP6.

PTM databases

iPTMnetiQ99JP6.
PhosphoSitePlusiQ99JP6.

Expressioni

Tissue specificityi

Expressed in the cerebellum, hippocampus, lung and thymus.

Gene expression databases

BgeeiENSMUSG00000003573.
CleanExiMM_HOMER3.
ExpressionAtlasiQ99JP6. baseline and differential.
GenevisibleiQ99JP6. MM.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Binary interactionsi

WithEntry#Exp.IntActNotes
FAT1Q145172EBI-6272061,EBI-1171918From a different organism.

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI

Protein-protein interaction databases

BioGridi205016. 4 interactors.
IntActiQ99JP6. 3 interactors.
MINTiMINT-3370168.
STRINGi10090.ENSMUSP00000003669.

Structurei

3D structure databases

ProteinModelPortaliQ99JP6.
SMRiQ99JP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 122Sequence analysisAdd BLAST29
Coiled coili191 – 353Sequence analysisAdd BLAST163

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX6. Eukaryota.
ENOG41101PM. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ99JP6.
KOiK15010.
OMAiSEVQWEA.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ99JP6.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99JP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAREQPIF STRAHVFQID PTTKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQQLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGEFTSTG LALASHQVPP SPLVSTNGPG
160 170 180 190 200
EEKLFRSQSA DTPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNQRLA
210 220 230 240 250
GALREANAAA TQWRQQLEVQ RAEAELLRQR VAELEAQVAV EPVRAGEKEA
260 270 280 290 300
TSQSVEQLEA RVQTKDQTLK NQSTGTREAP DTAEREETQQ QVQDLETRNA
310 320 330 340 350
ELEQQLRSME CNLEEARAER ERARAEVGRA AQLLDVRLFE LSELREGLAR

LAEAAP
Length:356
Mass (Da):39,694
Last modified:July 27, 2011 - v2
Checksum:i7E75F910EE1D0F3F
GO
Isoform 2 (identifier: Q99JP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-267: Q → QEIQ

Show »
Length:359
Mass (Da):40,065
Checksum:i10AC783E1D4ADFD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308S → A in AAH05773 (PubMed:15489334).Curated1
Sequence conflicti308S → A in AAC71025 (PubMed:9808458).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009078267Q → QEIQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158553 Genomic DNA. No translation available.
BC005773 mRNA. Translation: AAH05773.1.
AF093261 mRNA. Translation: AAC71025.1.
CCDSiCCDS22363.1. [Q99JP6-1]
CCDS52569.1. [Q99JP6-2]
RefSeqiNP_001139625.1. NM_001146153.1. [Q99JP6-2]
NP_036114.2. NM_011984.2. [Q99JP6-1]
UniGeneiMm.388127.
Mm.440659.

Genome annotation databases

EnsembliENSMUST00000003669; ENSMUSP00000003669; ENSMUSG00000003573. [Q99JP6-2]
ENSMUST00000110124; ENSMUSP00000105751; ENSMUSG00000003573. [Q99JP6-2]
ENSMUST00000140212; ENSMUSP00000117033; ENSMUSG00000003573. [Q99JP6-1]
GeneIDi26558.
KEGGimmu:26558.
UCSCiuc009lzs.2. mouse. [Q99JP6-1]
uc009lzt.2. mouse. [Q99JP6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158553 Genomic DNA. No translation available.
BC005773 mRNA. Translation: AAH05773.1.
AF093261 mRNA. Translation: AAC71025.1.
CCDSiCCDS22363.1. [Q99JP6-1]
CCDS52569.1. [Q99JP6-2]
RefSeqiNP_001139625.1. NM_001146153.1. [Q99JP6-2]
NP_036114.2. NM_011984.2. [Q99JP6-1]
UniGeneiMm.388127.
Mm.440659.

3D structure databases

ProteinModelPortaliQ99JP6.
SMRiQ99JP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205016. 4 interactors.
IntActiQ99JP6. 3 interactors.
MINTiMINT-3370168.
STRINGi10090.ENSMUSP00000003669.

PTM databases

iPTMnetiQ99JP6.
PhosphoSitePlusiQ99JP6.

Proteomic databases

PaxDbiQ99JP6.
PeptideAtlasiQ99JP6.
PRIDEiQ99JP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003669; ENSMUSP00000003669; ENSMUSG00000003573. [Q99JP6-2]
ENSMUST00000110124; ENSMUSP00000105751; ENSMUSG00000003573. [Q99JP6-2]
ENSMUST00000140212; ENSMUSP00000117033; ENSMUSG00000003573. [Q99JP6-1]
GeneIDi26558.
KEGGimmu:26558.
UCSCiuc009lzs.2. mouse. [Q99JP6-1]
uc009lzt.2. mouse. [Q99JP6-2]

Organism-specific databases

CTDi9454.
MGIiMGI:1347359. Homer3.

Phylogenomic databases

eggNOGiENOG410IIX6. Eukaryota.
ENOG41101PM. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ99JP6.
KOiK15010.
OMAiSEVQWEA.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ99JP6.
TreeFamiTF325627.

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiHomer3. mouse.
PROiQ99JP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003573.
CleanExiMM_HOMER3.
ExpressionAtlasiQ99JP6. baseline and differential.
GenevisibleiQ99JP6. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOME3_MOUSE
AccessioniPrimary (citable) accession number: Q99JP6
Secondary accession number(s): D3Z6N9, Q9Z215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.