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Protein

Anaphase-promoting complex subunit CDC26

Gene

Cdc26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-MMU-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-MMU-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-MMU-176412. Phosphorylation of the APC/C.
R-MMU-179409. APC-Cdc20 mediated degradation of Nek2A.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit CDC26
Alternative name(s):
Cell division cycle protein 26 homolog
Gene namesi
Name:Cdc26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913690. Cdc26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Anaphase-promoting complex subunit CDC26PRO_0000271195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99JP4.
MaxQBiQ99JP4.
PaxDbiQ99JP4.
PeptideAtlasiQ99JP4.
PRIDEiQ99JP4.

PTM databases

iPTMnetiQ99JP4.
PhosphoSiteiQ99JP4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066149.
CleanExiMM_CDC26.
GenevisibleiQ99JP4. MM.

Interactioni

Subunit structurei

V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.By similarity

Protein-protein interaction databases

BioGridi211475. 62 interactions.
IntActiQ99JP4. 65 interactions.
STRINGi10090.ENSMUSP00000081573.

Structurei

3D structure databases

ProteinModelPortaliQ99JP4.
SMRiQ99JP4. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili7 – 3731Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CDC26 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J05U. Eukaryota.
ENOG4111XZ8. LUCA.
GeneTreeiENSGT00390000008457.
HOGENOMiHOG000231545.
HOVERGENiHBG057346.
InParanoidiQ99JP4.
KOiK03359.
OMAiQFGNFEF.
OrthoDBiEOG091G02GH.
PhylomeDBiQ99JP4.
TreeFamiTF101057.

Family and domain databases

InterProiIPR018860. APC_suCDC26.
[Graphical view]
PfamiPF10471. ANAPC_CDC26. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99JP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPTRLE LKLDDIEEFE SIRKDLEARK KQKEDVEGVG TSDGEGAAGL
60 70 80
SSDPKSREQM INDRIGYKPQ LKSNNRTSQF GNFEF
Length:85
Mass (Da):9,761
Last modified:June 1, 2001 - v1
Checksum:iB70B307E7930C9EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012627 mRNA. Translation: BAC25372.1.
BC005775 mRNA. Translation: AAH05775.1.
BC114350 mRNA. Translation: AAI14351.1.
CCDSiCCDS38774.1.
RefSeqiNP_647452.1. NM_139291.3.
XP_006538236.1. XM_006538173.2.
UniGeneiMm.109930.
Mm.487307.

Genome annotation databases

EnsembliENSMUST00000084525; ENSMUSP00000081573; ENSMUSG00000066149.
ENSMUST00000107459; ENSMUSP00000103083; ENSMUSG00000066149.
ENSMUST00000134727; ENSMUSP00000120496; ENSMUSG00000066149.
GeneIDi66440.
KEGGimmu:66440.
UCSCiuc008teq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012627 mRNA. Translation: BAC25372.1.
BC005775 mRNA. Translation: AAH05775.1.
BC114350 mRNA. Translation: AAI14351.1.
CCDSiCCDS38774.1.
RefSeqiNP_647452.1. NM_139291.3.
XP_006538236.1. XM_006538173.2.
UniGeneiMm.109930.
Mm.487307.

3D structure databases

ProteinModelPortaliQ99JP4.
SMRiQ99JP4. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211475. 62 interactions.
IntActiQ99JP4. 65 interactions.
STRINGi10090.ENSMUSP00000081573.

PTM databases

iPTMnetiQ99JP4.
PhosphoSiteiQ99JP4.

Proteomic databases

EPDiQ99JP4.
MaxQBiQ99JP4.
PaxDbiQ99JP4.
PeptideAtlasiQ99JP4.
PRIDEiQ99JP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084525; ENSMUSP00000081573; ENSMUSG00000066149.
ENSMUST00000107459; ENSMUSP00000103083; ENSMUSG00000066149.
ENSMUST00000134727; ENSMUSP00000120496; ENSMUSG00000066149.
GeneIDi66440.
KEGGimmu:66440.
UCSCiuc008teq.1. mouse.

Organism-specific databases

CTDi246184.
MGIiMGI:1913690. Cdc26.

Phylogenomic databases

eggNOGiENOG410J05U. Eukaryota.
ENOG4111XZ8. LUCA.
GeneTreeiENSGT00390000008457.
HOGENOMiHOG000231545.
HOVERGENiHBG057346.
InParanoidiQ99JP4.
KOiK03359.
OMAiQFGNFEF.
OrthoDBiEOG091G02GH.
PhylomeDBiQ99JP4.
TreeFamiTF101057.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-MMU-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-MMU-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-MMU-176412. Phosphorylation of the APC/C.
R-MMU-179409. APC-Cdc20 mediated degradation of Nek2A.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

ChiTaRSiCdc26. mouse.
PROiQ99JP4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066149.
CleanExiMM_CDC26.
GenevisibleiQ99JP4. MM.

Family and domain databases

InterProiIPR018860. APC_suCDC26.
[Graphical view]
PfamiPF10471. ANAPC_CDC26. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC26_MOUSE
AccessioniPrimary (citable) accession number: Q99JP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.