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Protein

Homer protein homolog 3

Gene

Homer3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • identical protein binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

  • G-protein coupled glutamate receptor signaling pathway Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 3
Short name:
Homer-3
Gene namesi
Name:Homer3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1347359 Homer3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910121 – 356Homer protein homolog 3Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ99JP6
PeptideAtlasiQ99JP6
PRIDEiQ99JP6

PTM databases

iPTMnetiQ99JP6
PhosphoSitePlusiQ99JP6

Expressioni

Tissue specificityi

Expressed in the cerebellum, hippocampus, lung and thymus.

Gene expression databases

BgeeiENSMUSG00000003573
CleanExiMM_HOMER3
ExpressionAtlasiQ99JP6 baseline and differential
GenevisibleiQ99JP6 MM

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Binary interactionsi

WithEntry#Exp.IntActNotes
FAT1Q145172EBI-6272061,EBI-1171918From Homo sapiens.

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • identical protein binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI

Protein-protein interaction databases

BioGridi205016, 9 interactors
IntActiQ99JP6, 8 interactors
MINTiQ99JP6
STRINGi10090.ENSMUSP00000003669

Structurei

3D structure databases

ProteinModelPortaliQ99JP6
SMRiQ99JP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 122Sequence analysisAdd BLAST29
Coiled coili191 – 353Sequence analysisAdd BLAST163

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX6 Eukaryota
ENOG41101PM LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ99JP6
KOiK15010
OMAiQDKTELT
OrthoDBiEOG091G0CQ0
PhylomeDBiQ99JP6
TreeFamiTF325627

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99JP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAREQPIF STRAHVFQID PTTKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQQLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGEFTSTG LALASHQVPP SPLVSTNGPG
160 170 180 190 200
EEKLFRSQSA DTPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNQRLA
210 220 230 240 250
GALREANAAA TQWRQQLEVQ RAEAELLRQR VAELEAQVAV EPVRAGEKEA
260 270 280 290 300
TSQSVEQLEA RVQTKDQTLK NQSTGTREAP DTAEREETQQ QVQDLETRNA
310 320 330 340 350
ELEQQLRSME CNLEEARAER ERARAEVGRA AQLLDVRLFE LSELREGLAR

LAEAAP
Length:356
Mass (Da):39,694
Last modified:July 27, 2011 - v2
Checksum:i7E75F910EE1D0F3F
GO
Isoform 2 (identifier: Q99JP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-267: Q → QEIQ

Show »
Length:359
Mass (Da):40,065
Checksum:i10AC783E1D4ADFD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308S → A in AAH05773 (PubMed:15489334).Curated1
Sequence conflicti308S → A in AAC71025 (PubMed:9808458).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009078267Q → QEIQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158553 Genomic DNA No translation available.
BC005773 mRNA Translation: AAH05773.1
AF093261 mRNA Translation: AAC71025.1
CCDSiCCDS22363.1 [Q99JP6-1]
CCDS52569.1 [Q99JP6-2]
RefSeqiNP_001139625.1, NM_001146153.1 [Q99JP6-2]
NP_036114.2, NM_011984.2 [Q99JP6-1]
UniGeneiMm.388127
Mm.440659

Genome annotation databases

EnsembliENSMUST00000003669; ENSMUSP00000003669; ENSMUSG00000003573 [Q99JP6-2]
ENSMUST00000110124; ENSMUSP00000105751; ENSMUSG00000003573 [Q99JP6-2]
ENSMUST00000140212; ENSMUSP00000117033; ENSMUSG00000003573 [Q99JP6-1]
GeneIDi26558
KEGGimmu:26558
UCSCiuc009lzs.2 mouse [Q99JP6-1]
uc009lzt.2 mouse [Q99JP6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHOME3_MOUSE
AccessioniPrimary (citable) accession number: Q99JP6
Secondary accession number(s): D3Z6N9, Q9Z215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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